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| 1 | Protective effect of naringenin on acetic acid-induced ulcerative colitis in rats显示文摘AIM:To evaluate the ameliorative effect of naringenin(NG)during ulcerative colitis(UC)in rats.METHODS:Rats were treated with three different doses(25,50 and 100 mg/kg per day)of NG and a single dose of mesalazine(MES,300 mg/kg per day)for seven days prior to ulcerative colitis induction by4%acetic acid(AA).Twenty four hours after AA rectal administration,animals were scarified and the colonic tissues were dissected.Colonic mucus content was estimated using Alcian blue dye binding technique.In colon tissues,levels of total glutathione sulphadryls(T-GSH),non-protein sulphadryls(NP-SH)and thiobarbituric acid reactive substances(TBARS)were evaluated.The activities of the antioxidant enzymes,catalase(CAT)and superoxide dismutase(SOD)were measured.Concentrations of nucleic acids(DNA and RNA)and total protein were also estimated in colon tissues.Colonic levels of tumor necrosis factor-(TNF-),interleukin-1(IL-1),interleukin-6(IL-6),prostaglandin E2(PGE2)and nitric oxide(NO)were estimated.In cross section of colitis tissue the histopathological changes were observed.RESULTS:Colonic mucus content was decreased in AA compared to controls(587.09±65.59 mg/kg vs941.78±68.41 mg/kg,P<0.001).AA administration markedly reduced T-GSH(5.25±0.37 nmol/L vs 3.04±0.24 nmol/L,P<0.01),NP-SH(3.16±0.04 nmol/L vs 2.16±0.30 nmol/L,P<0.01),CAT(6.77±0.40 U/mg vs 3.04±0.2 U/mg,P<0.01)and SOD(3.10±0.11U/mg vs 1.77±0.18 U/mg,P<0.01)while TBARS,TNF-,IL-1,IL-6,PGE2 and NO levels(15.09±3.84nmol/L vs 59.90±16.34 nmol/L,P<0.01;113.56±1.91 pg/mg vs 134.24±4.77 pg/mg,P<0.01;209.20±36.38 pg/mg vs 422.19±31.47 pg/mg,P<0.01;250.83±25.09 pg/mg vs 638.58±115.9 pg/mg,P<0.01;248.19±36.98 pg/mg vs 541.74±58.34 pg/mg,P<0.01 and 81.26±2.98 mmol/g vs 101.90±10.73 mmol/g,P<0.001)were increased in colon of rats with UC compared controls respectively.Naringenin supplementation,significantly and dose dependently increased the colonic mucus content.The elevated TBARS levels were significantly decreased(39.35±5.86nmol/L,P<0.05;26.74±3.17 nmol/L,P<0.01 nmol/L and 17.74±2.69 nmol/L,P<0.01)compared to AA(59.90±16.34 nmol/L)group while the decreased levels of T-GSH and NP-SH and activities of CAT and SOD found increased by NG treatments in dose dependent manner.The decreased values of nucleic acids and total protein in AA group were also significantly(P<0.01)increased in all three NG supplemented groupsrespectively.NG pretreatment inhibited the TNF-levels(123.76±3.76 pg/mg,122.62±3.41 pg/mg and121.51±2.61 pg/mg vs 134.24±4.78 pg/mg,P<0.05)compared to AA group,respectively.Interleukins,IL-1 and IL-6 levels were also decreased in NG50+AA(314.37±16.31 pg/mg and 292.58±23.68 pg/mg,P<0.05)and NG100+AA(416.72±49.62 pg/mg and 407.96±43.87 pg/mg,P<0.05)when compared to AA(352.46±8.58 pg/mg and 638.58±115.98pg/mg)group.Similar decrease(P<0.05)was seen in PGE2and NO values when compared to AA group.The group pretreated with MES,as a reference drug,showed significant(P<0.01)protection against the changes induced in colon tissue by AA administration respectively.CONCLUSION:In present study,NG produced antioxidant and anti-inflammatory effects demonstrating protective effect in inflammatory bowel disease. | Salim S Al-Rejaie Hatem M Abuohashish Maher M Al-Enazi Abdullah H Al-Assaf Mihir Y Parmar Mohammed M Ahmed | 2013 | World Journal of Gastroenterology2013，19，34： | 20 |
| 2 | Novel pharmacological therapy in type 2 diabetes mellitus with established cardiovascular disease: Current evidence显示文摘Cardiovascular diseases(CVDs) remain the leading cause of death in the world and in most developed countries. Patients with type 2 diabetes mellitus(T2DM)suffer from both microvascular and macrovascular diseases and therefore have higher rates of morbidity and mortality compared to those without T2DM. If current trends continue, the Center for Disease Control and Prevention estimates that 1 in 3 Americans will have T2DM by year 2050. As a consequence of the controversy surrounding rosiglitazone and the increasing prevalence of diabetes and CVDs, in 2008 the Food and Drug Administration(FDA) established new expectations for the evaluation of new antidiabetic agents, advising for pre and,in some cases, post-marketing data on major cardiovascular events. As a direct consequence, there has been a paradigm shift in new antidiabetic agents that has given birth to the recently published American