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| 1 | Identification of pathologic features associated with “ulcerative colitis-like” Crohn's disease显示文摘AIM: To identify pathologic features associated with this 'ulcerative colitis(UC)-like' subgroup of Crohn's disease(CD).METHODS: Seventeen subjects diagnosed as having UC who underwent proctocolectomy(RPC) from 2003-2007 and subsequently developed CD of the ileal pouch were identified. UC was diagnosed based on preoperative clinical, endoscopic, and pathologic studies. Eighteen patients who underwent RPC for UC within the same time period without subsequently developing CD were randomly selected and used as controls. Pathology reports and histological slides were reviewed for a wide range of gross and microscopic pathological features, as well as extent of disease. The demographics, gross description and histopathology of the resection specimens were reviewed and compared between the two groups. RESULTS: Patients with 'UC-like' CD were on average 13 years younger than those with 'true' UC(P < 0.01). More severe disease in the proximal involved region and active ileitis with/without architectural distortion were observed in 6 of 17(35%) and 7 of 17(41%) 'UC-like' CD cases, respectively, but in none of the 'true' UC cases(P < 0.05). Active appendicitis occurred in 8 of 16(50%) 'UC-like' CD cases but in only two(11%) 'true' UC cases(P < 0.05). Conspicuous lamina propria neutrophils were more specific for 'UClike' CD(76% vs 22%, P < 0.05). In addition, prominent lymphoid aggregates tended to be more common in 'UC-like' CD(P = 0.07). The 'true' UC group contained a greater number of cases with severe activity(78% vs 47%). Therefore, the features more commonly seen in 'UC-like' CD were not due to a more severe disease process. Crohn's granulomas and transmural inflammation in non-ulcerated areas were absent in both groups.CONCLUSION: More severe disease in the proximal involved region, terminal ileum involvement, active appendicitis, and prominent lamina propria neutrophils may be morphological factors associated with 'UC-like' CD. | Samuel D James Paul E Wise Tania Zuluaga-Toro David A Schwartz M Kay Washington Chanjuan Shi | 2014 | World Journal of Gastroenterology2014，20，36： | 4 |
| 2 | Combination of corticosteroids and 5-aminosalicylates or corticosteroids alone for patients with moderate-severe active ulcerative colitis:A global survey of physicians'practice显示文摘AIM To examine treatment decisions of gastroenterologists regarding the choice of prescribing 5-aminosalycilates(5ASA) with corticosteroids(CS) versus corticosteroids alone for patients with active ulcerative colitis(UC). METHODS A cross-sectional questionnaire exploring physicians' attitude toward 5ASA + CS combination therapy vs CS alone was developed and validated. The questionnaire was distributed to gastroenterology experts in twelve countries in five continents. Respondents' agreement with stated treatment choices were assessed by standardized Likert scale. Background professional characteristics of respondents were analyzed for correlation with responses. RESULTS Six hundred and sixty-four questionnaires were distributed and 349 received(52.6% response rate). Of 340 eligible respondents, 221(65%) would continue 5ASA in a patient hospitalized for intravenous CS treatment due to a moderate-severe UC flare, while 108(32%) would stop the 5ASA(P < 0.001), and 11(3%) are undecided. Similarly, 62% would continue 5ASA in an out-patient starting oral CS. However, only 140/340(41%) would proactively start 5ASA in a hospitalized patient not receiving 5ASA before admission. Most(94%) physicians consider the safety profile of 5ASA as very good. Only 52% consider them inexpensive, 35% perceive them to be expensive and 12% are undecided. On multi-variable analysis, less years of practice and perception of a plausible additive mechanistic effect of 5ASA + CS were positively associated with the decision to continue 5ASA with CS. CONCLUSION Despite the absence of data supporting its benefit, most gastroenterologists endorse combination of 5ASA + CS for patients with active moderate-to-severe UC. Randomized controlled trials are needed to assess if 5ASA confer any benefit for these patients. | Shomron Ben-Horin Jane M Andrews Konstantinos H Katsanos Florian Rieder Flavio Steinwurz Konstantinos Karmiris Jae Hee Cheon Gordon William Moran Monica Cesarini Christian D Stone Doron Schwartz Marijana Protic Xavier Roblin Giulia Roda Min-Hu Chen Ofir Har-Noy Charles N Bernstein | 2017 | World Journal of Gastroenterology2017，23，16： | 3 |
