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| 1 | 帕博利珠单抗治疗伴脑转移NSCLC患者的一项非随机、开放Ⅱ期试验的长期随访结果和生物标志物分析显示文摘背景与目的我们开展了一项帕博利珠单抗用于伴未治疗脑转移的非小细胞肺癌(non-small cell lung cancer,NSCLC)或黑色素瘤患者的疗效和安全性的II期试验,旨在评估程序性死亡受体1(programmed cell death 1,PD-1)抑制剂在中枢神经系统(central nervous system,CNS)中的疗效。中期结果已发表,现报道对NSCLC队列的更新分析结果。方法这是一项开放性、单中心、II期试验。纳入标准:年龄≥18岁,诊断为晚期NSCLC并伴有≥1个5 mm-20 mm脑转移病灶,既往从未治疗或之前放疗后进展,无神经系统症状,不需要激素治疗且美国东部肿瘤协作组(Eastern Cooperative Oncology Group,ECOG)<2分。患者每2周接受一次帕博利珠单抗(10 mg/kg)治疗。队列1为程序性死亡配体1(programmed cell death ligand 1,PD-L1)≥1%的患者,队列2为PD-L1<1%或未评估的患者。主要终点是脑转移患者缓解比例。所有经治患者均纳入疗效与安全性终点的分析。该研究已结束入组,并于Clinicaltrials.gov登记注册,注册号为NCT02085070。结果2014年3月31日-2018年5月21日,共42例患者接受治疗。中位随访时间为8.3个月(IQR:4.5个月-26.2个月)。队列1的37例患者中11例有脑转移缓解[29.7%(95%CI:15.9%-47.0%)]。队列2未观察到缓解。治疗相关的3级-4级不良事件(adverse events,AEs)包括2例肺炎、1例全身症状、1例结肠炎、1例肾上腺皮质功能不全、1例高血糖症和1例低钾血症。6例(14%)患者发生了治疗相关的严重不良事件,包括肺炎、急性肾损伤、低钾血症和肾上腺皮质功能不全。没有观察到治疗相关死亡病例。结论帕博利珠单抗治疗PD-L1≥1%的NSCLC伴脑转移患者有效,且对所有纳入的未经治疗的脑转移患者安全。需要进一步探索免疫治疗用于NSCLC合并CNS转移。 | Sarah B GOLDBERG Kurt A SCHALPER Scott N GETTINGER Amit MAHAJAN Roy S HERBST Anne C CHANG Rogerio LILENBAUM Frederick H WILSON Sacit Bulent OMAY James B YU Lucia JILAVEANU Thuy TRAN Kira PAVLIK Elin ROWEN Heather GERRSH Annette KOMLO Richa GUPTA Hailey WYATT Matthew RIBEIRO Yuval KLUGER Geyu ZHOU Wei WEI Veronica L CHANG Harriet M KLUGER 董晓荣(翻译/校对) | 2021 | 中国肺癌杂志2021，24，9： | 34 |
| 2 | Colonic duplication in an adult mimicking a tumor of pancreas显示文摘Duplications of the alimentary tract are uncommon congenital malformations that can present diagnostic difficulties. We report a rare case of a cystic colonic duplication in a female adult. Preoperative investigations were suggestive of pancreatic tumor. The diagnosis was established based on the histopathological examination of the resected specimen. We concluded that, though uncommon, intestinal duplication should be considered in differential diagnosis of abdominal mass. | Fabiana Pirani Carneiro Maria de Nazareth Sobreira Ana Emília B de Azevedo Andréa Pedrosa Ribeiro Alves Karina Martins Campos | 2008 | World Journal of Gastroenterology2008，14，6： | 3 |
| 3 | Immediate and late effects of chronic stress in the testes of prepubertal and adult rats显示文摘这研究的目的是在 prepubertal 和成年老鼠的睾丸上调查长期的应力的效果并且评估任何改变是否能被颠倒什么时候强调正式就职被结束。老鼠被分到八的 76 男性组织取决于处理的类型(控制或强调) ,应力在被开始的年龄(prepubertal 或成年人) ,和评估的时间(立即或迟了) 。压力刺激 6 个星期被申请。在最后压力刺激以后立即评估的强调 prepubertal 和成年老鼠分别地在 SP-I 和 SA-I 组被包括。迟了的 prepubertal (系统程序设计语言) 和成年人(柳安) 强调老鼠组织 6 个星期在最后压力刺激以后被评估。匹配年龄的老鼠被用作控制(CP-I, CA-I, CP-L,和 CA-L 组) 。到在 SP-I 组的老鼠的压力刺激的申请导致了身体重量和生精的小管直径减小。在 SA-I 组的老鼠也显示出几功能(睾丸激素水平和精子参数) 并且词法(阴囊的重量和生精的小管直径) 减小。在系统程序设计语言组的老鼠显示出增加的身体重量和 intertubular 分隔空间容量、绝对的密度和减少的管状的分隔空间容量的密度。在柳安组的老鼠介绍了仅仅减少的精子生存能力。压力刺激在所有学习组在老鼠支持了变化。成年老鼠的睾丸是长期的应力影响的大多数。然而,强调成年老鼠从阴囊的改变恢复了很好。 | Carina T Ribeiro Diogo B De Souza Waldemar S Costa Francisco J B Sampaio Marco A Pereira-Sampaio | 2018 | Asian Journal of Andrology2018，20，4： | 2 |
| 4 | Effect of chemical interesterification on physicochemical properties and industrial applications of c anola oil and fully hydrogenated cottonseed oil blends 显示文摘 | RIBEIRO A P B BASSO R C GRIMALDI R | 2009 | Journal of Food Lipids2009，16，3： | 1 |
