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| 1 | Artificial intelligence in medical imaging of the liver显示文摘Artificial intelligence(AI), particularly deep learning algorithms, is gaining extensive attention for its excellent performance in image-recognition tasks. They can automatically make a quantitative assessment of complex medical image characteristics and achieve an increased accuracy for diagnosis with higher efficiency. AI is widely used and getting increasingly popular in the medical imaging of the liver, including radiology, ultrasound, and nuclear medicine. AI can assist physicians to make more accurate and reproductive imaging diagnosis and also reduce the physicians' workload. This article illustrates basic technical knowledge about AI, including traditional machine learning and deep learning algorithms, especially convolutional neural networks, and their clinical application in the medical imaging of liver diseases, such as detecting and evaluating focal liver lesions, facilitating treatment, and predicting liver treatment response. We conclude that machine-assisted medical services will be a promising solution for future liver medical care. Lastly, we discuss the challenges and future directions of clinical application of deep learning techniques. | Li-Qiang Zhou Jia-Yu Wang Song-Yuan Yu Ge-Ge Wu Qi Wei You-Bin Deng Xing-Long Wu Xin-Wu Cui Christoph F Dietrich | 2019 | World Journal of Gastroenterology2019，25，6： | 21 |
| 2 | A humanized neutralizing antibody against MERS-CoV targeting the receptor-binding domain of the spike protein显示文摘最新新兴的中东呼吸症候群 coronavirus (MERS-CoV ) 能在人引起严重、致命的急性呼吸疾病。尽管有全球努力,潜力为一联系在未来流行不能被排除。有效相对的措施的发展是迫切的。MERS-CoV-specific 抗病毒的药或疫苗是还没可得到的。使用 MERS-CoV (MERS-RBD ) 的尖铁受体绑定领域使老鼠免疫,我们识别了二抵销 monoclonal 抗体(mAbs ) 4C2 和 2E6。两 mAbs potently 与高功效在 vitro 绑在 MERS-RBD 和块病毒入口。我们进一步由使在 Fab 碎片和 RBD 之间的建筑群结晶调查了他们中立化的机制,并且解决了 4C2 Fab/MERS-RBD 建筑群的结构。结构证明 4C2 认出部分重叠的 epitope 在 MERS-RBD 的受体绑定脚印,从而由位的阻碍者和接口残余竞争防碍病毒 / 受体相互作用。2E6 也堵住受体绑定,并且为绑定与 4C2 竞争到 MERS-RBD。基于结构,我们进一步由保存仅仅 paratope 残余并且从人的免疫球蛋白与对应物代替留下的氨基酸使 4C2 人性化。人性化的 4C2 (4C2h ) 抗体支撑了类似的抵销的活动和生物化学的特征到父母老鼠抗体。最后,我们证明 4C2h 能显著地在感染 MERS-CoV 的 Ad5-hCD26-transduced 鼠标的肺消除病毒 titers,因此在临床的设置为预防和治疗代表一个有希望的代理人。 | Yan Li YuhuaWan Peipei Liu Jincun Zhao Guangwen Lu Jianxun Qi Qihui Wang Xuancheng LU Ying Wu Weniun Liu Buchang Zhang Kwok-Yung Yuen Stanley Perlman George F Gao Jinghua Yan | 2015 | Cell Research2015，25，11： | 14 |
| 3 | Artificial intelligence in breast ultrasound显示文摘Artificial intelligence(AI) is gaining extensive attention for its excellent performance in image-recognition tasks and increasingly applied in breast ultrasound. AI can conduct a quantitative assessment by recognizing imaging information automatically and make more accurate and reproductive imaging diagnosis. Breast cancer is the most commonly diagnosed cancer in women,severely threatening women's health, the early screening of which is closely related to the prognosis of patients. Therefore, utilization of AI in breast cancer screening and detection is of great significance, which can not only save time for radiologists, but also make up for experience and skill deficiency on some beginners. This article illustrates the basic technical knowledge regarding AI in breast ultrasound, including early machine learning algorithms and deep learning algorithms, and their application in the differential diagnosis of benign and malignant masses. At last, we talk about the future perspectives of AI in breast ultrasound. | Ge-Ge Wu Li-Qiang Zhou Jian-Wei Xu Jia-Yu Wang Qi Wei You-Bin Deng Xin-Wu Cui Christoph F Dietrich | 2019 | World Journal of Radiology2019，11，2： | 12 |
| 4 | Structural basis of anti-PD-L1 monoclonal antibody avelumab for tumor therapy显示文摘 | Kefang Liu ShuguangTan Yan Chai Danqing Chen Hao Song Catherine Wei-Hong Zhang yi Shi Jun Liu Wenjie Tan Jianxin Lyu Shah Gao Jinghua Yan Jianxun Qi George F Gao | 2017 | Cell Research2017，27，1： | 11 |
