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| 1 | Tumor necrosis factor-α and interleukin-6 in cirrhotic patients with spontaneous bacterial peritonitis显示文摘AIM:To evaluate the role of tumor necrosis factor-α(TNF-α) and interleukin-6(IL-6) in cirrhotic patients who have hepatic and renal impairment with spontaneous bacterial peritonitis(SBP).METHODS:We prospectively studied 120 cirrhotic patients with SBP and 80 cirrhotic patients with sterile ascitic fluid.They included 144 males and 56 females with ages ranging between 34 and 62 years.The diagnosis of cirrhosis was established by clinical and laboratory criteria that did not require histological confirmation.The severity of underlying liver disease was evaluated using Pugh's modification of Child's criteria(Child-Pugh scores).Ascitic fluid was sent to the laboratory for cell count,culture,sensitivity testing,and measurement of chemical elements(i.e.,albumin,glucose).Specimens were inoculated into aerobic and anaerobic blood culture bottles.Serum and ascitic fluid were also collected in sterile tubes at study entry(before the initiation of antibiotic treatment) and 48 h later.Assays for TNF-α and IL-6 in the serum and ascitic fluid were performed with an immunoenzymometric assay using manufacture's instructions.RESULTS:Cytokine levels in serum and ascitic fluid were significantly higher in the patients with SBP.(plasma TNF-α:135.35 ng/mL ± 11.21 ng/mL vs 92.86 ng/mL ± 17.56 ng/mL,P < 0.001;plasma IL-6:32.30 pg/mL ± 7.07 pg/mL vs 12.11 pg/mL ± 6.53 pg/mL,P < 0.001;ascitic fluid TNF-α:647.54 ± 107.11 ng/mL vs 238.43 ng/mL ± 65.42 ng/mL,P < 0.001);ascitic fluid IL-6:132.84 ng/mL ± 34.13 vs 40.41 ± 12.85 pg/mL,P < 0.001).About 48(40%) cirrhotic patients with SBP developed renal and hepatic impairment and showed significantly higher plasma and ascitic fluid cytokine levels at diagnosis of infection.[(plasma TNF-α:176.58 ± 17.84 vs 135.35 ± 11.21 ng/mL)(P < 0.001) and(IL-6:57.83 ± 7.85 vs 32.30 ± 7.07 pg/mL)(P < 0.001);ascitic fluid TNF-α:958.39 ± 135.72 vs 647.54 ± 107.11 ng/mL,(P < 0.001),ascitic fluid IL-6:654.74 ± 97.43 vs 132.84 ± 34.13 pg/mL,(P < 0.001)].Twenty nine patients(60.4%) with SBP and renal impairment died whereas,only four patients(5.55%) with SBP but without renal impairment died from gastrointestinal hemorrhage(P < 0.0005).CONCLUSION:It appears that TNF-α production may enhance liver cell injury and lead to renal impairment.This correlated well with the poor prognosis and significantly increased mortality associated with SBP in cirrhotic patients. | Muhammed AM Suliman Fawzy MH Khalil Salam SA Alkindi Anil V Pathare Ali AA Almadhani Neveen AAI Soliman | 2012 | World Journal of Gastrointestinal Pathophysiology2012，3，5： | 39 |
| 2 | Compromised HOXA5 function can limit p53 expression in human breast tumors 显示文摘 | Raman V Martensen SA Reisman D | 2000 | Nature2000，405，6789： | 2 |
| 3 | 遗传性肥胖与心房颤动的关系显示文摘观察性研究已经确定了体质量指数(body mass index,BMI)与心房颤动之间的关联。然而,从观察性研究中推断因果关系会受到混杂因素、逆因果关系和偏倚的影响。该研究的主要目的是应用BMI的遗传学预测因子评估BMI与心房颤动之间的因果关系。方法:纳入1987-2002年期间在美国、冰岛和荷兰实施的7个前瞻性人群队列研究中基线无心房颤动的欧洲血统个体51 646人, | 刘莉 叶鹏 Chatterjee NA Giulianini F Geelhoed B Lunetta KL Misialek JR Niemeijer MN Rienstra M Rose LM Smith AV Arking DE Ellinor PT Heeringa J Lin H Lubitz SA Soliman EZ Verweij N Alonso A Benjamin EJ Gudnason V Stricker BH van der Harst P Chasman DI Albert CM | 2017 | 中华高血压杂志2017，25，2： | 2 |
