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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | Nm23/nucleoside diphosphate kinase:toward a structural and biochemical understanding of its bio logical functions显示文摘 | de la Rosa A Williams R L Steeg P S | 1995 | Bioessays1995，17，1： | 1 |
| 3 | Evaluation of the role of genes encoding for At -pyrroline~5-carboxylate syn- thetase (P5CS) during drought stress in arbuscular mycor- rhizal Glycine max and Lactuca sativa plants 显示文摘 | ROSA P ROSARIO A JUAN M R | 2004 | Physiol Mol Plant P2004，65，4： | 1 |
| 4 | Expansion and reduction of thin-walled tubes using a die : Experimental and theoretical investigation 显示文摘 | Almeida B P P Alves M L Rosa P A R | 2006 | International Journal of Machine Tools and Manufacture2006，46，1213： | 1 |
| 5 | Statistical evaluation of E1S and ENM data collected for monitoring corrosion barrier prop- erties of organic coatings on AI - 2024 - T3 显示文摘 | De Rosa R L Earl D A Bierwagen G P | 2002 | Corrosion Sci- ence2002，44，： | 1 |
| 6 | Compression bead- ing and nosing of thin-walled tubes using a die : Experimental and theoretical investigation 显示文摘 | Gouveia B P P Alves M L Rosa P A R | 2006 | International Journal of Mechanics & Materials in Design2006，3，1： | 1 |
| 7 | Chromosomal abnormalities in couples with history of recurrent abortion 显示文摘 | Kiss A Rosa R F Dibi R P | 2009 | Rev Bras Ginecol Obstet2009，31，2： | 1 |
| 8 | Antidepressant-like effect of the novel thiadiazolidinone NP031115 in mice显示文摘 | ROSA A O KASTER M P BINFARE R W | 2008 | Biol Psychiatry2008，32，6： | 1 |
| 9 | Low temperature synthesis and structural characterization of nanocrystalline YAG prepared by a modified sol-gel method显示文摘 | Rosa E D Diaz-Torres L A Salas P Arredondo A Montoya J A Angeles C Rodríguez R A | | 0，，12： | 1 |
| 10 | Elevated glucose changes the expression of ionotropic glutamate receptors subunits and impairs calcium homeostasis in retinal neural cells显示文摘 | Santiago A R Rosa S C Santos P F | 2006 | Invest Ophthalmol Vis Sci2006，47，9： | 1 |
| 11 | Use of a recombinant envelope protein subunit antigen for specific serological diagnosis of West Nile virus infection显示文摘 | BEASLEY D W HOLBROOK M R TRAVASSOS DA ROSA A P | 2004 | J Clin Microbiol2004，42，6： | 1 |
| 12 | Casimir-Lifshitz Theory and Metamaterials显示文摘 | Rosa F S S Dalvit D A R Milonni P W | 2008 | Phys Rev Lett2008，100，18： | 1 |
| 13 | Emissoes de metano e dioxido de carbono de hidreletricas na Amazonia comparadas as termeletricas equivalents 显示文摘 | Rosa L P Schaeffer R Santos M A | 1996 | Cadernos de Energia1996，9，： | 1 |
| 14 | An innovative electromagnetic compressive split Hopkinson bar显示文摘 | Silva C M A Rosa P A R Martins P A F | 2009 | Int J Mech Mater Des2009，5，： | 1 |
| 15 | Useof a recombinant envelope protein subunit antigen for specific sero-logical diagnosis of West Nile virus infection显示文摘 | Beasley D W Holbrook M R Travassos Da Rosa A P | 2004 | Clin Microbiol2004，42，6： | 1 |
| 16 | Application of central composite design to the optimisation of aqueous two-phase extraction of human antibodies显示文摘 | Rosa P A J Azevedo A M Barros M R A | | 0，，1： | 1 |
| 17 | Application of central composite design to the optimisation of aqueous two-phase extraction of human antibodies 显示文摘 | Rosa P A J Azevedo A M Aires-Barros M R | 2007 | Chromatogr A2007，1141，12： | 1 |
| 18 | Revisiting the fundamentals of metal cutting by means of finite elements and ductile fracture mechanics 显示文摘 | Rosa P A R Martins P A F Atkins A G | 2007 | International journal of machine tools & manufacture2007，，47： | 1 |
| 19 | Correlation between pathological distal esophageal acid exposure and ineffective esophageal motility显示文摘 | De Gomes Jr M P R da Rosa P A R Sakae T | 2010 | Aeta chirurgica iugoslavica2010，57，2： | 1 |
| 20 | Sequence of the gene of murine complement component C4显示文摘 | Ogata R T Rosa P A Zepf N E | 1989 | J Biol Chem1989，264，16： | 1 |
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