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| 1 | Immunoexpression of cyclooxygenase-2 in primary gastric carcinomas and lymph node metastases显示文摘AIM: To evaluate immunoexpression of cyclooxygenase-2 (COX-2) in primary gastric carcinomas and respective lymph node metastases. METHODS: Immunohistochemistry to analyze COX-2 expression was performed on tissue microarray slices obtained from 36 specimens of gastrectomy and satellite lymph nodes from patients with gastric carcinoma. RESULTS: Immunostaining was seen in most cases, and COX-2 expression was higher in lymph node me-tastases than in corresponding primary gastric tumors of intestinal, diffuse and mixed carcinomas, with a statistically signif icant difference in the diffuse histotype (P = 0.0108). CONCLUSION: COX-2 immunoexpression occurs frequently in primary gastric carcinomas, but higher expression of this enzyme is observed in lymph node metastases of the diffuse histotype. | Paulo RC Almeida Francisco VA Ferreira Cássio C Santos Francisco D Rocha-Filho Raul RP Feitosa Esther AA Falco Belise K Cavada Roberto CP Lima-Júnior Ronaldo A Ribeiro | 2012 | World Journal of Gastroenterology2012，18，8： | 14 |
| 2 | Portal vein thrombosis with protein C-S deficiency in a noncirrhotic patient显示文摘There are several conditions that can lead to portal vein thrombosis(PVT), including including infection, malignancies, and coagulation disorders. Anew condition of interest is protein C and S deficiencies, associated with hypercoagulation and recurrent venous thromboembolism. We report the case of a non-cirrhotic 63-year-old male diagnosed with acute superior mesenteric vein thrombosis and PVT and combined deficiencies in proteins C and S, recanalized by short-term low molecular heparin plus oral warfarin therapy. | Gustavo A Rodríguez-Leal Segundo Morán Roberto Corona-Cedillo Rocío Brom-Valladares | 2014 | World Journal of Hepatology2014，6，7： | 10 |
| 3 | Pre-and postoperative systemic hemodynamic evaluation in patients subjected to esophagogastric devascularization plus splenectomy and distal splenorenal shunt:A comparative study in schistomomal portal hypertension显示文摘AIM: To investigate the systemic hemodynamic effects of two surgical procedures largely employed for treatment of schistosomal portal hypertension. METHODS: Thirty-six patients undergoing elective surgical treatment of portal hypertension due to hepatosplenic mansonic schistosomiasis were prospectively evaluated. All patients were subjected to preoperative pulmonary artery catheterization; 17 were submitted to esophagogastric devascularization and splenectomy (EGDS) and 19 to distal splenorenal shunt (DSRS). The systemic hemodynamic assessment was repeated 4 d after the surgical procedure. RESULTS: Preoperative evaluation revealed (mean ± SD) an increased cardiac index (4.78 ± 1.13 L/min per m2),associated with a reduction in systemic vascular resistance index (1457 ± 380.7 dynes.s/cm5.m2). The mean pulmonary artery pressure (18 ± 5.1 mmHg) as well as the right atrial pressure (7.9 ± 2.5 mmHg) were increased,while the pulmonary vascular resistance index (133 ± 62 dynes.s/cm5.m2) was decreased. Four days after EGDS,a significant reduction in cardiac index (3.80 ± 0.4 L/min per m2,P < 0.001) and increase in systemic vascular resistance index (1901.4 ± 330.2 dynes.s/cm5. m2,P < 0.001) toward normal levels were observed. There was also a significant reduction in pulmonary artery pressure (12.65 ± 4.7 mmHg,P < 0.001) and no significant changes in the pulmonary vascular resistance index (141.6 ± 102.9 dynes.s/cm5.m2). Four days after DSRS,a non-significant increase in cardiac index (5.2 ± 0.76 L/min per m2) and systemic vascular resistance index (1389 ± 311 dynes.s/cm5.m2) was observed. There was also a non-significant increase in pulmonary artery pressure (19.84 ± 5.2 mmHg),right cardiac work index (1.38 ± 0.4 kg.m/m2) and right ventricular systolic work index (16.3 ± 6.3 g.m/m2),without significant changes in the pulmonary vascular resistance index (139.7 ± 67.8 dynes.s/cm5.m2). CONCLUSION: The hyperdynamic circulatory state observed in mansonic schistosomiasis was corrected by EGDS,but was maintained in patients who underwent DSRS. Similarly,the elevated mean pulmonary artery pressure was corrected after EGDS and maintained after DSRS. EGDS seems to be the most physiologic surgery for patients with schistosomal portal hypertension. | Roberto de Cleva Paulo Herman Luis Augusto Carneiro D’albuquerque Vincenzo Pugliese Orlando Luis Santarem William Abro Saad | 2007 | World Journal of Gastroenterology2007，13，41： | 9 |
