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| 1 | Cerebral radiation necrosis: incidence, outcomes, and risk factors with emphasis on radiation parameters and chemotherapy显示文摘 | Ruben JD Dally M Bailey M Smith R McLean CA Fedele P | 2006 | 中国神经肿瘤杂志2006，4，3： | 15 |
| 2 | Proteomic analysis for developing new biomarkers of hepatocellular carcinoma显示文摘AIM: To identify new markers of hepatocellular carcinoma (HCC) using a proteomic analysis. METHODS: Patients with liver cirrhosis of the three most frequent etiologies: hepatitis C virus, hepatitis B virus and alcoholic liver disease, were included in the study. The samples were analysed by 2D-electrophoresis in order to determine the differential protein expression. The proteins were separated according to the charge in immobilized pH 3-10 gradient strips and then by sodium dodecyl sulfate polyacrylamide gel electrophoresis. Proteins of interest were excised, digested with trypsin and the resulting peptides were separated and identified. RESULTS: Three differentially expressed apolipoproteins (Apo) were identified based on the protein profile using proteomic techniques: Apo-A1, Apo-A4 and Apo-E. Apo-A4 levels were significantly lower in HCC than in non-HCC patients regardless of etiology (P < 0.01). Multivariate logistic regression showed that Apo-A4 and Apo-A1 were the only independent factors related to HCC diagnosis (P < 0.05). The receiver operating characteristic (ROC) curve including both Apo-A4 and Apo-A1 showed an area under the ROC of 0.944 (P < 0.001), a sensitivity of 0.89 and a specificity of 0.81 for diagnosis of HCC. CONCLUSION: Apo-A4 and Apo-A1 may be used clinically as biomarkers of HCC with a high sensibility and specificity. These findings may provide additional insights into the mechanism of HCC development and progression. | Maria Pleguezuelo Laura M Lopez-Sanchez Antonio Rodriguez-Ariza Jose L Montero Javier Briceno Ruben Ciria Jordi Muntane Manuel de la Mata | 2010 | World Journal of Hepatology2010，2，3： | 3 |
| 3 | 西班牙交通基础设施与城市体系建设显示文摘从社会和地方融合、均衡性与土地异质性、交通网等级体系和支路网与交通可持续性四个角度探讨西班牙交通基础设施网建设对土地开发和土地规划相关国家法规的影响。从城市地理学视角分析中央政府基于改善城市和区域连接度和可达性进行的高速公路网、高铁网、机场和港口等交通基础设施规划,通过1950年代以来土地开发和房价涨跌、新兴产业培育和交通状况改善刺激不同级别城市蔓延和分化的人口增长,重塑西班牙国家城市体系格局。随后,概括了蔓延的城市增长模式和房地产与交通投资泡沫破裂后带给区域增长中心的影响,对通过交通基础设施规划进行投机性投资政策进行了批评。最后建议中央政府应该避免投机投资行为,基于现有的城市体系层级改善核心城市和大城市周边的机动性,优化基础设施建设,建立新的城市与区域增长模式。 | Lois-Gonzalez Ruben C Pineira-Mantinan M J 翟炜 顾朝林 | 2016 | 地理研究2016，35，7： | 3 |
| 4 | 向在人的察觉到钙的受体的 allosteric 药的结构的理解显示文摘allosterically 指向人的察觉到钙的受体(CaSR ) 的药有实质的治疗学的潜力,但是当前被限制。给 CaSR 的高分辨率的结构的缺席,我们把 mutagenesis 与一条新奇分析途径并且开发 “ 的分子的建模相结合; enriched”为在 Ca 2+ 在 CaSRs 7 transmembrane (7TM ) 以内的 o 和 allosteric 调节的人领域。修改多重有约束力的地点以适应在结构上的一个扩大的洞多样的 ligands 被识别。Phenylalkylamines 绑在与通常认为的 Ca 2+ o -binding 地点并且向一个细胞外的门厅延长。相反,在结构上和 pharmacologically 不同的 AC-265347 在 7TM 领域以内更深绑。而且,不同氨基酸网络被发现调停由不同调节的人的 cooperativity。这些调查结果可以与不同、潜在地偏导小径的药理学效果便于 allosteric 调节的人的合理设计。 | Katie Leach Karen J Gregory Irina Kufareva Elham Khajehali Anna E Cook Ruben Abagyan Arthur D Conigrave Patrick M Sexton Arthur Christopoulos | 2016 | Cell Research2016，26，5： | 2 |
