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| 1 | 未破裂颅内动脉瘤患者管理指南美国心脏协会/美国卒中协会针对医疗专业人员的指南显示文摘目的这份更新版指南旨在为未破裂颅内动脉瘤患者的管理提供全面的循证建议。方法写作组采用系统文献回顾(1977年1月至2014年6月),参考同期已发表的循证指南、个人文件和专家意见来总结现有的证据,指出现有知识的差距;如果合适,则根据美国心脏协会( American Heart Association, AHA)标准做出推荐。本指南经过了包括卒中委员会领导层以及AHA科学声明监督委员会在内的广泛同行评议,然后由AHA科学咨询和协调委员会审批通过。结果本指南对未破裂颅内动脉瘤患者的医疗诊治提出了循证建议,涉及临床表现、自然史、流行病学、危险因素、筛查、诊断、影像学以及手术和血管内治疗的转归。 | B. Gregory Thompson Robert D. Brown Sepideh Amin-Hanjani Joseph P. Broderick Kevin M. Cockroft E. Sander Connolly Gary R. Duckwiler Catherine C. Harris Virginia J. Howard S. Claiborne (Clay) Johnston Philip M. Meyers Andrew Molyneux Christopher S. Ogilvy Andrew J. Ringer James Torner 肖国栋 徐加平 石际俊 尤寿江 张霞 刘慧慧 曹勇军 | 2015 | 国际脑血管病杂志2015，23，8： | 127 |
| 2 | FAIR Principles:Interpretations and Implementation Considerations显示文摘The FAIR principles have been widely cited,endorsed and adopted by a broad range of stakeholders since their publication in 2016.By intention,the 15 FAIR guiding principles do not dictate specific technological implementations,but provide guidance for improving Findability,Accessibility,Interoperability and Reusability of digital resources.This has likely contributed to the broad adoption of the FAIR principles,because individual stakeholder communities can implement their own FAIR solutions.However,it has also resulted in inconsistent interpretations that carry the risk of leading to incompatible implementations.Thus,while the FAIR principles are formulated on a high level and may be interpreted and implemented in different ways,for true interoperability we need to support convergence in implementation choices that are widely accessible and(re)-usable.We introduce the concept of FAIR implementation considerations to assist accelerated global participation and convergence towards accessible,robust,widespread and consistent FAIR implementations.Any self-identified stakeholder community may either choose to reuse solutions from existing implementations,or when they spot a gap,accept the challenge to create the needed solution,which,ideally,can be used again by other communities in the future.Here,we provide interpretations and implementation considerations(choices and challenges)for each FAIR principle. | Annika Jacobsen Ricardo de Miranda Azevedo Nick Juty Dominique Batista Simon Coles Ronald Cornet Melanie Courtot Merce Crosas Michel Dumontier Chris T.Evelo Carole Goble Giancarlo Guizzardi Karsten Kryger Hansen Ali Hasnain Kristina Hettne Jaap Heringa Rob W.W.Hooft Melanie Imming Keith G.Jeffery Rajaram Kaliyaperumal Martijn GKersloot Christine R.Kirkpatrick Tobias Kuhn Ignasi Labastida Barbara Magagna PeterMcQuilton Natalie Meyers Annalisa Montesanti Mirjam van Reisen Philippe Rocca-Serra Robert Pergl Susanna-Assunta Sansone Luiz Olavo Bonino da Silva Santos Juliane Schneider George Strawn Mark Thompson Andra Waagmeester Tobias Weigel Mark D.Wilkinson Egon L.Willighagen Peter Wittenburg Marco Roos Barend Mons Erik Schultes | 2020 | Data Intelligence2020，2，1： | 26 |
