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| 1 | Effect of rapamycin on hepatic osteodystrophy in rats with portasystemic shunting显示文摘瞄准:如果与推延的 portasystemic 有关的 T 房间激活通过 RANKL 依赖的小径引起调停骨破折的骨头损失,学习。如果用 rapamycin 的 T 房间抑制将在老鼠免于骨头损失,我们也调查了。方法:推延的 Portasystemic 在男 Sprague-Dawley 老鼠和 rapamycin 被执行 0.1 mg/kg 被管饲法为 15 wk 管理。老鼠收到了 powderized 食物并且补加喂在骨头作文上阻止营养不良的效果。重量获得和生长在推延的动物在外科以后被恢复。在结束,骨头周转和量的骨头组织学的生物化学的参数被估计。T 房间激活,煽动性的 cytokine 生产,和 RANKL 依赖的小径的标记被测量。另外, IGF-1 和性腺机能减退的角色被调查。结果:推延的 Portasystemic 引起了是 RANKL 独立人士的低周转骨质疏松症。包括 IL-1, IL-6 和 TNFalpha,骨头再吞 cytokine 层次没在浆液和 TNFalpha 被增加, RANKL 表示不起来在 PBMC 调整了。推延的 Portasystemic 增加了传播 CD8+T 房间人口。Rapamycin 减少了传播 CD8+T 房间人口,增加了 CD8+CD25+T 规章的房间人口并且改进了骨头周转的所有参数。结论:推延的 portasystemic 引起的骨质疏松症可以被 rapamycin 部分在肝的骨营养不良的老鼠模型改善。 | Schalk W van der Merwe Maria M Conradie Robert Bond Brenda J Olivier Elongo Fritz Martin Nieuwoudt Rhena Delport Tomas Slavik Gert Engelbrecht Del Kahn Enid G Shephard Maritha J Kotze Nico P de Villiers Stephen Hough | 2006 | World Journal of Gastroenterology2006，12，28： | 2 |
| 2 | The anaerobic oxidation of ammonium显示文摘 | Strous M Schalk J Graaf A A | 1998 | FEMS Microbiology Reviews1998，22，5： | 1 |
| 3 | The Wadsworth BCI Research and Development Program: At Home with BCI 显示文摘 | Theresa M Vaughan Dennis J McFarland Gerwin Schalk | 2006 | IEEE Transactions on Neural Systems and Rehabilitation Engineering2006，14，2： | 1 |
| 4 | Prevalence of Act inobacillus pleuropneumoniae,Actinobacillus suis,Haemophiluspara suis,Pasteurella multocida,and Streptococcus suis in representative Ontario swine herds显示文摘 | MACINNES J GOT T SCHALK M LONE A G | 2008 | Can J Vet Res2008，72，3： | 1 |
| 5 | Stress factors that can affect studies of drug metabolish in fish 显示文摘 | Sommer C V Binkowski F P Schalk M A | 1986 | Vet Hum Toxicol1986，28，： | 1 |
| 6 | Piperonylic acid,a selective,mechanism-based inactivator of trans-cinnamate 4-hydroxylase:A new tool to control the flux of metabolites in the phenylpropanoid pathway显示文摘 | Schalk M Cabellohurtado F Pierrel M A | 1998 | Plant Physiol1998，118，： | 1 |
| 7 | Immunohistological patterns of non-neoplastic changes in the thymus in Myasthenia gravis显示文摘 | Thomas Kirchner Berthold Schalke Arthur Melms Thomas Kügelgen Hans Konrad Müller-Hermelink | 1986 | Virchows Archiv B Cell Pathology Including Molecular Pathology1986，，1： | 1 |
| 8 | Anammox bacteria disguised as denitrfiers:nitrate reduc-tion to dinitrogen gas via nitrite and ammonium显示文摘 | Kartal B Kuypers M M M Lavik G Schalk J | | 0，，03： | 1 |
| 9 | The employee - organization relationship: a timely concept in a period of transition 显示文摘 | Shore L M Tetrick L E Taylor M S Coyle - Shapiro J A - M Liden R C McLean - Parks J Morrison E W Porter L W Robinson S L Roehling M V Rousseau D M Schalk R Tsui A S Van Dyne L | 2004 | Research in Personnel and Human Resources Management2004，，23： | 1 |
| 10 | Regulation of the cinnamate 4 bydroxylase (CYP73A1) in Jerusalem artichoke tubers in response to wounding and chemical treatments 显示文摘 | Batard Y Schalk M Pierrel M A | 1997 | Plant Physiology1997，113，3： | 1 |
| 11 | The wadsworth BCI research and development program:at home with BCI显示文摘 | Vaughan T M McFarland D J Schalk G | | 0，，02： | 1 |
| 12 | An apparently new respiratory disease of baby chicks显示文摘 | Schalk A K Hawn M C | 1931 | J Am Vet Med Assoc1931，78，： | 1 |
| 13 | Neurologi- cal multisystem manifestation in multiple symmetric lipomatosis: a clinical and electrophysiological study显示文摘 | Naumann M Schalke B Klopstock T | 1995 | Muscle Nerve1995，18，： | 1 |
| 14 | Metastatic adrenal neuroblastoma in an adult显示文摘 | Schalk E Mohren M Koenigsmann M | 2005 | Onkologie2005，28，67： | 1 |
| 15 | Redirection of cytosolic or plastidic isoprenoid precursors elevates terpene production in plants 显示文摘 | Wu S Schalk M Clark A | 2006 | Nat Biotechnol2006，24，： | 1 |
| 16 | Electrocortico- graphic frequency alteration mapping for extraoperative locali- zation of speech cortex 显示文摘 | WU M WISNESKI K SCHALK G | 2010 | Neurosurgery2010，66，2： | 1 |
| 17 | Asymmetrical effects of justice sensitivity perspectives on prosocial and antisocial behavior显示文摘 | Gollwitzer M Schmitt M Schalke R | 2005 | Social Justice Research2005，18，2： | 1 |
| 18 | An apparently new respiratory disease of baby chicks显示文摘 | Schalk A F Hawn M C | 1931 | J Am Vet Med Assoc1931，78，： | 1 |
| 19 | Piperonylic acid,a selective,mechanism-based inactivator of trans-cinnamate 4-hydroxylase:A new tool to control the flux of metabolites in the phenylpropanoid pathway显示文摘 | Schalk M Cabellohurtado F Pierrel M A | 1998 | Plant Physiol1998，118，： | 1 |
| 20 | Peripheral morphine analgesia in dental surgery显示文摘 | Likar R Sittl R Gragger K Pipam W Blatnig H Breschan C Schalk HV Stein C Schafer M | 1998 | Pain1998，76，： | 1 |
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