| 5 | Structure and receptor-binding properties of an airborne transmissible avian infl uenza A virus hemagglutinin H5(VN1203mut)显示文摘Avian infl uenza A virus continues to pose a global threat with occasional H5N1 human infections,which is em-phasized by a recent severe human infection caused by avian-origin H7N9 in China.Luckily these viruses do not transmit effi ciently in human populations.With a few ami-no acid substitutions of the hemagglutinin H5 protein in the laboratory,two H5 mutants have been shown to obtain an air-borne transmission in a mammalian ferret model.Here in this study one of the mutant H5 proteins devel-oped by Kawaoka’s group(VN1203mut)was expressed in a baculovirus system and its receptor-binding properties were assessed.We herein show that the VN1203mut had a dramatically reduced binding affi nity for the avianα2,3-linkage receptor compared to wild type but showed no detectable increase in affi nity for the humanα2,6-linkage receptor,using Surface Plasmon Resonance techonology.Further,the crystal structures of the VN1203mut and its complexes with either human or avian receptors demon-strate that the VN1203mut binds the human receptor in the same binding manner(cis conformation)as seen for the HAs of previously reported 1957 and 1968 pandemic influenza viruses.Our receptor binding and crystallo-graphic data shown here further confi rm that the ability to bind the avian receptor has to decrease for a higher hu-man receptor binding affi nity.As the Q226L substitution is shown important for obtaining human receptor binding,we suspect that the newly emerged H7N9 binds human receptor as H7 has a Q226L substitution. | Xishan Lu Yi Shi Wei Zhang Yanfang Zhang Jianxun Qi George F Gao | 2013 | Protein & Cell2013，4，7： | 9 |
| 6 | Gut microbiota mediated molecular events and therapy in liver diseases显示文摘Gut microbiota is a community of microorganisms that reside in the gastrointestinaltract. An increasing number of studies has demonstrated that the gutliveraxis plays a critical role in liver homeostasis. Dysbiosis of gut microbiota cancause liver diseases, including nonalcoholic fatty liver disease and alcoholic liverdisease. Preclinical and clinical investigations have substantiated that themetabolites and other molecules derived from gut microbiota and diet interactionfunction as mediators to cause liver fibrosis, cirrhosis, and final cancer. This effecthas been demonstrated to be associated with dysregulation of intrahepaticimmunity and liver metabolism. Targeting these findings have led to thedevelopment of novel preventive and therapeutic strategies. Here, we review thecellular and molecular mechanisms underlying gut microbiota-mediated impacton liver disease. We also summarize the advancement of gut microbiota-basedtherapeutic strategies in the control of liver diseases. | Xiaoqiang Qi Ming Yang Joseph Stenberg Rahul Dey Leslie Fogwe Muhammad Shawkat Alam Eric TKimchi Kevin F Staveley-O'Carroll Guangfu Li | 2020 | World Journal of Gastroenterology2020，26，48： | 5 |
| 7 | An octamer of enolase from Streptococcus suis显示文摘Enolase is a conserved cytoplasmic metalloenzyme existing universally in both eukaryotic and prokaryotic cells.The enzyme can also locate on the cell surface and bind to plasminogen,via which contributing to the mucosal surface localization of the bacterial pathogens and assisting the invasion into the host cells.The functions of the eukaryotic enzymes on the cell surface expression(including T cells,B cells,neutrophils,monocytoes,neuronal cells and epithelial cells)are not known.Streptococcus suis serotype 2(S.suis 2,SS2)is an important zoonotic pathogen which has recently caused two large-scale outbreaks in southern China with severe streptococcal toxic shock syndrome(STSS)never seen before in human sufferers.We recently identified the SS2 enolase as an important protective antigen which could protect mice from fatal S.suis 2 infection.In this study,a 2.4-angstrom structure of the SS2 enolase is solved,revealing an octameric arrangement in the crystal.We further demonstrated that the enzyme exists exclusively as an octamer in solution via a sedimentation assay.These results indicate that the octamer is the biological unit of SS2 enolase at least in vitro and most likely in vivo as well.This is,to our knowledge,the first comprehensive characterization of the SS2 enolase octamer both structurally and biophysically,and the second octamer enolase structure in addition to that of Streptococcus pneumoniae.We also investigated the plasminogen binding property of the SS2 enzyme. | Qiong Lu Hao Lu Jianxun Qi Guangwen Lu George F Gao | 2012 | Protein & Cell2012，3，10： | 4 |
