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| 1 | Magnetic resonance imaging in rectal cancer:A surgeon's perspective显示文摘Magnetic resonance imaging(MRI)in rectal cancer was first investigated in 1999 and has become almost mandatory in planning rectal cancer treatment.MRI has a high accuracy in predicting circumferential resection margin involvement and is used to plan neoadjuvant therapy.The accuracy of MRI in assessing mesorectal lymph nodes remains moderate,as there are no reliable criteria to assess nodal involvement.MRI seems to be good in assessing peritoneal involvement in upper rectal cancer;this however has been assessed in only a few studies and needs further research.For low rectal cancers,mesorectum is thin at the level of levator ani especially in relation to prostate;so predicting circumferential resection margin involvement is not easy.However high spatial resolution coronal imaging shows levator muscles,sphincter complex and intersphincteric plane accurately.This is used to stage low rectal tumors and plan plane of surgery(standard surgery,intersphincteric resection,Extralevator abdominoperineal resection).While most centres perform MRI post chemoradiotherapy,its role in accurate staging post neoadjuvant therapy remains debatable.THe role of Diffusion weighted MRI post neoadjuvant therapy is being evaluated in research settings. | Avanish P Saklani Sung Uk Bae Amy Clayton Nam Kyu Kim | 2014 | World Journal of Gastroenterology2014，20，8： | 11 |
| 2 | Role of stem cell therapies in treating chronic wounds:A systematic review显示文摘BACKGROUND The impairment of cutaneous wound healing results in chronic,non-healing wounds that are caused by altered wound environment oxygenation,tissue injury,and permissive microbial growth.Current modalities for the treatment of these wounds inadequately address the complex changes involved in chronic wound pathogenesis.Consequently,stem cell therapies have emerged as a potential therapeutic modality to promote cutaneous regeneration through trophic and paracrine activity.AIM To investigate current literature regarding use of stem cell therapies for the clinical treatment of chronic,non-healing wounds.METHODS PubMed,EMBASE,Cochrane Library,Web of Science,and Scopus were queried with combinations of the search terms“mesenchymal stem cells,”“adult stem cells,”“embryonic stem cells,”“erythroid precursor cells,”“stem cell therapies,”and“chronic wounds”in order to find relevant articles published between the years of 2000 and 2019 to review a 20-year experience.Reference lists from the articles were reviewed to identify additional pertinent articles.Retrieved manuscripts(reviews,case reports/series,retrospective/prospective studies,and clinical trials)were evaluated by the authors for their depiction of clinical stem cell therapy use.Data were extracted from the articles using a standardized collection tool.RESULTS A total of 43 articles describing the use of stem cell therapies for the treatment of chronic wounds were included in this review.While stem cell therapies have been explored in in vitro and in vivo applications in the past,recent efforts are geared towards assessing their clinical role.A review of the literature revealed that adipose-derived stem cells,bone marrow-derived stem cells,bone marrowderived mononuclear cells,epidermally-derived mesenchymal stem cells,fibroblast stem cells,keratinocyte stem cells,placental mesenchymal stem cells,and umbilical cord mesenchymal stem cells have all been employed in the treatment of chronic wounds of various etiologies.Most recently,embryonic stem cells have emerged as a novel stem cell therapy with the capacity for multifaceted germ cell layer differentiation.With the capacity for self-renewal and differentiation,stem cells can enrich existing cell populations in chronic wounds in order to overcome barriers impeding the progression of wound healing.Further,stem cell therapies can be utilized to augment cell engraftment,signaling and activity,and resultant patient outcomes.CONCLUSION Assessing observed clinical outcomes,potential for stem cell use,and relevant therapeutic challenges allows wound care stakeholders to make informed decisions regarding optimal treatment approaches for their patients’chronic wounds. | Anjali C Raghuram Roy P Yu Andrea Y Lo Cynthia J Sung Melissa Bircan Holly J Thompson Alex K Wong | 2020 | World Journal of Stem Cells2020，12，7： | 5 |
