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| 1 | Effects of bee propolis supplementation on glycemic control, lipid profile and insulin resistance indices in patients with type 2 diabetes: a randomized, double-blind clinical trial显示文摘BACKGROUND:Propolis,a natural resinous substance made by bees from material extracted from plants,flowers and bee's wax,has shown great therapeutic effects and been widely used in food and drug industries.Recently,some researchers have studied the effect of this substance in the treatment of diabetes.OBJECTIVE:The purpose of this trial was to determine the effect of bee propolis on glycemic control,serum lipid profile and insulin resistance indices in patients with type 2 diabetes(T2D).DESIGN,SETTING,PARTICIPANTS AND INTERVENTIONS:This randomized clinical trial involved 66 patients with T2 D,which were randomly divided into two groups of intervention(IG) and placebo(PG).IG received 300 mg three times a day for a total of 900 mg/d of propolis pills,while PG received similar pills,lacking propolis,on the same schedule for 12 weeks.MAIN OUTCOME MEASURES:Fasting blood glucose(FBG),hemoglobin A1c(HbA1c),total cholesterol(TC),low-density lipoprotein(LDL),high-density lipoprotein(HDL),triglyceride(TG),serum insulin and insulin resistance indices were the main outcome measures.RESULTS:The mean change in FBG between the IG((17.76 ± 27.72) mg/dL decrease) and the PG((6.48 ± 42.77) mg/dL increase) was significantly different(P= 0.01).Change in mean HbA1 c had a similar pattern to FBG.The mean change in TC between the IG((5.16 ± 43.80) mg/dL increase) and the PG((28.9 ± 27.4) mg/dL increase) was also significantly different(P= 0.01),showing the protective role of propolis against the increase in TC.The change in mean LDL was similar to mean TC.There was no significant difference in other lipids or insulin resistance indices between the two groups.CONCLUSION:Based on this study,the daily intake of 900 mg of bee propolis supplement for 12 weeks results in improvement of glycemic and some serum lipid levels in patients with T2 D.TRIAL REGISTRATION:This study is registered on the website of Iranian Ministry of Health(www.irct.ir)with proprietary code of IRCT2014080218659N1. | Nazli Samadi Hassan Mozaffari-Khosravi Masoud Rahmanian Mohsen Askarishahi | 2017 | Journal of Integrative Medicine2017，15，2： | 6 |
| 2 | Epicardial pulmonary vein isolation:a long-term histologic and imaging animal study comparing cryothermy versus radiofrequency显示文摘 | Rahmanian PB Castillo JG Mehta D | 2008 | Ann Thorac Surg2008，86，3： | 1 |
| 3 | Posterolateral versus posterior interbody fusion in isthmic spondylolisthesis 显示文摘 | Farrokhi MR Rahmanian A Masoudi MS | 2012 | J Neurotrauma2012，29，8： | 1 |
| 4 | Immunocytochemical localization of luteinizing hormone and follicle-stimulating hormone in the equine pituitary显示文摘 | RAHMANIAN M S THOMPSON D L J MELROSE P A | 1998 | J Anim Sci1998，76，： | 1 |
| 5 | Large annulo- plasty rings facilitate mitral valve repair in Barlow's disease显示文摘 | Adams DH Anyanwu AC Rahmanian PB | 2006 | Ann Thorac Surg2006，82，6： | 1 |
| 6 | Acute mesenteric ischemia:a vascular emergency显示文摘 | Klar E Rahmanian PB Bucker A | 2012 | Dtsch Arztebl Int2012，109，14： | 1 |
| 7 | Posterolateral versus posterior interbody fusion in isthmic spondylolis- thesis 显示文摘 | Farrokhi MR Rahmanian A Masoudi MS | 2012 | Neurotrauma2012，29，8： | 1 |
| 8 | Surfactant application in experiment lung transplantation 显示文摘 | Wittwer T Madershahian N Rahmanian P | 2013 | Heart Lung Transplant2013，32，3： | 1 |
| 9 | Immunocytochemical localization of luteinizing hormone and follicle-stimulating hormone in the equine pituitary显示文摘 | RAHMANIAN M S THOMPSON D L J MELROSE P A | 1998 | J Anim Sci1998，76，： | 1 |
| 10 | Synthesis of vertically a- ligned carbon nanotubes on carbon fiber 显示文摘 | Rahmanian S Suraya A R Zahari R | 2013 | Applied Surface Science2013，271，4： | 1 |
| 11 | Acute mesenteric ische- mia:a vascular emergency 显示文摘 | Klar E Rahmanian PB BUcker A | 2012 | Dtsch Arztebl Int2012，109，14： | 1 |
| 12 | Association of Rose angina with cardiovascular risk factors among men and women: a population-based study 显示文摘 | SHOJAEI M RAHMANIAN K MOAYEDY-RAD M | 2013 | Jentashapir J Health Res2013，4，6： | 1 |
| 13 | Impact of bodymass indexon early outcome and late survival in pa- tients undergoing coronary artery bypass grafting or valve surgery or both显示文摘 | Rahmanian PB Adams DH Castillo JG | 2007 | Am J Cardiol2007，100，11： | 1 |
| 14 | Incidence, to- pograpay, predictors and long-term survival after stroke in patients undergoing coronary artery bypass grafting 显示文摘 | Filsoufi F Rahmanian PB Castillo JG | 2008 | Ann Thorac Surg2008，85，10： | 1 |
| 15 | Posterolateral versus posterior interbody fusion in isthmic spondylolisthesis显示文摘 | Farrokhi MR Rahmanian A Masoudi MS | 2012 | J Neurotrauma2012，29，8： | 1 |
| 16 | A postoperative analysis of perfusion dynamics in deep inferior epigastric perforator flap breast reconstruction:A noninvasive quantitative measurement of flap oxygen saturation and blood flow显示文摘 | Rahmanian Schwarz A Rothenberger J Amr A | 2012 | Annals of Plastic Surgery2012，69，5： | 1 |
| 17 | Predictors and outcome of gastrointestinal complications in patients undergoing cardiac surgery 显示文摘 | Filsoufi F Rahmanian PB Castillo JG | 2007 | Ann Surg2007，246，2： | 1 |
| 18 | A combined experimental and numerical method for extracting temperature-dependent ther- mal conductivity of gypsum boards 显示文摘 | RAHMANIAN I WANG Y C | 2012 | Construction and Building Materials2012，26，1： | 1 |
| 19 | Siliciclastic sequence stratigraphy in well logs, cores and outcrops: Concepts for high-resolution correlation of time and facies 显示文摘 | VAN WAGONER J V MITCHUM R M COMPION K M RAHMANIAN V D | 1990 | AAPG Bulletin1990，7，： | 1 |
| 20 | The prevalence of pre-hypertension and its association to established cardiovascular risk factors in south of Iran显示文摘 | Rahmanian K Shojaie M | 2012 | BMC Res Notes2012，5，2： | 1 |
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