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| 1 | Relationship between angiotensin-(1-7) and angiotensin Ⅱ correlates with hemodynamic changes in human liver cirrhosis显示文摘AIM:To measure circulating angiotensins at different stages ofhuman cirrhosis and to further evaluate a possible relationship between renin angiotensin system (RAS) components and hemodynamic changes.METHODS: Patients were allocated into 4 groups: mild-to-moderate liver disease (MLD), advanced liver disease (ALD), patients undergoing liver transplantation, and healthy controls. Blood was collected to determine plasma renin activity (PRA), angiotensin (Ang) , Ang Ⅱ, and Ang-(1-7) levels using radioimmunoassays. During liver transplantation, hemodynamic parameters were determined and blood was simultaneously obtained from the portal vein and radial artery in order to measure RAS components.RESULTS: PRA and angiotensins were elevated in ALD when compared to MLD and controls (P < 0.05). In contrast, Ang was signicantly reduced in MLD. Ang-(1-7)/Ang Ⅱ ratios were increased in MLD when compared to controls and ALD. During transplantation, Ang Ⅱ levels were lower and Ang-(1-7)/Ang Ⅱ ratios were higher in the splanchnic circulation than in the peripheral circulation (0.52 ± 0.08 vs 0.38 ± 0.04, P < 0.02), whereas the peripheral circulating Ang /Ang ratio was elevated in comparison to splanchnic lev-els (0.18 ± 0.02 vs 0.13 ± 0.02, P < 0.04). Ang-(1-7)/Ang Ⅱ ratios positively correlated with cardiac output (r= 0.66) and negatively correlated with systemic vascular resistance (r =-0.70).CONCLUSION: Our ndings suggest that the relation-ship between Ang-(1-7) and Ang Ⅱmay play a role in the hemodynamic changes ofhuman cirrhosis. | Walkíria Wingester Vilas-Boas Antnio Ribeiro-Oliveira Jr Regina Maria Pereira Renata da Cunha Ribeiro Jerusa Almeida Ana Paula Nadu Ana Cristina Simoes e Silva Robson Augusto Souza dos Santos | 2009 | World Journal of Gastroenterology2009，15，20： | 11 |
| 2 | Role of endoscopic vacuum therapy in the management of gastrointestinal transmural defects显示文摘A gastrointestinal(GI) transmural defect is defined as total rupture of the GI wall,and these defects can be divided into three categories: perforations,leaks,and fistulas. Surgical management of these defects is usually challenging and may be associated with high morbidity and mortality rates. Recently,several novel endoscopic techniques have been developed,and endoscopy has become a firstline approach for therapy of these conditions. The use of endoscopic vacuum therapy(EVT) is increasing with favorable results. This technique involves endoscopic placement of a sponge connected to a nasogastric tube into the defect cavity or lumen. This promotes healing via five mechanisms,including macrodeformation,microdeformation,changes in perfusion,exudate control,and bacterial clearance,which is similar to the mechanisms in which skin wounds are treated with commonly employed wound vacuums. EVT can be used in the upper GI tract,small bowel,biliopancreatic regions,and lower GI tract,with variable success rates and a satisfactory safety profile. In this article,we review and discuss the mechanism of action,materials,techniques,efficacy,and safety of EVT in the management of patients with GI transmural defects. | Diogo Turiani Hourneaux de Moura Bruna Furia Buzetti Hourneaux de Moura Michael A Manfredi Kelly E Hathorn Ahmad N Bazarbashi Igor Braga Ribeiro Eduardo Guimaraes Hourneaux de Moura Christopher C Thompson | 2019 | World Journal of Gastrointestinal Endoscopy2019，11，5： | 6 |