| 3 | Efficacy and safety of tenofovir in chronic hepatitis B: Australian real world experience显示文摘AIM To evaluate the long-term treatment outcomes of tenofovir therapy in patients in a real world Australian tertiary care setting.METHODS We performed a retrospective analysis of treatment outcomes among treatment-na?ve and treatment-experienced patients receiving a minimum 3 mo tenofovir therapy through St Vincent's Hospital Melbourne, Australia. We included patients receiving tenofovir [tenofovir disoproxil fumarate(TDF)] monotherapy, as well as patients treated with TDF in combination with a second antiviral agent. Patients were excluded if they demonstrated human immune-deficiency virus/hepatitis C virus/hepatitis delta virus coinfection or were less than 18 years of age. We considered virological and biochemicalresponse, as well as safety outcomes. Virological response was determined by measurement of hepatitis B virus(HBV) DNA using sensitive assays; biochemical response was determined via serum liver function tests; histological response was determined from liver biopsy and fibroscan; safety analysis focused on glomerular renal function and bone mineral density. The primary efficacy endpoint was complete virological suppression over time, defined by HBV DNA < 20 IU/m L. Secondary efficacy endpoints included rates of biochemical response, and HB e antigen(HBe Ag)/HB surface antigen loss and seroconversion over time.RESULTS Ninety-two patients were identified who fulfilled the enrolment criteria. Median follow-up was 26 mo(range 3-114). Mean age was 46(24-78) years, 64(70%) were male and 77(84%) were of Asian origin. 55(60%) patients were treatment-na?ve and 62 patients(67%) were HBe Ag-negative. Complete virological suppression was achieved by 45/65(71%) patients at 12 mo, 37/46(80%) at 24 mo and 25/28(89%) at 36 mo. Partial virological response(HBV DNA 20-2000 IU/m L) was achieved by 89/92(96.7%) of patients. Multivariate analysis showed a significant relationship between virological suppression at end of follow-up and baseline HBV DNA level(OR = 0.897, 95%CI: 0.833-0.967, P = 0.0046) and HBe Ag positive status(OR = 0.373, 95%CI: 0.183-0.762, P = 0.0069). There was no difference in response comparing treatment-na?ve and treatment-experienced patients. Three episodes of virological breakthrough occurred in the setting of noncompliance. Tenofovir therapy was well tolerated.CONCLUSION Tenofovir is an efficacious, safe and well-tolerated treatment in an Australian real-world tertiary care setting. Our data are similar to the reported experience from registration trials. | Grace C Lovett Tin Nguyen David M Iser Jacinta A Holmes Robert Chen Barbara Demediuk Gideon Shaw Sally J Bell Paul V Desmond Alexander J Thompson | 2017 | World Journal of Hepatology2017，9，1： | 7 |
| 4 | Preoperative radiotherapy versus selective postoperative chemoradiotherapy in patients with rectal cancer (MRC CR07 and NCIC-CTG C016): a multicentre, randomised trial显示文摘 | David Sebag-Montefiore Richard J Stephens Robert Steele John Monson Robert Grieve Subhash Khanna Phil Quirke Jean Couture Catherine de Metz Arthur Sun Myint Eric Bessell Gareth Griffiths Lindsay C Thompson Mahesh Parmar | 2009 | The Lancet2009，，9666： | 5 |
