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| 1 | Multiplexed activation of endogenous genes by CRISPR-on, an RNA-guided transcriptional activator system显示文摘允许的技术内长的基因的特定的规定为基因功能的学习是珍贵的并且在治疗学有大潜力。我们创造了在 CRISPR 上系统,由核酸酶死者 Cas9 (dCas9 ) 蛋白质组成的二部件的 transcriptional 使活跃之物与互补顺序与 transcriptional 激活域和单个指南 RNA (sgRNAs ) 熔化了到基因倡导者。我们证明在 CRISPR 上能高效地以一种悦耳的方式在人和老鼠房间激活外长的记者基因。另外,我们证明在 vivo 的柔韧的记者基因激活能被把系统部件注入老鼠接合子完成。而且,我们证明在 CRISPR 上能激活内长的 IL1RN, SOX2,和 OCT4 基因。最有效的基因激活被对近似倡导者有约束力的 3-4 sgRNAs 的簇完成,建议他们在基因正式就职的 synergistic 行动。显著地,当指向多重基因的 sgRNAs 同时被介绍进房间时,柔韧的多路的内长的基因激活被完成。染色体宽的表示介绍表明了系统的高特性。 | Albert W Cheng Haoyi Wang Hui Yang Linyu Shi Yarden Katz Thorold W Theunissen Sudharshan Rangarajan Chikdu S Shivalila Daniel B Dadon Rudolf Jaenisch | 2013 | Cell Research2013，23，10： | 65 |
| 2 | Intensive blood pressure reduction in acute cerebral haemorrhage trial (INTERACT): a randomised pilot trial显示文摘 | Craig S Anderson Yining Huang Ji Guang Wang Hisatomi Arima Bruce Neal Bin Peng Emma Heeley Christian Skulina Mark W Parsons Jong Sung Kim Qing Ling Tao Yue Chun Li Jian Dong Jiang Li Wen Tai Jin Li Zhang En Xu Yan Cheng Stephane Heritier Lewis B Morgenste | 2008 | Lancet Neurology2008，，5： | 4 |
| 3 | Projection of the Zhujiang(Pearl) River Delta's potential submerged area due to sea level rise during the 21st century based on CMIP5 simulations显示文摘Projections of potential submerged area due to sea level rise are helpful for improving understanding of the influence of ongoing global warming on coastal areas. The Ensemble Empirical Mode Decomposition method is used to adaptively decompose the sea level time series in order to extract the secular trend component. Then the linear relationship between the global mean sea level(GMSL) change and the Zhujiang(Pearl) River Delta(PRD)sea level change is calculated: an increase of 1.0 m in the GMSL corresponds to a 1.3 m(uncertainty interval from1.25 to 1.46 m) increase in the PRD. Based on this relationship and the GMSL rise projected by the Coupled Model Intercomparison Project Phase 5 under three greenhouse gas emission scenarios(representative concentration pathways, or RCPs, from low to high emission scenarios RCP2.6, RCP4.5, and RCP8.5), the PRD sea level is calculated and projected for the period 2006–2100. By around the year 2050, the PRD sea level will rise 0.29(0.21 to 0.40) m under RCP2.6, 0.31(0.22 to 0.42) m under RCP4.5, and 0.34(0.25 to 0.46) m under RCP8.5, respectively.By 2100, it will rise 0.59(0.36 to 0.88) m, 0.71(0.47 to 1.02) m, and 1.0(0.68 to 1.41) m, respectively. In addition,considering the extreme value of relative sea level due to land subsidence(i.e., 0.20 m) and that obtained from intermonthly variability(i.e., 0.33 m), the PRD sea level will rise 1.94 m by the year 2100 under the RCP8.5scenario with the upper uncertainty level(i.e., 1.41 m). Accordingly, the potential submerged area is 8.57×103 km2 for the PRD, about 1.3 times its present area. | XIA Jiangjiang YAN Zhongwei ZHOU Wen FONG Soi Kun LEONG Ka Cheng TANG Iu Man CHANG S W LEONG W K JIN Shaofei | 2015 | Acta Oceanologica Sinica2015，34，9： | 3 |
| 4 | Genetic transformation of wheat mediated by Agrobacterium tumefaciens显示文摘 | Cheng M Fry J E Pang S Zhou H Hironaka C M Duncan D R Conner T W Wan Y | 1997 | Plant Physiol1997，，： | 2 |
