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| 1 | Psychotropic drugs and liver disease:A critical review of pharmacokinetics and liver toxicity显示文摘The liver is the organ by which the majority of sub-stances are metabolized, including psychotropic drugs. There are several pharmacokinetic changes in end-stage liver disease that can interfere with the metabolization of psychotropic drugs. This fact is particularly true in drugs with extensive first--pass metabolism, highly protein bound drugs and drugs depending on phase I hepatic metabolic reactions. Psychopharmacological agents are also associated with a risk of hepatotoxicity. The evidence is insufficient for definite conclusions regarding the prevalence and severity of psychiatric drug-induced liver injury. High-risk psychotropics are not advised when there is pre-existing liver disease, and after starting a psychotropic agent in a patient with hepatic impairment, frequent liver function/lesion monitoring is advised. The authors carefully review the pharmacokinetic disturbances induced by end-stage liver disease and the potential of psychopharmacological agents for liver toxicity. | Diogo Telles-Correia António Barbosa Helena Cortez-Pinto Carlos Campos Nuno B F Rocha Sérgio Machado | 2017 | World Journal of Gastrointestinal Pharmacology and Therapeutics2017，8，1： | 3 |
| 2 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 3 | Probiotic potential of Mi-nas fresh cheese prepared with the addition of Lactobacillus paracasei显示文摘 | Buriti F A da Rocha J S Assis E G | | 0，，02： | 1 |
| 4 | Probiotic potential of Minas fresh cheese prepared with the addition of Lactobacillus paracasei 显示文摘 | BURITI F C A DA ROCHA J S ASSIS E G | 2005 | Lebensmittel-Wissenschaft und Tehonlogie2005，38，2： | 1 |
| 5 | Replication of the tumor necrosis factor receptor-associated factor 1/complement component 5 region as a susceptibility locus for rheumatoid arthritis in a European family-based study显示文摘 | Kurreeman F A S Rocha D Houwing-Duistermaat J | 2008 | Arthritis &Rheumatism2008，58，9： | 1 |
| 6 | Preparation and characterization of affinity magnetoliposomes useful for the detection of antiphospholipid antibodies显示文摘 | ROCHA F M DE PINDO S C ZOLLERATION R L | 2001 | J Magn Magn Mater2001，225，12： | 1 |
| 7 | Glucose overload in yolk has little effect on the long-term modulation of carbohydrate metabolic genes in zebrafish(Danio rerio)显示文摘 | Rocha F Dias J Engrola S | 2014 | The Journal of Experimental Biology2014，217，7： | 1 |
| 8 | Oil sludge treatment by photocatalysis applying black and white light显示文摘 | ROCHA O R S DANTAS R F DUARTE M M M B | 2010 | Chemical Engineering Journal2010，157，1： | 1 |
| 9 | Lipase immobilization onto polymeric membrance 显示文摘 | CARNERIRO-da-CUNDA M C ROCHA J M S GARCIA F A P | 1979 | Biotechnol Techniques1979，13，： | 1 |
| 10 | Wet depositionand related atmospheric chemistry in the S(a)o Paulo Metropolis,Brazil:Part 1-Major inorganic ions in rainwater as evaluated by capillary electrophoresis with contactless conductivity detection显示文摘 | F R Rocha S Fracassi A José | 2003 | Atmos Environ2003，37，： | 1 |
| 11 | Hydroxyapatite nano-powders produced hydrothermally from nacreous material显示文摘 | Lemos A F Rocha J H G Quaresma S S F | 2006 | Journal of the European Ceramic Society2006，26，16： | 1 |
| 12 | Widely linear adaptive equalization of digital communication channel 显示文摘 | de Aquino F J A Resende L S da Rocha C A F | 2010 | IEEE Latin America Transactions2010，8，1： | 1 |
| 13 | Emission quantum yield of europium (Ⅲ) mixed complexes with thenoyhriiluoroacetonate and some aromatic ligands 显示文摘 | Silva F R G E Menezes J F S Rocha G B Rocha G B Alves S Brito H F Longo R L Malta O L | 2000 | Journal of Alloys and Compounds2000，303，304： | 1 |
| 14 | Trace elements determination in edible seaweeds by an optimized and validated ICP-MS method显示文摘 | R6denas de la Rocha S S6nchez-Muniz F J G6mez-Juaristi M | 2009 | Journal of Food Composition and Analysis2009，22，4： | 1 |
| 15 | Mechanism of the synergistic effect ofamiodarone and fluconazole in Candida albicans显示文摘 | Gamarra S Rocha E M F Zhang Y Q | 2010 | Antimicrobial agents and chemotherapy2010，54，5： | 1 |
| 16 | Notch-dependent VEGFR3 up- regulation allows angiogenesis without VEGF-VEGFR2 signalling显示文摘 | Benedito R Rocha S F Woeste M Zamykal M Radtke F Casanovas O | 2012 | Nature2012，484，： | 1 |
| 17 | Effects of olive oil polyphenols on erythrocyte oxidative damage 显示文摘 | Paiva-Martins F Femandes J Rocha S | 2009 | Mol Nutr Food Res2009，53，5： | 1 |
| 18 | The effect of magnesite calcination conditions on magnesia hydration显示文摘 | Birchal V S S Rocha S D F Ciminelli V S T | 2000 | Minerals Engineering2000，13，1415： | 1 |
| 19 | Volatile composition of Baga red wine: assessment of the identification of the would-be impact odoumnts显示文摘 | ROCHA S M RODRIGUES F COCO P | 2004 | Analytica Chimica Acta2004，513，1： | 1 |
| 20 | Toxicity of some glucose/mannose-binding lectins to Biomphalaria glabrata and Artemia salina显示文摘 | SANTOS A F D CAVADA B S ROCHA B A M D | 2010 | Bioresource Technology2010，101，2： | 1 |
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