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| 1 | pRB expression in esophageal mucosa of individuals at high risk for squamous cell carcinoma of the esophagus显示文摘AIM: To investigate the pRb expression in a large group of patients with history of chronic exposure to the main risk factors for development of squamous cell carcinoma of the esophagus. METHODS: One hundred and seventy asymptomatic individuals at high risk for esophageal squamous cell carcinoma (consumption of more than 80 g of ethanol and 10 cigarettes/d for at least 10 years) underwent upper gastrointestinal endoscopy with biopsies of the esophageal mucosa. As a control group, specimens of esophageal mucosa obtained from 20 healthy subjects were also studied. Immunohistochemical assessment of the tissues was performed using a monoclonal antibody anti-pRB protein. RESULTS: Absence of the pRB staining, indicating loss of RB function, was observed in 33 (19.4%) of the individuals at risk for esophageal cancer, but in none of the healthy controls (P < 0.02). Loss of pRb expression increased in a stepwise fashion according to the severity of the histological findings (P < 0.005): normal mucosa (11/97 or 11.3%), chronic esophagitis (17/60 or 28.3%), low-grade dysplasia (3/10 or 30%), high-grade dysplasia 1/2 or 50%) and squamous cell carcinoma (1/1 or 100%). CONCLUSION: Our findings suggest that abnormal expression of the pRB protein may be implicated in the process of esophageal carcinogenesis. Additional studies are warranted to define the role of the pRBprotein as a biomarker for development of esophageal squamous cell carcinoma in individuals at high risk for this malignancy. | Simone S Contu Paulo C Contu Daniel C Damin Renato B Fagundes Fabiano Bevilacqua Aline S Rosa Joo C Prolla Luis F Moreira | 2007 | World Journal of Gastroenterology2007，13，11： | 5 |
| 2 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 3 | Historical CO2 emission and concentrations due to land use change of croplands and pastures by country显示文摘 | Campos C P D Muylaert M S Rosa L P | 2005 | Science of the Total Environment2005，346，： | 1 |
| 4 | The Future of Nuclear Power: Value Orientations and Risk Perception 显示文摘 | WHITFIELD S C ROSA E A DAN A | 2009 | Risk Analysis2009，29，3： | 1 |
| 5 | Auction-based mechanisms for electronic procurement显示文摘 | Chandrashekar T S Narahari Y Rosa C H | 2007 | IEEE Transactions on Automation Science and Engineering2007，4，3： | 1 |
| 6 | Glutathione deficiency is associated with impaired survival in HIV disease 显示文摘 | HERZENBERG L A DE ROSA S C DUBS J G | 1997 | Proc Nat Acad Sci1997，94，5： | 1 |
| 7 | A Competitive Mean-squared Error Approach to Beamforming显示文摘 | Eldar Y C Nehorai A La Rosa P S | 2007 | IEEE Trans on Signal Processing2007，55，11： | 1 |
| 8 | A competitive mean squared error approach to beamforming 显示文摘 | Eldar Y C Nehorai A La Rosa P S | 2007 | IEEE Transac- tions on Signal Processing2007，55，11： | 1 |
| 9 | Perceived value of the purchase of a tourism product显示文摘 | Javier S Luis C Rosa M | | 0，，： | 1 |
| 10 | Amino acid mobilization and growth of juvenile Octopus maya(Mollusca:Cephalopoda)under inanition and re-feeding显示文摘 | George-Zamora A Viana M T Rodriguez S Espinoza G Rosas C | | 0，，： | 1 |
| 11 | P450cl7 deficiency : clinical andmolecular characterization of six patients 显示文摘 | Rosa S Duff C Meyer M | 2006 | J Clin Endocrinol Metab2006，92，： | 1 |
| 12 | Anorexigen (TNF-a, eho lecystokinin) and orexigen (neuropeptide Y) plasma levels in per itoneal dialysis (PD) patients: their relationship with nutritiona parameters显示文摘 | Abelardo A Rosa C Rafael S | 1998 | Nephrol Dial Transplant1998，13，： | 1 |
| 13 | Mixed endocrine-exocrinetumors of the gastrointestinal tract显示文摘 | Capella C La Rosa S Uccella S | 2000 | Semin Diagn Pathol2000，17，： | 1 |
| 14 | New malaria vaccine candidates based on the Plasmodium vivax merozoite surface protein-1 and the TLR-5 agonist Salmonella Typhimurium FliC flagellin显示文摘 | Bargieri D Y Rosa D S Braga C J | 2008 | Vaccine2008，26，： | 1 |
| 15 | A competitive mean-squared error approach to beamforming 显示文摘 | Eldar Y C Nehorai A Rosa L P S | 2007 | Signal Processing IEEE Transactions2007，55，11： | 1 |
| 16 | Gastroenteropancreatic (neuro) endocrine neoplasms : the histology report显示文摘 | Rindi G Bordi C La Rosa S | | Dig Liver Dis0，43，4： | 1 |
| 17 | Does early decompression improve neurological outcome of spinal cord injured patients? Ap- praisal of the literature using a meta- analytical approach 显示文摘 | La Rosa C Conti A Cardali S | 2004 | Spinal Cord2004，42，9： | 1 |
| 18 | The influence of starch gelatinization on the rheological,thermal,and morphological properties of poly(?-caprolactone)with corn starch blends显示文摘 | Rosa D S Guedes C G F Pedroso A G | 2004 | Materials Science and Engineering:C2004，24，5： | 1 |
| 19 | Activation of 5-hydroxytryptamine 1 B/1 D/1F receptors as a mechanism of action of antimigraine drugs 显示文摘 | RAMIREZ ROSAS M B LABRUIJERE S VILLALON C M | 2013 | Expert Opin Pharmacother2013，14，12： | 1 |
| 20 | Neridronate improves bone mineral density and reduces back pain in β-thalassaemia patients with osteoporosis:results from a phase 2,randomized,parallel-arm,open-label study显示文摘 | Forni GL Perrotta S Giusti A Quarta G Pitrolo L Cappellini MD D'Ascola DG Borgna Pignatti C Rigano P Filosa A Iolascon G Nobili B Baldini M Rosa A Pinto V Palummeri E | | 0，，： | 1 |
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