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| 1 | Inflammatory bowel disease-related colorectal cancer:Past,present and future perspectives显示文摘Inflammatory bowel disease-related colorectal cancer(IBD-CRC)is one of the most serious complications of IBD contributing to significant mortality in this cohort of patients.IBD is often associated with diet and lifestyle-related gut microbial dysbiosis,the interaction of genetic and environmental factors,leading to chronic gut inflammation.According to the“common ground hypothesis”,microbial dysbiosis and intestinal barrier impairment are at the core of the chronic inflammatory process associated with IBD-CRC.Among the many underlying factors known to increase the risk of IBD-CRC,perhaps the most important factor is chronic persistent inflammation.The persistent inflammation in the colon results in increased proliferation of cells necessary for repair but this also increases the risk of dysplastic changes due to chromosomal and microsatellite instability.Multiple pathways have been identified,regulated by many positive and negative factors involved in the development of cancer,which in this case follows the‘inflammation-dysplasia-carcinoma’sequence.Strategies to lower this risk are extremely important to reduce morbidity and mortality due to IBD-CRC,among which colonoscopic surveillance is the most widely accepted and implemented modality,forming part of many national and international guidelines.However,the effectiveness of surveillance in IBD has been a topic of much debate in recent years for multiple reasons—cost-benefit to health systems,resource requirements,and also because of studies showing conflicting long-term data.Our review provides a comprehensive overview of past,present,and future perspectives of IBD-CRC.We explore and analyse evidence from studies over decades and current best practices followed globally.In the future directions section,we cover emerging novel endoscopic techniques and artificial intelligence that could play an important role in managing the risk of IBD-CRC. | Snehali Majumder Uday Nagesh Shivaji Rangarajan Kasturi Alben Sigamani Subrata Ghosh Marietta Iacucci | 2022 | World Journal of Gastrointestinal Oncology2022，14，3： | 5 |
| 2 | 局限期小细胞肺癌化疗联合加速超分割放疗疗效初步分析显示文摘背景与目的:局限期小细胞肺癌(small cell lung cancer,SCLC)对放疗和化疗均敏感。放疗可提高局限期SCLC患者总生存率,降低局部复发率。本研究总结在化疗基础上应用加速超分割放射治疗(hyperfractionated accelerated radiotherapy,HART)对局限期SCLC的疗效,评价相关治疗毒性,归纳治疗失败方式。方法:55例局限期SCLC患者经过EP方案诱导化疗,放疗后再以EP方案巩固化疗,完全缓解(complete remission,CR)者行预防性全脑照射(prophylactic cranial irradiation,PCI)。治疗结束后对患者进行随访,并评价其疗效及毒副作用。结果:55例患者放化疗结束时总有效率(CR+PR)为87.3%。1、3、5年总生存率分别为79.1%、40.3%、16.1%,中位生存时间18.7个月。Ⅲ度和Ⅳ度血液学毒性分别为23例(41.8%)和16例(29.1%);Ⅰ度和Ⅱ度急性放射性肺炎分别为21例(38.2%)和2例(3.6%),Ⅰ度和Ⅱ度放射性食管炎分别为29例(52.7%)和12例(21.8%),未发生Ⅲ~Ⅳ度非血液学毒性。11例(20.0%)患者出现Ⅰ度肺纤维化,5例(9.1%)为Ⅱ度。2例(3.6%)发生Ⅰ度后期食管损伤。16例(29.1%)局部/区域复发,21例(38.2%)发生远处转移。结论:EP方案化疗合并HART治疗局限期SCLC毒性轻至中度,患者可以耐受。局部复发和远处转移为主要治疗失败原因。 | 胡晓 包勇 陈媛媛 高剑铭 王卫华 刘源 何瀚 孙宗文 Shivaji Poudel 王彦 庄婷婷 张力 陈明 | 2008 | 癌症2008，27，10： | 4 |
| 3 | 葡萄糖调节蛋白前体GRP78和肿瘤排斥抗原GP96为仓鼠附睾头部精子特有显示文摘哺乳动物睾丸中的精子经过“附睾成熟”期,由静止状态转变成为运动状态。该过程中精子从附睾头部向附睾尾部移动,同时精子发生了一系列的形态、生理和生化改变,如蛋白组成和蛋白修饰的改变可能会影响精子获能的潜能。本实验使用基质辅助激光解吸/电离串联质谱(MALDI-MS/MS)法分析仓鼠睾丸头部和尾部精子的蛋白组学,成功发现了113个蛋白质点。对113个蛋白质点进一步对照比较发现30个蛋白质点(对应20个蛋白)的密度发生了显著改变,其中附睾尾部精子5个蛋白的密度增加,11个蛋白密度减少;此外,葡萄糖调节蛋白前体GRP78和肿瘤排斥抗原GP96为仓鼠附睾头部精子特有,而纤维蛋白原样蛋白1为附睾尾部精子所特有。几个蛋白密度增加可能与附睾成熟过程中精子代谢和ATP产生相关。一些蛋白如ERp57,GRP78,GP96,Hsp60,Hsp70和二氢硫辛酰胺S-乙酰转移酶的密度改变通过免疫印迹法得到验证。本研究首次报道了仓鼠精子的蛋白质组学研究,全面展示了仓鼠精子附睾成熟过程中的蛋白结构改变。 | Duvvuri Butchi Kameshwari Satish Bhande Curam Sreenivasacharlu Sundaram Venkatesh Kota Archana B. Siva Sisinthy Shivaji | 2010 | Asian Journal of Andrology2010，12，3： | 3 |
