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| 1 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 2 | Pro- moters in Heterogeneous Catalysis : The Role of CI on Ethy- lene Epoxidation overAg 显示文摘 | Rocha T C R Haevecker M Knop-Gericke A | 2014 | J Catal2014，312，： | 1 |
| 3 | Molecular differenc- es between hydrocarbon and fluorocarbon surfaetants at the COJ water interface 显示文摘 | Stone M T Da Rocha S R P Rossky P J | 2003 | Journal of Physics Chemistry2003，107，10： | 1 |
| 4 | Toxicology and pharmacology of selenium:emphasis on synthetic organoselenium compounds显示文摘 | Nogueira C W Rocha J B T | 2011 | Arch Toxicol2011，85，： | 1 |
| 5 | Anticancer, antichemotactic and antimicrobial activities of marine sponges collected off the coast of Santa Catarina, southern Brazil显示文摘 | Noel R Monks Clea Lerner Amélia T Henriques Fabiane M Farias Elfrides E.S Schapoval Edna S Suyenaga Adriana B da Rocha Gilberto Schwartsmann Beatriz Mothes | 2002 | Journal of Experimental Marine Biology and Ecology2002，，1： | 1 |
| 6 | Detection of rabbit haemorrhagic disease virus (RHDV) in nonspeeificverteb- rate hosts sympatric to the European wild rabbit (Oryctolagus cuniculus)显示文摘 | Merchan T Rocha G Alda F | 2011 | Infect Genet Evol2011，，11： | 1 |
| 7 | Editorial Comment to Chronic bacterial seminal vesiculitis as a potential disease entity in men with chronic prostatitis 显示文摘 | Andrade Rocha F T | 2015 | International Journal of Urology2015，22，5： | 1 |
| 8 | Microstructural Evolution at the Initial Stages of Continuous Annealing of Cold Rolled Dual phase Steels 显示文摘 | Rocha R O Melo T M F Pereloma E V | 2005 | Materials Science and Engineering2005，391，12： | 1 |
| 9 | Pathophysiological effects of aldosterone in cardiovascular tissues显示文摘 | Ricardo Rocha Charles T Stier | 2001 | Trends in Endocrinology & Metabolism2001，，7： | 1 |
| 10 | Hyperosmotic NaCl and severe hemorrhagic shock显示文摘 | VELASCO I T PONTIERI V ROCHAE SILVA M JR | 1980 | Am J Phsiol1980，239，5： | 1 |
| 11 | Results of intracoronary recombinant human vascular endothelial growth factor (rhVEGF) administration trial显示文摘 | Henry T Rocha SK Isner J | 1998 | J Am Coll Cardiol1998，31，： | 1 |
| 12 | The effect of magnesite calcination conditions on magnesia hydration显示文摘 | Birchal V S S Rocha S D F Ciminelli V S T | 2000 | Minerals Engineering2000，13，1415： | 1 |
| 13 | Microstructural evolution at the initial stages of continuous annealing of cold rolled dual-phase steel显示文摘 | Rocha R O Melo T M F Pereloma E V Santos D B | 2005 | Materials Science and Engineering A2005，391，： | 1 |
| 14 | A shape analysis model with applica-tions to a character recognition system 显示文摘 | Rocha J Pavlidis T | 1994 | IEEE Transac-tions on Pattern Analysis and Machine Intelligence1994，16，4： | 1 |
| 15 | Microstructure evolution at the initial stages of continuous annealing of cold rolled dual-phase steel显示文摘 | ROCHA R O MELO T M F PERELOMA E V | 2005 | Materials Science and Engineering A2005，391，12： | 1 |
| 16 | Microstructural evolution at the initial stages of continuous annealing of cold rolled dual-phase steel 显示文摘 | Rocha R O Melo T M F Pereloma E V Santos D B | 2005 | Materials Science and Engineering2005，391，： | 1 |
| 17 | Determination of sulfur dioxide in wine using a quartz crystal microbalance显示文摘 | Comes M T Rocha T A Duarte A C | | 0，，09： | 1 |
| 18 | Steviol effect, a glycoside of Stevia rebaudiana, on glucose clearances in rats 显示文摘 | Mehs M S Rocha S T Augusto A | 2009 | Brazilian Journal of Biology2009，69，2： | 1 |
| 19 | Prevalence of congenital heart diseases in oral cleft patients显示文摘 | Barbosa MM Rocha CM Katina T | 2003 | Pediatr Cardiol2003，24，4： | 1 |
| 20 | The effect of magnesite calcination conditions on magnesia hydration显示文摘 | Birchal V S S Rocha S D F Ciminelli V S T | | 0，，： | 1 |
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