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| 1 | Liver expression of steroid hormones and Apolipoprotein D receptors in hepatocellular carcinoma显示文摘AIM: To evaluate the tissular expression of Androgen (A), Estrogen (E) and Progesterone (Pg) receptors, and Apolipoprotein D (ApoD), in liver tumors from resected hepatocellular carcinoma (HCC) cases in order to assess their possible relationship to prognosis. METHODS: We performed an immunohistochemical study using tissue microarrays (containing more than 260 cancer specimens, from 31 HCC patients and controls) to determine the presence of specif ic antibodies against AR, ER, PgR and ApoD, correlating their findings with several clinico-pathological and biological variables. The staining results were categorized using a semi-quantitive score based on their intensity, and the percentage of immunostained cells was measured. RESULTS: A total of 21 liver tumors (67.7%) were positive for AR; 16 (51.6%) for ER; 26 (83.9%) for PgR and 12 (38.7%) stained for ApoD. We have found a wide variability in the immunostaining score values for each protein, with a median (range) of 11.5 (11.5-229.5) for AR; 11.1 (8.5-65) for ER; 14.2 (4-61) for PgR; and 37.7 (13.8-81.1) for ApoD. A history of heavy ethanol consumption, correlated positively with AR and PgR and negatively with ER status. HCV chronic infection also correlated positively with AR and PgR status. However, the presence of ApoD immunostaining did not correlate with any of these variables. Tumors with a positive immuno-staining for PgR showed a better prognosis. CONCLUSION: Our results indicate a moderate clinical value of the steroid receptor status in HCC, emphasizing the need to perform further studies in order to evaluate the possible role of new hormonal-based therapies. | FJ Vizoso M Rodriguez A Altadill ML González-Diéguez A Linares LO González S Junquera F Fresno-Forcelledo MD Corte L Rodrigo | 2007 | World Journal of Gastroenterology2007，13，23： | 11 |
| 2 | Risk of uncomplicated peptic ulcer among users of aspirin and nonaspirin nonsteroidal antiinflammatory drugs 显示文摘 | Garcia Rodriguez L A Hernandez Diaz S | 2004 | Am J Epidemiol2004，159，1： | 1 |
| 3 | Optimiza- tion of wind farm turbines layout using an evolutive algorithm 显示文摘 | Gonzalez J S Rodriguez A G G Mora J C | 2010 | Renewable Energy2010，35，8： | 1 |
| 4 | Requirement of bic/mi- croRNA-155 for normal immune function显示文摘 | Rodriguez A Vigorito E Clare S | 2007 | Science2007，316，5824： | 1 |
| 5 | The age of multilevel converters arrives显示文摘 | L G Franquelo J Rodriguez J I Leon S Kouro R Portillo and M A M Prats | | 0，，02： | 1 |
| 6 | Dynamics of Black Band Disease in a Diploria strigosa population subjected to annual upwelling on the northeastern coast of Venezuela显示文摘 | RODRIGUEZ S CROQUER A | | Coral Reefs0，，： | 1 |
| 7 | CRM1-Mediated Nuclear Export determines the cytoplasmic localization of the antiapoptotic protein survivin显示文摘 | Rodriguez J A Span S W Ferreira C G | 2002 | Exp Cell Res2002，275，1： | 1 |
| 8 | Hysteroscopic evaluation of endometrial polyps显示文摘 | Fernandez-Parra J Rodriguez Oliver A Lopez Criado S | 2006 | Int J Gynaecol Obstet2006，95，2： | 1 |
| 9 | Physical characterization of hydroxyapatite porous scaffolds for tissue engineering 显示文摘 | Teixeira S Rodriguez M A Pena P De Aza A H De Aza S Ferraz M P Monteiro F J | 2009 | Materials Science & Engineering C-Biomimetic and Supramolecular Systems2009，29，5： | 1 |
| 10 | In vivo evaluation of acellular human dermis for abdominal wall repair显示文摘 | Eberli D Rodriguez S Atala A | 2010 | J Biomed Mater Res A2010，93，4： | 1 |
| 11 | Multiple pathways for triacylglycerol biosynthesis in Streptomyces coelicolor显示文摘 | Arabolaza A Rodriguez E Altabe S | | 0，，9： | 1 |
| 12 | Physical characterization of hydroxyapatite porous scaffolds for tissue engineering 显示文摘 | Teixelra S Rodriguez M A Pena P ctal | 2009 | Materials Science and Engineering: C2009，29，5： | 1 |
| 13 | Fracture properties of epoxy/poly(styrene-co-allylalcohol)blends显示文摘 | Salazar A Prolongo S G Rodriguez J | 2007 | Journal of Applied Polymer Science2007，106，5： | 1 |
| 14 | A stationary reference frame grid synchronization system for three-phase grid-connected p6wer converters under adverse grid conditions 显示文摘 | Rodriguez P Luna A Munoz-Aguilar R S | 2012 | IEEE Transactions on Power Electronics2012，27，1： | 1 |
| 15 | Effects of Ca( OH)2 treatments( 'overtiming' ) on the composition and toxicity of bagasse hemicellulose hydrolysates显示文摘 | MARTINEZ A RODRIGUEZ M E YORK S W | 2000 | Biotechnology and Bioengineering2000，69，5： | 1 |
| 16 | Mechanisms of endothelial dysfunction with development of type 1 diabetes mellitus role of insulin and C-peptide显示文摘 | Bratcher A P Rodriguez W E Tyagi S C | 2005 | Cell Biochem2005，96，6： | 1 |
| 17 | Requirement of bic/mi- croRNA-155 for Normal Immune Function显示文摘 | Rodriguez A Vigorito E Clare S | 2007 | Science2007，316，5824： | 1 |
| 18 | Fluoro-2,3-dihydro- 1-benzothiopyran-4-ones 显示文摘 | FRAVOLINI A RODRIGUEZ S C | 1968 | Ann Chim (Rome)1968，58，10： | 1 |
| 19 | Simultaneous muhi-analyte determination of estrone, isoprpturon, and atrazine in natural waters by the River ANAlyzer ( RIANA), an optical immunosensoroptical immunosenso 显示文摘 | RODRIGUEZ -MOZAZ S REDER S LOPEZ A M J | 2004 | Biosensors & Bioelectronics2004，19，： | 1 |
| 20 | Expression analysis of the Toll-like receptor and TIR domain adaptor families of zebrafish 显示文摘 | Meijer A H Gabby Krens S Medina Rodriguez I A | 2004 | Molecular Immunology2004，40，11： | 1 |
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