Diabetes Association/European Association for the Study of Diabetes consensus statement recommending sodium-glucose cotransporter-2 inhibitors(SGLT2i) and glucagon like peptide-1 receptor agonists(GLP-1RA) in patients with T2DM and established CVD. As a result of over a decade of randomized placebo controlled cardiovascular outcome trials, the aforementioned drugs have received FDA approval for risk reduction of cardiovascular(CV) events in patients with T2DM and established CV disease.SGLT2i have been shown to have a stronger benefit in patients with congestiveheart failure and diabetic kidney disease when compared to their GLP-1RA counterparts. These benefits are not withstanding additional considerations such as cost and the multiple FDA Black Box warnings. This topic is currently an emerging research area and this mini-review paper examines the role of these two novel classes of drugs in patients with T2DM with both confirmed, and at risk for, CVD. | Leonardo Pozo Fatimah Bello Andres Suarez Francisco E Ochoa-Martinez Yamely Mendez Chelsea H Chang Salim Surani | 2019 | World Journal of Diabetes2019，10，5： | 2 |
| 3 | New 3-((2′:2',5':2''-terthiophene)-3 '-yl) acrylic acid as active layer for organic fieldeffect transistor显示文摘 | SALIM N T AW K C PENG H | 2008 | Mater Chem Phys2008，111，1： | 1 |
| 4 | Photocatalytic decomposi- tion of perfluorooctanoic acid by iron and niobium co-doped tita- nium dioxide显示文摘 | Estrellan C R Salim C Hinode H | 2010 | J Hazard Mater2010，179，13： | 1 |
| 5 | Economic growth with coal,oil and renewable energy consumption in China:Prospects for fuel substitution显示文摘 | Bloch H Rafiq S Salim R | 2015 | Economic Modelling2015，，44： | 1 |
| 6 | Adaptive Logical Framework for Integrated Flood Management A- long Sarawak River 显示文摘 | POON H PUTUHENA F SAID SALIM B | 2009 | International Journal of Hydro- Climatic Engineering2009，1，1： | 1 |
| 7 | Diagnosis and management of endometrial polyps: a critical review of the literature 显示文摘 | Salim S Won H Nesbitt-Hawes E | 2011 | J Minim Invasive Gynecol2011，18，5： | 1 |
| 8 | Impact of crude oil price volatility on economic activities: An empirical investigation in the Thaie conomy显示文摘 | Ratiq S Salim R Bloch H | 2009 | Resources Policy2009，34，3： | 1 |
| 9 | Liver tumorge- nicity o f trimethylarsine oxide in male Fischer 344 rats - associat ion with oxidative DNA damage and enhanced cell proliferation 显示文摘 | Shen J Wanibuchi H Salim E I | 2003 | Carcinogenesis2003，24，11： | 1 |
| 10 | Analysis and design of pultruded FRP shapes under bending显示文摘 | DAVALOS J F SALIM H A QIAO P | 1996 | Composite Part B: Engineering1996，27，34： | 1 |
| 11 | Virtual Communities of Practice Success Model to Support Knowledge Sharing Behaviour in Health- care Sector显示文摘 | Alali H Salim J | 2013 | Procedia Technology2013，，11： | 1 |
| 12 | Evaluation of selected crop water production functions for an irrigated maize crop显示文摘 | Igbadun H E Tarimo A K Salim B A | 2007 | Agricultural Water Management2007，94，13： | 1 |
| 13 | Comparative study of the ad- sorption on chitosan beads of phthalate esters and their degrada- tion products 显示文摘 | SALIM C J LIU H KENNEDY J F | 2010 | Carbohydrate Polymers2010，81，3： | 1 |
| 14 | Analysis of Sudan Vegetation Dynamics Using NOAA AVHRR NDVI Data from 1982- 1993显示文摘 | Salim H A Chen X Gong J | 2008 | Asian Journal of Earth Sciences2008，1，1： | 1 |
| 15 | Diagnosis andmanagement of endometrial polyps:a critical review of theliterature显示文摘 | Salim S Won H Nesbitt-Hawes E | 2011 | J Minim Invasive Gynecol2011，18，： | 1 |
| 16 | Surgical outcomes of the Ex-PRESS glaucoma filtration device in African American and Caucasian glaucoma patients显示文摘 | Salim S Du H Boonyaleephan S | 2012 | Clin Ophthalmol2012，6，： | 1 |
| 17 | Evaluation of selected crop water production functions for an irrigated maize crop显示文摘 | Igbadun H E Andrew K P R T Salim B A | 2007 | Agricultural Water Man- agement2007，94，3： | 1 |
| 18 | Extended fault-location formulation for power distribution systems显示文摘 | Salim R H Resener M Filomena A D | 2009 | Power Delivery IEEE Trans on Industrial Electronics2009，24，2： | 1 |
| 19 | Comparative study of the adsorption on chitosan beads of phthalate esters and their degradation products显示文摘 | Salim C J Liu H Kennedy J F | 2010 | Carbohydrate Polymers2010，81，3： | 1 |
| 20 | Modeling the impact of ferrihydrite on adsorption-desorption of soil phosphorus 显示文摘 | Wilson G V Rhoton F E Salim H M | 2004 | Soil Sci2004，169，： | 1 |
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