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| 1 | Evaluation of VEGF gene polymorphisms and proliferative diabetic retinopathy in Mexican population显示文摘● AIM: To assess if the included vascular endothelial growth factor(VEGF) polymorphisms rs3025035, rs3025021 and rs2010963 are associated to proliferative retinopathy in a Mexican population with type 2 diabetes mellitus(T2DM).● METHODS: A case-control study was conducted in adult individuals with T2 DM associated to proliferative retinopathy or non-proliferative retinopathy from Oct. 2014 to Jun. 2015 from the Retina Department of the Asociation to Prevent Blindness in Mexico. The selected patients were adults with a diagnosis of T2 DM ≥5y. All subjects had a comprehensive ocular examination and the classification of the retinopathy severity was made considering the Early Treatment Diabetic Retinopathy Study(ETDRS) standardization protocols. Genomic DNA was extracted from whole fresh blood. All samples were genotyped by q PCR for selected VEGF polymorphisms. Hardy-Weinberg equilibrium was calculated by comparing Chi-square values between the expected and the observed values for genotype counts.● RESULTS: In total 142 individuals were enrolled, 71 individuals with T2 DM and associated proliferative retinopathy and 71 individuals with non-proliferative retinopathy. One-sided Fisher's exact test was performed for rs3025021[OR(95% CI)=0.44(0.08-2.2); P=0.25] and rs2010963 [OR(95% CI)=0.63(0.25-1.6); P=0.23]. The minor allelic frequencies obtained were 26% for rs3025021, 10% for rs3025035 and 61% for rs2010963. The pairwise linkage disequilibrium between the three SNP was assessed, and was as follows: rs3025021 vs rs3025035: D'=1.0, r^2=0.1043, P≤0.0001; rs3025021 vs rs2010963: D'=0.442, r^2=0.0446, P=0.149; rs3025035 vs rs2010963: D'=0.505, r^2=0.0214, P=0.142.● CONCLUSION: This is the first analysis involving VEGFA polymorphisms and proliferative diabetic retinopathy in a Mexican population. A major finding of the present study is that none of the polymorphisms studied was significantly associated with proliferative retinopathy. Based on these results, we can infer that different populations have different associations for the same polymorphisms. | Roberto Gonzalez-Salinas Maria C Garcia-Gutierrez Gerardo Garcia-Aguirre Virgilio Morales-Canton Raul Velez-Montoya Vidal R Soberon-Ventura Victoria Gonzalez Rodrigo Lechuga Pablo Garcia-Solis David G Garcia-Gutierrez Marco Vinicio Garcia-Solis Manuel Saenz de Viteri Juan C Solis-S | 2017 | International Journal of Ophthalmology(English edition)2017，10，1： | 12 |
| 2 | Thymic stromal lymphopoietin-mediated extramedullary hematopoiesis promotes allergic inflammation显示文摘 | SIRACUSA M C SAENZ S A WOJNO E D | 2013 | Immunity2013，39，： | 1 |
| 3 | Equivalent models of wind farms by using aggregated wind turbines and equivalent winds显示文摘 | Fernandez L M Garcia C A Saenz J R | 2009 | Energy Conversion and Management2009，50，3： | 1 |
| 4 | Head and spinal cord injury: diagnosis and management 显示文摘 | CHITTIBOINA P CUELLAR SAENZ H NOTARIANNI C | 2012 | Neurol Clin2012，30，1： | 1 |
