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| 1 | Down syndrome and the molecular pathogenesis resulting from trisomy of human chromosome 21显示文摘Chromosome copy number aberrations, anueploidies, are common in the human population but generally lethal. However, trisomy of human chromosome 21 is compatible with life and people born with this form of aneuploidy manifest the features of Down syndrome, named after Langdon Down who was a 19th century British physician who first described a group of people with this disorder. Down syndrome includes learning and memory deficits in all cases, as well as many other features which vary in penetrance and expressivity in different people. While Down syndrome clearly has a genetic cause - the extra dose of genes on chromosome 21-we do not know which genes are important for which aspects of the syndrome, which biochemical pathways are disrupted, or, generally how design therapies to ameliorate the effects of these disruptions. Recently, with new insights gained from studying mouse models of Down syndrome, specific genes and pathways are being shown to be involved in the pathogenesis of the disorder. This is opening the way for exciting new studies of potential therapeutics for aspects of Down syndrome, particularly the learning and memory deficits. | Aarti Ruparelia Frances Wiseman Olivia Sheppard Victor L.J.Tybulewicz Elizabeth M.C.Fisher | 2010 | The Journal of Biomedical Research2010，24，2： | 4 |
| 2 | Role of coronary physiology in the contemporary management of coronary artery disease显示文摘Coronary artery disease(CAD) remains the leading cause of death worldwide with approximately 1 in 30 patients with stable CAD experiencing death or acute myocardial infarction each year. The presence and extent of resultant myocardial ischaemia has been shown to confer an increased risk of adverse outcomes. Whilst, optimal medical therapy(OMT) forms the cornerstone of the management of patients with stable CAD, a significant number of patients present with ischaemia refractory to OMT. Historically coronary angiography alone has been used to determine coronary lesion severity in both stable and acute settings. It is increasingly clear that this approach fails to accurately identify the haemodynamic significance of lesions; especially those that are visually 'intermediate' in severity. Revascularisation based upon angiographic appearances alone may not reduce coronary events above OMT. Technological advances have enabled the measurement of physiological indices including the fractional flow reserve, the index of microcirculatory resistance and the coronary flow reserve. The integration of these parameters into the routine management of patients presenting to the cardiac catheterization laboratory with CAD represents a critical adjunctive tool in the optimal management of these patients by identifying patients that would most benefit from revascularisation and importantly also highlighting patients that would not gain benefit and therefore reducing the likelihood of adverse outcomes associated with coronary revascularisation. Furthermore, these techniques are applicable to a broad range of patients including those with left main stem disease, proximal coronary disease, diabetes mellitus, previous percutaneous coronary intervention and with previous coronary artery bypass grafting. This review will discuss current concepts relevant to coronary physiology assessment, its role in the management of both stable and acute patients and future applications. | Neil Ruparelia Rajesh K Kharbanda | 2015 | World Journal of Clinical Cases2015，3，2： | 2 |
| 3 | The Acute Medicine-Speciality Interface : Experience in a large teaching hospital 显示文摘 | Southgate J Ruparelia P Phillips S | 2011 | Acute Med2011，10，2： | 1 |
| 4 | Comparison of the effects of the chemopreventive agent resveratrol and its synthetic analog trans -3,4,5,4'-tetramethoxystilbene (DMU-212) on adenoma development in the Apc (Min +) mouse and cyclooxygenase-2 in human-derived colon cancer cells显示文摘 | Sale S Tunstall R G Ruparelia K C | 2005 | Int J Cancer2005，115，2： | 1 |
| 5 | Strain specificity in antimicrobial activity of silver and copper nanoparticles显示文摘 | Jayesh P. Ruparelia Arup Kumar Chatterjee Siddhartha P. Duttagupta Suparna Mukherji | 2007 | Acta Biomaterialia2007，，3： | 1 |
| 6 | Enhancement of chemotherapy and radiotheraopy of murine tumours by AQ4N,a bioreductively activated anti-tumour agent显示文摘 | MCKEOWN SR RUPARELIA K | 2000 | British Journal of Cancer2000，82，12： | 1 |
| 7 | Is a drug-eluting stent the default treatment strategy for drug-eluting stent restenosis?显示文摘 | Colombo A Ruparelia N | 2015 | J Am Coll Cardiol2015，66，1： | 1 |
| 8 | Perioperative management of anticoagulation during device implantation-the UK perspective显示文摘 | de Bono J Nazir S Ruparelia N | 2010 | Pacing Clin Electrophysiol2010，33，4： | 1 |
| 9 | Potential of carbon nanomaterials for removal of heavy metals from water显示文摘 | Ruparelia J P Duttagupta S P Chatterjee A K | 2008 | Desalination2008，232，： | 1 |
| 10 | Strain specificity in antimicrobial activity of silver and copper nanopartieles显示文摘 | Ruparelia JP Chatteriee AK Duttagupta SP | 2008 | Acta Biomater2008，4，3： | 1 |
| 11 | Effects of the potential chemopreventive agent DMU-135 on adenoma development in the ApcMin+ mouse显示文摘 | Sale S Tunstall R G Ruparelia K C | 2006 | Invest New Drugs2006，24，6： | 1 |
| 12 | Enhancement of chemotherapy and radiotherapy of murine tumours by AQ4N, a bioreductively activated anti-tumour agent显示文摘 | Patterson L h McKeown S R Ruparelia K | 2000 | British Journal of Cancer2000，82，12： | 1 |
| 13 | National registry for juvenile-onset recurrent respiratory papillomatosis显示文摘 | REEVES W C RUPARELIA S S SWANSON K I | 2003 | Arch Otolaryngol Head Neck Surg2003，129，： | 1 |
| 14 | CYPI-mediated antiproliferative activity of dietary flavonoids in MDA-MB-468 breast cancer cells显示文摘 | Androutsopoulos VP Ruparelia K Arroo RR | 2009 | Toxicology2009，264，4： | 1 |
| 15 | Effects of the potential chemopreventive agent DMU-135 on adenoma development in the ApcMin+ mouse显示文摘 | Sale S Tunstall R G Ruparelia K C | 2006 | Invest New Drugs2006，24，6： | 1 |
| 16 | Is the neutrophil the key effector cell in severe asthma显示文摘 | Kamath AV Pavord ID Ruparelia PR | | 0，，： | 1 |
| 17 | Comparison of the effects of the chemo-preventive agent resveratrol and its synthetic analog trans 3, 4, 5, 4'-tetramethoxystilbene (DMU-212) on adenoma development in the Apc(Min+) mouse and cycloox ygenase-2 in human-deri ved colon cancer cells显示文摘 | Tunstall RG Sale S Ruparelia KC | 2005 | Int J Cancer2005，115，2： | 1 |
| 18 | Management of advanced-stage laryngeal cancer显示文摘 | LEVINE P A BRASNU D F RUPARELIA A | 1997 | Otolaryngol Clin North Am1997，30，： | 1 |
| 19 | National registry for juvenile-onset recurrent respiratory papillomatosis显示文摘 | REEVES W C RUPARELIA S S SWANSON K I | 2003 | Arch Otolaryngol Head Neck Surg2003，129，： | 1 |
| 20 | Strain specificity in antimicrobial activity of silver and copper nanopartieles显示文摘 | RUPARELIA J P CHATTERJEE A K DUTTAGUPTA S P | 2008 | Acta Biomater2008，4，3： | 1 |
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