| 3 | X-linked myopia:Bornholm eye disease-linkage to DNA markers on the distal part of Xq显示文摘 | Schwartz M Haim M Skarsholm D | 1990 | Clin Genet1990，38，： | 3 |
| 4 | Preparation and comparison of supported gold nanocatalysts on anatase, brookite, rutile, and P25 polymorphs of TiO2 for catalytic oxidation of CO 显示文摘 | Yan Wenfu Chen Bei Mahurin S M Schwartz V Mullins D R Lupini R Andrew Pennycook S J Dai Sheng Overbury S H | 2005 | Journal of Physical Chemistry B2005，109，10： | 1 |
| 5 | A model to predict peach phenology and maturity using meteorolgical variables显示文摘 | Schwartz M D Carbone G J Reighard G L | | 0，，02： | 1 |
| 6 | Is daily mortality asso- ciated specifically with fine particles 显示文摘 | SCHWARTZ J DOCKERY D W NEAS L M | 1996 | Journal of the Air & Waste Man- agement Association1996，46，10： | 1 |
| 7 | Central nervous system control of food intake显示文摘 | Schwartz M W Woods S C Porte D Jr | 2000 | Nature2000，404，： | 1 |
| 8 | Bactere- mic hypocalcemia: A comparison between the calcium levels of bacteremic and nonbacteremic patients with in- fection显示文摘 | ADERKA D SCHWARTZ D DAN M | 1987 | Arch Intern Med1987，147，2： | 1 |
| 9 | Oral cancer risk in relation to sexual history and evidence of human papillomavirus infection显示文摘 | Schwartz S M Daling J R Doody D R | | 0，，21： | 1 |
| 10 | The psychiatric presentations of Wilson's disease显示文摘 | Akil M Schwartz J A Dutchak D | 1991 | J Neuropsychiatry Clin Neurosci1991，3，： | 1 |
| 11 | Disco-vering shared interests u-sing graph analysis显示文摘 | SCHWARTZ M F WOOD D C M | 1993 | Communications of the ACM1993，36，8： | 1 |
| 12 | Reproductive function after conservative surgery and chemotherapy for malignant germ cell tumors of the ovary显示文摘 | TANGIR T ZELTERMAN D M W SCHWARTZ P E | 2003 | Obstet Gynecol2003，101，： | 1 |
| 13 | Diarrheal epidemics in Dhaka,Bangladesh, during three consecutive floods: 1988,1998,and 2004显示文摘 | Schwartz B S Harris J B Khan A I Larocque R C Sack D A Malek M A | 2006 | Am J Trop Med Hyg2006，74，： | 1 |
| 14 | Screening for anthocyanins using high-performance liquid chromatography coupled to electrospray ionization tandem mass spectrometry with precursor- ion analysis, product-ion analysis, common-neutral-loss analysis, and selected reaction monitoring显示文摘 | Tian Q Giusti M M Stoner G D Schwartz S J | 2005 | Journal of Chromatography A2005，1091，12： | 1 |
| 15 | Is daily mortality associated specifically with fine particles? 显示文摘 | SCHWARTZ J DOCKERY D W NEAS L M | 1996 | J Air Waste Manage Assoc1996，46，10： | 1 |
| 16 | Large-scale characterization of HeLa cell nuclear phosphoproteins 显示文摘 | Beausoleil S A Jedrychowski M Schwartz D | 2004 | Proc Natl Acad Sci U S A2004，101，12： | 1 |
| 17 | Preimplantation genetic diagnosis (PGD)for Duc-hennemusculardystrophy (DMD)bytriplexnested PCR显示文摘 | Malcov M Ben-Yosef D Schwartz T | 2005 | Prenat Diagn2005，25，13： | 1 |
| 18 | Accuracy and Significance of Computed Tomographic Scan Assessment of He patic Volume in Patients Undergoing Liver Transplantation 显示文摘 | Schiano T D Bodian C Schwartz M E | 2000 | Transplantation2000，69，4： | 1 |
| 19 | Utility of a lung biopsy for the diagnosis of idiopathic pulmonary fibrosis显示文摘 | Hunninghake G W Zimmerman M B Schwartz D A | 2001 | Am J Respir Crit Care Med2001，164，2： | 1 |
| 20 | Characterization and expression of the structural gene for pullulanase,a maltose-inducible secreted protein of Klebsiella pneumoniae显示文摘 | Michaelis S Chapon C d'Enfert C Pugsley A Schwartz M | | 0，，02： | 1 |
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