| 5 | The major genetic determinants of HIV-1control affect HLA class I peptide presentation显示文摘 | International HIV Controllers Study Pereyra F Jia X McLaren P J Telenti A de Bakker P I Walker B D Ripke S Brumme C J Pulit S L Carrington M Kadie C M Carlson J M Heckerman D Graham R R Plenge R M Deeks S G Gianniny L Crawford G Sullivan J Gonzalez E Davies L Camargo A Moore JM Beattie N Gupta S Crenshaw A Burtt N P Guiducci C Gupta N Gao X Qi Y Yuki Y Piechocka-Trocha A Cutrell E Rosenberg R Moss K L Lemay P O'Leary J Schaefer T Verma P Toth I Block B Baker B Rothchild A Lian J Proudfoot J Alvino D M Vine S Addo M M Allen T M Altfeld M Henn M R Le Gall S Streeck H Haas D W Kuritzkes D R Robbins G K Shafer R W Gulick R M Shikuma C M Haubrich R Riddler S Sax P E Daar E S Ribaudo H J Agan B Agarwal S Ahern R L Allen B L Altidor S Altschuler E L Ambardar S Anastos K Anderson B Anderson V Andrady U Antoniskis D Bangsberg D Barbaro D Barrie W Bartczak J Barton S Basden P Basgoz N Bazner S Bellos N C Benson A M Berger J Bernard N F Bernard A M Birch C Bodner S J Bolan R K Boudreaux E T Bradley M Braun J F Brndjar J E Brown S J Brown K Brown S T Burack J Bush LM Cafaro V Campbell O Campbell J Carlson R H Carmichael J K Casey K K Cavacuiti C Celestin G Chambers S T Chez N Chirch L M Cimoch P J Cohen D Cohn LE Conway B Cooper D A Cornelson B Cox D T Cristofano M V Cuchural G Jr Czartoski J L Dahman J M Daly J S Davis B T Davis K Davod S M DeJesus E Dietz C A Dunham E Dunn M E Ellerin T B Eron J J Fangman J J Farel C E Ferlazzo H Fidler S Fleenor-Ford A Frankel R Freedberg K A French N K Fuchs JD Fuller J D Gaberman J Gallant J E Gandhi R T Garcia E Garmon D Gathe J C Jr Gaultier C R Gebre W Gilman F D Gilson I Goepfert P A Gottlieb M S Goulston C Groger R K Gurley T D Haber S Hardwicke R Hardy W D Harrigan P R Hawkins T N Heath S Hecht F M Henry W K Hladek M Hoffman R P Horton J M Hsu R K Huhn G D Hunt P Hupert M J Illeman M L Jaeger H Jellinger R M John M Johnson J A Johnson K L Johnson H Johnson K Joly J Jordan W C Kauffman C A Khanlou H Killian R K Kim A Y Kim D D Kinder C A Kirchner J T Kogelman L Kojic E M Korthuis P T Kurisu W Kwon D S LaMar M Lampiris H Lanzafame M Lederman M M Lee D M Lee J M Lee M J Lee E T Lemoine J Levy J A Llibre J M Liguori M A Little S J Liu A Y Lopez A J Loutfy M R Loy D Mohammed D Y Man A Mansour M K Marconi V C Markowitz M Marques R Martin J N Martin H L Jr Mayer K H McElrath M J McGhee T A McGovern B H McGowan K McIntyre D Mcleod GX Menezes P Mesa G Metroka CE Meyer-Olson D Miller A O Montgomery K Mounzer K C Nagami E H Nagin I Nahass R G Nelson M O Nielsen C Norene D L O'Connor D H Ojikutu B O Okulicz J Oladehin O O Oldfield E C Olender S A Ostrowski M Owen WF Jr Pae E Parsonnet J Pavlatos A M Perlmutter A M Pierce M N Pincus J M Pisani L Price L J Proia L Prokesch R C Pujet H C Ramgopal M Rathod A Rausch M Ravishankar J Rhame F S Richards C S Richman D D Rodes B Rodriguez M Rose R C 3rd Rosenberg E S Rosenthal D Ross P E Rubin D S Rumbaugh E Saenz L Salvaggio M R Sanchez WC Sanjana V M Santiago S Schmidt W Schuitemaker H Sestak P M Shalit P Shay W Shirvani V N Silebi V I Sizemore J M Jr Skolnik P R Sokol-Anderson M Sosman J M Stabile P Stapleton J T Starrett S Stein F Stellbrink H J Sterman FL Stone V E Stone D R Tambussi G Taplitz R A Tedaldi E M Telenti A Theisen W Torres R Tosiello L Tremblay C Tribble M A Trinh P D Tsao A Ueda P Vaccaro A Valadas E Vanig T J Vecino I Vega V M Veikley W Wade B H Walworth C Wanidworanun C Ward D J Warner D A Weber R D Webster D Weis S Wheeler D A White D J Wilkins E Winston A Wlodaver C G van't Wout A Wright D P Yang O O Yurdin D L Zabukovic B W Zachary K C Zeeman B Zhao M | 2010 | Science2010，330，6010： | 1 |
