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| 1 | 欧洲和中国的心脏与肾脏远程缺血预适应研究:一项随机对照试验显示文摘远程缺血预适应(remote ischemic preconditioning,RIPC)对经皮冠状动脉介入治疗(percutaneous coronary intervention,PCI)术后造影剂肾病(contrast-induced nephropathy,CIN)的潜在保护作用尚待确定。该研究为双盲、随机、安慰剂对照的多中心研究,纳入年龄〈85岁,肾清除率为30~60mL/(min·1.73m^2)的有临床适应证的患者,除了直接PCI外均按1∶1给予RIPC或标准治疗。主要终点是CIN的发生率。次要终点是围手术期心肌梗死(peri-procedural myocardial infarction,PMI)的发生率。 | 刘青 叶鹏 Moretti C Cerrato E Cavallero E Lin S Rossi ML Picchi A Sanguineti F Ugo F Palazzuoli A Bertaina M Presbitero P Shao-Liang C Pozzi R Giammaria M Limbruno U Lefèvre T Gasparetto V Garbo R OmedèP Sheiban I Escaned J Biondi-Zoccai G Gaita F Perl L D'Ascenzo F | 2018 | 中华高血压杂志2018，26，4： | 3 |
| 2 | Desferrioxamine in warm reperfusion media decreases liver injury aggravated by cold storage显示文摘AIM:To evaluate whether desferrioxamine decreases ischemia and perfusion injury aggravated by cold storage(CS)in a rat liver perfusion model. METHODS:Isolated rat livers were kept in CS in University of Wisconsin Solution for 20 h at 4℃,then exposed to 25 min of warm ischemia(WI)at 37℃ followed by 2 h of warm perfusion(WP)at 37℃with oxygenated(95%oxygen and 5%carbon dioxide) Krebs-Henseleit buffer.Desferrioxamine(DFO),an iron chelator,was added at different stages of storage,ischemia and perfusion:in CS only,in WI only,in WP only, in WI and perfusion,or in all stages.Effluent samples were collected after CS and after WI.Perfusate samples and bile were collected every 30 min(0,0.5,1,1.5 and 2 h)during liver perfusion.Cellular injury was assessed by the determination of lactate dehydrogenase(LDH) and aspartate aminotransferase(AST)in the effluent and perfusate samples.Total iron was analysed in the perfusate samples.After WP,the liver was collected for the determination of liver swelling(wet to dry ratio) and liver morphological examination(hematoxylin and eosin staining). RESULTS:Increased CS time caused increased liver dysfunction during WP.After 2 h of WP,liver injury was indicated by increased release of AST(0.5 h CS:9.4± 2.2 U/g liver vs 20 h CS:45.9±10.8 U/g liver,P<0.05) and LDH(0.5 h CS:59±14 U/g liver vs 20 h CS:297 ±71 U/g liver,P<0.05).There was an associated increase in iron release into the perfusate(0.5 h CS:0.11 ±0.03μmoL/g liver vs 20 h CS:0.58±0.10μmoL/g liver,P<0.05)and reduction in bile flow(0.5 h CS: 194±12μL/g vs 20 h CS:71±8μL/g liver,P<0.05). When DFO was added during WI and WP following 20 h of CS,release of iron into the perfusate was de- creased(DFO absent 0.58±0.10μmoL/g liver vs DFO present 0.31±0.06μmoL/g liver,P<0.05),and liver function substantially improved with decreased release of AST(DFO absent 45.9±10.8 U/g liver vs DFO present 8.1±0.9 U/g liver,P<0.05)and LDH(DFO absent 297±71 U/g liver vs DFO present 56±7 U/g liver,P<0.05),and increased bile flow(DFO absent 71±8μL/g liver vs DFO present 237±36μL/g liver, P<0.05).DFO was also shown to improve liver morphology after WP.Cellular injury(the release of LDH and AST)was significantly reduced with the addition of DFO in CS medium but to a lesser extent compared to the addition of DFO in WP or WI and perfusion.There was no effect on liver swelling or bile flow when DFO was only added to the CS medium. CONCLUSION:DFO added during WI and perfusion decreased liver perfusion injury aggravated by extended CS. | Peter G Arthur Xian-Wa Niu Wen-Hua Huang Bastiaan DeBoer Ching Tat Lai Enrico Rossi John Joseph Gary P Jeffrey | 2013 | World Journal of Gastroenterology2013，19，5： | 2 |
