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| 1 | Methylation-dependent loss of RIP3 expression in cancer represses programmed necrosis in response to chemotherapeutics显示文摘交往受体的蛋白质 kinase-3 (RIP3 或 RIPK3 ) 是执行 “ 的细胞的机械的必要部分; programmed”或 “ regulated”坏死。这里,我们证明那规划坏死响应许多化学疗法的代理人被激活并且贡献导致化疗的房间死亡。然而,我们证明那 RIP3 表情经常在化学疗法的死亡期间由于它的 transcriptional 开始地点, MLKL 的这样 RIP3 依赖的激活和下游地规划的坏死附近的 genomic methylation 是在癌症房间的 silenced 大部分被镇压。不过,有 hypomethylating 代理人的治疗恢复 RIP3 表示,并且从而以一种 RIP3 依赖的方式把敏感提升到 chemotherapeutics。RIP3 表示在 85% 乳癌病人与正常织物相比在肿瘤被减少,建议那 RIP3 缺乏断然在肿瘤生长 / 发展期间被选择。因为 hypomethylating 代理人在病人是相当容忍得好的,我们建议病人们可以从收到 hypomethylating 代理人与常规 chemotherapeutics 在治疗以前导致 RIP3 表示有益于的那 RIP3 缺乏的癌症。 | Gi-Bang Koo Michael J Morgan Da-Gyum Lee Woo-Jung Kim Jung-Ho Yoon Ja Seung Koo Seung I1 Kim Soo Jung Kim Mi Kwon Son Soon Still Hong Jean M Mulcahy Levy Daniel A Pollyea Craig T Jordan Pearlly Yan David Frankhouser Deedra Nicolet Kati Maharry Guido Marcucci Kyeong Sook Choi Hyeseong Cho ndrew Thorbum You-Sun Kim | 2015 | Cell Research2015，25，6： | 20 |
| 2 | Elucidation of the ‘Honeycrisp’ pedigree through haplotype analysis with a multi-family integrated SNP linkage map and a large apple (Malus×domestica) pedigree-connected SNP data set显示文摘The apple(Malus×domestica)cultivar Honeycrisp has become important economically and as a breeding parent.An earlier study with SSR markers indicated the original recorded pedigree of‘Honeycrisp’was incorrect and‘Keepsake’was identified as one putative parent,the other being unknown.The objective of this study was to verify‘Keepsake’as a parent and identify and genetically describe the unknown parent and its grandparents.A multi-family based dense and high-quality integrated SNP map was created using the apple 8 K Illumina Infinium SNP array.This map was used alongside a large pedigree-connected data set from the RosBREED project to build extended SNP haplotypes and to identify pedigree relationships.‘Keepsake’was verified as one parent of‘Honeycrisp’and‘Duchess of Oldenburg’and‘Golden Delicious’were identified as grandparents through the unknown parent.Following this finding,siblings of‘Honeycrisp’were identified using the SNP data.Breeding records from several of these siblings suggested that the previously unreported parent is a University of Minnesota selection,MN1627.This selection is no longer available,but now is genetically described through imputed SNP haplotypes.We also present the mosaic grandparental composition of‘Honeycrisp’for each of its 17 chromosome pairs.This new pedigree and genetic information will be useful in future pedigree-based genetic studies to connect‘Honeycrisp’with other cultivars used widely in apple breeding programs.The created SNP linkage map will benefit future research using the data from the Illumina apple 8 and 20 K and Affymetrix 480 K SNP arrays. | Nicholas P Howard Eric van de Weg David S Bedford Cameron P Peace Stijn Vanderzande Matthew D Clark Soon Li Teh Lichun Cai James J Luby | 2017 | Horticulture Research2017，4，1： | 9 |
| 3 | Laparoscopie versus open simple prosta tectomy an evaluation of morbidity显示文摘 | McCullough T C Heldwein F L Soon S J Galiano M Barret E Cathelineau X | 2009 | J Endourol2009，23，： | 1 |
