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| 1 | Combined carriership of TLR9 -1237C and CD14 -260T alleles enhances the risk of developing chronic relapsing pouchitis显示文摘AIM: To investigate the single nucleotide polymorphisms (SNPs) in genes involved in bacterial recognition and the susceptibility to pouchitis or pouchitis severity.METHODS: Analyses of CD14 -260C>T, CARD15/NOD2 3020insC, Toll-like receptor (TLR)4 +896A>G,TLR9 -1237T>C, TLR9+ 2848G>A, and IRAKM +22148G>A SNPs were performed in 157 ileal-pouch anal anastomosis (IPAA) patients (79 patients who did not develop pouchitis, 43 infrequent pouchitis patients,35 chronic relapsing pouchitis patients) and 224 Italian Caucasian healthy controls.RESULTS: No significant differences were found in SNP frequencies between controls and IPAA patients.However, a significant difference in carriership frequency of the TLR9-1237C allele was found between the infrequent pouchitis and chronic relapsing pouchitis groups [P = 0.028, odd's ratio (OR) = 3.2, 95%CI = 1.2-8.6].This allele uniquely represented a 4-locus TLR9 haplotype comprising both studied TLR9 SNPs in Caucasians.Carrier trait analysis revealed an enhanced combined carriership of the alleles TLR9 -1237C and CD14 -260T in the chronic relapsing pouchitis and infrequent pouchitis group (P = 0.018, OR = 4.1, 95%CI = 1.4 -12.3).CONCLUSION: There is no evidence that the SNPs predispose to the need for IPAA surgery. The significant increase of the combined carriership of the CD14 -260T and TLR9 -1237C alleles in the chronic relapsing pouchitis group suggests that these markers identify a subgroup of IPAA patients with a risk of developing chronic or refractory pouchitis. | KM Lammers S Ouburg SA Morré JBA Crusius P Gionchetti F Rizzello C Morselli E Caramelli R Conte G Poggioli M Campieri AS Pea | 2005 | World Journal of Gastroenterology2005，11，46： | 7 |
| 2 | Risk factors and outcomes of delayed graft function in renal transplant recipients receiving a steroid sparing immunosuppression protocol显示文摘AIM To analyse the risk factors and outcomes of delayed graft function(DGF) in patients receiving a steroid sparing protocol. METHODS Four hundred and twenty-seven recipients of deceased donor kidney transplants were studied of which 135(31.6%) experienced DGF. All patients received monoclonal antibody induction with a tacrolimus based, steroid sparing immunosuppression protocol.RESULTS Five year patient survival was 87.2% and 94.9% in the DGF and primary graft function(PGF) group respectively, P = 0.047. Allograft survival was 77.9% and 90.2% in the DGF and PGF group respectively, P < 0.001. Overall rejection free survival was no different between the DGF and PGF groups with a 1 and 5 year rejection free survival in the DGF group of 77.7% and 67.8% compared with 81.3% and 75.3% in the PGF group, P = 0.19. Patients with DGF who received IL2 receptor antibody induction were at significantly higher risk of rejection in the early post-transplant period than the group with DGF who received alemtuzumab induction. On multivariate analysis, risk factors for DGF were male recipients, recipients of black ethnicity, circulatory death donation, preformed DSA, increasing cold ischaemic time, older donor age and dialysis vintage.CONCLUSION Alemtuzumab induction may be of benefit in preventing early rejection episodes associated with DGF. Prospective trials are required to determine optimal immunotherapy protocols for patients at high risk of DGF. | Michelle Willicombe Anna Rizzello Dawn Goodall Vassilios Papalois Adam G Mc Lean David Taube | 2017 | World Journal of Transplantation2017，7，1： | 4 |
