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| 1 | Evaluation of VEGF gene polymorphisms and proliferative diabetic retinopathy in Mexican population显示文摘● AIM: To assess if the included vascular endothelial growth factor(VEGF) polymorphisms rs3025035, rs3025021 and rs2010963 are associated to proliferative retinopathy in a Mexican population with type 2 diabetes mellitus(T2DM).● METHODS: A case-control study was conducted in adult individuals with T2 DM associated to proliferative retinopathy or non-proliferative retinopathy from Oct. 2014 to Jun. 2015 from the Retina Department of the Asociation to Prevent Blindness in Mexico. The selected patients were adults with a diagnosis of T2 DM ≥5y. All subjects had a comprehensive ocular examination and the classification of the retinopathy severity was made considering the Early Treatment Diabetic Retinopathy Study(ETDRS) standardization protocols. Genomic DNA was extracted from whole fresh blood. All samples were genotyped by q PCR for selected VEGF polymorphisms. Hardy-Weinberg equilibrium was calculated by comparing Chi-square values between the expected and the observed values for genotype counts.● RESULTS: In total 142 individuals were enrolled, 71 individuals with T2 DM and associated proliferative retinopathy and 71 individuals with non-proliferative retinopathy. One-sided Fisher's exact test was performed for rs3025021[OR(95% CI)=0.44(0.08-2.2); P=0.25] and rs2010963 [OR(95% CI)=0.63(0.25-1.6); P=0.23]. The minor allelic frequencies obtained were 26% for rs3025021, 10% for rs3025035 and 61% for rs2010963. The pairwise linkage disequilibrium between the three SNP was assessed, and was as follows: rs3025021 vs rs3025035: D'=1.0, r^2=0.1043, P≤0.0001; rs3025021 vs rs2010963: D'=0.442, r^2=0.0446, P=0.149; rs3025035 vs rs2010963: D'=0.505, r^2=0.0214, P=0.142.● CONCLUSION: This is the first analysis involving VEGFA polymorphisms and proliferative diabetic retinopathy in a Mexican population. A major finding of the present study is that none of the polymorphisms studied was significantly associated with proliferative retinopathy. Based on these results, we can infer that different populations have different associations for the same polymorphisms. | Roberto Gonzalez-Salinas Maria C Garcia-Gutierrez Gerardo Garcia-Aguirre Virgilio Morales-Canton Raul Velez-Montoya Vidal R Soberon-Ventura Victoria Gonzalez Rodrigo Lechuga Pablo Garcia-Solis David G Garcia-Gutierrez Marco Vinicio Garcia-Solis Manuel Saenz de Viteri Juan C Solis-S | 2017 | International Journal of Ophthalmology(English edition)2017，10，1： | 12 |
| 2 | Intraoperative laparoscopic complications for urological cancer procedures显示文摘AIM: To structure the rate of intraoperative complications that requires an intraoperative or perioperative resolution. METHODS: We perform a literature review of Medline database. The research was focused on intraoperative laparoscopic procedures inside the field of urological oncology. General rate of perioperative complications in laparoscopic urologic surgery is described to be around 12.4%. Most of the manuscripts published do not make differences between pure intraoperative, intraoperative with postoperative consequences and postoperative complications. RESULTS: We expose a narrative statement of complications, possible solutions and possible preventions for most frequent retroperitoneal and pelvic laparoscopic surgery. We expose the results with the following order: retroperitoneal laparoscopic surgery(radical nephrectomy, partial nephrectomy, nephroureterectomy and adrenalectomy) and pelvic laparoscopic surgery(radical prostatectomy and radical cystectomy).CONCLUSION: Intraoperative complications vary from different series. More scheduled reports should be done in order to better understand the real rates of complications. | Sergio Fernández-Pello Montes Ivan Gonzalez Rodríguez Rodrigo Gil Ugarteburu Luis Rodríguez Villamil Begoa Diaz Mendez Patricio Suarez Gil Javier Mosquera Madera | 2015 | World Journal of Clinical Cases2015，3，5： | 4 |