| 3 | Mitochondrial H2O2 generated from electron transport chain complex I stimulates muscle differentiation显示文摘Mitochondrial 反应的氧种类(mROS ) 被认为有害到房间。然而,他们的生理的角色一直不作为表明调停人是彻底地探索了。这里,我们调查了 mROS 是否从 mitochondrial 电子运输链(mETC ) 产生了复杂我刺激了肌肉区别。我们的结果证明 mROS 的数量被增加并且锰 superoxide dismutase (MnSOD ) 在肌肉区别期间经由 NF-B 激活被导致。指向线粒体的抗氧化剂(MitoQ 和 MitoTEMPOL ) 和指向线粒体的过氧化氢酶减少了没有影响 ATP 的数量的 mROS 数量和压制的肌肉区别。Mitochondrial 改变包括在线粒体的数字和尺寸的 mitochondrial 抄写因素 A 和增加的正式就职,并且功能的激活在肌肉区别期间被观察。特别地,增加了 mETC 建筑群的表示层次我子单元和建筑群的一项更高的活动我比另外的建筑群被观察。毒鱼藤素, mETC 建筑群的一个禁止者我,减少 mitochondrial NADH/NAD+ 比率和 mROS 层次在肌肉区别期间。mROS 铺平的我用小介入 RNA 和毒鱼藤素减少了的建筑群的抑制,压制的肌肉区别,和有伴随物的弄空的 ATP 层次在 glycolysis 增加。从这些结果,我们结束那复杂我导出 | Seonmin Lee Eunyoung Tak Jisun Lee MA Rashid Michael P Murphy Joohun Ha Sung Soo Kim | 2011 | Cell Research2011，21，5： | 4 |
| 4 | Non-planar dynamic modeling for the optical disk drive spindles equipped with an automatic balancer显示文摘 | Chao P C Huang Y D Sung C K | 2003 | Mechanism and Machine Theory2003，38，： | 1 |
| 5 | Numerical and experimental analysis of spray atomization characteristics of a GDI injector 显示文摘 | Sung W P Hyung J K | 2003 | KSME International Journal2003，17，3： | 1 |
| 6 | Methylation and acetylation characteristics of cloned bovine embryos from donor cells treat with 5-aza-2' deoxyeytidine 显示文摘 | Enright B P Sung L Y Chang C C | 2005 | Biol Reprod2005，72，4： | 1 |
| 7 | New briaranes fromthe octocorals Briareum excavatum (Briareidae) andJunceella fragilis ( Ellisellidae) 显示文摘 | Sung P J Lin M R Su Y D | 2008 | Tetrahedron2008，64，11： | 1 |
| 8 | Finding the most vital edges with respect to the number of spanning trees 显示文摘 | TSEN F P SUNG TY YLINM | 1994 | IEEE Trans on Reliability1994，43，4： | 1 |
| 9 | Novel eytotoxic diterpenes, exeavatolides A-E, isolated from the Formosan Gorgonian Briareum excavatrum 显示文摘 | Sheu J Sung P Cheng M | 1998 | J Nat Prod1998，61，： | 1 |
| 10 | Infrared studies of hydrogen bonding in toluene diisocyanate based polyurethanes 显示文摘 | Sung C S P Schneider N S | 1975 | Macromolecules1975，8，1： | 1 |
| 11 | Shift toward T helper 1 cytokines by type II collagen-reactive T cells in patients with Rheumatoid Arthritis显示文摘 | Sung H P Do J M | 2001 | Arthritis Rheum2001，44，： | 1 |
| 12 | Heat integration analysis for an industrial ethylbenzene plant using pinch analysis 显示文摘 | SUNG GEUN Y JEONGSEOK L SUNWON P | 2007 | Applied Thermal Engineering2007，27，56： | 1 |
| 13 | Second Flow Velocity Patterns in a Pulmonary Artery Model with Varying Degrees of Valvular Pulmonic Stenosis: Pulsatile in Vitro Studies 显示文摘 | H W Sung Ajit P Yoganathan | 1990 | J Biomech Eng (SO 148-0731)1990，112，2： | 1 |
| 14 | Specific complex formation between yeast RAD6 and RAD18 proteins: a potential mechanism for targeting RAD6 ubiqui- tin-conjugating activity to DNA damage sites 显示文摘 | Bailly V Lamb J Sung P | 1994 | Genes Dev1994，8，7： | 1 |
| 15 | BriaexcavatinsM-P,four new briarane-related diterpenoids from cul-tured octocoral Briareum excavatum (Briareidae) 显示文摘 | Sung P J Lin M R Hwang T L | 2008 | Chem Pharm Bull2008，56，7： | 1 |
| 16 | Exceptional chemical and thermal stability of zeolitic imidazolate frameworks显示文摘 | Sung Park Kyo Ni Zheng Cete Adrien P Choi Jae Yong Huang Rudan Uribe-Romo Femando J Chae Hee K O'Keeffe Michael Yaghi Omar M | 2006 | Proceedings of the National Academy of Sciences2006，103，10： | 1 |
| 17 | Spectroscopic character- ization of model urea, urethane compound and diam ine extencler for polyurethane-urea显示文摘 | WANG S K SUNG C S P | 2002 | Macromole cules2002，35，2： | 1 |
| 18 | Zerumbone enhances TRAIL-induced apoptosis through the induction of death receptors in human colon cancer cells: evidence for an essential role of reactive oxygen species 显示文摘 | Yodkeeree S Sung B Limtrakul P Aggarwal B B | 2009 | Cancer Res2009，69，16： | 1 |
| 19 | The current move of lithium ion batteries towards the next phase显示文摘 | TAE-HEE K JEONG-SEOK P SUNG K | 2012 | Advanced Energy Materials2012，2，7： | 1 |
| 20 | Finding the most vital edges with respect to the number of spanning trces显示文摘 | Tsen F P Sung T Y Lin M Y | 1994 | IEEE Trans Reliability1994，43，4： | 1 |
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