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1Chronic kidney disease severely deteriorates the outcome of gastrointestinal bleeding: A meta-analysis显示文摘AIM To understand the influence of chronic kidney disease(CKD) on mortality, need for transfusion and rebleeding in gastrointestinal(GI) bleeding patients.METHODS A systematic search was conducted in three databases for studies on GI bleeding patients with CKD or endstage renal disease(ESRD) with data on outcomes of mortality, transfusion requirement, rebleeding rate and length of hospitalization(LOH). Calculations were performed with Comprehensive Meta-Analysis software using the random effects model. Heterogeneity was tested by using Cochrane's Q and I2 statistics. Mean difference(MD) and OR(odds ratio) were calculated.RESULTS1063 articles(EMBASE: 589; PubM ed: 459; Cochrane: 15) were found in total. 5 retrospective articles and 1 prospective study were available for analysis. These 6 articles contained data on 406035 patients, of whom 51315 had impaired renal function. The analysis showed a higher mortality in the CKD group(OR = 1.786, 95%CI: 1.689-1.888, P < 0.001) and the ESRD group(OR = 2.530, 95%CI: 1.386-4.616, P = 0.002), and a rebleeding rate(OR = 2.510, 95%CI: 1.521-4.144, P < 0.001) in patients with impaired renal function. CKD patients required more unit red blood cell transfusion(MD = 1.863, 95%CI: 0.812-2.915, P < 0.001) and spent more time in hospital(MD = 13.245, 95%CI: 6.886-19.623, P < 0.001) than the controls.CONCLUSION ESRD increases mortality, need for transfusion, rebleeding rate and LOH among GI bleeding patients. Prospective patient registries and observational clinical trials are crucially needed.Roland Hágendorn Nelli Farkas Aron Vincze Zoltán Gyongyi Dezso Csupor Judit Bajor Bálint Eross Péter Csécsei Andrea Vasas Zsolt Szakács László Szapáry Péter Hegyi Alexandra Mikó 2017World Journal of Gastroenterology2017,23,47:3
2A comparison of the postoperative analgesic efficacy of single-dose epidural tramadol versus morphine in children显示文摘Demiraran Y Kocaman B Akman RY 2005Br J Anaesth2005,95,4:1
3Percutaneous intravascular stents for treatment of portal venous stenosis after hver transplantation : midterm results 显示文摘Wang JF Zhai RY Wei B J 2006Transplant Proc2006,38,:1
4Different frequencies of angiotensin- converting enzyme genotypes in older hypertensive individuals显示文摘Morris B J Zee RY Schrader AP 1994J Clin Invest1994,94,3:1
5Different frequencies of angiotensinconverting enzyme genotypes in older hypertensive individuals 显示文摘Morris B J Zee RY Schrader AP 1994J Clin Invest1994,94,3:1
6Spiral computed tomography with two and three dimensional reconstruction in the management of tibial plateau fractures显示文摘Liow RY Birdsall PD Mucei B 1999Orthopedics1999,22,10:1
7A prospective evaluation of the CD14 C (-260)T gene polymorphism and the risk of myocanlial infarction显示文摘Zee RY Lindpaintner K Stink B 2001Atheroscleros is2001,154,:1
8Synthesis, characterization and MRI application of dextran-coated Fe3O4 magnetic nanoparticles显示文摘Hong RY Feng B Chen LL 2008Bio Engineering2008,42,3:1
9Effect of carbon substrates on rock phosphate solubilization by bacteria from composts and macrofauna显示文摘Hameeda B Hafish K RY Rupela O P 2006Current Microbiology2006,53,:1
10Skeletal metastases from cancer of the uterine cervix : frequency, pattenas, and radiotherapeutic significance显示文摘Kim RY Weppelmann B Salter MM 1987Int J Radiat Oncol Biol Phys1987,13,5:1
11Regulation of archicortical arealization by the transcription factor Zbtb20 显示文摘Rosenthal E H Tonchev A B Stoykova A Chowdhu- ry K 2012Hippocampus2012,22,:1
12A comparison of the postoperative analgesic efficacy of single-dose epidural tramadol versus morphine in children显示文摘Demiraran Y Kocaman B Akman RY 2005Br J Anaesth2005,95,4:1
13Evaluation of right ventricu- lar remodeling using cardiac magnetic resonance imaging in co-exist- ent chronic obstructive pulmonary' disease and obstructive sleep apnea 显示文摘Sharma B Neilan TG Kwong RY 2013COPD2013,10,1:1
14Spiral computed tomography with two-and-three-dimensional reconstruction in the management of tibial plateau fractures 显示文摘Liow RY Birdsll PD Mucci B etal 1999Orthopedics1999,22,10:1
15Rituximab in the treatment of refractory autoimmune hemolytic anemia in children显示文摘Zecca M Nobili B Raminga RY 0,,:1
16Fingolimod is a potential novel therapy for multiple sclerosis显示文摘Aktas O Küry P Kieseier B 0,,07:1
17Effects of hawthorn on cardiac remodeling and left ventricular dysfunction after 1 month of pressure overload-induce cardiac hypertrophy in rats 显示文摘Hyun S H Bm'ry E B Michael M J G 2008Cardiovasc Drugs Ther2008,22,1:1
18Spinal computer to mography with two and three-dimensional reconstruction in the management of tibial plateau fractures显示文摘Liow RY Birdsall PD Mucci B Greiss ME 1999J Orthopedics1999,22,:1
19An environment-sensitive synthetic microbial ecosystem 显示文摘Hu B Du J Zou RY Yuan YJ 2010PLoS ONE2010,5,10:1
20A prospective evaluation of theCD14 C (-260) T gene polymorphism and the risk of myocardial infarc-tion 显示文摘Zee RY Lindpaintner K Struk B 2001Atherosclerosis2001,154,3:1
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