| 5 | Simple passivealignment packaging technique for laser diode modules显示文摘 | Wang S C Chi S Cheng W H | 1998 | Material Chemistry and Physics1998，56，2： | 2 |
| 6 | A MyD88-dependent IFNyR-CCR2 signaling circuit is required for mobilization of monocytes and host defense against systemic bacterial challenge显示文摘 | Eric M Pietras Lloyd S Miller Carl T Johnson Ryan M O'Connell Paul W Dempsey Genhong Cheng | 2011 | Cell Research2011，21，7： | 2 |
| 7 | Effects of the phase-separated melt on crystallization behavior and morphology in short chain branched metallocene polyethylenes显示文摘 | Fu Q Chiu F C McCreight K W Guo M Tseng W W Cheng S Z Keating M Y Hsieh E T and DesLauriers P J | | 0，，： | 2 |
| 8 | Distribution feeder reconfiguration with refined genetic algorithm显示文摘 | Lin M W Cheng F S Tsay M T | 2000 | IEE Proceedings of Generation Transmission and Distribution2000，147，6： | 2 |
| 9 | High corrosion resistance of electroless composite plating coatings on AZ91D magnesium alloys显示文摘 | SONG Y W SHAN D Y CHENG R S | 2008 | Electrochimica Acta2008，53，5： | 1 |
| 10 | The application of competitive hopfield neural network to medical image segmentation显示文摘 | CHENG K S LIN J S MAO C W | 1996 | IEEE T Med Imaging1996，15，4： | 1 |
| 11 | A DNA vaccineagainst Foot-and-mouth disease elicits an immune response in swine which is enhanced by co-admlnistration with interleukln-2显示文摘 | Wong HT Cheng SC S Sin F W Y | 2002 | Vaccine2002，20，： | 1 |
| 12 | Monitoring process mean and variability with one EWMA chart 显示文摘 | Chen G M Cheng S W Xie H S | 2001 | Journal of Quality Technology2001，33，2： | 1 |
| 13 | Acetone extract of Bupleurum scorzonerifolium inhibits proliferation of A549 human lung cancer cells via inducing apoptosis and suppressing telomerase activity 显示文摘 | Cheng Y L Chang W L Lee S C | 2003 | Life Sci2003，73，18： | 1 |
| 14 | Prevalence of Alzheimer's disease and other dementing disorders in an urban community of Beijing, China显示文摘 | Wang W Wu S Cheng X | 2000 | Neuroepidemiology2000，19，4： | 1 |
| 15 | Antioxidant and antimicrobial effects of four garlic- derived organosulfur compounds in ground beef 显示文摘 | YIN M C CHENG W S | 2003 | Meat Science2003，63，1： | 1 |
| 16 | Changes in venous hemody-namics after superficial vein surgery for mixed superficial and deep ve-nous insufficiency显示文摘 | Ting A C Cheng S W Wu L L | 2001 | World J Surg2001，25，2： | 1 |
| 17 | Family Ownership and the Interna- tional Involvement of Taiwan's High -technology Firms: The Moder- ating Effect of High - discretion Organizational Slack 显示文摘 | Liu Y S Lin W T Cheng K Y | 2011 | Manage- ment and Organization Review2011，7，2： | 1 |
| 18 | Effects of temperature, pH, salinity and ammonia on the phagocytic activity and clearance efficiency of giant freshwater prawn Macrobrachium rosenbergii to Lactococcus garvieae 显示文摘 | CHENG W CHEN S M WANG F I | 2003 | Aquaculture2003，219，1： | 1 |
| 19 | Expression of PPAR-gamma in human hilar bile duct carcinoma cell line QBC939 and the effects of PPAR-Y activated by its ligand on the growth of QBC939显示文摘 | CHENG W CHENG N S XIONG X Z | 2006 | Journal of Sichuan University (Med- ical Science Edition)2006，37，5： | 1 |
| 20 | A high-power millimeter-wave sheet beam free-electron laser amplifier显示文摘 | Cheng S Destler W W Granatstein V L | 1996 | IEEE Trans on Plasma Sci1996，24，3： | 1 |
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