| 5 | 中国传统医学在泌尿系结石疾病中的应用(英文)显示文摘目的追溯中国传统医学的核心理念及其历史,评估其在治疗肾结石方面扮演的重要角色。方法从以下几个数据库搜集相关所有文献资料:OVID Medline,EMBASE,Cochrane数据库。关键词包括'中国传统医学''、尿石症''、结石''、中药''、汉方医学''、肾'。查找到的相关综述、病例报告和书籍均来源于英国伦敦皇家医学会的惠康基金会藏书资源。结果中国传统医学已经存在了2500多年。它由针灸学、中药学、推拿学和气功学组成。现存最早的中药学专著是《神农本草经》,约成书于汉代。纵观中国历史,在治疗慢性病方面,本书扮演了极重要的角色,且在中国和日本(即'汉方医学')广泛应用了数十年,直到18世纪后期西方医学的引入。中国传统医学在泌尿外科学方面广受欢迎,包括用中药'人参'治疗勃起功能障碍,用针灸和中药联合治疗膀胱过度活动症和肾结石。在中国传统医学的观点中,膀胱气化失调引起了湿热向下扩散并累积到泌尿系统,日积月累引起了结石形成。尿石症阻滞了气的流动,引起了疼痛。而血尿源于结石对经络系统的损伤。目前,中国传统医学在预防和治疗肾结石方面的文献证据虽说有限,但日益增长。1994年,中国国家医药管理局就治疗尿石症发布了指南,指南将尿石症分型为4种(湿热蕴结型,气滞血瘀型,肾阴不足型和肾阳不足型),每种症状的治疗方式都不同。近年来的证据表明中医药能有效增加结石排出率,减少尿石症的并发症形成,这些能间接减少住院时间及花销。结论中国传统医学的根源来自于中国传统文化,现在逐渐有了世界范围内的影响力,我们要认可其在泌尿外科学临床实践过程中起到的重要补充作用。 | 陈始均 古迪 L.J.TAY Robert GRAY 荆涛 陈定南 郑少斌 Peter THOMPSON | 2016 | 分子影像学杂志2016，39，2： | 4 |
| 6 | U. S. Householder survey of functional gastrointestinal disorders显示文摘 | Douglas A. Drossman Zhiming Li Eileen Andruzzi Robert D. Temple Nicholas J. Talley W. Grant Thompson William E. Whitehead Josef Janssens Peter Funch-Jensen Enrico Corazziari Joel E. Richter Gary G. Koch | 1993 | Digestive Diseases and Sciences1993，，9： | 4 |
| 7 | Comparison of Cold and Warm Ischemia During Partial Nephrectomy in 660 Solitary Kidneys Reveals Predominant Role of Nonmodifiable Factors in Determining Ultimate Renal Function显示文摘 | Brian R. Lane Paul Russo Robert G. Uzzo Adrian V. Hernandez Stephen A. Boorjian R. Houston Thompson Amr F. Fergany Thomas E. Love Steven C. Campbell | 2011 | The Journal of Urology2011，，2： | 3 |
| 8 | Preoperative radiotherapy versus selective postoperative chemoradiotherapy in patients with rectal cancer (MRC CR07 and NCIC-CTG C016): a multicentre, randomised trial显示文摘 | David Sebag-Montefiore Richard J Stephens Robert Steele John Monson Robert Grieve Subhash Khanna Phil Quirke Jean Couture Catherine de Metz Arthur Sun Myint Eric Bessell Gareth Griffiths Lindsay C Thompson Mahesh Parmar | 2009 | The Lancet2009，，9666： | 3 |
| 9 | Preoperative radiotherapy versus selective postoperative chemoradiotherapy in patients with rectal cancer (MRC CR07 and NCIC-CTG C016): a multicentre, randomised trial显示文摘 | David Sebag-Montefiore Richard J Stephens Robert Steele John Monson Robert Grieve Subhash Khanna Phil Quirke Jean Couture Catherine de Metz Arthur Sun Myint Eric Bessell Gareth Griffiths Lindsay C Thompson Mahesh Parmar | 2009 | The Lancet . 2009 (9666)2009，，9666： | 3 |
| 10 | Phoenix phylogeny, and analysis of genetic variation in a diverse collection of date palm(Phoenix dactylifera) and related species显示文摘Date palm(Phoenix dactylifera),one of the most ancient crops,is grown commercially in>30 countries.Using whole plastome assemblies,phylogenetic analyses revealed that cultivated date palm accessions share the same clade with Phoenix sylvestris,Phoenix pusilla and Phoenix acaulis,which are native to the Indian subcontinent,and Phoenix caespitosa that is native to the Arabian Peninsula and the deserts of Somalia.Analysis of genetic diversity and genetic relationships among date palm accessions from 13 producing countries involved 195 date palm accessions that were genotyped at 19 microsatellite loci.Extensive genetic