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| 1 | Brain changes in diabetes mellitus patients withgastrointestinal symptoms显示文摘Diabetes mellitus is a common disease and its prevalence is increasing worldwide. In various studies up to 30%-70% of patients present dysfunction and complications related to the gut. To date several clinical studies have demonstrated that autonomic nervous system neuropathy and generalized neuropathy of the central nervous system(CNS) may play a major role. This systematic review provides an overview of the neurodegenerative changes that occur as a consequence of diabetes with a focus on the CNS changes and gastrointestinal(GI) dysfunction. Animal models where diabetes was induced experimentally support that the disease induces changes in CNS. Recent investigations with electroencephalography and functional brain imaging in patients with diabetes confirm these structural and functional brain changes. Encephalographic studies demonstrated that altered insular processing of sensory stimuli seems to be a key player in symptom generation. In fact one study indicated that the more GI symptoms the patients experienced, the deeper the insular electrical source was located. The electroencephalography was often used in combination with quantitative sensory testingmainly showing hyposensitivity to stimulation of GI organs. Imaging studies on patients with diabetes and GI symptoms mainly showed microstructural changes,especially in brain areas involved in visceral sensory processing. As the electrophysiological and imaging changes were associated with GI and autonomic symptoms they may represent a future therapeutic target for treating diabetics either pharmacologically or with neuromodulation. | Anne M Drewes Eirik Søfteland Georg Dimcevski Adam D Farmer Christina Brock Jens B Frøkjær Klaus Krogh Asbjørn M Drewes | 2016 | World Journal of Diabetes2016，7，2： | 4 |
| 2 | 印度Ganga-Meghna-Brahmaputra平原及周围地区与孟加拉国地下水砷污染及其对健康影响的19年研究显示文摘基于近19年对印度Ganga—Meghna—Brahmaputra(简称GMB)平原(面积569749km^2,人口超过5亿)地下水砷污染的调查,可以确定印度Ganga—Brahmaputra平原(包括北方邦、比哈尔邦、恰尔康得邦、西孟加拉邦、阿萨姆邦)和孟加拉国普遍受到砷的污染。近期的调查研究也表明,除米佐拉姆邦外,其他各邦的地下水也受到不同程度的砷污染。至今为止.已对印度各邦和孟加拧国的175000份和50808份压把井水样进行了含砷量检测。并组织了一支包括皮肤科、神经科和妇产科医生在内的有经验的专家组,对上述地区125000人进行了临床检查,其中9%患有砷导致的皮肤病损症状。至今共采集分析了60000份生物样品。包括发样、指甲、尿样及皮肤鳞屑,其中80%的样品含砷量超过允许值,很多人由此受到砷的亚临床损害。在上述砷暴露地区.19000名儿童经过检查,近1100人患有砷导致的皮肤病损。该调查结果表明.儿童比成人更容易受到砷的毒性损害。在这种状况下.应着力解决饮水安全问题来减轻砷的苊害. | Ahamed S Hossain MA Mukharjee A Sengupta MK Das B Nayak B Pal A Mukherjee SC Pati S Dutta RN Saha KC Quamruzzaman Q Chakraborti D 付松波(译) 孙殿军(审校) | 2007 | 中国地方病学杂志2007，26，1： | 3 |
| 3 | 补体B因子是代谢综合征模型代谢与心血管特征的一个决定因素显示文摘补体B因子(complenment factor B,CFB)在2型糖尿病及心血管病患者脂肪组织及血清中水平升高,但与疾病发病机制的因果关系不明确。自发性高血压大鼠(spontaneously hypertensive rats,SHR)脂肪组织及血清中CFB也升高。为明确CFB在代谢综合征中的作用,研究者在SHR中敲除Cfb基因。 | 赵狄 练桂丽 Coan PM Barrier M Alfazema N Carter RN Marion de Procé S Dopico XC Garcia Diaz A Thomson A Jackson-Jones LH Moyon B Webster Z Ross D Moss J Arends MJ Morton NM Aitman TJ | 2017 | 中华高血压杂志2017，25，8： | 3 |
| 4 | In Inland China, Rice, Rather than Fish, Is the Major Pathway for Methylmercury Exposure显示文摘 | Zhang Hua Feng Xinbin Larssen Thorj?rn Qiu Guangle Vogt Rolf D | 2010 | Environmental Health Perspectives2010，，9： | 3 |