| 4 | Appendicitis in double cecal appendix: Case report显示文摘Double cecal appendix is a rare anatomical variation. Approximately 100 cases have been reported worldwide. It is usually diagnosed incidentally during emergency appendectomies due to inflammatory processes in the cecal appendix. Case presentation: male, white, 36 years old, obese, presenting with pain in the lower abdomen for 24 h followed by nausea, vomiting and mild fever. He was subjected to additional tests, with the leukogram showing leukocytosis and abdominal ultrasonography depicting cecal appendix with thickened wall, locally associated with small quantities of liquid and intestinal loop obstruction. He underwent laparotomy, revealing acute appendicitis. Another intestinal loop obstruction was identified next to the ileum, leading to recognizing another cecal appendix after local dissection. Double appendectomy and segmental iliectomy were performed although not needed. Results of the anatomopathological examination of the surgical samples showed acute inflammation in the two cecal appendices. So, performing a routine retroperitoneal release and a complete cecum evaluation during such surgical procedures is recommended and suggested due to the possibility of not identifying a second cecal appendix. | José Roberto Alves Ícaro Godeiro de Oliveira Maranhão Patrick Vanttinny Vieira de Oliveira | 2014 | World Journal of Clinical Cases2014，2，8： | 4 |
| 5 | Celiac disease serology in patients with different pretest probabilities: Is biopsy avoidable?显示文摘AIM: To establish the diagnostic performance of sev-eral serological tests, individually and in combination, for diagnosing celiac disease (CD) in patients with different pretest probabilities, and to explore potential se- rological algorithms to reduce the necessity for biopsy. METHODS: We prospectively performed duodenal biopsy and serology in 679 adults who had either high risk (n = 161) or low risk (n = 518) for CD. Blood samples were tested using six assays (enzyme-linked immunosorbent assay) that detected antibodies to tissue transglutaminase (tTG) and deamidated gliadin peptide (DGP). RESULTS: CD prevalence was 39.1% in the high-risk population and 3.3% in the low-risk group. In high-risk patients, all individual assays had a high diagnostic efficacy [area under receiving operator characteristic curves (AU ROC): 0.968 to 0.999]. In contrast, assays had a lower diagnostic efficacy (AU ROC: 0.835 to 0.972) in the low-risk group. Using assay combinations, it would be possible to reach or rule out diagnosis of CD without biopsy in 92% of cases in both pretest populations. We observed that the new DGP/tTG Screen assay resulted in a surplus compared to more conventional assays in any clinical situation. CONCLUSION: The DGP/tTG Screen assay could be considered as the best initial test for CD. Combinations of two tests, including a DGP/tTG Screen, might be able to diagnose CD accurately in different clinical scenarios making biopsy avoidable in a high proportion of subjects. | Emilia Sugai María L Moreno Hui J Hwang Ana Cabanne Adriana Crivelli Fabio Nach-man Horacio Vázquez Sonia Niveloni Julio Argonz Roberto Mazure Graciela La Motta María E Caniggia Edgardo Smecuol Néstor Chopita Juan C Gómez Eduardo Maurińo Julio C Bai | 2010 | World Journal of Gastroenterology2010，16，25： | 4 |
