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| 1 | Passive expansion of sub-maximally dilated transjugular intrahepatic portosystemic shunts and assessment of clinical outcomes显示文摘AIM To assess for passive expansion of sub-maximally dilated transjugular intrahepatic portosystemic shunts(TIPS) and compare outcomes with maximally dilated TIPS.METHODS Polytetrafluoroethylene covered TIPS(Viatorr) from July 2002 to December 2013 were retrospectively reviewed at two hospitals in a single institution. Two hundred and thirty patients had TIPS maximally dilated to 10 mm(m TIPS), while 43 patients who were at increased risk for hepatic encephalopathy(HE), based on clinical evaluation or low pre-TIPS portosystemic gradient(PSG), had 10 mm TIPS sub-maximally dilated to 8 mm(sm TIPS). Group characteristics(age, gender, Model for End-Stage Liver Disease score, post-TIPS PSG and clinical outcomes were compared between groups, including clinical success(ascites or varices), primary patency,primary assisted patency, and severe post-TIPS HE. A subset of fourteen patients with sm TIPS underwent follow-up computed tomography imaging after TIPS creation, and were grouped based on time of imaging(< 6 mo and > 6 mo). Change in diameter and crosssectional area were measured with 3D imaging software to evaluate for passive expansion.RESULTS Patient characteristics were similar between the sm TIPS and m TIPS groups, except for pre-TIPS portosystemic gradient, which was lower in the sm TIPS group(19.4 mm Hg ± 6.8 vs 22.4 mm Hg ± 7.1, P = 0.01). Primary patency and primary assisted patency between sm TIPS and m TIPS was not significantly different(P = 0.64 and 0.55, respectively). Four of the 55 patients(7%) with sm TIPS required TIPS reduction for severe refractory HE, while this occurred in 6 of the 218 patients(3%) with m TIPS(P = 0.12). For the 14 patients with follow-up computed tomography(CT) imaging, the median imaging follow-up was 373 d. There was an increase in median TIPS diameter, median percent diameter change, median area, and median percent area change in patients with CT follow-up greater than 6 mo after TIPS placement compared to follow-up within 6 mo(8.45 mm, 5.58%, 56.04 mm^2, and 11.48%, respectively, P = 0.01).CONCLUSION Passive expansion of sm TIPS does occur but clinical outcomes of sm TIPS and m TIPS were similar. Sub-maximal dilation can prevent complications related to overshunting in select patients. | Michael C Hsu Charles N Weber S William Stavropoulos Timothy W Clark Scott O Trerotola Richard D Shlansky Goldberg Michael C Soulen Gregory J Nadolski | 2017 | World Journal of Hepatology2017，9，12： | 11 |
| 2 | Per-oral endoscopic myotomy for achalasia: An American perspective显示文摘Achalasia is an uncommon esophageal motility disorder characterized by the selective loss of enteric neurons leading to absence of peristalsis and impaired relaxation of the lower esophageal sphincter.Per-oral endoscopic myotomy(POEM) is a novel modality for the treatment of achalasia performed by gastroenterologists and surgeons.It represents a natural orifice transluminal endoscopic surgery(NOTES) approach to Heller myotomy.POEM has the minimal invasiveness of an endoscopic procedure that can duplicate results of the surgical Heller myotomy.POEM is conceptually similar to a surgical myotomy without the inherent external incisions and post-operative care associated with surgery.Initial high success and low complications rates promise a great future for this technique.In fact,POEM has been successfully performed on patients with end-stage achalasia as an initial treatment reserving esophagectomy for those without good response.The volume of POEMs performed worldwide has grown exponentially.In fact,surgeons who have performed Heller myotomy have embraced POEM as the preferred intervention for achalasia.However,the niche of POEM remains to be defined and long term results are awaited.We describe our experience with POEM having performed the first POEM outside of Japan in 2009,the evolution of our technique,and give our perspective on its future. | David Friedel Rani Modayil Shahzad Iqbal James H Grendell Stavros N Stavropoulos | 2013 | World Journal of Gastrointestinal Endoscopy2013，5，9： | 8 |
| 3 | Per-oral endoscopic myotomy:Major advance in achalasia treatment and in endoscopic surgery显示文摘Per-oral endoscopic myotomy(POEM)represents a natural orifice endoscopic surgery(NOTES)approach to laparoscopy Heller myotomy(LHM).POEM is arguably the most successful clinical application of NOTES.The growth of POEM from a single center in 2008 to approximately 60 centers worldwide in 2014 with several thousand procedures having been performed attests to the success of POEM.Initial efficacy,safety and acid reflux data suggest at least equivalence of POEM to LHM,the previous gold standard for achalasia therapy.Adjunctive techniques used in the West include impedance planimetry for real-time intraprocedural luminal assessment and endoscopic suturing for challenging mucosal defect closures during POEM.The impact of POEM extends beyond the realm of esophageal motility disorders as it is rapidly popularizing endoscopic submucosal dissection in the West and spawning offshoots that use the submucosal tunnel technique for a host of new indications ranging from resection of tumors to pyloromyotomy for gastroparesis. | David Friedel Rani Modayil Stavros N Stavropoulos | 2014 | World Journal of Gastroenterology2014，20，47： | 7 |