| 3 | The Use of Data Mining Techniques in Rockburst Risk Assessment显示文摘目前在世界范围内的很多地下矿山,岩爆已经成为一个与矿山采矿生产密切相关的重要现象。深入理解这类现象,不仅有助于岩爆管理,而且还有可能节约采矿成本,减少人身伤亡事故。其中,实验室实验是深入研究岩爆机理的一个重要途径。在本文作者前期的研究中,已经建立了实验室岩爆实验数据库。与此同时,借助于数字采矿技术,也建立了岩爆最大应力和岩爆风险指数的预测模型。为实现基于矿山地质条件和矿山井巷建筑结构特性对岩爆类型即岩爆强度等级的准确预测,本文的重点是,基于对岩爆实例的分析来建立岩爆影响矩阵,明确岩爆现象的诱发因子,并厘清这些影响因子之间的相互关系。运用人工神经网络(ANN)和初始贝叶斯分类器等数字矿山技术,对矿山岩爆数据库进行了更深入的研究。最后给出了研究得出的各项结论。 | Luis Ribeiro e Sousa Tiago Miranda Rita Leal e Sousa Joaquim Tinoco | 2017 | Engineering2017，3，4： | 6 |
| 4 | Role of pentoxifylline in non-alcoholic fatty liver disease in high-fat diet-induced obesity in mice显示文摘AIM:To study pentoxifylline effects in liver and adipose tissue inflammation in obese mice induced by high-fat diet(HFD).METHODS: Male swiss mice(6-wk old) were fed a highfat diet(HFD; 60% kcal from fat) or AIN-93(control diet; 15% kcal from fat) for 12 wk and received pentoxifylline intraperitoneally(100 mg/kg per day) for the last 14 d. Glucose homeostasis was evaluated by measurements of basal glucose blood levels and insulin tolerance test two days before the end of the protocol. Final body weight was assessed. Epididymal adipose tissue was collected and weighted for adiposity evaluation. Liver and adipose tissue biopsies were homogenized in solubilization buffer and cytokines were measured in supernatant by enzyme immunoassay or multiplex kit, respectively. Hepatic histopathologic analyses were performed in sections of paraformaldehyde-fixed, paraffin-embedded liver specimens stained with hematoxylin-eosin by an independent pathologist. Steatosis(macrovesicular and microvesicular), ballooning degeneration and inflammation were histopathologically determined. Triglycerides measurements were performed after lipid extraction in liver tissue. RESULTS: Pentoxifylline treatment reduced microsteatosis and tumor necrosis factor(TNF)-α in liver(156.3 ± 17.2 and 62.6 ± 7.6 pg/mL of TNF-α for non-treated and treated obese mice, respectively; P < 0.05). Serum aspartate aminotransferase levels were also reduced(23.2 ± 6.9 and 12.1 ± 1.6 U/L for nontreated and treated obese mice, respectively; P < 0.05) but had no effect on glucose homeostasis. In obese adipose tissue, pentoxifylline reduced TNF-α(106.1 ± 17.6 and 51.1 ± 9.6 pg/mL for non-treated and treated obese mice, respectively; P < 0.05) and interleukin-6(340.8 ± 51.3 and 166.6 ± 22.5 pg/mL for non-treated and treated obese mice, respectively; P < 0.05) levels; however, leptin(8.1 ± 0.7 and 23.1 ± 2.9 ng/mL for non-treated and treated lean mice, respectively; P < 0.05) and plasminogen activator inhibitor-1(600.2 ± 32.3 and 1508.6 ± 210.4 pg/mL for non-treated and treated lean mice, respectively; P < 0.05) levels increased in lean adipose tissue. TNF-α level in the liver of lean mice also increased(29.6 ± 6.6 and 75.4 ± 12.6 pg/mL for non-treated and treated lean mice, respectively; P < 0.05) while triglycerides presented a tendency to reduction.CONCLUSION: Pentoxifylline was beneficial in obese mice improving liver and adipose tissue inflammation. Unexpectedly, pentoxifylline increased pro-inflammatory markers in the liver and adipose tissue of lean mice. | Simone Coghetto Acedo Cintia Rabelo e Paiva Caria érica Martins Ferreira Gotardo José Aires Pereira José Pedrazzoli Marcelo Lima Ribeiro Alessandra Gambero | 2015 | World Journal of Hepatology2015，7，24： | 2 |
| 5 | GATA3 controls Foxp3^sup +^ regulatory T cell fate during inflammation in mice显示文摘 | Wohlfert Elizabeth A Grainger John R Bouladoux Nicolas Konkel Joanne E Oldenhove Guillaume Ribeiro Carolina Hager Hall Jason A Yagi Ryoji Naik Shruti Bhairavabhotla Ravikiran Paul William E Bosselut Remy Wei Gang Zhao Keji Oukka Mohamed Zhu | 2011 | Journal of Clinical Investigation2011，，11： | 2 |