diversity was observed,with many accessions heterozygous for most markers in this clonally propagated crop.The average number of alleles per locus(42.1),expected heterozygosity(0.8),observed heterozygosity(0.47)and fixation indices(FST=0.42)demonstrated substantial genetic diversity and population structure.Iraqi accessions were found to have the richest allelic diversity,and the most private alleles.The model-based Bayesian method indicated that these accessions could be broadly divided into two structure groups,one group with predominantly African accessions and another predominantly Asian.Some germplasm,especially from Tunisia and Iraq,deviated from this generalization.Many accessions in the STRUCTURE-derived groups were found to be genetic admixtures,with gene flow between Asian and African groups.Indian and Pakistani date palms were found to be most closely related to North African germplasm. | Srinivasa R.Chaluvadi Porter Young Kentrez Thompson Bochra Amina Bahri Bhavesh Gajera Subhash Narayanan Robert Krueger Jeffrey L.Bennetzen | 2019 | Plant Diversity2019，41，5： | 3 |
| 11 | Gene therapy and erectile dysfunction: the current status显示文摘为可勃起的机能障碍(编辑) 的当前的可得到的处理选择是有效的然而并非没有失败或副作用。尽管 phosphodiesterasetype 的发展 5 (PDE5 ) 禁止者(即 sildenafil, tadalafil 和 vardenafil ) 革命化了编辑的治疗,这些口头的药要求按需的存取并且不作为与糖尿病、前列腺切除术以后、严重的 veno 闭塞的疾病状态有关的有效 intreating 编辑。在编辑的治疗的改进依赖于理解人的肉体的光滑的肌肉音调并且在相关分子的目标的鉴定上的规定。未来编辑治疗可能考虑象基因治疗那样的分子的技术的申请。作为一个潜在的治疗学的工具,没有影响休息阴茎功能,基因治疗可能“在需求上”为 alteringintracavernous 压力提供一个有效、特定的工具。然而,基因治疗的安全仍然是一个主要障碍在作为一个主流的处理被接受让编辑基因治疗目的在编辑治好内在的条件前克服,包括纤维变性。而且,基因治疗可能帮助由改进阴茎氮的 oxidebioactivity 延长 PDE5 禁止者的功效。因为它的地点和可接近性,处于松驰的状态的低阴茎循环流动和 endotheliallined (花格平顶) 的存在空格,把基因治疗用于阴茎是可行的。这评论在编辑的管理提供基因治疗的当前的角色的简短卓见。 | David H. W. Lau Sashi S. Kommu Emad J. Siddiqui Cecil S. Thompson Robert J. Morgan Dimitri P. Mikhailidis Faiz H. Mumtaz | 2007 | Asian Journal of Andrology2007，9，1： | 2 |
| 12 | Portal Hypertension in Children: Expert Pediatric Opinion on the Report of the Baveno V Consensus Workshop on Methodology of Diagnosis and Therapy in Portal Hypertension显示文摘 | Benjamin L. Shneider Jaime Bosch Roberto de Franchis Sukru H. Emre Roberto J. Groszmann Simon C. Ling Jonathan M. Lorenz Robert H. Squires Riccardo A. Superina Ann E. Thompson George V. Mazariegos | 2012 | Pediatric Transplantation2012，，5： | 2 |
| 13 | A randomized trial comparing uncovered and partially covered self-expandable metal stents in the palliation of distal malignant biliary obstruction显示文摘 | Jennifer J. Telford David L. Carr-Locke Todd H. Baron John M. Poneros Brenna C. Bounds Peter B. Kelsey Robert H. Schapiro Christopher S. Huang David R. Lichtenstein Brian C. Jacobson John R. Saltzman Christopher C. Thompson David G. Forcione Christopher J | 2010 | Gastrointestinal Endoscopy2010，，： | 2 |
