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| 1 | Immunoexpression of cyclooxygenase-2 in primary gastric carcinomas and lymph node metastases显示文摘AIM: To evaluate immunoexpression of cyclooxygenase-2 (COX-2) in primary gastric carcinomas and respective lymph node metastases. METHODS: Immunohistochemistry to analyze COX-2 expression was performed on tissue microarray slices obtained from 36 specimens of gastrectomy and satellite lymph nodes from patients with gastric carcinoma. RESULTS: Immunostaining was seen in most cases, and COX-2 expression was higher in lymph node me-tastases than in corresponding primary gastric tumors of intestinal, diffuse and mixed carcinomas, with a statistically signif icant difference in the diffuse histotype (P = 0.0108). CONCLUSION: COX-2 immunoexpression occurs frequently in primary gastric carcinomas, but higher expression of this enzyme is observed in lymph node metastases of the diffuse histotype. | Paulo RC Almeida Francisco VA Ferreira Cássio C Santos Francisco D Rocha-Filho Raul RP Feitosa Esther AA Falco Belise K Cavada Roberto CP Lima-Júnior Ronaldo A Ribeiro | 2012 | World Journal of Gastroenterology2012，18，8： | 14 |
| 2 | Hepatic abscess induced by foreign body:Case report and literature review显示文摘Hepatic abscess due to perforation of the gastrointestinal tract caused by ingested foreign bodies is uncommon. Pre-operative diagnosis is difficult as patients are often unaware of the foreign body ingestion and symptoms and imagiology are usually non-specific. The authors report a case of 62-year-old woman who was admitted with fever and abdominal pain. Further investigation revealed hepatic abscess, without resolution despite antibiotic therapy. A liver abscess resulting from perforation and intra-hepatic migration of a bone coming from the pilorum was diagnosed by surgery. The literature concerning foreign body-induced perforation of the gastrointestinal tract complicated by liver abscess is reviewed. | Sofia A Santos Sara CF Alberto Elsa Cruz Eduardo Pires Tomás Figueira lia Coimbra José Estevez Mário Oliveira Luís Novais Joo R Deus | 2007 | World Journal of Gastroenterology2007，13，9： | 10 |
| 3 | Thiopurine-methyltransferase variants in inflammatory bowel disease:Prevalence and toxicity in Brazilian patients显示文摘AIM:To analyze the prevalence of thiopurine-methyltransferase(TPMT)genotypes and their associationwith drug toxicity in inflammatory bowel disease(IBD)patients from southeastern Brazil.METHODS:A total of 219 consecutive patients with IBD,of which 146 had Crohn’s disease and 73 had ulcerative colitis,regularly seen at the outpatient unit of the Division of Gastroenterology at the University Hospital Pedro Ernesto of the State University of Rio de Janeiro,a tertiary referral center,were enrolled in this study from February 2009 to January 2011.We analyzed the presence of major TPMT genetic variants(TPMT*2,*3A,*3C)in IBD patients by means of a specific allele and RFLP-PCR.Genomic DNA was isolated from peripheral blood leukocytes by proteinase-K/Sodium Dodecyl Sulfate digestion and phenol-chloroform extraction.TPMT*2(C238G),TPMT*3A(G460A/A719G),and TPMT*3C(A719G)genotypes were detected by real-time polymerase chain reaction followed by direct sequencing with specific primers.Clinical data were systematically recorded,and correlated with the genotype results.RESULTS:The distribution of the selected TPMT gene polymorphism TPMT*2(C238G),TPMT*3A(G460A/A719G),and TPMT*3C(A719G)genotypes was 3.6%,5.4%,and 7.7%of the patients,respectively.Among the side effects recorded from patients taking azathioprine,14 patients presented with pancreatitis and/or an elevation of pancreatic enzymes,while 6 patients had liver toxicity,and 2 patients exhibited myelosuppression/neutropenia.TPMT polymorphisms were detected in 37/219 patients(8 heterozygous for*2,11 heterozygous for*3A,and 18 heterozygous for*3C).No homozygotic polymorphisms were found.Despite the prevalence of the TPMT*3C genotype,no differences among the genotype frequencies were significant.Although no association was detected regarding myelotoxicity or hepatotoxicity,a trend towards the elevation of pancreatic enzymes was observed for TPMT*2 and TPMT*3C genotypes.CONCLUSION:The prevalence of TPMT genotypes was high among Brazilian patients.Variants genes*2and*3C may be associated with azathioprine pancreatic toxicity in a IBD southeastern Brazilian population. | Ana Teresa P Carvalho Barbara C Esberard Renata S B Fróes Davy C M Rapozo Ana B Grinman Tatiana A Simo Juliana C V C Santos Antonio José V Carneiro Luis Felipe Ribeiro-Pinto Heitor S P de Souza | 2014 | World Journal of Gastroenterology2014，20，12： | 3 |