| 5 | Acidic triterpenes compromise growth and survival of astrocytoma cell lines by regulating reactive oxygen species accumulation显示文摘 | RUBEN M JULIANA C ELVIRA I | 2007 | Cancer Research2007，67，8： | 1 |
| 6 | Oxidation of thioacetamide by ferrate(VI)显示文摘 | Frank J M | 2000 | Marine Chemistry2000，70，1： | 1 |
| 7 | Soft sensors development for on-line bioreactor state estimation显示文摘 | AJILSON J D A RUBENS M F | 2000 | Computers and Chemical Engineering2000，24，： | 1 |
| 8 | Acidic triterpenes compromisegrowth and survival of astrocytoma cell lines by regulating reactive oxygen species accumulation 显示文摘 | Ruben M Juliana C Elvira I | 2008 | Cancer Res2008，67，8： | 1 |
| 9 | Experimental and full scale pilot plant constructed wetlands for municipat wastewaters treatment显示文摘 | Gemma A Juan M G Ruben C and Estanistao de L | 2003 | Ecological Engineering2003，21，1： | 1 |
| 10 | Elastic management of Web server dusters on distributed virtual infrastructures显示文摘 | Rafael Moreno-Vozmediano Ruben S Montero Ignacio M Llorente | 2011 | Concurrency and Computation:Practice & Experience2011，23，13： | 1 |
| 11 | Modeling and simulation of lithium-ion batteries 显示文摘 | ERNESTO M R RUBEN V M ANTONIO F T | 2011 | Computers and Chemical Engineering2011，35，1： | 1 |
| 12 | Late incidence and predietorsof persistent or recurrent heart failure in patients with aorticprosthetic valves显示文摘 | Ruel M Rubens FD Masters RG | 2004 | J Thorac Cardiovasc Surg2004，127，： | 1 |
| 13 | Predictors of early neurocognitive deficits in low--risk patients undergoing on--pump coronary artery bypass surgery显示文摘 | Boodhwani M Rubens F D Wozny D | 2006 | Circulation2006，114，1： | 1 |
| 14 | The regulatory role of nitric oxide in apoptosis 显示文摘 | PETER K M K RUBEN Zamora | 2001 | Inter Immunophamacology2001，，1： | 1 |
| 15 | Late incidence and predictors of persistent or recurrent heart failure in patients with mitral prosthetic valves显示文摘 | Ruel M Rubens FD Masters RG | | 0，，2： | 1 |
| 16 | Surgery for chronic throm- boembolic pulmonary hypertension--inclusive experience from a na- tional referral center 显示文摘 | Rubens FD Bourke M Hynes M | 2007 | Ann Thorac Surg2007，83，3： | 1 |
| 17 | Regularization methods for ill- posed problems in multiple Hilbert scales 显示文摘 | Gisela M L Ruben S O | 2012 | Inverse Problems2012，28，5： | 1 |
| 18 | Effects of sustained mild hypothermia on neurocognitive function after coronary artery bypass surgery:a randomized,double-blind study显示文摘 | Boodhwani M Rubens F Wozny D | 2007 | J Thorac Cardiovasc Surg2007，134，6： | 1 |
| 19 | The inflation-hedging effectiveness of real estate 显示文摘 | Rubens J H Bond M T Webb J R | 1989 | Journal of Real Estate Research1989，2，4： | 1 |
| 20 | The furcation problem, etiology, diognosis, therapy and prognosis 显示文摘 | ABDALLAH F KONS RUBEN M P | 1987 | J West Soc Periodontol1987，35，： | 1 |
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