| 6 | Effect of propranolol on the splanchnic and peripheral renin angiotensin system in cirrhotic patients显示文摘AIM:To evaluate the effect of β-blockade on angiotensins in the splanchnic and peripheral circulation of cirrhotic patients and also to compare hemodynamic parameters during liver transplantation according to propranolol pre-treatment or not. METHODS:Patients were allocated into two groups:outpatients with advanced liver disease(LD) and during liver transplantation(LT). Both groups were subdivided according to treatment with propranolol or not. Plasma was collected through peripheral venipuncture to determine plasma renin activity(PRA),Angiotensin(Ang) Ⅰ,Ang Ⅱ,and Ang-(1-7) levels by radioimmunoassay in LD group. During liver transplantation,hemodynamic parameters were determined and blood samples were obtained from the portal vein to measure renin angiotensin system(RAS) components.RESULTS:PRA,Ang Ⅰ,Ang Ⅱ and Ang-(1-7) were signifi cantly lower in the portal vein and periphery in all subgroups treated with propranolol as compared to non-treated. The relationships between Ang-(1-7) and Ang Ⅰ levels and between Ang Ⅱ and Ang Ⅰ were significantly increased in LD group receiving propranolol. The ratio between Ang-(1-7) and Ang Ⅱ remained unchanged in splanchnic and peripheral circulation in patients under β-blockade,whereas the relationship between Ang Ⅱ and Ang Ⅰ was significantly increased in splanchnic circulation of LT patients treated with propranolol. During liver transplantation,cardiac output and index as well systemic vascular resistance and index were reduced in propranolol-treated subgroup. CONCLUSION:In LD group,propranolol treatment reduced RAS mediators,but did not change the ratio between Ang-(1-7) and Ang Ⅱ in splanchnic and peripheral circulation. Furthermore,the modification of hemodynamic parameters in propranolol treated patients was not associated with changes in the angiotensin ratio. | Walkíria Wingester Vilas-Boas Antnio Ribeiro-Oliveira Jr Renata da Cunha Ribeiro Renata Lúcia Pereira Vieira Jerusa Almeida Ana Paula Nadu Ana Cristina Sim■es e Silva Robson Augusto Souza Santos | 2008 | World Journal of Gastroenterology2008，14，44： | 2 |
| 7 | Operative Versus Nonoperative Treatment for Stage 0 Distal Rectal Cancer Following Chemoradiation Therapy: Long-term Results显示文摘 | Angelita Habr-Gama Rodrigo Oliva Perez Wladimir Nadalin Jorge Sabbaga Ulysses Ribeiro Afonso Henrique Silva e Sousa Fábio Guilherme Campos Desidério Roberto Kiss Joaquim Gama-Rodrigues | 2004 | Annals of Surgery2004，，4： | 2 |
| 8 | Two CCAAT/enhancer binding protein sites in the cytochrome P4503A1 locus 显示文摘 | Rodrigues E Vilarem M J Ribeiro V | 2003 | Eur J Bioehem2003，270，： | 1 |
| 9 | Apolipoproteins A Ⅰand A Ⅱ downregulate neutrophil functions 显示文摘 | Furlaneto C J Ribeiro FP Hatanaka E | 2002 | Lipids2002，37，9： | 1 |
| 10 | Fault detection of open-switch damage in voltage fed PWM motor drive systems 显示文摘 | Ribeiro R L A Jacobina C B Silva E R C D | 2003 | IEEE Transactions on Power Electronics2003，18，2： | 1 |
| 11 | Assessment of genetic damage induced by dental bleaching agents on mouse lymphoma cells by single cell gel (comet) assay显示文摘 | Ribeiro D A Marques M E Salvadori D M | 2005 | J Oral Rehabil2005，32，10： | 1 |
| 12 | Preparation, characterization and application of Pt-Ru-Sn/C trimetallic electrocatalysts for ethanol oxidation in direct fuel cell 显示文摘 | Cunha E Ribeiro J Kokoh K | 2011 | Int J Hydrogen Energy2011，36，11： | 1 |
| 13 | Risk stratification systems for diabetic foot ulcers: a systematic review 显示文摘 | Monteiro-Soares M Boyko E J Ribeiro J | 2011 | Diabetolo- gia2011，54，5： | 1 |
