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| 1 | Microbiota-host interactions in irritable bowel syndrome: Epithelial barrier, immune regulation and brain-gut interactions显示文摘Irritable bowel syndrome(IBS) is a common, sometimes debilitating, gastrointestinal disorder worldwide. While altered gut motility and sensation, as well as aberrant brain perception of visceral events, are thought to contribute to the genesis of symptoms in IBS, a search for an underlying aetiology has, to date, proven unsuccessful. Recently, attention has been focused on the microbiota as a possible factor in the pathogenesis of IBS. Prompted by a number of clinical observations, such as the recognition of the de novo development of IBS following enteric infections, as well as descriptions of changes in colonic bacterial populations in IBS and supported by clinical responses to interventions, such as antibiotics and probiotics, that modify the microbiota, various approaches have been taken to investigating the microbiota-host response in IBS, as well as in animal models thereof. From such studies a considerable body of evidence has accumulated to indicate the activation or upregulation of both factors involved in bacterial engagement with the host as well host defence mechanisms against bacteria. Alterations in gut barrier function, occurring in response, or in parallel, to changes in the microbiota, have also been widely described and can be seen to play a pivotal role in generating and sustaining host immune responses both within and beyond the gut. In this manner a plausible hypothesis, based on an altered microbiota and/or an aberrant host response, for the pathogenesis, of at least some instances of IBS, can be generated. | Niall P Hyland Eamonn MM Quigley Elizabeth Brint | 2014 | World Journal of Gastroenterology2014，20，27： | 22 |
| 2 | Humoral immunity: a2- macroglobulin activity in the plasma of mollusks显示文摘 | Armstrong P B Quigley J P | 1992 | The Veliger1992，35，3： | 1 |
| 3 | The definition and classification of glaucoma in prevalence surveys 显示文摘 | FOSTER P J BUHRMANN R QUIGLEY H A | 2002 | Br J Ophthalmol2002，86，2： | 1 |
| 4 | Integrated optical dull Mach-Zehnder interferometer sensor显示文摘 | Hua P Jonathan L B Quigley G Q | 2002 | Sensors and Actuators B2002，87，2： | 1 |
| 5 | Importance of acid polysaccharides for 234Th complexation to marine organic matter显示文摘 | Quigley M S Santschi P H Hung C C | 2002 | Limnology and Oceanography2002，47，： | 1 |
| 6 | Importance of acid polysaccharides for 234Th complexation to marine organic mat ter显示文摘 | QUIGLEY M S SANTSCHI P H HUNG C C | 2002 | Limnology and Oceanography2002，47，2： | 1 |
| 7 | Gas hydrate nucleation and cage formation at a water/methane interface 显示文摘 | Hawtin R W Quigley D Rodger P M | 2008 | Physical Chemistry Chemi- cal Physics2008，10，32： | 1 |
| 8 | Matrix Metalloproteinases and Tumor Metastasis显示文摘 | Deryugina E I Quigley J P | 2006 | Cancer Metastasis Rev2006，25，1： | 1 |
| 9 | Reversal of Misfortune: TIMP-2 Inhibits Tumor Cell Invasion显示文摘 | Testa J E Quigley J P | 1991 | Journal of the National Cancer Irtstitute1991，83，： | 1 |
| 10 | A multilevel investigation of the motivational mechanisms underlying knowledge sharing and performance显示文摘 | Quigley N R Tesluk P E Locke E A Bartol K M | 2007 | Organization Science2007，18，1： | 1 |
| 11 | Matrix metalloproteinases and tumor metastasis显示文摘 | DERYUGINA E I QUIGLEY J P | 2006 | Cancer and Metastasis Rev2006，325，1： | 1 |
| 12 | The m, p-xylenes: ethlbenzene ration-a technique for estimating hydrocarbon age in ambient atmospheres 显示文摘 | NELSON P F QUIGLEY S M | 1983 | Atmos Environ1983，17，3： | 1 |
| 13 | Matrix metalloproteinases and tumor metastasis显示文摘 | Deryugina E I Quigley J P | | 0，，01： | 1 |
| 14 | Calculation of petroleum masses generated and expelled from source rocks 显示文摘 | Cooles G P Mackenzie A S Quigley T M | 1986 | Org Geochem1986，10，12： | 1 |
| 15 | Small intestinal bacterial overgrowth in nonalcoholic steatohepatitis: association with Toll-like receptor 4 expression and plasma levels of interleukin 8 显示文摘 | Shanab AA Scully P Crosbie O Buckley M O'Mahony L Shanahan F Gazareen S Murphy E Quigley EM | 2011 | Dig Dis Sci2011，56，5： | 1 |
| 16 | Land use regulations and the value of land and housing: An intra - metropolitan analysis显示文摘 | Kok N Monkkonen P Quigley J M | 2014 | Journal of Urban Economics2014，81，3： | 1 |
| 17 | A multi- mechanisms un- derlying knowledge sharing and performance显示文摘 | Quigley N R Tesluk level investigation of P E Locke E A the motivational | 2007 | Orga- nization Science2007，18，1： | 1 |
| 18 | Odor and air emissions control using biotechnology for both collection and wastewater treatment systems 显示文摘 | Easter C Quigley C Burrowes P | 2005 | Chem Eng J2005，113，23： | 1 |
| 19 | Evaluation of supplemental nutrition assistance program education:Application of behavioral theory and survey validation 显示文摘 | Wyker B A Jordan P Quigley D L | 2012 | J NutrEduc Behave2012，44，4： | 1 |
| 20 | Effects of Neotyphodium lolli infection and sowing rate of perennial ryegrass on the dynamics of ryegrass/subterranean clover swards显示文摘 | Quigley P E | 2000 | Aust J Agriculture Research2000，50，： | 1 |
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