| 14 | Mutifactorial analysis of risk factors for reduced bone mineral density in patients with Crohn’s disease显示文摘AIM: To determine the prevalence of osteoporosis in a cohort of patients with Crohn’s disease (CD) and to identify the relative significance of risk factors for osteoporosis. METHODS: Two hundred and fifty-eight unselected patients (92 M, 166 F) with CD were studied. Bone mineral density (BMD) was measured at the lumbar spine and hip by dual X-ray absorptiometry. Bone formation was assessed by measuring bone specific alkaline phosphatase (BSAP) and bone resorption by measuring urinary excretion of deoxypyridinoline (DPD) and N-telopeptide (NTX). RESULTS: Between 11.6%-13.6% patients were osteoporotic (T score < -2.5) at the lumbar spine and/or hip. NTX levels were significantly higher in the patients with osteoporosis (P < 0.05) but BSAP and DPD levels were not significantly different. Independent risk factors for osteoporosis at either the lumbar spine or hip were a low body mass index (P < 0.001), increasing corticosteroid use (P < 0.005), and male sex (P < 0.01). These factors combined accounted for 23% and 37% of the reduction in BMD at the lumbar spine and hip respectively. CONCLUSION: Our results confirm that osteoporosis is common in patients with CD and suggest that increased bone resorption is the mechanism responsible for thebone loss. However, less than half of the reduction in BMD can be attributed to risk factors such as corticosteroid use and low BMI and therefore remains unexplained. | Sarah A Bartram Robert T Peaston David J Rawlings David Walshaw Roger M Francis Nick P Thompson | 2006 | World Journal of Gastroenterology2006，12，35： | 2 |
| 15 | Efficacy of everolimus in advanced renal cell carcinoma: a double-blind, randomised, placebo-controlled phase III trial显示文摘 | Robert J Motzer Bernard Escudier Stéphane Oudard Thomas E Hutson Camillo Porta Sergio Bracarda Viktor Grünwald John A Thompson Robert A Figlin Norbert Hollaender Gladys Urbanowitz William J Berg Andrea Kay David Lebwohl Alain Ravaud | 2008 | The Lancet2008，，9637： | 2 |
| 16 | Temperature Compensation of Total Power Radiometers显示文摘 | David A Thompson Robert L Rogers | 2003 | IEEE Transactions on Microwave and Techniques2003，51，10： | 1 |
| 17 | Preclinical and clinical evaluations of ABX-EGF, a fully human anti-epidermal growth factor receptor antibody显示文摘 | Kenneth A Foon Xiao-Dong Yang Louis M Weiner Arie S Belldegrun Robert A Figlin Jeffrey Crawford Eric K Rowinsky Janice P Dutcher Nicholas J Vogelzang Jared Gollub John A Thompson Garry Schwartz Ronald M Bukowski Lorin K Roskos Gisela M Schwab | 2004 | International Journal of Radiation Oncology Biology Physics2004，，3： | 1 |
| 18 | Sequence and the developmental and tissue-specific regulation of the first complete vitellogenin messenger RNA from ticks responsible for heme sequestration显示文摘 | Deborah M. Thompson Sayed M.S. Khalil Laura A. Jeffers Daniel E. Sonenshine Robert D. Mitchell Christopher J. Osgood R. Michael Roe | 2007 | Insect Biochemistry and Molecular Biology2007，，4： | 1 |
| 19 | An analytic expression for the field dependence of Zernike polynomialrotationally symmetric optical systems显示文摘 | Robert W Gray Christina Dunn Kevin P Thompson | 2012 | Opt Express2012，20，16： | 1 |
| 20 | The oxygen free radical system: a fundamental mechanism in the production of myocardial necrosis显示文摘 | Roberts MT Born VR | 1986 | progcardiovas Dis1986，28，： | 1 |
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