| 5 | Identification, expression and phylogenetic analysis of the Anticarsia gemmatalis, multicapsid nucleopolyhedrovirus ( AgMNPV ) helicase 显示文摘 | Lima L Pinedo F J Ribeiro B M | 2004 | Virus Genes2004，29，： | 1 |
| 6 | Difficulties Encountered by Farmers in the Implementation of Traceability Bovine显示文摘 | Lopes M A Demeu A A Ribeiro A D B | 2012 | Arquivo Brasileiro De Medicina Veterinaria E Zootecnia2012，64，6： | 1 |
| 7 | Fault detection of open-switch damage in voltage fed PWM motor drive systems 显示文摘 | Ribeiro R L A Jacobina C B Silva E R C D | 2003 | IEEE Transactions on Power Electronics2003，18，2： | 1 |
| 8 | The order of genetic events associated with colorectal cancer progression inferred from meta-analysis of copy number changes显示文摘 | Diep C B Kleivi K Ribeiro F R | 2006 | Genes Chromosomes Cancer2006，45，1： | 1 |
| 9 | Solvent recovery from soybean oil/hexane mis- celia by polymeric membranes 显示文摘 | RIBEIRO A P B DE MOUR J M L N GONCALVES L A G | 2006 | Journal of Membrane Science2006，282，12： | 1 |
| 10 | Transcriptional analysis of in vivo Plasmodium yoelii liver stage gene expression 显示文摘 | SACCI J B Jr RIBEIRO J M HUANG F | 2005 | Mol Biochem Parasitol2005，142，2： | 1 |
| 11 | Additive partitioning of butterfly diversity in a fragmented landscape : Importance of scale and implications for conservation 显示文摘 | Ribeiro D B Prado P I Brown Jr K S | 2008 | Diversity and Distributions2008，14，6： | 1 |
| 12 | A dynamic model for the eIectrokinetic removal of copper from a polluted soil显示文摘 | RIBEIRO A B MEXIA J T | 1997 | Journal of Hazardous Materials1997，56，3： | 1 |
| 13 | Removal of organic contaminants from soils by an electrokinetic process:the case of atrazine显示文摘 | RIBEIRO A B RODRIGUEZ-MAROTO J M MATEUS E P | 2005 | Chemosphere2005，59，： | 1 |
| 14 | Alginate/chitosan nanoparticles are effective for oral insulin delivery显示文摘 | Sarmento B Ribeiro A Veiga F | 2007 | Pharm Res2007，24，12： | 1 |
| 15 | Case study on the strategy and application of enhancement solutions to improve remediation of soils contaminated with Cu,Pb and Zn by means of electrodialysis显示文摘 | Ottoson L M Pederscn A J Ribeiro A B | 2005 | Engi-neering Geology2005，77，： | 1 |
| 16 | Fault detection of open-switch damage in voltage-fed PWM motor drive systems显示文摘 | Ribeiro R L A Jacobina C B Silva E R C | 2003 | IEEE Transactions on Power Electronics2003，18，2： | 1 |
| 17 | Reticulo-rumen biohydrogenation and the enrichment of ruminant edible products with linoleic acid conjugated isomers显示文摘 | Bessa R J B Santos-Silva J Ribeiro J M R | 2000 | Live Prod Sci2000，63，： | 1 |
| 18 | Enzyme-enhanced extraction of phenolic compounds and proteins from flaxseed meal显示文摘 | Ribeiro B D Barreto D W Coelho M A Z | 2012 | ISRN Biotechnology2012，2013，： | 1 |
| 19 | The Christie Hospital breast conservation trial: an update at 8 years from inception 显示文摘 | Ribeiro GG Magee B Swindell R | 1993 | Clin Oncol (R Coll Radiol)1993，5，5： | 1 |
| 20 | Analysis of the reflective-matched fiber Bragg grating sensing interrogation scheme显示文摘 | Lobo Ribeiro A B Ferreira L A Santos J L | 1997 | Applied Optics1997，36，4： | 1 |
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