| 3 | Two pathways for base excision repair in mammalian cells显示文摘 | Frosina G Fortini P Rossi O | 1996 | J Biol Chem1996，271，16： | 1 |
| 4 | Clinical study of the efficacy of and tolerance to nimesulide in suppository formulation in paininflammatory pathologies of hte ear,node,and throat显示文摘 | Rossi M Monea P Lomeo G | 1991 | Minerva Med1991，82，12： | 1 |
| 5 | Modeling Consumer Demand for Va- riety 显示文摘 | Kim J Allenby G M Rossi P E | 2002 | Marketing Science2002，21，3： | 1 |
| 6 | Bayesian analysis of stochastic volatility models显示文摘 | Jacquier E Polson N G Rossi P E | | 0，，： | 1 |
| 7 | A microsatellite marker based linkage map of tobacco 显示文摘 | Bindler G Hoeven R Gunduz I Plieske J Ganal M Rossi L Gadani F Donini P | 2007 | Theor Appl Genet2007，114，： | 1 |
| 8 | Anti-inflammatory cyclopentenone prostaglandins are direct inhibitors of IkappaB kinase 显示文摘 | Rossi A Kapahi P Natoli G | 2000 | Nature2000，403，10： | 1 |
| 9 | Vibrational properties of ibuprofen-cyclodextrin inclusion complexes in- vestigated by Raman scattering and numerical simulation显示文摘 | Rossi B Verrocchio P Viliani G | 2009 | J Raman Spectrose2009，40，4： | 1 |
| 10 | Imatinibmesylate in- duces responses in patients with liver metastases from gastroin- testinal stromal tumor failing intra- arterial hepatic chemotherapy 显示文摘 | Fiorentini G Bernardeschi P Rossi S | 2006 | Cancer Res Ther2006，2，2： | 1 |
| 11 | Identification of apeptide from a-gliadin resistant to digestive enzymes : Implicationsfor celiac disease显示文摘 | Mamone G Ferranti P Rossi M | 2007 | Journal of Chromatography B2007，855，2： | 1 |
| 12 | Bayesian analysis of stochastic volatility models with fat-tails and correlated errors显示文摘 | Jacquier E Polson N G Rossi P E | | 0，，： | 1 |
| 13 | Efficacy of human papillomavirus testing for the detection of invasive cervical cancers and cervical intraepithelial neoplasia:a randomised controlled trial显示文摘 | Ronco G Giorigi Rossi P Carozzi F | 2010 | Lancet Oncol2010，11，3： | 1 |
| 14 | Bayesian analysis of stochastic volatility models显示文摘 | Poison N G Rossi P E | 1994 | Journal of Business and Economic Statistics1994，12，： | 1 |
| 15 | The dynamic behaviour of concrete:Influence of free water显示文摘 | Rossi P Van Mier J G M Boulay C | 1992 | Material and Structure1992，25，： | 1 |
| 16 | Treatment of small cell lung cancer in elderly显示文摘 | Rossi A Maione P Colantuoni G | 2005 | Oncologist2005，10，6： | 1 |
| 17 | Stress/Rest myocardial perfusion abnormalities by gated SPECT:still the best predictor of cardiac events in stable ischemic heart disease显示文摘 | GIMELLI A ROSSI G LANDI P | 2009 | Nucl Med2009，16，： | 1 |
| 18 | Therapeutic vaccination against Helieobaeter pylori in the beagle dog experimental model: safety, immunogenicity, and efficacy 显示文摘 | Rossi G Ruggiero P Peppoloni S | 2004 | Infect Immun2004，72，6： | 1 |
| 19 | Anti inflammatory cyclopentenone prostaglandins are direct inhibitors of IκB kinase 显示文摘 | Rossi A kapahi P Natoli G | 2000 | Nature2000，403，6765： | 1 |
| 20 | Stress/rest myocardial perfusion abnormalities by gated SPECT: still the best predictor of cardiac events in stable ischemic heart disease显示文摘 | Gimelli A Rossi G Landi P | 2009 | J Nucl Med2009，50，4： | 1 |
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