| 6 | Host-specific involve- ment of the HC protein in the long-distance movement of potyvirus- es显示文摘 | Saenz P Salvador B Sim6n-Mateo C | 2002 | Journal of Virology2002，76，4： | 1 |
| 7 | Equivalent models of wind farms by using aggregated wind turbines and equivalent winds显示文摘 | FERNáNDEZ L M GARCíA C A SAENZ J R | 2009 | Energy Conversion and Management2009，50，3： | 1 |
| 8 | Histologic findings of disc, end plate and neural elements after coblation of nucleus pulposus: an experimental nucleoplasty study 显示文摘 | Chen Y C Lee S H Saenz Y | 2003 | Spine2003，3，6： | 1 |
| 9 | Equivalent models of wind farms by using aggregated wind turbines and equivalent winds显示文摘 | FERNANDEZ L M GARCIA C A SAENZ J R | 2009 | Energy Conversion and Management2009，50，3： | 1 |
| 10 | Sister chromatid exchanges,Proliferating rate index,and Micronuclei in biomonitoring of internal exposure to vinyl chloride monomer in plastic industry workers显示文摘 | Sinues B Sanz A Bernal ML Tres A Alcala A Lanuza J Ceballos C and Saenz MA | 1991 | Toxicology and applied pharmacology1991，108，： | 1 |
| 11 | Equivalem models of wind farms by using aggregated wind turbines and equivalent wind显示文摘 | Fernandez L M Garcia C A saenz J R | 2009 | Energy Conversion and Management2009，，50： | 1 |
| 12 | Treatment of terminal peritoneal carcinomatosis by a transducible p53-activating peptide 显示文摘 | SnyderE L Meade B R Saenz C C Dowdy S F | 2004 | PLoS Biol2004，2，： | 1 |
| 13 | Pediatric chestwall Ewing's sarco -ma显示文摘 | SAENZ N C HASS D J MEYER S P | 2000 | J Pediatr Surg2000，35，4： | 1 |
| 14 | Estrogen contributes to structural recovery after a lesion 显示文摘 | Saenz C Dominguez R de Lacalle S | 2006 | Neurosci Lett2006，392，3： | 1 |
| 15 | H2S and volatile fatty acids elimination by biofiltration : Clean - up process for biogas potential use 显示文摘 | D Ramrez - Saenz P B Zarate - Segura C Guerrero - Barajas | 2009 | Journal of Hazardous Materials2009，163，： | 1 |
| 16 | Treatment of terminal peritoneal carcinomatosis by a transducible p53-activating peptide显示文摘 | SNYDER E L MEADE B R SAENZ C C | 2004 | PLos Biol2004，2，2： | 1 |
| 17 | Antihistaminic and antieicosanoid effects of oleanolic and ursolic acid fraction from Helichrysum picardii 显示文摘 | Santos Rosa C Garca Gimenez M D Saenz Rodriguez M T | 2007 | Pharmazie2007，62，6： | 1 |
| 18 | Treatment of termi-nal peritoneal carcinomatosis by a transducible p53-acti~vating peptide显示文摘 | Snyder EL Meade BR Saenz C | 2004 | PLoS Biol2004，2，2： | 1 |
| 19 | Histologic findings of disc, end plate and neural elements after coblation of nucleus pulposus: an experimental nueleoplasty study 显示文摘 | Chen Y C Lee S H Saenz Y | 2003 | Spine J2003，3，6： | 1 |
| 20 | Microencapsulation by spray drying of bioactive compounds from cactus pear ( Opuntia ficus-indica) 显示文摘 | Saenz C Tapia S Ch6vez J | 2009 | Food Chem2009，114，2： | 1 |
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