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| 1 | The Calcineurin B-Like Calcium Sensors CBL1 and CBL9 Together with Their Interacting Protein Kinase ClPK26 Regulate the Arabidopsis NADPH Oxidase RBOHF显示文摘象反应的氧种类(ROS ) 和 Ca2+ 一样的第二个送信人的刺激特定的累积对许多在植物发信号和规定过程中央。然而,管理发信号的 Ca2+ 和 ROS 的相互的相互关系的机制开始仅仅正在出现。呼吸爆炸 oxidase 相当或相同的事物(RBOH ) 的 NADPH oxidases 家庭是当和他们的交往的 kinases (CIPK ) 的 Calcineurin 象 B 一样(CBL )Ca2+ 传感器蛋白质被显示了在表明过程的许多 Ca2+- 工作时,贡献 ROS 的产生的批评部件。在这研究,我们识别在两个都表明系统之间的直接功能的相互作用。我们报导交往 CBL 蛋白质 kinase CIPK26 明确地在酵母与 RBOHF 的 N 终端领域交往二混血儿的分析并且与在植物房间的全身的 RBOHF 蛋白质。另外,在有 CIPK26 的 CBL1 或 CBL9 的 vitro 和合作表示的 CIPK26 phosphorylates RBOHF 强烈在 HEK293T 房间由 RBOHF 提高 ROS 生产。一起,这些调查结果识别在调停 CBLCIPK 的 Ca2+ 在植物发信号并且 ROS 发信号之间的直接互联并且为 NADPH oxidase RBOHF 的 synergistic 激活提供证据由对它由 CBL1/9CIPK26 建筑群的 EF 传递和导致 Ca2+ 的 phosphorylation 直接 Ca2+ 有约束力。 | Maria Magdalena Drerup Kathrin Schlückinga Kenji Hashimoto Prabha Manishankar Leonie Steinhorst Kazuyuki Kuchitsu Jōrg Kudl | 2013 | Molecular Plant2013，6，2： | 35 |
| 2 | Clinical trial:Lactobacillus plantarum 299v(DSM 9843)improves symptoms of irritable bowel syndrome显示文摘AIM:To assess the symptomatic efficacy of Lactobacillus plantarum 299v(L.plantarum 299v)(DSM 9843) for the relief of abdominal symptoms in a large subset of irritable bowel syndrome(IBS) patients fulfilling the Rome Ⅲ criteria.METHODS:In this double blind,placebo-controlled,parallel-designed study,subjects were randomized to daily receive either one capsule of L.plantarum 299v(DSM 9843) or placebo for 4 wk.Frequency and intensity of abdominal pain,bloating and feeling of incomplete rectal emptying were assessed weekly on a visual analogue scale while stool frequency was calculated.RESULTS:Two hundred and fourteen IBS patients were recruited.After 4 wk,both pain severity(0.68 + 0.53 vs 0.92 + 0.57,P < 0.05) and daily frequency(1.01 + 0.77 vs 1.71 + 0.93,P < 0.05) were lower with L.plantarum 299v(DSM 9843) than with placebo.Similar results were obtained for bloating.At week 4,78.1 % of the patients scored the L.plantarum 299v(DSM 9843) symptomatic effect as excellent or good vs only 8.1 % for placebo(P < 0.01).CONCLUSION:A 4-wk treatment with L.plantarum 299v(DSM 9843) provided effective symptom relief,particularly of abdominal pain and bloating,in IBS patients fulfilling the Rome Ⅲ criteria. | Philippe Ducrotté Prabha Sawant Venkataraman Jayanthi | 2012 | World Journal of Gastroenterology2012，18，30： | 17 |
| 3 | Mechanisms responsible for pulmonary hypertension显示文摘 | Mainali Prabha JIN Hong-fang TIAN Yue TANG Chao-shu DU Jun-bao | 2008 | Chinese Medical Journal2008，，24： | 13 |
| 4 | 二氧化硫对低氧性肺动脉高压大鼠肺动脉胶原堆积的影响显示文摘目的探讨二氧化硫(SO2)对低氧性肺动脉高压大鼠肺动脉胶原堆积的影响。方法将雄性Wistar大鼠34只分为对照组(8只)、低氧组(8只)、低氧加SO2组(腹腔注射亚硫酸钠/亚硫酸氢钠混合液0.5mL/d)(9只)和低氧加天冬氨酸异羟肟酸(HDX)组[腹腔注射HDX3.7mg/(kg·d)](9只)。对低氧组、低氧加SO2组和低氧加HDX组大鼠进行低氧处理21d,氧体积分数为(100±5)mL/L,低氧处理6h/d。采用羟脯氨酸水平测定及天狼猩红染色法分析低氧性肺动脉高压大鼠肺组织及肺动脉胶原的变化。采用SPSS13.0软件进行统计学分析。结果4组大鼠肺组织羟脯氨酸水平有显著性差异(F=12.363 Pa<0.01)。与对照组比较,低氧组大鼠羟脯氨酸水平升高34.53%(P<0.01),随着低氧性肺动脉高压的形成,大鼠肺动脉中羟脯氨酸水平升高。与低氧组比较,低氧加SO2组大鼠羟脯氨酸水平降低17.58%(P<0.05),低氧加HDX组大鼠羟脯氨酸水平升高21.30%(P<0.05)。天狼猩红偏振光法分析显示,与对照组比较,低氧组大鼠血管壁胶原纤维明显增加;与低氧组比较,低氧加SO2组大鼠血管壁Ⅰ型胶原较少,呈红色或黄色粗纤维状,与Ⅲ型胶原伴行,低氧加HDX组大鼠血管壁胶原明显增加。结论SO2能显著降低低氧大鼠的肺动脉胶原堆积。 | Mainali prabha 田悦 金红芳 刘雪芹 唐朝枢 杜军保 | 2008 | 实用儿科临床杂志2008，23，10： | 12 |