| 5 | Early Mucosal Healing With Infliximab Is Associated With Improved Long-term Clinical Outcomes in Ulcerative Colitis显示文摘 | Jean Frédéric Colombel Paul Rutgeerts Walter Reinisch Dirk Esser Yanxin Wang Yinghua Lang Colleen W. Marano Richard Strauss Bj?rn J. Oddens Brian G. Feagan Stephen B. Hanauer Gary R. Lichtenstein Daniel Present Bruce E. Sands William J. Sandborn | 2011 | Gastroenterology2011，，4： | 3 |
| 6 | Repair of total anomalous pulmonary venous connection in early infancy显示文摘 | Anil Kumar D Kumar RN Narasinga Rao P | 2003 | Asian Cardiovasc Thorac Ann2003，11，1： | 1 |
| 7 | Analgesic activity of the hexapeptide dalargin absorbed on the surface of polysorbate-80 coated polybutylcyanoacrylate nanoparticles 显示文摘 | ALYAUDTIN RN GOTHER D PETROV V | 1995 | Euro J Pharm Biopharm1995，41，： | 1 |
| 8 | CeUular, Molecular and genetic determinants of tooth eruptionl显示文摘 | Wise GE Frazier-Bowers D'Souza RN | 2002 | Crit Rev Oral Biol Mecl2002，13，4： | 1 |
| 9 | Lung volume reduction surgery: an overview显示文摘 | Sardenberg RA Younes RN Deheizelin D | 2010 | Rev Assoc Med Bras2010，56，6： | 1 |
| 10 | Tissue engineering approaches for regenerative dentistry显示文摘 | Gal er KM D'Souza RN | | 0，，01： | 1 |
| 11 | A role for humoral mechanisms in the pathogenesis of Devic's neuromyelitis optica 显示文摘 | Lucchinetti CF Mandler RN McGavern D | 2002 | Brain2002，125，： | 1 |
| 12 | Follow-up in lung cancer:how often andforwhat purpose?显示文摘 | Younes RN Gross JL Deheinzelin D | 1999 | Chest1999，115，6： | 1 |
| 13 | A role for humoralmechanismsin the pathogenesis of Devic' s neuromyelitis optioa显示文摘 | Lucchinetti CF Mandler RN McGavern D | 2002 | Brain2002，125，7： | 1 |
| 14 | Sca- ffolds for dental pulp tissue engineering显示文摘 | Galler KM D'Souza RN Hartgerink JD | 2011 | Adv Dent Res2011，23，3： | 1 |
| 15 | Adverse clinical outcomes associated with short stature at dialysis initiation: a report of the North America Pediatric Renal Transplant Cooperative Study 显示文摘 | Furth SL Stablein D Fine RN | 2002 | Pediatrics2002，109，5： | 1 |
| 16 | The Alexander project 1996-1997:a test susceptibility data from this international study of bacterial pathogens from community-acquired lower respiratory tract infections显示文摘 | Felmingham D Gruneberg RN | 2000 | J Antimicrob Chemother2000，45，2： | 1 |
| 17 | Probabilistic load flow considering dependence between input nodal powers显示文摘 | Leite D S Arienti V L Allan RN | 1984 | IEEE Transactions on Power Apparatus and Systems1984，103，6： | 1 |
| 18 | Nitinol stent implantation versus balloon angioplasty for lesions in the superficial femoral artery and proximal popliteal artery: twelve-month results from the RESILIENT randomized trial显示文摘 | Laird rn Katzen BT Scheinert D | 2010 | Circ Cardiovasc Interv2010，3，3： | 1 |
| 19 | Individual and cumulative ef- fect of type 2 diabetes genetic susceptibility variants on risk of cor- onary heart disease显示文摘 | Pfister R Bames D Luben RN | 2011 | Diabetologia2011，549，： | 1 |
| 20 | Detecting glaucoma using automated pu- pillography 显示文摘 | TATHAM AJ MEIRA-FREITAS D WEINREB RN ZANGWILL LM MEDEIROS FA | 2014 | Ophthalmology2014，121，6： | 1 |
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