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| 1 | RTOG 0211:a phase 1/2 study of radiation therapy with concurrent gefitinib for newly diagnosed glioblastoma patients显示文摘PURPOSE: To determine the safety and efficacy of gefitinib,an epidermal growth factor receptor(EGFR) tyrosine kinase inhibitor,in combination with radiation for newly diagnosed glioblastoma(GBM) patients.METHODS AND MATERIALS: Between March 21,2002,and May 3,2004,Radiation Therapy Oncology Group(RTOG) 0211 enrolled 31 and 147GBM patients in the phase 1 and 2 arms,respectively.Treatment consisted of daily oral gefinitnib started at the time of conventional cranial radiation therapy(RT) and continued post RT for 18 months or until progression.Tissue microarrays from 68 cases were analyzed for EGFR expression.RESULTS: The maximum tolerated dose(MTD) of gefitinib was determined to be 500 mg in patients on non-enzyme-inducing anticonvulsant drugs(non-EIAEDs).All patients in the phase 2 component were treated at a gefitinib dose of 500 mg;patients receiving EIADSs could be escalated to 750 mg.The most common side effects of gefitinib in combination with radiation were dermatologic and gastrointestinal.Median survival was 11.5 months for patients treated per protocol.There was no overall survival benefit for patients treated with gefitinib + RT when compared with a historical cohort of patients treated with RT alone,matched by RTOG recursive partitioning analysis(RPA) class distribution.Younger age was significantly associated with better outcome.Per protocol stratification,EGFR expression was not found to be of prognostic value for gefitinib + RT-treated patients.CONCLUSIONS: The addition of gefitinib to RT is well tolerated.Median survival of RTOG 0211 patients treated with RT with concurrent and adjuvant gefitinib was similar to that in a historical control cohort treated with radiation alone. | Chakravarti A Wang M Robins HI Lautenschlaeger T Curran WJ Brachman DG Schultz CJ Choucair A Dolled-Filhart M Christiansen J Gustavson M Molinaro A Mischel P Dicker AP Bredel M Mehta M | 2013 | 中国神经肿瘤杂志2013，11，1： | 8 |
| 2 | Precision atomic gravimeter based on Bragg diffraction显示文摘 | P A Altin M T Johnsson V Negnevitsky G R Dennis R P Anderson J E Debs S S Szigeti K S Hardman S Bennetts G D McDonald L D Turner J D Close N P Robins | 2013 | New Journal of Physics2013，，2： | 2 |
| 3 | A Resource-Based Approach to the Multibusiness Firm: Empirical Analysis of Portfolio Interrelationships and Corporate Financial Performance显示文摘 | Robins J M F Wiersema | 1995 | Strategic Management Journal1995，16，： | 1 |
| 4 | Systemic hyperthermia and ICE chemotherapy for sarcoma patients:rationale and clinical status 显示文摘 | Wiedemann G J Robins H I Katschinski D M | 1997 | Anticancer Res1997，17，4： | 1 |
| 5 | Biochemical attributes of tea flowers (Camellia sinensis)at different developmental stages in the Kangra region of India显示文摘 | ROBIN J POONA M ASHU G | 2011 | Scientia Horticulturaef2011，130，： | 1 |
| 6 | 20,26-Dihydro-xyecdysone, a new steroid with moulting hormone activity from the tobacco homworm, Manduca sexta (Johannson) 显示文摘 | Thompson M J Kaplanis J N Robins W E | 1967 | Chem Comm1967，38，： | 1 |
| 7 | Femtosecond laser‐assisted cataract surgery compared with conventional cataract surgery显示文摘 | Robin G Abell Nathan M Kerr Brendan J Vote | 2013 | Clin Experiment Ophthalmol2013，，5： | 1 |
| 8 | Turning, compacting and the addition of water as factors affecting gaseous emissions in farm manure composting显示文摘 | E1 Kader N A Robin P Paillat J M | 2007 | Bioresource Technology2007，98，14： | 1 |
| 9 | Network-based analysis of stochastic SIR epidemic models with random and proportionate mixing显示文摘 | Kenah E Robins J M | 2007 | Journal of theoretical biology2007，249，4： | 1 |
| 10 | Combinedeffects of dietary HUFA level and temperature on sea bass (Dicentrarchus labracr) larvae development 显示文摘 | Vagner M Robin H Zambonino J | 2007 | Aquaculture2007，266，1： | 1 |
| 11 | Biochar Incorporation into Pasture Soil Suppresses in situ Nitrous Oxide Emissions from Ruminant Urine Patches显示文摘 | Taghizadeh-Toosi Arezoo Clough Tim J Condron Leo M Sherlock Robert R Anderson Craig R Craigie Robin A | 2011 | EN2011，，2： | 1 |
| 12 | Waterbird assemblages and associated habitat characteristics of farm ponds in the Western Cape, South Africa显示文摘 | Froneman A Michael J M Robin M L | 2001 | Biediversity and Conservation2001，10，2： | 1 |
| 13 | Minimal sufficient causation and directed acyclic graphs 显示文摘 | VanderWeele T J Robins J M | 2009 | Annals of Statistics2009，37，3： | 1 |
| 14 | Confounding ahd Collapsibility in Causal Inference显示文摘 | Greenland S Robins J M Pearl J | 1999 | Statistical Science1999，14，1： | 1 |
| 15 | Cd, Zn, Ni and Cu in the India Ocean 显示文摘 | qPaul M S Hein J W Robin H | 1992 | Deep -Sea Research1992，39，1： | 1 |
| 16 | Doppler ultrasound color flow imaging in the study of breast cancer:Preliminary findings显示文摘 | Alder D D Carson P L Robin J M | 1990 | Ultrasond Med Biol1990，16，： | 1 |
| 17 | Systemic hyperthermia and ICE chemotherapy for sarcoma patients:rationale and clinical status显示文摘 | Wiedemann G J Robins H I Katschinski D M | 1997 | Anticancer Res1997，17，4： | 1 |
| 18 | Spatial variability of strontium distribution coefficients and their correlation with hydraulic conductivity in the Canadian Forces Air Base Borden aquifer 显示文摘 | ROBIN M J L SUDICKY E A GILLHAM R W | 1991 | Water Resour Res1991，27，10： | 1 |
| 19 | Generation of cytotoxic T lymphocytes to autologous human leukemia cells by sensitization to pooled aUogeneic normal cells显示文摘 | Zarling J M Robins H I Raich P C | 1978 | Nature(Lond)1978，274，： | 1 |
| 20 | Gontrolled Nanofabrication of Highly Oriented Pyrolytic Graphite with the Scanning Tunneling Microscope 显示文摘 | ROBIN L M HENDRIGKS S A BARD A J | 1992 | J Phys Chem1992，96，10： | 1 |
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