| 3 | An elastin-like recombinamer-based bioactive hydrogel embedded with mesenchymal stromal cells as an injectable scaffold for osteochondral repair显示文摘The aim of this study was to evaluate injectable,in situ cross-linkable elastin-like recombinamers(ELRs)for osteochondral repair.Both the ELR-based hydrogel alone and the ELR-based hydrogel embedded with rabbit mesenchymal stromal cells(rMSCs)were tested for the regeneration of critical subchondral defects in 10 New Zealand rabbits.Thus,cylindrical osteochondral defects were filled with an aqueous solution of ELRs and the animals sacrificed at 4months for histological and gross evaluation of features of biomaterial performance,including integration,cellular infiltration,surrounding matrix quality and the new matrix in the defects.Although both approaches helped cartilage regeneration,the results suggest that the specific composition of the rMSC-containing hydrogel permitted adequate bone regeneration,whereas the ELR-based hydrogel alone led to an excellent regeneration of hyaline cartilage.In conclusion,the ELR cross-linker solution can be easily delivered and forms a stable well-integrated hydrogel that supports infiltration and de novo matrix synthesis. | Filippo Cipriani Blanca Arino Palao Israel Gonzalez de Torre Aurelio Vega Castrillo Hector Jose Aguado Hernandez Matilde Alonso Rodrigo Angel Jose Alvarez Barcia Ana Sanchez Veronica Garcıa Diaz Monica Lopez Pena Jose Carlos Rodriguez-Cabello | 2019 | Regenerative Biomaterials2019，6，6： | 3 |
| 4 | Podoplanin expression in the development and progression of laryngeal squa- mous cell carcinomas显示文摘 | Rodrigo JP Garcia-Carracedo D Gonzalez MV | 2010 | Mol Cancer2010，9，： | 1 |
| 5 | Short-term effects of temperature and COD in a microbial fuel cell显示文摘 | A. Gonzalez del Campo J. Lobato P. Ca?izares M.A. Rodrigo F.J. Fernandez Morales | 2013 | Applied Energy2013，，： | 1 |
| 6 | TNF-alpha308A promoter polymorphism is associated with enhanced TNF-alpha production and inflammatory activity in Crohn's patients with fistulizing disease显示文摘 | Gonzalez S Rodrigo L Martinez-Borra J | 2003 | Am J Gastroenterol2003，98，5： | 1 |
| 7 | TNF-alpha -308A promoter polymorphism is associated with enhanced TNF-alpha production and inflammatory activity in Crohn's patients with fistulizing disease 显示文摘 | GONZALEZ S RODRIGO L MARTINEZ-BORRA J | 2003 | Am J Gastroenterol2003，98，5： | 1 |
| 8 | Transcriptionalregulation of MICA and MICB:A novel polymorphism in MICB promoter alters transcriptional regulation by Sp1显示文摘 | Rodriguez-Rodero S Gonzalez S Rodrigo L | | 0，，： | 1 |
| 9 | Genetic alterations in squamous cell carcinomas of the hypopharynx with correlations to clinicopathological features显示文摘 | Rodrigo J P Gonzalez M V Lazo P S | 2002 | Oral Oncol2002，38，4： | 1 |
| 10 | Surgical treatment of femoroacetabular impingement:evaluation of the effect of the size of the resection显示文摘 | Rodrigo M Mardones Carlos Gonzalez Qingshan Chen | 2005 | The Journal of Bone and Joint Surgery2005，87，2： | 1 |
| 11 | DNA extraction using Chelex resin for oneogenic amplification analysis in head and neck tumours 显示文摘 | Garcia Gonzalez L A Rodrigo Tapia J P Sanehez Lazo P | 2004 | Acta Otorrinolaringol Esp2004，55，3： | 1 |
| 12 | TNF-α-308A promoter polymorphism is associated with enhanced TNF-α production and inflammatory activity in Crohn's patients with fistulizing disease 显示文摘 | GONZALEZ S RODRIGO L BORRA J M | 2003 | Am J Gastroenterology2003，98，5： | 1 |
| 13 | Short-term effects of temperature and COD in a microbial fuel cell显示文摘 | GONZALEZ DEL CAMPO A LOBATO J CAIZARESB P RODRIGO M A FERNANDEZ MORALESA F J | 2013 | Appl Energy2013，101，： | 1 |
| 14 | Cellular video-phoneassisted transmission and interpretation of prehospital 12-leadelectrocardiogram in acute st-segment elevation myocardialinfarction 显示文摘 | Gonzalez MA SatlerLF Rodrigo ME | 2011 | J Interv Cardiol2011，24，2： | 1 |
| 15 | Variability of genetic alterations in different sites of head and neck cancer 显示文摘 | Rodrigo JP Suarez C Gonzalez MV | 2001 | Laryngoscope2001，111，7： | 1 |
| 16 | TN- F-alpha-308A promoter polymorphism is associated with enhanced TNF-alpha production and inflamma- tory activity in Crohn's patients with fistulizing dis- ease 显示文摘 | Gonzalez S Rodrigo L Martinez-Borra J | 2003 | Am J Gastroenterol2003，98，5： | 1 |
| 17 | Progenies of Allotriploids of Oriental× Asiatic Lilies (Lilium) Examined by GISH Analysis 显示文摘 | Rodrigo Barba Gonzalez | 2006 | Euphytica2006，151，： | 1 |
| 18 | Skp2, p27kip1 and EGFR assessment in head and neck squamous cell carcinoma:Prognostic implications显示文摘 | Dario Carracedo Aurora Astudillo Juan Rodrigo Carlos Suarez Maria Gonzalez | 2008 | Oncology Reports2008，，3： | 1 |
| 19 | TNF: alpha - 308A promoter polymorphism is associated with enhanced TNF- alpha production and inflammatory activity in Crohn$ patients with fistuliz- ing disease显示文摘 | Gonzalez S Rodrigo L Martinez-Borra J | 2003 | Am J Gastroenterol2003，98，： | 1 |
| 20 | TNF-α-308A promoter polymerphism is associated with enhanced TNF-α production and inflammatory activity in Crohn's patients with fistulizing disease显示文摘 | GONZALEZ S RODRIGO L BORRA JM | 2003 | Am J Gastroenterol2003，98，5： | 1 |
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