| 6 | Role of the HLA-DQ locus in the development of chronic gastritis and gastric carcinoma in Mexican patients显示文摘AIM: To determine the HLA-DQ locus in Mexican patients with Chronic gastritis and gastric adenocarcinoma. METHODS: Oligotyping for HLA-DQ locus was performed in 45 Mexican patients with chronic gastritis and 13 Mexican patients with diffuse-type gastric adenocarcinoma, and was then compared with 99 clinically healthy unrelated individuals. H pylori infection and CagA status were assessed in patients by enzyme-linked immunosor-bent assay (ELISA) method. RESULTS: We found a significant increased frequency of HLA-DQB1*0401 allele in H pylori-positive patients with chronic gastritis when compared with healthy subjects [19 vs 0%, P= 1 × 10-7, odds ratio (OR) = 4.96; 95% confidence interval (95% CI), 3.87-6.35]. We also found a significant increased frequency of HLA-DQB1*0501 in patients with diffuse-type gastric carcinoma in comparison with healthy individuals (P = 1 × 10-6, OR = 13.07; 95% CI, 2.82-85.14). CONCLUSION: HLA-DQ locus may play a different role in the development of H pylori-related chronic gastritis and diffuse-type gastric adenocarcinoma in the Mexican Mestizo population. | Roberto Herrera-Goepfert Jesús K Yamamoto-Furusho Luis F Oate-Ocaa Margarita Camorlinga-Ponce Leopoldo Muoz Jorge A Ruiz-Morales Gilberto Vargas-Alarcón Julio Granados Cellular Biology Section | 2006 | World Journal of Gastroenterology2006，12，48： | 4 |
| 7 | 慢性细菌性前列腺炎和肠易激综合征:利福昔明联合益生菌VSL#3的治疗效果显示文摘本研究评价了利福昔明联合益生菌VSL#3对慢性前列腺炎转化为微生物性前列腺精囊炎(PV)或前列腺精囊附睾炎(PVE)的作用。106例伴有细菌学治愈的慢性细胞性前列腺炎和肠易激综合征的男性不育患者随机予以利福昔明(200mg,20:/日,每月服用7日,持续12个月)和益生菌VSL#3(450×10^9CFU/日)治疗及无处理。95名患者(89.6%)完成治疗计划,纳入本研究。将患者分为四组:A组前6个月予治疗,后6月无治疗(n=26);B组予12个月治疗(n=22);C组前6个月不予治疗后6个月予治疗(n=23);D组在12个月内均无治疗(n=24)。A组和B组患者慢性前列腺炎发生率最高(分别为88.5%和86.4%)。相反,D组患者前列腺炎发生率最低(33.4%)。前列腺炎进展为PV的发生率在B组(15.5%)和C组(13.6%)低于D组(45.8%)。B组和C组最终无患者进展为PVE,而D组有20.8%诊断为PVE。长期服用利福昔明联合益生菌VSL#3能有效降低伴有治愈的CBP伴IBS的男性不育患者的前列腺炎进展为更复杂形式的男性附属性腺感染。 | Enzo Vicari Sandro La Vignera Roberto Castiglione Rosita A Condorelli Lucia O Vicari Aldo E Calogero | 2014 | Asian Journal of Andrology2014，16，5： | 3 |
| 8 | Celecoxib enhances the detoxification of diethylnitrosamine in rat liver cancer显示文摘AIM:To study the effect of celecoxib(CXB) on diethylnitrosamine activation through the regulation of cytochrome P450 in a hepatocarcinogenesis model.METHODS:Six-week-old male Sprague-Dawley rats were randomly divided into fi ve groups,a non-treated group(NT) ,a diethylnitrosamine-treated group(DEN) ,a DEN+CXB-treated group(DEN+CXB) ,and CXB 8 d-treated and CXB 32 d-treated groups.The effects of celecoxib on the enzymatic activities of CYP1A1,2A,2B1/2,and 2E1 were assessed in hepatic microsomes 24 h after DEN administration.Changes in CYP1A1 and CYP2B1/2 protein expression were also evaluated.The rate of DEN metabolism was measured by the production of the deethylation metabolite acetaldehyde,and the denitrosation metabolite nitrite.RESULTS:DEN+CXB administration produced a significant increase in the enzymatic activities of CYP2B1/2 and 1A1,whereas it did not change the activities of CYP2A and 2E1,compared to that of the DEN group.CXB treatment for eight days did not produce a signif icant effect on enzymatic activity when compared to the NT group;however,when it was administered for prolonged times(CXB 32 d group) ,the enzymatic activities were increased in a similar pattern to those in the DEN+CXB group.The observed increase in the enzymatic activities in the DEN+CXB group was accompanied by an increase in the CYP2B1/2 protein levels;no changes were observed in the levels of CYP1A1.In vitro,CXB increased the denitrosation of DEN,a pathway of metabolic detoxification.The addition of SKF-525A,a preferential inhibitor of CYP2B,abrogated the denitrosation of DEN.CONCLUSION:These results suggest that the mechanism of action of CXB involves enhancement of the detoxif ication of DEN by an increasing denitrosation via CYP2B1/2. | Martha Estela Salcido-Neyoy Adolfo Sierra-Santoyo Olga Beltrán-Ramírez José Roberto Macías-Pérez Saúl Villa-Trevio | 2009 | World Journal of Gastroenterology2009，15，19： | 3 |