| 4 | Personalized medicine in gastric cancer:Where are we andwhere are we going?显示文摘Despite improvements in adjuvant therapies for gastric cancer in recent years, the disease is characterized by high recurrence rates and a dismal prognosis. The major improvement in the treatment of recurrent or metastatic gastric cancer in recent years has been the incorporation of trastuzumab, a monoclonal antibody that inhibits human epidermal growth factor receptor 2(HER2) heterodimerization, after the demonstrated predictive value of the overexpression and/or amplification of this receptor. Beyond HER2, other genetic abnormalities have been identified, and these mutations may be targetable by tyrosine kinase inhibitors or monoclonal antibodies. The demonstration of four distinct molecular subtypes of gastric cancer by the Cancer Genome Atlas study highlight the enormous heterogeneity of the disease and its complex interplay between genetic and epigenetic alterations and provide a roadmap to implement genome-guided personalized therapy in gastric cancer. In the present review, we aim to discuss, from a clinical point of view, the genomic landscape of gastric cancer described in recent studies, the therapeutic insights derived from these findings, and the clinical trials that have been conducted and those in progress that take into account tailored therapies for gastric cancer. | Alexandre A Jácome Anelisa K Coutinho Enaldo M Lima Aline C Andrade JoséSebastião dos Santos | 2016 | World Journal of Gastroenterology2016，22，3： | 2 |
| 5 | Agro- industrial residues as low-price feedstock for diesel- like fuel production by thermal cracking显示文摘 | Santos A L F Martins D U Iha O K | 2010 | Bioresource Technology2010，101，： | 1 |
| 6 | Expression of alpha-hemoglobin stabilizing protein gene during human erythropoiesis显示文摘 | DOS SANTOS C O DUARTE A S SAAD S T | 2004 | Exp Hematol2004，32，2： | 1 |
| 7 | Natural-based plasticizers and biopolymer films: A review 显示文摘 | Vieira M G A da Silva M A dos Santos L O | 2011 | European Polymer Journal2011，47，3： | 1 |
| 8 | Contact endoscopy during microlaryngeal surgery: a new technique for endoscopic examination of the lar-ynx显示文摘 | Andrea M Dias O Santos A | 1995 | Ann Otol Rhinol Laryngol1995，104，5： | 1 |
| 9 | Angiotensin-(1-7) through receptor Mas mediates endothelial nitric oxide synthase activation via Akt-dependent pathways显示文摘 | Sampaio W O Souza dos Santos R A Faria-Silva R | 2007 | Hypertension2007，49，1： | 1 |
| 10 | Rupestris stem pitting associated virus isolates are composed by mixtures of genomic variants which share a highly conserved coat protein 显示文摘 | NOLASCO G SANTOS C PETROVIC N SANTOS M T CORTEZ I FONSECA F BOBEN J PEREIRA A M SEQUEIRA O | 2006 | Archives of Virology2006，151，： | 1 |
| 11 | Relationship between protozoan and metazoan communities and operation and performance parameters in a textile sewage activated sludge system 显示文摘 | Dos Santos L A Ferreira V Pereira M O | 2014 | European Journal of Protistology2014，0，4： | 1 |
| 12 | Effect of heatingand cooling on rheological parameters of edible vegetable oils显示文摘 | SANTOS J C O SANTOS I M G SOUZA A G | 2005 | Journalof Food Engineering2005，67，4： | 1 |
| 13 | Evaluation of autofocus functions in molecular cytogenetic analysis显示文摘 | SANTOS A SOLORZANO C O VAQUERO J J | 1997 | Microscopy1997，188，3： | 1 |
| 14 | A Study on Blowouts in Ultra Deep Waters 显示文摘 | Santos O L A | 2001 | SPE 695302001，，： | 1 |
| 15 | A real-time visualization tool for forest eccsystem management decision support显示文摘 | Falcao A O Santos M P D Borges J G | 2006 | Computers and Electronics in Agriculture2006，53，： | 1 |
| 16 | Pharmaceutical care for patients with persistent asthma: assessment of treatment compliance and use of inhaled medications 显示文摘 | Santos Dde O Martins MC Cipfiano SL Pinto RM Cukier A Stelmaeh R | 2010 | J Brag Pneumo12010，36，1： | 1 |
| 17 | Quali- tative Study of Thixotropy in Gelled Hydrocarbon Fuels 显示文摘 | Santos P H S Carignano M A Campanella O H | 2011 | Engineering Letters2011，19，1： | 1 |
| 18 | Supercritical fluid extraction of phenolic compounds from Eucalyptus globulus Labillbark显示文摘 | SANTOS S A O VILLAVERDE J J SILVA C M | 2012 | The Journal of Supercritical Fluids2012，71，1： | 1 |
| 19 | Auto- matic detection of small lung nodules in 3D CT data using Gaussian mixture models, Tsallis entropy and SVM 显示文摘 | SANTOS A M FILHO A O D C SILVA A C | 2014 | Engineering applications of artificial intelligence2014，，36： | 1 |
| 20 | Electromagnetic Stimulation Combined with Aloe vera Increases Collagen Reorganization in Burn Repair显示文摘 | Sofia Poletti Leticia D. Lucke Fernanda O Bortolazzo Renata M. Acunha Marcos G. Mattos Femanda OG. Gaspi Thiago A. M. Andrade Maria Esmeria C. Amaral Andrea A .Aro Edson R Pimentel Marcelo AM. Esquisatto Fernanda A. S. Mendonga Glaucia M. T. Santos | 2018 | Journal of Pharmacy and Pharmacology2018，6，7： | 1 |
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