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| 1 | Clinical outcomes following salvage Gamma Knife radiosurgery for recurrent glioblastoma显示文摘Glioblastoma multiforme(GBM) is the most common malignant primary brain tumor with a survival prognosis of 14-16 mo for the highest functioning patients. Despite aggressive, multimodal upfront therapies, the majority of GBMs will recur in approximately six months. Salvage therapy options for recurrent GBM(r GBM) are an area of intense research. This study compares recent survival and quality of life outcomes following Gamma Knife radiosurgery(GKRS) salvage therapy. Following a Pub Med search for studies usingGKRS as salvage therapy for malignant gliomas, nine articles from 2005 to July 2013 were identified which evaluated rG BM treatment. In this review, we compare overall survival following diagnosis, overall survival following salvage treatment, progression-free survival, time to recurrence, local tumor control, and adverse radiation effects. This report discusses results for rG BM patient populations alone, not for mixed populations with other tumor histology grades. All nine studies reported median overall survival rates(from diagnosis, range:16.7-33.2 mo; from salvage, range:9-17.9 mo). Three studies identified median progression-free survival(range:4.6-14.9 mo). Two showed median time to recurrence of GBM. Two discussed local tumor control. Six studies reported adverse radiation effects(range:0%-46% of patients). The greatest survival advantages were seen in patients who received GKRS salvage along with other treatments, like resection or bevacizumab, suggesting that appropriately tailored multimodal therapy should be considered with each rG BM patient. However, there needs to be a randomized clinical trial to test GKRS for rG BM before the possibility of selection bias can be dismissed. | Erik W Larson Halloran E Peterson Wayne T Lamoreaux Alexander R MacKay Robert K Fairbanks Jason A Call Jonathan D Carlson Benjamin C Ling John J Demakas Barton S Cooke Christopher M Lee | 2014 | World Journal of Clinical Oncology2014，5，2： | 5 |
| 2 | 百乐锌与氧化锌的比较试验:减少猪饲粮中的锌添加量同时维持猪的生长性能显示文摘猪的饲料原料通常含有适量浓度的锌(Zn)似乎可以满足猪对Zn的需要。研究证实,高浓度饲粮锌能刺激保育猪的生长和改善饲料利用率。但是,近年来养殖业日渐意识到饲粮中高浓度的矿物质会引起环境问题。人们也日益关注使用有机微量元素作为一种减少矿物质添加量和排泄量的方法。Wedekind(1990,1992)的试验表明,与硫酸锌(100%)相比,蛋氨酸锌(Zn—Met)的生物学效价在117%~206%。 | Carlson M S Veum T L 汪静霞 | 2007 | 养猪2007，，3： | 2 |
| 3 | Reversible middle cerebral artery occlusion without craniectomy in rats显示文摘 | Longa E Z WeinsteinP R Carlson S | 1989 | stroke1989，20，1： | 2 |
| 4 | Performance of ILU preconditioning techniques in simulating anisotropic diffusion in the human brain显示文摘 | Kang N Zhang J Carlson E S | 2004 | Future Generation Computer Systems2004，20，4： | 2 |
| 5 | Modeling and control of magnetorheological dampers forseismic response reduction 显示文摘 | DYKE S J SPENCER B F SAIN M K CARLSON J D | 1996 | Smart Materials and Structures1996，5，5： | 2 |
| 6 | Reyersible Middle Cerebral Artery Occlusion without Craniectomy in rats 显示文摘 | Zea Longa EL Weinstein PR Carlson S | 1989 | Stroke1989，20，： | 2 |
| 7 | Reversible middle cerebral artery occlusion without craniectomy in rats显示文摘 | Longa E Z Weinstein P R Carlson S | 1989 | Stroke1989，20，1： | 2 |
| 8 | Reversible middle cerebral artery occlusion without craniectomy in rats显示文摘 | Longa EZ Weinstem PR Carlson S | 1989 | Stroke1989，20，1： | 2 |
| 9 | The impact of land use-land cover changes due to urbanization on surface microclimate and hydrology: a satellite perspective 显示文摘 | Carlson T N and Arthur S T | 2000 | Global and Planetary Changes2000，25，： | 2 |
| 10 | Reversible middle cerebral artery occlusion without craniectomy in rats显示文摘 | Longa EZ Weinstein PR Carlson S | 1989 | Stroke1989，20，1： | 2 |
| 11 | Reversible middle cere-bralartery occlusion without craniectomy in rats 显示文摘 | Longa ZE Weinstein PR Carlson S | 1989 | Stroke1989，20，： | 1 |
| 12 | Reversible middle cerebral artery occlusion without craniectomy in rats显示文摘 | Longa EZ Weinstein PR Carlson S | 1989 | Stroke1989，20，1： | 1 |
| 13 | Reversible middle cerebralartery occlusion without craniectomy in rats显示文摘 | Zea Longa EL Weinstein PR Carlson S | 1989 | Stroke1989，，20： | 1 |
| 14 | Reversible middle cerebral artery occlusion without craniectomy in rats 显示文摘 | Longa EZ Weinstein PR Carlson S | 1989 | Stroke1989，20，1： | 1 |
| 15 | Rhgl alleles from soybean PI 437654 and PI 88788 respond differentially to isolates of Heterodera glycines in the greenhouse 显示文摘 | Brucker E Carlson S Wright E | 2005 | Theor Appl Genet2005，111，1： | 1 |
| 16 | Reversible middle cerebral artery occlusion without craniectomy in rats显示文摘 | Weinstein PR Carlson S | 1989 | Stroke1989，20，： | 1 |
| 17 | Reversible middle cerebral artery occlusion without craniectomy in rats显示文摘 | Zea Longa E L Weinstein P R Carlson S | 1989 | Stroke1989，20，1： | 1 |
| 18 | Reversible middle cerebral artery occlousion without cranieclomy in rats显示文摘 | Zea Longa E Weinstein P R Carlson S | 1989 | Stroke1989，20，： | 1 |
| 19 | Reversible Middle Cerebral artery occlusion without craniectomy in rats显示文摘 | Zealonga EL Weinstein PR Carlson S | 1989 | Stroke1989，20，1： | 1 |
| 20 | Reversible middle cerebral artery occlusion without craniectomy in rats 显示文摘 | Longa EZ Weinstein PR Carlson S | 1959 | Stroke1959，20，1： | 1 |
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