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| 1 | Stratification of outcomes for mucinous appendiceal adenocarcinoma with peritoneal metastasis by histological grade显示文摘AIM To investigate the importance of a three-tiered histologic grade on outcomes for patients with mucinous appendiceal adenocarcinoma(MAA).METHODS Two hundred and sixty-five patients with MAA undergoing cytoreductive surgery and hyperthermic intraperitoneal chemotherapy were identified from a prospective database from 2004 through 2014. All pathology was reviewed by our gastrointestinal subspecialty pathologists and histological grade was classified as well-differentiated, moderately differentiated, and poorly differentiated. Survival analysis was performed using Cox proportional hazards regression.RESULTS There were 201(75.8%) well-, 45(16.9%) moderatelyand 19(7.2%) poorly-differentiated tumors. Histological grade significantly stratified the 5-year overall survival(OS), 94%, 71% and 30% respectively(P < 0.001) as well as the 5-year disease-free survival(DFS) 66%, 21% and 0%, respectively(P < 0.001). Independent predictors of DFS included tumor grade(HR = 1.78, 95%CI: 1.21-2.63, P = 0.008), lymph node involvement(HR = 0.33, 95%CI: 0.11-0.98, P < 0.02), previous surgical score(HR = 1.31, 95%CI: 1.1-1.65, P = 0.03) and peritoneal carcinomatosis index(PCI)(HR = 1.05, 95%CI: 1.02-1.08, P = 0.002). Independent predictors of OS include tumor grade(HR = 2.79, 95%CI: 1.26-6.21, P = 0.01), PCI(HR = 1.10, 95%CI: 1.03-1.16, P = 0.002), and complete cytoreduction(HR = 0.32, 95%CI: 0.11-0.92, P = 0.03). Tumor grade and PCI were the only independent predictors of both DFS and OS. Furthermore, histological grade and lymphovascular invasion stratified the risk of lymph node metastasis into a low(6%) and high(40%) risk groups. CONCLUSION Our data demonstrates that moderately differentiated MAA have a clinical behavior and outcome that is distinct from well-and poorly-differentiated MAA. The threetier grade classification provides improved prognostic stratification and should be incorporated into patient selection and treatment algorithms. | Travis Edward Grotz Richard E Royal Paul F Mansfield Michael James Overman Gary N Mann Kristen Ashlee Robinson Karen A Beaty Safiea Rafeeq Auerlio Matamoros Michelle W Taggart Keith Francis Fournier | 2017 | World Journal of Gastrointestinal Oncology2017，9，9： | 2 |
| 2 | A temporal link between the Emeishan large igneous province (SW China) and the end-Guagalupian mass extinction 显示文摘 | Zhou M F Malpas J Song X Y Robinson P T Sun M Kennedy A K Lesher C M Keays R R | 2002 | Earth arut Planetary Science Letters2002，196，： | 1 |
| 3 | Triazole induced concentration-related gene signatures in rat whole embryo culture 显示文摘 | Robinson J F Tonk E C Verhoef A | 2012 | Reproductive Toxicology2012，34，： | 1 |
| 4 | Conservation and variation in off virus genomes显示文摘 | Barns G F raser K | 1987 | Virology1987，157，1： | 1 |
| 5 | Data assimilation via error subspace statistical estimation Part Ⅰ: theory and schemes 显示文摘 | Lermusiaux P F J Robinson A R | 1999 | Monthly Weather Review1999，127，7： | 1 |
| 6 | Concentration of two 1, 4- benzoxazinones in dent corn at various stages of develop- ment of the plant and its relation to resistance of the host plant to the European Corn borer 显示文摘 | KLUN J A ROBINSON J F | | Journal of Econom- ic Entomology0，62，1： | 1 |
| 7 | A heuristic for packing boxes into a con- tainer显示文摘 | eorge J A Robinson D F | 1980 | Computers and Operations Research1980，7，3： | 1 |
| 8 | Evaluation of neonic-otinoid,organophosphate and avermectin trunk injections for themanagement of avocado thrips in California avocado groves 显示文摘 | Byrne F J Urena A A Robinson L J | 2012 | Pest Management Science2012，68，5： | 1 |
| 9 | Real-world automotive emissions-summary of studies in the Fort McHenry and Tuscarora Mountain Tunnels显示文摘 | Pierson W R Gertler A W Robinson N F | 1996 | Atmospheric Environment1996，30，12： | 1 |
| 10 | Real world automotive emissions-a summary of studies in the Fort McHemy andTuscarora Mountain Tunnels 显示文摘 | PIERSON W R GERTLER A W ROBINSON N F | 1996 | Atmospheric Environment1996，30，12： | 1 |
| 11 | Recent secular variations in the extent of Northern Hemisphere snow cover显示文摘 | ROBINSON D A DEWEY K F | 1990 | Geophysical Research Letters1990，17，10： | 1 |
| 12 | Rules of engagement: interspecies interactions that regulate microbial communities显示文摘 | Little A E F Robinson C J Peterson S B | 2008 | Annual Review of Microbiology2008，62，： | 1 |
| 13 | Long-term outcomes of low-dose catheter-directed thrombolytic thera- py: a 5-year single-center experience 显示文摘 | Sebastian A J Robinson G J Dyet J F | 2010 | J Vase Interv Radiol2010，21，7： | 1 |
| 14 | How can stomata contribute to salt tolerance显示文摘 | ROBINSON M F VERY A A SANDERS D | 1997 | Annals of Botany1997，80，4： | 1 |
| 15 | Effects of Photostimulatory Light Intensity on Ovarian Morphology and Carcass Traits at Sexual Maturity in Modem and Antique EggType Pullets 显示文摘 | Renema R A Robinson F E Oosterhoff H H | 2001 | Poultry Science2001，80，： | 1 |
| 16 | Concentration of Two 1, 4-Benzoxazinones in Dent Corn at Various Stages of Development of the Plant and Its Relation to Resistance of the Host Plant to the European Corn Borer1, 2, 显示文摘 | Klun Jerome A Robinson John F | 1969 | Journal of economic entomology1969，62，1： | 1 |
| 17 | Groundnut rosette disease virus complex biology and molecular biology 显示文摘 | Taliansky M E Robinson D J Murant A F | 2000 | Ad- vances in Virus Research2000，55，： | 1 |
| 18 | Branchiomycosis: a new fungal disease of north american Fishes 显示文摘 | MEYER F P ROBINSON J A | 1973 | The Progressive Fish-Culturist1973，35，2： | 1 |
| 19 | Ectopic ossification following total hip replacement: incidence and a method of classification 显示文摘 | Brooker A F Bowerman J W Robinson R A | 1973 | J Bone Joint Surg Am1973，55，8： | 1 |
| 20 | Bacte- rial iron homeostasis 显示文摘 | Andrews S C Robinson A K Rodriguez-Quifiones F | 2003 | Ferns Micro-biol2003，，27： | 1 |
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