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| 1 | The role of gut microbiota(commensal bacteria)and the mucosal barrier in the pathogenesis of inflammatory and autoimmune diseases and cancer:contribution of germ-free and gnotobiotic animal models of human diseases显示文摘Metagenomic approaches are currently being used to decipher the genome of the microbiota(microbiome),and,in parallel,functional studies are being performed to analyze the effects of the microbiota on the host.Gnotobiological methods are an indispensable tool for studying the consequences of bacterial colonization.Animals used as models of human diseases can be maintained in sterile conditions(isolators used for germ-free rearing)and specifically colonized with defined microbes(including non-cultivable commensal bacteria).The effects of the germ-free state or the effects of colonization on disease initiation and maintenance can be observed in these models.Using this approach we demonstrated direct involvement of components of the microbiota in chronic intestinal inflammation and development of colonic neoplasia(i.e.,using models of human inflammatory bowel disease and colorectal carcinoma).In contrast,a protective effect of microbiota colonization was demonstrated for the development of autoimmune diabetes in non-obese diabetic(NOD)mice.Interestingly,the development of atherosclerosis in germ-free apolipoprotein E(ApoE)-deficient mice fed by a standard low-cholesterol diet is accelerated compared with conventionally reared animals.Mucosal induction of tolerance to allergen Bet v1 was not influenced by the presence or absence of microbiota.Identification of components of the microbiota and elucidation of the molecular mechanisms of their action in inducing pathological changes or exerting beneficial,disease-protective activities could aid in our ability to influence the composition of the microbiota and to find bacterial strains and components(e.g.,probiotics and prebiotics)whose administration may aid in disease prevention and treatment. | Helena Tlaskalova-Hogenova Renata Stepankova Hana Kozakova Tomas Hudcovic Luca Vannucci Ludmila Tuckova Pavel Rossmann TomasHrncır Miloslav Kverka Zuzana Zakostelska Klara Klimesova Jaroslava Pribylova Jirina Bartova Daniel Sanchez Petra Fundova Dana Borovska Dagmar Sru˚tkova Zdenek Zıdek Martin Schwarzer Pavel Drastich David P Funda | 2011 | Cellular & Molecular Immunology2011，8，2： | 47 |
| 2 | Variability in B-cell Antigen Expression: Implications for the Treatment of B-Cell Lymphomas and Leukemias With Monoclonal Antibodies显示文摘 | ROSSMANN ED LUNDIN J LENKEI R | 2001 | Hematol J2001，2，5： | 1 |
| 3 | Influence of the distillation step on the ratiosof stable isotopes of ethanol in cherry brandies显示文摘 | BAUDLER R ADAM L ROSSMANN A | 2006 | Journal of Agricultural and Food Chemistry2006，54，3： | 1 |
| 4 | Structure of dengue virus: implications for flavivirus organization, maturation and fusion显示文摘 | Kuhn R J Zhang W Rossmann MG | 2002 | Cell2002，108，5： | 1 |
| 5 | The structure of parvoviruses显示文摘 | Agbandje M Parrish C R Rossmann M G | 1995 | Virology1995，6，： | 1 |
| 6 | Structure of dengue virus: implications for flavivirus organization, maturation, and fusion显示文摘 | Kuhn R J Zhang W Rossmann MG | 2002 | Cell2002，108，5： | 1 |
| 7 | Structure determination of feline panleukopenia virus empty particles显示文摘 | Agbandje M Mc Kenna R Rossmann M G | 1993 | Proteins1993，16，： | 1 |
| 8 | Influence of the distillation step on the ratiosof stable isotopes of ethanol in cherry brandies显示文摘 | BAUDLER R ADAM L ROSSMANN A | 2006 | Journal of Agricultural and Food Chemistry2006，54，3： | 1 |
| 9 | A structural perspective of the flavivirus life cycle 显示文摘 | Mukhopadhyay S Kuhn R J Rossmann MG | 2005 | Nat Rev Microbiol2005，3，1： | 1 |
| 10 | Structure of dengue virus: implications for flavivirus organization, maturation, and fusion 显示文摘 | Kuhn R J Zhang W Rossmann MG | 2002 | Cell2002，108，5： | 1 |
| 11 | A structural perspective of the flavivirus life cycle显示文摘 | MUKHOPADHYAY S KUHN R J ROSSMANN M G | 2005 | Nat Rev Microbiol2005，3，1： | 1 |
| 12 | Isotopic and elemental data for tracing the origin of European olive oils显示文摘 | Camin F Larcher R Nicolini G Bontempo L Bertoldi D Perini M Schlicht C Schellenberg A Thomas F Heinrich K Voerkelius S Horacek M Ueckermann H Froeschl H Wimmer B Heiss G Baxter M Rossmann A HoogewerffJ | 2010 | Journal of Agricultural and Food Chemistry2010，58，1： | 1 |
| 13 | A structural perspective of the flavivirus life cycle显示文摘 | Mukhopadhyay S Kuhn R J Rossmann MG | 2005 | Nat Rev Microbiol2005，3，1： | 1 |
| 14 | A structural perspective of the flavivirus life cycle显示文摘 | Mukhopadhyay S Kuhn R J Rossmann M G | 2005 | Nat Rev Microbiol2005，3，1： | 1 |
| 15 | lnfluence of the distillation step on the ratios of stable isotopes of ethanol in cherry brandies显示文摘 | Baudler R Adam L Rossmann A | 2006 | Journal of Agricuhural and Food Chemistry2006，54，： | 1 |
| 16 | Struc- ture determination of feline panleukopenia virus empty particles显示文摘 | Agbandje M McKenna R Rossmann M G | 1993 | Proteins1993，16，2： | 1 |
| 17 | A structuralperspective of the flavivirus life cycle显示文摘 | Mukhopadhyay S Kuhn R J Rossmann M G | 2005 | Nat Rev Microbiol2005，3，1： | 1 |
| 18 | A structural perspective of the flavivirus life cycle显示文摘 | Mukhopadhyay S Kuhn R J Rossmann M G | 2005 | Nat Rev Microbiol2005，3，1： | 1 |
| 19 | Multielement stable isotope ratio analysis of glycerol to determine its origin in wine显示文摘 | Rossmann A Schmidt H L Hermann A Ristow R | 1998 | Zeitschrift fur Lebensmitteluntersuchung und-Forschung A1998，207，3： | 1 |
| 20 | A structural perspective of the flavivirus life cycle显示文摘 | Mukhopadhyay S Kuhn R J Rossmann M G | 2005 | Nat Rev Microbiol2005，3，1： | 1 |
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