| 8 | Current status of research and application in vascular stents显示文摘Cardiovascular diseases have been the leading cause of death in modern society.Using vascular stents to treat these coronary and peripheral artery diseases has been one of the most effective and rapidly adopted medical interventions.During the twenty-five years’development of vascular stents,revolutionary cardiovascular stents like drug eluting stents and endothelial progenitor cells capture stents have emerged.In this review,the evolution of vascular stents is summarized,aiming to provide a glimpse into the future of vascular stents.Advanced designs,focusing on the investigations of new substrates,new platforms,new drugs and new biomolecules are currently under evaluation with promising clinical studies.The concept of'time sequence functional stent'has been raised in this paper.It presents anti-proliferative properties in the first phase after implantation and subsequently support endothelialization.It also shows long-term inertness without release of toxic ions or toxic degradation products.The success of this concept is briefly presented with a clinical study in this model stents. | QI PengKai YANG Ying MAITZ F Manfred HUANG Nan | 2013 | Chinese Science Bulletin2013，58，35： | 3 |
| 9 | One-step preparation of antibody and otigonucleotide dual-labeled gold nanoparticle bio-probes and their properties显示文摘 | Kong X Qiao F Qi H | 2008 | Biotechnol Lett2008，30，： | 1 |
| 10 | Preparation and electromagnetic properties of low-temperature sintered ferroelectric-ferrite composite ceramics 显示文摘 | YUE Z X CHEN S F QI X W | 2004 | J Alloys Compd2004，375，： | 1 |
| 11 | On the construction of Boolean functions with optimal algebraic immunity显示文摘 | Li N Qu L J Qi W F | 2008 | IEEE Trans on Information Theory2008，54，3： | 1 |
| 12 | Small interfering RNA targeting of S phase kinase-interacting protein 2 inhibits cell proliferation of pterygium fibroblasts显示文摘 | SU Y Wang F Qi H | 2011 | Mol Vis2011，17，： | 1 |
| 13 | An ideal multi-secret sharing scheme based on MSP显示文摘 | HSU C F CHANG Qi TANG Xue-ming | 2011 | Information Sciences2011，181，7： | 1 |
| 14 | Effects of all- trans retinoic acid and epidermal growth factor on the expression of nm23 - H1 in human hepatocarcinoma cells显示文摘 | Liu F Qi HL Chen HL | 2000 | J Cancer Res Clin Oncol2000，126，2： | 1 |
| 15 | Monotonicities of two sequences显示文摘 | Qi F Chen Ch -P | 1999 | Mathematics and Informatics Quarterly1999，9，4： | 1 |
| 16 | A novel drought-inducible gene,A TAF1,encodes a NAC family protein that negatively regulates the expression of stress-responsive genes in Arabidopsis显示文摘 | LU P L CH EN N Z AN R SU Z QI B S REN F CHEN J WANG X C | 2007 | Plant Molecular Biology2007，63，2： | 1 |
| 17 | Numerical simulations of LNG vapor dispersion in brayton fire training field tests with ANSYS CFX显示文摘 | Qi R F Ng D Cormier B R | 2010 | Journal of Hazardous Materials2010，183，13： | 1 |
| 18 | A genetic variant in the promoter region of mi R-106b-25 cluster predict clinical outcome of HBVrelated hepatocellular carcinoma in Chinese显示文摘 | Qi F Huang M Pan Y | 2014 | PLo S One2014，9，85： | 1 |
| 19 | Geranylgeranylacetone protectsmice against morphine-induced hyperlocomotion, rewardingeffect, and withdrawal syndrome 显示文摘 | Luo F C Qi L Lv T | 2012 | Free Radic Biol Med2012，52，7： | 1 |
| 20 | 查看详情显示文摘 | Zhu Q H Jiang H F Li J H Zhang M Wang X J Qi C R | | 0，，： | 1 |
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