| 4 | Current applications of endoscopic suturing显示文摘Endoscopic suturing had previously been considered an experimental procedure only performed in a few centers and often by surgeons. Now, however, endoscopic suturing has evolved sufficiently to be easily implemented during procedures and is more commonly used by gastroenterologists. We have employed the Apollo Over Stitch suturing device in a variety of ways including closure of perforations, closure of full thickness defects in the gastrointestinal wall created during endoscopic full thickness resection, closure of mucosotomies during peroral endoscopic myotomy, stent fixation, fistula closure, post endoscopic submucosal dissection, endoscopic mucosal resection and Natural Orifice Transluminal Endoscopic Surgery defect closures, post-bariatric surgery gastrojejunal anastomosis revision and primary sleeve gastroplasty. | Stavros N Stavropoulos Rani Modayil David Friedel | 2015 | World Journal of Gastrointestinal Endoscopy2015，7，8： | 5 |
| 5 | Laparoscopic cholecystectomy: A report from a single center显示文摘瞄准:在 laparoscopic 胆囊炎考察并且评估我们的经验。方法:回顾的分析在从经历了 laparoscopic 胆囊炎的 1220 个病人在一个 13 年的时期(1992-2005 ) 期间收集的数据上被执行。结果:死亡率是 0% 。全面患病率是 5.08%(n = 62 ) ,与从损害产生到胆汁的树和膀胱的动脉的最严肃的复杂并发症。在 23 (1.88%) 案例,胆囊炎不能 laparoscopically 被完成,操作被变换成一个开的过程。尽管病人作为天外科案例被安排,医院停留的平均持续时间是 2.29 d,当有延长医院停留的复杂案例在计算被包括。结论:Laparoscopic 胆囊炎是有病人的有利结果的一种安全、最低限度地侵略的技术。 | Konstantinos Vagenas Stavros N Karamanakos Charalambos Spyropoulos Spyros Panagiotopoulos Menelaos Karanikolas Michalis Stavropoulos | 2006 | World Journal of Gastroenterology2006，12，24： | 5 |
| 6 | The Swiss litho-clast; an ideal intracorporeal lithotripter显示文摘 | Kostakopoulos A Stavropoulos N J Picramenos D | 1995 | Urol Int1995，55，10： | 1 |
| 7 | The swiss litholast:an ideal intracorporeal lithotripter显示文摘 | STAVROPOULOS N J PICRAMENOS D | 1995 | Urol Int1995，55，： | 1 |
| 8 | A functional role for Tsix transcription in blocking Xist RNA accumulation but not in Xchromosome choice 显示文摘 | Stavropoulos N Lu N Lee J T | 2001 | Proc Natl Acad Sci USA2001，98，10： | 1 |
| 9 | Expression pattems of cyclins D1, E and cyclin-dependent kinase inhibitors p21 and p27 in urothelial carcinoma : correlation with other cell-cycle-related proteins (Rb, 163, Ki-67 and PCNA) and clinicopathological features显示文摘 | Ioachim E Michael M Stavropoulos N E | 2004 | Urol Int2004，73，1： | 1 |
| 10 | Value of the prostatic LDH levels in the diagnosis of bacterial prostatitis显示文摘 | Becopoulos T Stavropoulos N Kastriotis J | 1989 | Eur Urol1989，16，3： | 1 |
| 11 | Mini percutaneous nephrolitho- tomy in the treatment of renal and upper ureteral stones : lessons learned from a review of the literature显示文摘 | FETAKIS N STAVROPOULOS M | 2015 | Urol Ann2015，7，2： | 1 |
| 12 | Varicocelein schoolboys显示文摘 | Stavropoulos N E Mihailidis I Hastazeris K | 2002 | Arch Andro2002，48，： | 1 |
| 13 | Numerical modeling of simulated blood flow in idealized composite arterial coronary grafts: Steady state simulations显示文摘 | Politis A K Stavropoulos G P Christolis M N | 2007 | Journal of Biomechanies2007，40，： | 1 |
| 14 | The Swiss litho-clast:an ideal intracorporeal lithotripter显示文摘 | KOSTAKOPOULOS STAVROPOULOS N J PICRAMENOS D | 1995 | Urol Int1995，55，： | 1 |
| 15 | The Swiss lithoclast:an ideal intercorporeal lithotripter显示文摘 | Kostakopulos A Stavropoulos N J Picramenos D | 1995 | Urol Int1995，55，： | 1 |
| 16 | The Swiss lithoclast: an ideal intra-cosporeal lithotriptor显示文摘 | Kostak opoulos A Stavropoulos N J Prcramenos D | 1995 | Urol int1995，55，： | 1 |
| 17 | The Swiss lithoclast:an ideal intracorporeal lithotripter显示文摘 | Kostakopoulos A Stavropoulos N J Piccramenos D | 1995 | Urol Int1995，55，1： | 1 |
| 18 | Expression patterns of cyclins D1, E and cyclin-dependent kinase inhibitors p21 (Waf1/Cip1) and p27 (Kip1) in urothelial carcinoma: correlation with other cell-cycle-related proteins (Rb, p53, Ki-67 and PCNA) and clinicopathological features 显示文摘 | IOACHIM E MICHAEL M STAVROPOULOS N E | 2004 | Urol Int2004，73，1： | 1 |
| 19 | Numerical modeling of simulated blood in idealized composite arterial coronary grafts: steady state simulations显示文摘 | Politis A K Stavropoulos G P Christolis M N | 2007 | Journal of Biomechanies2007，40，： | 1 |
| 20 | A new hybrid genetic algorithm for global optimization显示文摘 | SOTIROPOULOS D G STAVROPOULOS E C VRAHATIS M N | 1997 | Nonlinear Analysis1997，30，7： | 1 |
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