| 4 | Thermoelectric Properties of Bi, Nb Co-substituted CaMn03 at High Temperature显示文摘 | PARK J W KWAK D H SOON S H | 2009 | J Alloys Compds2009，487，： | 1 |
| 5 | Highly textured, magnetic Fe(1+x)S nanorods grown on silicon 显示文摘 | Soon J M Goh L Y Loh K P | 2007 | Appl Phys Lett2007，91，08： | 1 |
| 6 | A novel cooling system to reduce thermally-induced errors of machine tools显示文摘 | DONMEZ M A HAHN M H SOONS J A | 2007 | CIRP Annals-Manufacturing Technology2007，56，1： | 1 |
| 7 | Giant single coronary system with coronary cameral fistula diagnosed on MSCT显示文摘 | Soon KH Selvanayagam J Bell KW | 2006 | Int J Cardiol2006，106，2： | 1 |
| 8 | Aquaculture farm food safety and diseases risk assessment ( AquaFRAM ) : development of a spreadsheet tool for salmon farms 显示文摘 | Soon J M Baines R N | 2012 | Aquacult Eng2012，49，： | 1 |
| 9 | Giant single coronary system with coronary cameral fistula diagnosed on MSCT 显示文摘 | Soon KH Selvanayagam J Bell KW | 2006 | Int J Cardiol2006，106，2： | 1 |
| 10 | Selective catalytic reduction of nitrogen oxides with NH3 over natural manganese ore at low temperature显示文摘 | Tae S P Soon K J Sung H H | 2001 | Industrial Engineering Chemical Research2001，40，21： | 1 |
| 11 | Pitch alteration technique in speech synthesis system显示文摘 | Jong soon J Jeong Jin K Myung Jin B | 2001 | IEEE Transactions on Consumer Electronics2001，47，1： | 1 |
| 12 | Molecular mimicry regulates ABA signaling by SnRK2 kinases and PP2C phosphatases显示文摘 | Soon F F Ng L M Zhou X E West G M Kovach A Tan M H Suino-Powell K M He Y Xu Y Chalmers M J Brunzelle J S Zhang H Yang H Jiang H Li J Yong E L Cutler S Zhu J K Griffin P R Melcher K Xu H E | 2012 | Science2012，335，6064： | 1 |
| 13 | Non-random seed abscission, long-distance wind dispersal and plant migration rates显示文摘 | Soons M B Bullock J M | 2008 | Journal of Ecology2008，96，： | 1 |
| 14 | Molecular Mimicry Regulates ABA Signaling by SnRK2 Kinases and PP2C Phosphatases显示文摘 | Soon F F Ng L M Zhou X E West G M Kovach A Tan M H Suino-Powell KM He Y Xu Y Chalmers MJ Brunzelle JS Zhang H Yang H Jiang H Li J Yong EL Cutler S Zhu JK Griffin PR Melcher K Xu HE | 2012 | Science2012，335，6064： | 1 |
| 15 | Sustainable utilization of oil shale resources and comparison of contemporary technologies used for oil shale processing显示文摘 | Soone J Doilov S | 2003 | OilShale2003，20，3： | 1 |
| 16 | Effects of coexisting hydrocarbons on hydrogen permeation through a palladium membrane显示文摘 | Soon H J Katsuki K Shigeharu M | 2000 | J Membr Sci2000，170，1： | 1 |
| 17 | Echogenicity of breast cancer:is it of prognostic value显示文摘 | Soon PS Vallentine J Palmer A | 2004 | Breast2004，13，3： | 1 |
| 18 | Selective catalytic reduction of nitrogen oxides with NH3 over natural manganese ore at low temperature 显示文摘 | Tae S P Soon K J Sung H H | 2001 | Industrial and Engineering Chemistry Research2001，40，： | 1 |
| 19 | Highly efficient single-layer phosphorescent white organic light-emitting diodes using a spirofluorene-based host material 显示文摘 | Soon 0 J Kyoung S Y Chul W J | 2009 | Op-tics Letters2009，34，4： | 1 |
| 20 | Microstructural evo- lution and mechanical properties of low alloy ste~l tem- pered by induction heating 显示文摘 | SOON T A DAE S K WON J N | 2005 | Materials processing Technology2005，160，： | 1 |
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