| 14 | Serological re- sponse of guinea pigs to oily and aqueous inactivated vac- cines containing a Brazilian isolate of the Bovine Viral Di- arrhea Virus (BVDV) 显示文摘 | Jordao R S Ribeiro C P Pituco E M | 2011 | Res Vet Sei2011，91，2： | 1 |
| 15 | Comparative effects of salinity and water stress on photosynthesis, water relations and growth of Jatropha curcas plant 显示文摘 | SILVA E N RIBEIRO R V FERREIRA-SILVA S L VIEGAS R A SILVEIRA J A G | 2010 | Journal of Arid Environment2010，74，10： | 1 |
| 16 | Prognostic implications of tumor-infiltrating lymphocytes in association with programmed cell death ligand 1 expression in remnant gastric cancer显示文摘Objective:Remnant gastric cancer(RGC)is usually associated with a worse prognosis.As they are less common and very heterogeneous tumors,new prognostic and reliable determinants are required to predict patients’clinical course for RGC.This study aimed to investigate the tumor-infiltrating lymphocytes(TILs)and programmed cell death ligand 1(PD-L1)status as prognostic biomarkers in a cohort of patients with RGC to develop an immunerelated score.Methods:Patients with gastric cancer(GC)who underwent curative intent gastrectomy were retrospectively investigated.RGC resections with histological diagnosis of gastric adenocarcinoma were enrolled in the study.The risk score based on immune parameters was developed using binary logistic regression analysis.RGCs were divided into high-risk(HR),intermediate-risk(IR),and low-risk(LR)groups based on their immune score.The markers(CD3+,CD4+/CD8+T cells and PD-L1)were selected for their potential prognostic,therapeutic value,and evaluated by immunohistochemistry(IHC).Results:A total of 42 patients with RGC were enrolled in the study.The score based on immune parameters exhibited an accuracy of 79%[the area under the receiver operating characteristic curve(AUC)=0.79,95%confidence interval(95%CI),0.63-0.94,P=0.002],and the population was divided into 3 prognostic groups:10(23.8%)patients were classified as LR,15(35.7%)as IR,and 17(40.5%)as HR groups.There were no differences in clinicopathological and surgical characteristics between the three groups.In survival analysis,HR and IR groups had worse disease-free survival and overall survival rates compared to the LR group.In the multivariate analysis,lymph node metastasis and the immune score risk groups were independent factors related to worse survival.Conclusions:A scoring system with immune-related markers was able to distinguish prognostic groups of RGC associated with survival.Accordingly,tumor-infiltrating immune lymphocytes and PD-L1 status may serve as a potential prognostic biomarker for patients with RGC. | Marina Alessandra Pereira Marcus Fernando Kodama Pertille Ramos André Roncon Dias Leonardo Cardili Rafael Dyer Rodrigues de Moraes Renan Ribeiro E Ribeiro Venancio Avancini Ferreira Alves Bruno Zilberstein Evandro Sobroza de Mello Ulysses Ribeiro Jr | 2022 | Chinese Journal of Cancer Research2022，34，6： | 1 |
| 17 | A case study on process optimization using the gradient loss function显示文摘 | Elsayed E A | 1995 | Int J Prod Res1995，33，12： | 1 |
| 18 | The influence of the implantation temperature on the photoluminescence characteristics of Si nanocrystals embedded into SiO2 matrix显示文摘 | Sias U S Moreira E C Ribeiro E | 2004 | Nucl Instrum Methods B2004，218，： | 1 |
| 19 | Removal of organic contaminants from soils by an electrokinetic process:the case of atrazine显示文摘 | RIBEIRO A B RODRIGUEZ-MAROTO J M MATEUS E P | 2005 | Chemosphere2005，59，： | 1 |
| 20 | Serotonergic neurons in the caudal raphe nuclei discharge in association with activity of masticatory muscles显示文摘 | Ribeiro D O Valle L E | 1997 | Braz J Med Biol Res1997，30，1： | 1 |
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