| 9 | Photonic implementation of boson sampling:a review显示文摘Boson sampling is a computational problem that has recently been proposed as a candidate to obtain an unequivocal quantum computational advantage.The problem consists in sampling from the output distribution of indistinguishable bosons in a linear interferometer.There is strong evidence that such an experiment is hard to classically simulate,but it is naturally solved by dedicated photonic quantum hardware,comprising single photons,linear evolution,and photodetection.This prospect has stimulated much effort resulting in the experimental implementation of progressively larger devices.We review recent advances in photonic boson sampling,describing both the technological improvements achieved and the future challenges.We also discuss recent proposals and implementations of variants of the original problem,theoretical issues occurring when imperfections are considered,and advances in the development of suitable techniques for validation of boson sampling experiments.We conclude by discussing the future application of photonic boson sampling devices beyond the original theoretical scope. | Daniel J.Brod Ernesto F.Galvão Andrea Crespi Roberto Osellame NicolòSpagnolo Fabio Sciarrino | 2019 | Advanced Photonics2019，1，3： | 3 |
| 10 | Gastric cancer in relation to the intake of nutrients involved in one-carbon metabolism among MTHFR 677 TT carriers显示文摘 | Marcia V. Galván-Portillo Alejandra Cantoral Luis F. O?ate-Oca?a Jia Chen Roberto Herrera-Goepfert Luisa Torres-Sanchez Raul U. Hernandez-Ramirez Oswaldo Palma-Coca Lizbeth López-Carrillo | 2009 | European Journal of Nutrition2009，，5： | 3 |
| 11 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 12 | Low temperature induced changes in activity and protein levels of the enzymes associated to conversion of starch to sucrose in banana fruit显示文摘 | Roberta Ghedini Der Agopian Fernanda Helena Gon?alves Peroni-Okita Claudinéia Aparecida Soares Janaína Aparecida Mainardi Jo?o Roberto Oliveira do Nascimento Beatriz Rosana Cordenunsi Franco Maria Lajolo Eduardo Purgatto | 2011 | Postharvest Biology and Technology2011，，2： | 2 |
| 13 | Localized (solitary) fibrous tumors of the pleura: an analysis of 55 patients显示文摘 | Giuseppe Cardillo Francesco Facciolo Andrea O Cavazzana Girolamo Capece Roberto Gasparri Massimo Martelli | 2000 | The Annals of Thoracic Surgery2000，，6： | 2 |
| 14 | Sequential assembly and polymerization of the polyprenol-linked pentasacchariderepeating unit of the Xanthan polysaccharide in Xanthomonas campestris显示文摘 | Luis I Roberto O C Marcelo A D | 1993 | Journal of Bacteriology1993，175，9： | 1 |
| 15 | Valsartan benefits left ventricular structure and function in heart failure: Val-HeFT echocardiographic study显示文摘 | Maylene Wong Lidia Staszewsky Roberto Latini Simona Barlera Alberto Volpi Yann-Tong Chiang Raymond L Benza Sidney O Gottlieb Thomas D Kleemann Franco Rosconi Pieter M Vandervoort Jay N Cohn | 2002 | Journal of the American College of Cardiology2002，，： | 1 |
| 16 | Does Social Performance Really Lead to Financial Performance? Accounting for Endogeneity显示文摘 | Roberto Garcia-Castro Miguel A. Ari?o Miguel A. Canela | 2010 | Journal of Business Ethics2010，，1： | 1 |
| 17 | Tumor thickness as a predictive factor of lymph node metastasis and disease recurrence in T1N0 and T2N0 squamous cell carcinoma of the oral tongue显示文摘 | Leandro Luongo de Matos Gabriel Manfro Ricardo Vieira dos Santos Elaine Stabenow Evandro Sobroza de Mello Venancio Avancini F. Alves Fábio Roberto Pinto Marco Aurélio Vamondes Kulcsar Lenine Garcia Brand?o Cláudio Roberto Cernea | 2014 | Oral Surgery Oral Medicine Oral Pathology and Oral Radiology2014，，： | 1 |
| 18 | Discrimination of sugarcane varieties in Southeastern Brazil with EO-1 Hyperion data显示文摘 | LENIO SOARES GALV(A)O ANT(O)NIO ROBERTO FORMAGGIO DANIELA ARNOLD TISOT | 2005 | Remote Sensing of Environment2005，，94： | 1 |
| 19 | Robust and efficient authentication of video stream broadcasting显示文摘 | GABRIELE O STEFANO C ROBERTO D P | 2011 | ACM Transactions on Information and System Security (TISSEC)2011，14，1： | 1 |
| 20 | Omega-3 Fatty Acids for Cardioprotection显示文摘 | John H. Lee James H. O’Keefe Carl J. Lavie Roberto Marchioli William S. Harris | 2008 | Mayo Clinic Proceedings2008，，3： | 1 |
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