| 3 | Effect of sour dough fermentation on stabilization and chemical and nutritional characteristics of wheat germ 显示文摘 | C G Rizzello L Nionelli R Coda | 2010 | Food Chemistry2010，119，3： | 1 |
| 4 | Bran bioprocessing for enhanced functional properties 显示文摘 | Rossana Coda Kati Katina Carlo G Rizzello | 2015 | Food Science2015，1，： | 1 |
| 5 | Manufacture and characterization of functional emmet beverages fermented by selected lactic acid bacteria显示文摘 | CODA P RIZZELLO C G TRANI A | | Food Microbiology0，28，： | 1 |
| 6 | Antifungal activity of sourdough fermented wheat germ used as an Ingredient for bread making显示文摘 | RIZZELLO C G CASSONE A CODA R | 2011 | Food Chemistry2011，127，3： | 1 |
| 7 | Long-term effects of laparoscopic sleeve gastrectomy, gastric bypass, and adjustable gastric banding on type 2 diabetes 显示文摘 | Abbatini F Rizzello M Casella G | 2010 | Surg Endosc2010，24，5： | 1 |
| 8 | Ovarian surgery for bilateral endometriomas influences age at menopause显示文摘 | Coccia ME Rizzello F Mariani G | 2011 | Hum Reprod2011，26，11： | 1 |
| 9 | Antifungal Activity of Wickerhamomyces anomalus and Lactobacillus plantarum during sourdough fermentation: identification of novel compounds and long-term effect during storage of wheat bread 显示文摘 | Coda R Cassone A Rizzello C G | 2011 | Applied and Environmental Microbiology2011，77，10： | 1 |
| 10 | Sourdough fermentation as a tool for the manufacture of low-glycemic index white wheat bread enriched in dietary fibre显示文摘 | M De Angelis N Damiano C G Rizzello | 2009 | European Food Research and Technology2009，229，4： | 1 |
| 11 | Use of sourdough lactobacilli and oat fibre to decrease the glycaemic index of white wheat bread 显示文摘 | De Angelis M Rizzello C G Alfonsi G | 2007 | British Journal of Nutrition2007，98，6： | 1 |
| 12 | AngiotensinIConverting-Enzyme-Inhibitory and Antibacterial Peptides from Lactobacillus helveticus PR4 Proteinase-Hydrolyzed Caseins of Milk from Six Species显示文摘 | F Minervini F Algaron C G Rizzello | 2003 | Applied and Environmental Microbiology2003，69，9： | 1 |
| 13 | Antifungal activity of sourdough fermented wheat germ used as an ingredient for bread rnaking显示文摘 | Rizzello C G Cassone A Coda R | 2011 | Food Chemistry2011，127，3： | 1 |
| 14 | Use of sourdough fermented wheat germ for enhancing the nutritional, texture and sensory characteristics of the white bread显示文摘 | RIZZELLO C G NIONELLI L CODA R | 2010 | Eur Food Res Technol2010，230，4： | 1 |
| 15 | Angiotensin I-converting-enzyme-inhibitory and antimicrobial bioactive peptides显示文摘 | Gobbetti M Minervini F Rizzello C G | 2004 | Int J Dairy Technol2004，57，： | 1 |
| 16 | Long-term effects of laparoscopic sleeve gastrectomy, gastric bypass, and adjustable gastric banding on type 2 diabetes显示文摘 | Abbatini F Rizzello M Casella G | 2009 | Surg Endose2009，24，5： | 1 |
| 17 | Impact of endometriosis on in vitro fertilization and embryo transfer cycles in young women:a stage-dependent interference显示文摘 | Coccia ME Rizzello F Mariani G | 2011 | ACTA Obstet Gynecol2011，90，11： | 1 |
| 18 | Antibacterial activities of peptides from the water - soluble extracts of Italian cheeses varieties 显示文摘 | Rizzello C G Losito I Gobbetti M | 2005 | J DairySci2005，88，7： | 1 |
| 19 | Laparoscopic sleeve gastreetomy as first stage or definitive intent in 300 consecutive cases显示文摘 | Basso N Casella G Rizzello M | 2011 | Surg Endosc2011，25，2： | 1 |
| 20 | Modulation of CD4 +CD 28 null T lymphocytes by tumor necrosis factor-alpha blockade in patients with unstable angina显示文摘 | Rizzello V Liuzzo G Brugaletta S | | 0，，19： | 1 |
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