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| 1 | 脑缺氧是影响严重颅脑创伤患者短期预后的独立危险因素(英文)显示文摘Background:Brain hypoxia(BH)can aggravate outcome after severe traumatic brain injury(TBI).Whether BH or reduced brain oxygen(Pbto2)is an independent outcome predictor or a marker of disease severity is not fully elucidated.Objective To analyze the relationship between Pbto2,intracranial pressure(ICP),and cerebral perfusion pressure(CPP)and to examine whether BH correlates with worse outcome independently of ICP and CPP.Methods We studied103patients | Oddo M Levine JM Mackenzie L Frangos S Feihl F Kasner SE Katsnelson M Pukenas B Macmurtrie E Maloney-Wilensky E Kofke WA Leroux PD | 2011 | 中华神经外科疾病研究杂志2011，10，5： | 21 |
| 2 | Ultrasound-assessed non-culprit and culprit coronary vessels differ by age and gender显示文摘AIM: To investigate age-and gender-related differences in non-culprit versus culprit coronary vessels assessed with virtual histology intravascular ultrasound (VH-IVUS). METHODS: In 390 patients referred for coronary angiography to a single center (Luzerner Kantonsspital, Switzerland) between May 2007 and January 2011, 691 proximal vessel segments in left anterior descending, circumflex and/or right coronary arteries were imaged by VH-IVUS. Plaque burden and plaque composition(fibrous, fibro-fatty, necrotic core and dense calcium volumes) were analyzed in 3 age tertiles, according to gender and separated for vessels containing non-culprit or culprit lesions. To classify as vessel containing a culprit lesion, the patient had to present with an acute coronary syndrome, and the VH-IVUS had to be performed in a vessel segment containing the culprit lesion according to conventional coronary angiography. RESULTS: In non-culprit vessels the plaque burden increased significantly with aging (in men from 37% ± 12% in the lowest to 46% ± 10% in the highest age tertile, P < 0.001; in women from 30% ± 9% to 40% ± 11%, P < 0.001); men had higher plaque burden than women at any age (P < 0.001 for each of the 3 age tertiles). In culprit vessels of the lowest age tertile, plaque burden was significantly higher than that in non- culprit vessels (in men 48% ± 6%, P < 0.001 as compared to non-culprit vessels; in women 44% ± 18%, P = 0.004 as compared to non-culprit vessels). Plaque burden of culprit vessels did not significantly change during aging (plaque burden in men of the highest age tertile 51% ± 9%, P = 0.523 as compared to lowest age tertile; in women of the highest age tertile 49% ± 8%, P = 0.449 as compared to lowest age tertile). In men, plaque morphology of culprit vessels became increasingly rupture-prone during aging (increasing percentages of necrotic core and dense calcium), whereas plaque morphology in non-culprit vessels was less rupture-prone and remained constant during aging. In women, necrotic core in non-culprit vessels was very low at young age, but increased during aging resulting in a plaque morphology that was very similar to men. Plaque morphology in culprit vessels of young women and men was similar. CONCLUSION: This study provides evidence that age-and gender-related differences in plaque burden and plaque composition significantly depend on whether the vessel contained a non-culprit or culprit lesion. | Andreas W Schoenenberger Nadja Urbanek Stefan Toggweiler Andreas E Stuck Thérèse J Resink Paul Erne | 2013 | World Journal of Cardiology2013，5，3： | 7 |
