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| 1 | Alpha-fetoprotein expression is a potential prognostic marker in hepatocellular carcinoma显示文摘AIM: To characterize the alpha-fetoprotein (AFP) positive and negative hepatocellular carcinoma (HCC) samples.METHODS: Thirty-seven paraffin-embedded human HCC samples were analyzed by immunohistochemistry for the following antigens: AFP, β-catenin, p53, CD44, MSH-2,MLH-1, and HNF-4. The tumors were divided into two groups based on the AFP expression. The immunophenotypic data and important clinical parameters were studied between the two groups.RESULTS: Twenty-one of the thirty-seven examined HCCs were AFP positive. Seven with nuclear p53 staining were AFP positive, while seven tumors with nuclear β-catenin staining were AFP negative. CD44 staining and high histological tumor grade were more frequent among the AFP-positive HCCs. The other immunophenotypical and dinical parameters did not show statistically significant difference in their distribution between the AFP positive and negative samples.CONCLUSION: AFP expression in HCC correlates with unfavorable prognostic factors, while nuclear β-catenin positivity is more common among the AFP-negative liver tumors. This observation supports the microarray data onin vivo human tumors. | Dénes Grg János Regly-Mérei Sándor Paku László Kopper Péter Nagy | 2005 | World Journal of Gastroenterology2005，11，32： | 6 |
| 2 | Estimation Performance and Strategies Use of Mexican 5^th and 8^th Grade Student Sample 显示文摘 | Reys R E Reys B J Alfinio F P | 1991 | Educational Students in Mathematics1991，22，4： | 1 |
| 3 | Acute paraquat poisoning:report of a survival case following intake of a potential lethal dose显示文摘 | DINIS-OLIVEIRA R J SARMENTO A REIS P | 2006 | Pediatr Emerg Care2006，22，7： | 1 |
| 4 | Acute paraquat poisoning: report of a survival case following intake of a potential lethal dose 显示文摘 | Dinis-Oliveira R J Sarmento A Reis P | 2006 | Pediatr Emerg Care2006，22，7： | 1 |
| 5 | Starch-based mi- crospheres produced by emulsion crosslinking with a potential media dependent responsive behavior to be used as drug delivery carriers显示文摘 | Malafaya P B Stappers F Reis R L | 2006 | Journal of Materials Science : Materials in Medicine2006，17，4： | 1 |
| 6 | Genetic evidence of the neo- plastic nature of gemistocytes in astrocytomas 显示文摘 | Reis R M Hara A Kleihues P | 2001 | Acta neuropatho- logica2001，102，： | 1 |
| 7 | The biocompatibility of novel starch-based polymers and composites: in vitro studies 显示文摘 | Marques A P Reis R L Hunt J A | 2002 | Biomaterials2002，23，： | 1 |
| 8 | Methods for preparation of drug-loaded polymeric nanoparticles 显示文摘 | REIS C P NEUFELD R J RIBEIRO A J | 2006 | Nanomedicine : Nanotechnology Biology and Medicine2006，2，1： | 1 |
| 9 | Smart thermoresponsive coatings and surfaces for tissue engineering: switching cell-material boundaries显示文摘 | da Silva R M P Mano J F Reis R L | 2007 | Trends Bioteehn2007，25，12： | 1 |
| 10 | Bone tissue engineering: state of the art and future trends显示文摘 | SALGADO A J COUTINHO O P REIS R L | 2004 | Macromol Biosci2004，4，： | 1 |
| 11 | A grobacterium tumefaciens-mediated genetic transformation of the entomopathogenic fungus Beauveria bassiana 显示文摘 | Dos Reis M C Fungaro M H P Duarte R T D | 2004 | Journal of Microbiological Methods2004，58，： | 1 |
| 12 | The soil and water assessment tool historical development,applications,and future research directions显示文摘 | Gassman P W Reys M R Green C H | 2007 | Trans ASARE2007，50，4： | 1 |
| 13 | A model for melting rate phenomena in GMA welding显示文摘 | Modenesi P J Reis R I | 2007 | Journal of Materials Processing Technology2007，，： | 1 |
| 14 | Effect of environment on the creep behavior of the Ti-6A1- 4V alloy显示文摘 | Reis D A P Silva C R M Nono M C A | 2005 | Materials Science and Engineering: A2005，399，1： | 1 |
| 15 | The abdominal compartment syndrome显示文摘 | Reis R Labas P Vician M | 2003 | Bratisl Lek Listy2003，104，1： | 1 |
| 16 | Effect of operating parameters on molinate biodegradation 显示文摘 | Correia P Boaventura R A R Reis M A M | 2006 | Water Research2006，411，2： | 1 |
| 17 | Cutting performance of time-modulated chemical vapour deposited diamond coated tool inserts during machining graphite显示文摘 | Cabral G Reis P Polini R | 2006 | Diamond and Related Materials2006，15，10： | 1 |
| 18 | Biocompatibility testing of novel starch-based materials with potential ap- plication in orthopaedic surgery:a preliminary study 显示文摘 | Mendes S C Reis R L Bovell Y P | 2001 | Biomaterials2001，22，14： | 1 |
| 19 | Bone morphogenetic pro- teins in tissue engineering: the road from the laboratory to the clinic, part I (basic concepts) 显示文摘 | Bessa P C Casal M Reis R L | 2008 | J Tissue Eng Re- gen Med2008，2，1： | 1 |
| 20 | Pharma- cological interventions to treat phlebitis: systematic re- view显示文摘 | dos Reis P E Silveira R C Vasques C I | 2009 | J Infus Nuts2009，32，2： | 1 |
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