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| 1 | Anticancer immunotherapy by CTLA-4 blockade: obligatory contribution of IL-2 receptors and negative prognostic impact of soluble CD25显示文摘堵住抗体 ipilimumab 的细胞毒素的 T 淋巴细胞 antigen-4 (CTLA-4 ) 在很少的病人导致变形黑瘤的调停免疫者的长期的控制。尽管 ipilimumab 无疑经由 immunostimulation 施加它的治疗学的效果,这样远的临床上有用的、 immunologically 相关的 biomarkers 预言治疗效率是逃犯的。这里,我们显示出 IL-2 的那中立化或堵住 α并且 βIL-2 受体的子单元(CD25 和 CD122,分别地) 否则在现出症状之前的潜的老鼠模型由 CTLA-4 封锁导致了,废除了 antitumor 效果和 intratumoral T 受动器对规章的房间(Tregs ) 的比率的伴随的改进,它是。CTLA-4 封锁导致了在失去了 FoxP3 表示并且在 regressing 肿瘤积累了的 IL-2-producing 受动器房间与伴随物上升表示 Lag3, ICOS, IL-10 和 Egr2 的一个镇压 CD4 + T 房间子集的减小。当 recombinant IL-2 改进了 CTLA-4 封锁的治疗学的功效时,圈套 IL-2 受体 α(IL-2Rα, sCD25 ) 禁止了 CTLA-4 的 anticancer 效果封锁。在收到 ipilimumab 的 262 个变形黑瘤病人, sCD25 的基线浆液集中代表了全面幸存的独立指示物,与预言到治疗的抵抗的高水平。总的来说,这些结果解开为在 CTLA-4 的 anticancer 活动的 IL-2 和 IL-2 受体的一个角色封锁。重要地,我们的学习提供第一 immunologically 相关的 biomarker,也就是提高的浆液 sCD25,那与黑瘤在病人预言抵抗到 CTLA-4 封锁。 | Dalil Hannani Marie Vetizou David Enot Sylvie Rusakiewicz Nathalie Chaput David Klatzmann Melanie Desbois Nicolas Jacquelot Nadege Vimond Salem Chouaib Christine Mateus James P Allison Antoni Ribas Jedd D Wolchok Jianda Yuan Philip Wong Michael Postow Andrzej Mackiewicz Jacek Mackiewicz Dirk Schadendorff Dirk Jaeger Alan J Korman Keith Bahjat Michele Maio Luana Calabro Michele WL Teng Mark J Smyth Alexander Eggennont Caroline Robert Guido Kroemer Laurence Zitvogel | 2015 | Cell Research2015，25，2： | 14 |
| 2 | Prostate-targeted radiosensiti zation via aptamer-shRNA chimeras in human tumor xeno grafts显示文摘 | Ni X Zhang Y Ribas J | 2011 | J Clin Invest2011，121，6： | 1 |
| 3 | Characterization of the surface tension of vegetable oils to be used as fuel in diesel engines 显示文摘 | Esteban B Riba J R Baquero G | 2012 | Fuel2012，102，2： | 1 |
| 4 | Video-nystagmography findings in healthy elderly subjects显示文摘 | Amor Dorado J C Rubio Rodríguez J P Costa Ribas C | 2003 | Acta Otorrinolaringol Esp2003，54，3： | 1 |
| 5 | Ferromagnetic Nickel ( Ⅱ ) polynuelear complexes with end-on azido as bridging ligand: The first Nickel ( Ⅱ)-azido one- dimensional ferromagnetic systems 显示文摘 | Ribas J Monfort M Diaz C | 1994 | Inorg Chem1994，33，： | 1 |
| 6 | An experimental study of the hydrodynamic characteristics of external loop airlift contactors显示文摘 | Bentifraouine C Xuereb C Riba J P | 1997 | Journal of Chemical Technology and Biotech- nology1997，69，3： | 1 |
| 7 | Effects of allelochemicals on plant respirationand oxygen isotope fractionation by the alternative oxidase 显示文摘 | Penuelas J Ribas C M Giles L | 1996 | Journal of Chemical Ecology1996，22，： | 1 |
| 8 | Fenton reagent advanced oxidation of polynuclear aromatic hydrocarbons in water显示文摘 | Beltran F J Gonzalea M Ribas F J | 1998 | Water Air Soil Pollution1998，105，34： | 1 |
| 9 | In?uence of individual differences in the Behavioral Inhibition System and stimulus content(fear versus blood-disgust)on affective startle re?ex modulation显示文摘 | Caseras FX Fullana MA Riba J | 2006 | Biol Psychol2006，72，： | 1 |
| 10 | Low - cost high - power - factor electronic ballast based on the self - oscillating buck - boost inverter显示文摘 | Ribas J Alonso J M Calleja | 2000 | Proceedings of the IEEE APEC2000，1，1： | 1 |
| 11 | The first 1D nickel (Ⅱ) complex with a single azido bridge: structure and magnetic behavior of catena-(μ-N3) (CIO4)H2O显示文摘 | Escuer A Vicente R Ribas J | 1993 | Inorg Chem1993，32，： | 1 |
| 12 | Low cost single - stage electronic ballast based on a self oscillating resonant inverter in- tegrated with a buck - boost PFC circuit 显示文摘 | Ribas J Alonso J M Calleja A J | 2001 | IEEE Trans Nd Electron2001，48，6： | 1 |
| 13 | Two new μ-zido Nickel (Ⅱ) uniform chains: syntheses, sructures, andmagneto-structural correlations显示文摘 | Escuer A Vicente R Ribas J | 1993 | Inorg Chem1993，32，： | 1 |
| 14 | Patterns of seedling recruitment in West-Mediterranean Quercus flex forests influenced by canopy development显示文摘 | Espelta J M Riba M Retana J | 1995 | Journal of Vegetation Science1995，，： | 1 |
| 15 | Exogenous ochronosis hydroquinone induced: a report of four cases 显示文摘 | Ribas J Schettini AP Cavalcante MS | 2010 | An Bras Dermatol2010，85，5： | 1 |
| 16 | Combining cancer immunotherapy and targeted therapy 显示文摘 | Ribas A Wolchok J D | 2013 | Current opinion in immunology2013，25，2： | 1 |
| 17 | Inhibition of biological TCE and sulphate reduction in the presence of iron nanoparticles显示文摘 | BARMES R J RIBA O GARDNER M N | 2010 | Chemosphere2010，80，5： | 1 |
| 18 | Single - stage high - power - factor self oscillating electronic ballast for fluorescent lamps with rapid start 显示文摘 | Ribas J Alonso J M Calleja A J | 2002 | Proceedings of the IEEEAPEC2002，，2000： | 1 |
| 19 | Teicoplanin population pharmacokinetic analysis in hospitalized patients显示文摘 | Soy D Lopez E Ribas J | 2006 | Ther Drug Monit2006，28，6： | 1 |
| 20 | Plate osteosynthe-sis for severe olecranon fractures显示文摘 | Munoz-Mahamud E Fernandez-Valencia JA Riba J | 2010 | J Orthop Surg(Hong Kong)2010，1，： | 1 |
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