| 4 | Lithium bromide catalyzed solvent free method for synthesis of 2-substituted benzimidazoles and imidazopyridines显示文摘The first successful lithium bromide mediated solvent free condensation of arylenediamine and esters to obtain 2-substituted benzimidazole and imidazopyridine in good to excellent yields is described. | Deepak V.Dekhane Shivaji S.Pawar Sunil V.Gupta Murlidhar S.Shingare Shivaji N.Thore | 2010 | Chinese Chemical Letters2010，21，5： | 3 |
| 5 | Glyoxylic acid as catalyst:A simple selective synthesis of 1,2-disubstituted benzimidazoles in aqueous media显示文摘Glyoxylic 酸(5 mol%) 从大量代替的 o-phenylenediamines 和各种各样的代替的醛为 2-aryl-1-arylmethyl-1H-benzimidazoles 的合成作为新奇高度水溶性的催化剂表现在对优秀孤立的收益好(85 鈥 ?5%) 在周围的温度把水用作溶剂。这个方法提供的显著优点是容易并且便宜可得到的催化剂,简单过程,温和条件,快得多(20 鈥 ? 0 min ) 反应和产品的优秀收益。 | Shivaji S.Pawar Deepak V.Dekhane Murlidhar S.Shingare Shivaji N.Thore | 2008 | Chinese Chemical Letters2008，19，9： | 2 |
| 6 | Existence results for classes of Laplacian systems with sign-changing weight显示文摘 | Shivaji R | 2007 | Appl Maths Letters2007，20，： | 1 |
| 7 | Logistic equation with the p-Laplacian and constant yield harvesting显示文摘 | ORUGANTI S SHI J SHIVAJI R | 2004 | Abstr Appl A- nal2004，2004，9： | 1 |
| 8 | Diffusive equations withconstant yield harvesting,I:Steady states显示文摘 | Shi J Shivaji R | 2002 | Trans Amer Math Soc2002，354，： | 1 |
| 9 | Nonnegative solutions for a class of nonpositone problems显示文摘 | CASTRO A SHIVAJI R | 1988 | Proc Roy Soc Edinburgh1988，108，34： | 1 |
| 10 | Studies of Mixed Surfactant Solution of Cationic Dimeric(Gemini) Surfactant with Nonionic Surfactant C12E6 in Aqueous Medium显示文摘 | Shivaji S K Rodgers C Palepu R M | 2003 | J Colloid Interface Sci2003，268，2： | 1 |
| 11 | Existence Results for Superlinear Semi-positone BVP's显示文摘 | Anuradha V Hai D D Shivaji R | 1996 | Proc Amer Soc1996，124，： | 1 |
| 12 | Multiple solutions for a dirichlet problem with jumping onlinearities显示文摘 | Shivaji R | 1998 | Math Anal Appl1998，133，： | 1 |
| 13 | Heat Shock Response in Heat Tolerant and Nontolerant Variants of Agros- tis palustris Huds 显示文摘 | PARK S Y SHIVAJI R KRANS J V | 1996 | Plant Physiol1996，111，2： | 1 |
| 14 | Diffusive logistic equation with non-linear boundary conditions显示文摘 | Goddard H J Shivaji R Lee E K | 2011 | Journal of Mathematical Analysis and Applications2011，375，1： | 1 |
| 15 | Multiple positive elliptic boundary solutions for a class value problems显示文摘 | Maya C Shivaji of semilinear R | 1999 | Nonlinear Anal1999，38，： | 1 |
| 16 | Persistence in reaction diffusion models with weak allee effect显示文摘 | Shi J Shivaji R | 2006 | Journal of Mathematical Biology2006，52，6： | 1 |
| 17 | Basic Research Needs for Design of Adsorptive Gas Separation Processes 显示文摘 | Shivaji S | 2006 | Ind Eng Chem Res2006，45，16： | 1 |
| 18 | Bacterial diversity of soil in the vicinity of Pindari glacier,Himalayan mountain ranges,India,using culturable bacteria and soil 16S r RNA gene clones显示文摘 | Shivaji S Pratibha M S Sailaja B | 2011 | Extremophiles2011，15，1： | 1 |
| 19 | Novel,efficient,and green procedure for the synthesis of 1,5-benzodiazepines catalyzed by MgBr_2 in aqueous media显示文摘MgBr_2 performs as a novel catalyst for the synthesis of various 1,5-benzodiazepine derivatives from wide range of substituted ophenylenediamines and various ketones in good to excellent isolated yields(93-98%)using water as solvent at ambient temperature.Several solvents were examined for this reaction;however,in terms of reaction yield and time,water was found to be the optimum solvent.The remarkable advantages offered by this method are easily and inexpensive available catalyst,simple procedure,mild conditions,much faster(40-60 min)reactions and good to excellent yields of products. | Shivaji S.Pawar Murlidhar S.Shingare Shivaji N.Thore | 2009 | Chinese Chemical Letters2009，20，1： | 1 |
| 20 | Toxicological effects of malachite green显示文摘 | Shivaji Srivastava Ranjana Sinha D. Roy | 2003 | Aquatic Toxicology2003，，3： | 1 |
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