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| 1 | L-arginine-induced experimental pancreatitis显示文摘Despite medical treatment, the lethality of severe acute pancreatitis is still high (20-30%). Therefore, it is very important to find good animal models to characterise the events of this severe disease. In 1984, Mizunuma et. al. developed a new type of experimental necrotizing pancreatitis by intraperitoneal administration of a high dose of L-arginine in rats. This non-invasive model is highly reproducible and produces selective, dose-dependent acinar cell necrosis.Not only is this a good model to study the pathomechanisne of acute necrotizing pancreatitis, but it is also excellent to observe and influence the time course changes of the disease. By writing this review we iluminate some new aspects of cell physiology and pathology of acute necrotizing pancreatitis. Unfortunately, the reviews about acute experimental pancreatitis usually did not discuss this model.Therefore, the aim of this manuscript was to summarise the observations and address some challenges for the future in L-arginine-induced pancreatitis. | PéterHegyi ZoltánRakonczayJr RékaSári CsabaGóg JánosLonovics TamásTakács LászlóCzakó | 2004 | World Journal of Gastroenterology2004,10,14: | 7 |
| 2 | Compared efficacy of preservation solutions on the outcome of liver transplantation:Meta-analysis显示文摘AIM To compare the effects of the four most commonly used preservation solutions on the outcome of liver transplantations.METHODS A systematic literature search was performed using MEDLINE, Scopus, EMBASE and the Cochrane Library databases up to January 31^(st), 2017. The inclusion criteria were comparative, randomized controlled trials(RCTs) for deceased donor liver(DDL) allografts with adult and pediatric donors using the gold standard University of Wisconsin(UW) solution or histidinetryptophan-ketoglutarate(HTK), Celsior(CS) and Institut Georges Lopez(IGL-1) solutions. Fifteen RCTs(1830 livers) were included; the primary outcomes were primary non-function(PNF) and one-year posttransplant graft survival(OGS-1). RESULTS All trials were homogenous with respect to donor and recipient characteristics. There was no statistical difference in the incidence of PNF with the use of UW, HTK, CS and IGL-1(RR = 0.02, 95%CI: 0.01-0.03, P = 0.356). Comparing OGS-1 also failed to reveal any difference between UW, HTK, CS and IGL-1(RR = 0.80, 95%CI: 0.80-0.80, P = 0.369). Two trials demonstrated higher PNF levels for UW in comparison with the HTK group, and individual studies described higher rates of biliary complications where HTK and CS were used compared to the UW and IGL-1 solutions. However, the meta-analysis of the data did not prove a statistically significant difference: the UW, CS, HTK and IGL-1 solutions were associated with nearly equivalent outcomes.CONCLUSION Alternative solutions for UW yield the same degree of safety and effectiveness for the preservation of DDLs, but further well-designed clinical trials are warranted. | Agnes Lilla Szilágyi Péter Mátrai Péter Hegyi Eszter Tuboly Daniella Pécz András Garami Margit Solymár Erika Pétervári Márta Balaskó Gábor Veres László Czopf Bastian Wobbe Dorottya Szabó Juliane Wagner Petra Hartmann | 2018 | World Journal of Gastroenterology2018,24,16: | 5 |
| 3 | 强制对流条件下不同传热流体对含相变材料柱形容器放热性能的影响显示文摘本文采用数值模拟方法研究了强制对流条件下不同传热流体对含相变材料柱形容器的放热性能的影响。以空气、氢、水和含氧化铝颗粒的纳米流体作为传热流体,同时考虑了含相变材料(PCM)区域的结构变化,采用有限元法进行求解。研究了不同传热流体类型、雷诺数(100~300)和含PCM区域结构变化(h_(x)在0.01d_(1)~0.65d_(1),h_(y)在0.1h_(1)~0.4h_(1))下不同相的换热动力学特征。研究发现,换热流体类型对放热时间影响较大,以空气为换热流体时相变完成时间比以空气为换热流体时的长10倍以上,而以纳米流体为换热流体时的时间最短。当含PCM区域减小时,放热时间缩短。含PCM区域的结构导致涡流的形成,这使在内筒的半径和高度最大处的性能下降。当内筒半径从h_(x)=0.35d_(1)增加到h_(x)=0.45d_(1)时,放热时间延长约12%。在不同雷诺数下,PCM的温度和液体组分的动态特性均受雷诺数的影响,与最小雷诺数相比,最大雷诺数下的PCM的放电时间缩短了48%左右。 | SELİMEFENDİGİL Fatih ŞİRİN Ceylin ÖZTOP Hakan F | 2021 | Journal of Central South University2021,28,11: | 2 |
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| 16 | Attracting foreign manufacturing:investment promotion and agglomeration 显示文摘 | Head C K Ries J C Swenson D L | 1999 | Regional Science and Urban Economics1999,29,: | 1 |
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