| 3 | Antioxidant, hepatoprotective and hypolipidemic effects of methanolic root extract of Cassia singueana in rats following acute and chronic carbon tetrachloride intoxication显示文摘Objective: To evaluate in vivo antioxidant and hepatoprotective activities of the methanolic extract of the root of Cassia singueana in rats following acute and chronic carbon tetrachloride intoxication. Methods: Malondialdehyde (MDA), aspartate aminotransferase (AST), alanine aminotransferase (ALT) and bilirubin as indices of liver damage and lipid peroxidation were detected in rats after intraperitoneal administration of extract (5 mg/kg). Results: The liver, kidney and heart showed significant reduction ( P <0.05) in the levels of MDA from (0.18依0.04), (0.23 依0.07) and (0.26依0.10) nmol/mg respectively in the CCl 4 control to (0.15依0.03), (0.17依0.04) and (0.17 依0.07) nmol/mg protein in groups pre-treated with the extract for three days at 5 mg/kg). Similarly, compared to the CCl 4 control, significant reduction ( P<0.05) in serum AST, ALT and bilirubin as well as in level of total cholesterol and MDA with concomitant increase in HDL cholesterol, superoxide dismutase and catalase levels when CCl 4 -intoxicated rats were treated with Cassia singueana root extract for two weeks. Conclusions: These results suggest that methanolic extract of Cassia singueana contain potent antioxidant compounds that can offer significant protection against hepatic and oxidative injuries. | Ottu OJ Atawodi SE Onyike E | 2013 | Asian Pacific Journal of Tropical Medicine2013，6，8： | 5 |
| 4 | Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin显示文摘 | Knowler WC Barrett-Connor E Fowler SE | | 0，，： | 2 |
| 5 | Indocyanine ￡ reen-assist-ed peeling of the retinal internal lim iting mem brane显示文摘 | Burk SE Da M ata AP Snyder M E | 2000 | Ophthalmolo-gy2000，107，： | 1 |
| 6 | The human vitamin D receptor gene(VDR) is localized to region 12cen-ql2 by fluorescent in situ hybridization and radiation hybrid mapping: genetic and physical VDR map显示文摘 | Taymans SE Pack S Pak E | 1999 | J Bone Miner Res1999，14，7： | 1 |
| 7 | Smad4 deficiency in cervical carcinoma cells显示文摘 | Baldus SE Schwarz E Lohrey C | 2005 | Oncogene2005，24，5： | 1 |
| 8 | T regulatory cells and the control of 'allergic disease 显示文摘 | Xystrakis E Boswell SE Hawrylowicz CM | 2006 | Expert Opin Biol Ther2006，6，2： | 1 |
| 9 | Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin显示文摘 | Knowler WC Barrett-Connor E Fowler SE | 2002 | N Engl J Med2002，346，6： | 1 |
| 10 | Small RNA expression and strain specificity in the rat显示文摘 | Linse SE de Wit E de Bruijn E | | 0，，： | 1 |
| 11 | Assessment and management of falls in older people 显示文摘 | Kwan E Straus SE | 2014 | CMAJ2014，186，16： | 1 |
| 12 | Altered lipid metabolism in the presence and absence of extracellular Ca2 + during combined oxygen-glucose deprivation in primary astrocyte cultures 显示文摘 | Haun SE Rosenberger TA | 1995 | J Neurosci R es1995，42，1： | 1 |
| 13 | BMP- induced growth suppression in colon cancer cells is mediated by p21WAF1 stabilization and modulated by RAS/ERK 显示文摘 | Beck SE Jung BH Del Rosario E | 2007 | Cell Signal2007，19，7： | 1 |
| 14 | Aromatase and other steroidogenie genes in endometriosis : translational aspects 显示文摘 | Attar E Bulun SE | 2006 | Hum Reprod Update2006，12，： | 1 |
| 15 | Sarety of high - dose recombinant erythropoietin in a neonatal rat mode! 显示文摘 | McPherson R J Demers E J Juul SE | 2007 | Neonatology2007，91，1： | 1 |
| 16 | A new method of intralesional bleomycin therapy in the treatment of recalcitrant warts显示文摘 | Munn SE Higgins E Marshall M | 1996 | Br-J-Dermato1996，135，6： | 1 |
| 17 | Endogenous plasmacarnitine pool composition and response to erythropoietin treatment in chronic haemodialysis patients显示文摘 | Reuter SE Faull R J Ranieri E | 2009 | Nephrol Dial Transplant2009，24，3： | 1 |
| 18 | Identifying causes of adverse events detected by an automated trigger tool through in-depth analysis显示文摘 | Muething SE Conway PH Kloppenborg E | 2010 | Qual Saf Health Care2010，19，： | 1 |
| 19 | Janus phenomenon : the interre- lated tradeoffs inherent in therapies designed to enhance collateral forma- tion and those designed to inhibit atherogenesis 显示文摘 | Epstein SE Stabile E Kinnaird T | 2004 | Circulation2004，109，23： | 1 |
| 20 | Gender differences in regression of electrocardiographic left ventricular hypertrophy during antihypertensive therapy显示文摘 | Okin PM Gerdts E Kjeldsen SE | | 0，，01： | 1 |
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