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| 1 | Dietary advanced glycation end-products aggravate non-alcoholic fatty liver disease显示文摘AIM To determine if manipulation of dietary advanced glycation end product(AGE), intake affects nonalcoholic fatty liver disease(NAFLD) progression and whether these effects are mediated via RAGE. METHODS Male C57Bl6 mice were fed a high fat, high fructose, high cholesterol(HFHC) diet for 33 wk and compared with animals on normal chow. A third group were given a HFHC diet that was high in AGEs. Another group was given a HFHC diet that was marinated in vinegar to prevent the formation of AGEs. In a second experiment, RAGE KO animals were fed a HFHC diet or a high AGE HFHC diet and compared with wildtype controls. Hepatic biochemistry, histology, picrosirius red morphometry and hepatic mR NA were determined. RESULTS Long-term consumption of the HFHC diet generated significant steatohepatitis and fibrosis after 33 wk. In this model, hepatic 4-hydroxynonenal content(a marker of chronic oxidative stress), hepatocyte ballooning, picrosirius red staining, α-smooth muscle actin and collagen type 1A gene expression were all significantly increased. Increasing the AGE content of the HFHC diet by baking further increased these markers of liver damage, but this was abrogated by pre-marination in acetic acid. In response to the HFHC diet, RAGE-/-animals developed NASH of similar severity to RAGE+/+ animals but were protected from the additional harmful effects of the high AGE containing diet. Studies in isolated Kupffer cells showed that AGEs increase cell proliferation and oxidative stress, providing a likely mechanism through which these compounds contribute to liver injury. CONCLUSION In the HFHC model of NAFLD, manipulation of dietary AGEs modulates liver injury, inflammation, and liver fibrosis via a RAGE dependent pathway. This suggests that pharmacological and dietary strategies targeting the AGE/RAGE pathway could slow the progression of NAFLD. | Christopher Leung Chandana B Herath Zhiyuan Jia Sof Andrikopoulos Bronwyn E Brown Michael J Davies Leni R Rivera John B Furness Josephine M Forbes Peter W Angus | 2016 | World Journal of Gastroenterology2016，22，35： | 7 |
| 2 | Accuracy of biometric formulae for intraocular lens power calculation in a teaching hospital显示文摘AIM: To evaluate the accuracy of three commonly used biometric formulae across different axial lengths(ALs) at one United States Veterans Affairs teaching hospital.METHODS: A retrospective chart review was conducted from November 2013 to May 2018. One eye of each patient who underwent cataract surgery with a monofocal intraocular lens(IOL) was included. The range of postoperative follow-up period was from 3 wk to 4 mo. The Holladay 2, Barrett Universal II, and Hill-Radial Basis Function(Hill-RBF) formulae were used to predict the postoperative refraction for all cataract surgeries. For each formula, we calculated the prediction errors [including mean absolute prediction error(MAE)] and the percentage of eyes within ±0.25 diopter(D) and ±0.5 D of predicted refraction. We performed subgroup analyses for short(AL<22.0 mm), medium(AL 22.0-25.0 mm), and long eyes(AL>25.0 mm).RESULTS: A total of 1131 patients were screened, and 909 met the inclusion criteria. Resident ophthalmologists were the primary surgeons in 710(78.1%) cases. We found no statistically significant difference in predictive accuracy among the three formulae over the entire AL range or in the short, medium, and long eye subgroups. Across the entire AL range, the Hill-RBF formula resulted in the lowest MAE(0.384 D) and the highest percentage of eyes with postoperative refraction within ±0.25 D(42.7%) and ±0.5 D(75.5%) of predicted. All three formulae had the highest MAEs(>0.5 D) and lowest percentage within ±0.5 D of predicted refraction(<55%) in short eyes.CONCLUSION: In cataract surgery patients at our teaching hospital, three commonly used biometric formulae demonstrate similar refractive accuracy across all ALs. Short eyes pose the greatest challenge to predicting postoperative refractive error. | Kevin S Tang Elaine M Tran Allison J Chen David R Rivera Jorge J Rivera Paul B Greenberg | 2020 | International Journal of Ophthalmology(English edition)2020，13，1： | 3 |