| 4 | Expression of a truncated Pasteurella multocida toxin antigen in Bordetella bronchiseptica显示文摘 | Rajeev S Nair R V Kania SA Bemis D A | 2003 | Vet Microbiol2003，94，4： | 1 |
| 5 | Quantitative real-time RT- PCR-a perspective 显示文摘 | Bustin SA Benes V Nolan T | 2005 | Journal of Molecular Endocrinology2005，34，3： | 1 |
| 6 | Compromised HOXA5 function can limit p53 expression in human breast tumors 显示文摘 | Martensen SA Rekman D | 2000 | Nature2000，405，6789： | 1 |
| 7 | Acute effects of righl ventricular apical pacing on left ventricublr synchrony and mechanics 显示文摘 | Delgado V Tops LF Trines SA el al | 2009 | Circ Arrhythmia Electrophysiol2009，2，： | 1 |
| 8 | Analytical modelling of normal and oblique ballistic impact on ceramic/metal lightweight armours显示文摘 | Zaera R Sa'nchez-Ga'lvez V | 1998 | International Journal of Impact Engineering1998，21，1： | 1 |
| 9 | Testosterone and breast Cancer显示文摘 | Hall SA Araujo AB Kupetian V | 2010 | J Sex Med2010，7，22： | 1 |
| 10 | The mitochondria regulated death pathway mediates asbestos-induced alveolar epithelial cell apoptosis 显示文摘 | Panduri V Weitzman SA Chandel N | 2003 | Am J Respir Cell Mol Biol2003，28，2： | 1 |
| 11 | Lipid pleural effusions 显示文摘 | Agrawal V Sahn SA | 2008 | Am J Med Sci2008，335，1： | 1 |
| 12 | Atorvastatin preferentially reduces LDL-associated platelet-activating factor acetyl- hydrolase activity in dyslipidemias of type IIA and type IIB显示文摘 | Tsimihodimos V Karabina SA Tambaki AP | 2002 | Arterioscler Thromb Vasc Biol2002，22，2： | 1 |
| 13 | Interference alignment and degrees of freedom of the K-user interference channel显示文摘 | Cadambe V R Jafar SA | | 0，，8： | 1 |
| 14 | Diagnosis and laparoscopic management of a rudimentary uterine horn in a teenage girl,presenting with haematometra and severe endometriosis:our experience and review of literature显示文摘 | Liatsikos SA Tsikouras P Souftas V | 2010 | Minim Invasive Ther Allied Technol2010，19，4： | 1 |
| 15 | Fusion to green fluorescent protein improves expression levels of Theileria parva sporozoite surface antigen p67 in insect cells显示文摘 | Kaba SA Neve V Musoke A J | | 0，，： | 1 |
| 16 | Identification of miR-374a as a prognostic marker for survival in patients with early-stage nonsmall cell lung cancer显示文摘 | V(o)sa U Vooder T Kolde R | 2011 | Genes Chromosomes Cancer2011，50，10： | 1 |
| 17 | Medullary thyroid cancer显示文摘 | You YN Lakhani V Wells SA Jr | 2006 | Surg Oncol Clin N Am2006，15，3： | 1 |
| 18 | ACC/AHA guidelines for the martagement of patients with ST-elevation myocardial infarction-executive summary:port of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Revise the 1999 Guidelines for the Management of patients with Acute Myocardial Infarction) 显示文摘 | Antman EM Anbe DT Armstrong PW Bates ER Green LA Hand M Hochman JS Krumholz HM Kushner FG Lamas GA Mullany CJ Ornato JP pearle DL Sloan MA Smith SCJr Alpert JS Anderson JL Faxon DP Fuster V Gibbons RJ Gregoratos G Halperin JL Hiratzka LF Hunt SA Jacobs AK American College of Cardiology American Heart Association Task Force on Practice Guidelines | 2004 | Circulation2004，110，5： | 1 |
| 19 | The mitochondriaregulated death pathway mediates asbestos-induced alveolar epithelial cell apoptosis显示文摘 | Panduri V Weitzman SA Chandel N | 2003 | Am J Respir Cell Mol Biol2003，28，： | 1 |
| 20 | Natural killer cell cytotox- icity: a methods analysis of 51chromium release versus flow cytometry 显示文摘 | Motzer SA Tsuji J Hertig V | 2003 | Biol Res2003，5，： | 1 |
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