| 3 | Application of games with incomplete information for pricing electricity in deregulated power pools显示文摘 | Fenrero R W Rivera J F | 1998 | IEEE Trans on Power Systems1998，13，1： | 2 |
| 4 | Application of games with incomplete information for pricing electricity in deregulated power pools显示文摘 | Ferrero R W Rivera J F Shahidehpour S M | 1998 | IEEE Trans on Power Systems1998，13，1： | 2 |
| 5 | 2-Week triple therapy for Helicobacter pylori infection is better than 1-week in clinical Practice: a large prospective single-center randomized st udy显示文摘 | Paoluzi P Iacopini F Crispino P Nardi F Bella A Rivera M Rossi P Gurnari M Caracciolo F Zippi M Pica R | 2006 | Helicobacter2006，11，： | 1 |
| 6 | Novel process for low temperature crystallization of a-SiC: H for optoelectronic applications显示文摘 | Hossain M Perez J R S Rivera J M R | 2009 | Journal of Materials Science2009，20，： | 1 |
| 7 | Small increases in extravascular lungwater are accu- rately detected by transpulmonary thermodilution 显示文摘 | Fern Adez - Mond jar E Rivera - Fern Adez R Garc a - Del- gadoM | 2005 | J Trauma2005，59，： | 1 |
| 8 | T-bet-dependent S1 P5 expression in NK cells promotes egress from lymph nodes and bone marrow显示文摘 | Jenne C N Enders A Rivera R | 2009 | The Journal of experimental medicine2009，206，11： | 1 |
| 9 | Enterobacterial repetitive intergenic consensus sequences and the PCR to generate fingerprints of genomic DNAs from Vibrio cholerae O1,O139,and non-O1 strains显示文摘 | Rivera I G M A R Chowdhury A Huq | 1995 | Appl Environ Microbiol1995，61，： | 1 |
| 10 | Musa genetic diversityrevealed by SRAP and AFLP显示文摘 | Youssef M James A C Rivera M R | 2011 | Molecular Biotechnology2011，47，3： | 1 |
| 11 | Thermodynamic analysis of monomethylamine-water solutions in a single-stage solar absorption refrigeration cycle at low generator temperatures 显示文摘 | Pilatowsky I Rivera W Romero R J | 2001 | Solar Energy Mater Solar Cells2001，70，： | 1 |
| 12 | Platinum based chemotherapy plus cetuximab in head and neck cancer 显示文摘 | Vermorken J B Mesia R Rivera F | 2008 | N Engl J Med2008，359，11： | 1 |
| 13 | Mathematical mod- eling of fluid flow in a water physical model of an aluminum degas- sing ladle equipped with an impeller-injector显示文摘 | GOMEZ E R ZENIT R RIVERA C G | 2013 | Metallurgical and Materials Transactions2013，，： | 1 |
| 14 | Analytical tools for the analysis of earotenoids in diverse materials 显示文摘 | Rivera S M Canela - Garayoa R | 2012 | Journal of Chromatography A2012，1224，： | 1 |
| 15 | Effect of different sources and levels of selenium on performance, meat quality, and tissue characteristics of broilers显示文摘 | Oliveira T F B Rivera F R Mesquita F R | 2014 | The Journal of Applied Poultry Research2014，23，1： | 1 |
| 16 | Platinum-based chemotherapy plus Cetuximab in head and neck Caneer显示文摘 | Vermorken J Mesia R Rivera F | 2008 | N Engl J Med2008，359，11： | 1 |
| 17 | Quercetin ameliorates metabolic syndrome and improves the inflammatory status in obese Zueker rats显示文摘 | Rivera L Moron R Sanchez M | 2008 | Obesity (Silver Spring)2008，16，9： | 1 |
| 18 | Plasma concentration of Big endothelin-1 and its relation with plasma NT-preBNP and ventricular func- tion in heart failure patients显示文摘 | Rivera M Cortes R Portoles M | 2005 | Rev Esp Cardiol2005，58，1： | 1 |
| 19 | Novel process for low temperature crystallization of α-SIC: H for optoelectronic applications显示文摘 | Hossain M Perez J R S Rivera J M R | 2009 | Journal of Materials Science2009，20，1： | 1 |
| 20 | 显示文摘 | Weinberg AD Rivera MM Prell R | 2000 | J Immunol2000，164，4： | 1 |
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