| 5 | Effects of nitric oxide and hydrogen sulfide on the relaxation of pulmonary arteries in rats显示文摘背景:在血管舒张和血管缩小之间的平衡在维持脉管的动态平衡起一个主要作用。然而,内在的机制是不清楚的。越来越多的证据建议在在氮的氧化物之间的血管舒张的规定有一个相互作用(没有) 并且硫化氢(H (2 ) S ) 。我们探索了在之间的相互作用和效果没有并且在老鼠的肺的动脉的松驰上的 H (2 ) S。方法:七只男 Sprague-Dawley 老鼠与水合氯醛和为脉管的活动的学习分开的每只老鼠的肺的动脉被使麻木。响应不同剂量的肺的动脉戒指的 vasorelaxing 活动一没有施主,硝普化钠(SNP ) ,或 H (2 ) S 施主,钠硫化氢(NaHS ) ,被测量在试管内。当肺的动脉戒指与一个 cystathionine-gamma-lyase 禁止者被对待时, DL-propargylglycine 面对 SNP 或一个氮的氧化物 synthase 禁止者, N (终止)-nitro-L-arginine 甲基酉旨面对 NaHS,在放松活动的变化被分析。结果:肺的动脉戒指的松驰以响应 SNP 或 NaHS 的一种剂量依赖者方式。肺的动脉戒指的松驰率增加了从(30.90+/-4.62 )% 到(60.50+/-8.08 )% 当 SNP 的集中从 1 micromol/L 增加了到 3 micromol/L 并且从时(26.13+/-4.12 )% 到(53.09+/-14.01 )% 当 NaHS 的集中从 25 micromol/L 增加了到 100 micromol/L 时。然而,当适当禁止者被增加时,对 SNP 和 NaHS 的松驰回答减少了。结论:结果同样建议了那到没有, H (2 ) S 是行动了 vasorelaxant 独立于,或 synergistically 没有在血管舒张的规定。在之间的相互作用没有并且 H (2 ) S 在调整肺的动脉的令人放松的活动起了一个重要作用。 | WANG Yan-fei MAINALI Prabha TANG Chao-shu SHI Lin ZHANG Chun-yu YAN Hui LIU Xue-qin DU Jun-bao | 2008 | Chinese Medical Journal2008，，5： | 8 |
| 6 | Antitumor Research on Artemisinin and Its Bioactive Derivatives显示文摘Cancer is the leading cause of human death which seriously threatens human life.The antimalarial drug artemisinin and its derivatives have been discovered with considerable anticancer properties.Simultaneously,a variety of target-selective artemisinin-related compounds with high efficiency have been discovered.Many researches indicated that artemisinin-related compounds have cytotoxic effects against a variety of cancer cells through pleiotropic effects,including inhibiting the proliferation of tumor cells,promoting apoptosis,inducing cell cycle arrest,disrupting cancer invasion and metastasis,preventing angiogenesis,mediating the tumor-related signaling pathways,and regulating tumor microenvironment.More importantly,artemisinins demonstrated minor side effects to normal cells and manifested the ability to overcome multidrug-resistance which is widely observed in cancer patients.Therefore,we concentrated on the new advances and development of artemisinin and its derivatives as potential antitumor agents in recent 5 years.It is our hope that this review could be helpful for further exploration of novel artemisinin-related antitumor agents. | Yunqin Zhang Guowei Xu Shuqun Zhang Dong Wang PSaravana Prabha Zhili Zuo | 2018 | Natural Products and Bioprospecting2018，8，4： | 8 |
| 7 | Management of pregnancy in Crigler Najjar syndrome type 2显示文摘Crigler Najjar syndrome is associated with indirect hyperbilirubinemia due to a deficiency of enzyme Uridine Di Phospho Glucoronosyl Transferase(UDPGT).Presented here is a case of a female in the first trimester of pregnancy,who was diagnosed to have type 2 Crigler Najjar syndrome.We also discuss the management of this rare disease especially in pregnancy.Unconjugated bilirubin can cross the placental barrier causing neuro-logical damage in the newborn.Patient was carefully monitored during pregnancy and treatment with pheno-barbitone in low doses was adjusted such that the serum bilirubin levels were below 10 mg/d L.Crigler Najjar syndrome being rare needs to be diagnosed early in pregnancy to avoid adverse fetal outcomes.Phenobarbitone being an inducer of enzyme UDPGT is used as the first line of treatment and is not teratogenic in the low doses used.Treatment protocol followed was on the basis of previous reported cases and successful perinatal outcome was achieved. | Alisha Nitin Chaubal Ruchir Patel Dhaval Choksi Kaivan Shah Meghraj Ingle Prabha Sawant | 2016 | World Journal of Hepatology2016，8，11： | 4 |
| 8 | Effect of angiotensin converting enzyme gene I/D polymorphism in South Indian children with nephrotic syndrome显示文摘Nephrotic syndrome is one of the most common childhood kidney diseases. It is mostly found in the age group of 2 to 8 years. Around 10%-15% of nephrotic syndrome cases are non-responders of steroid treatment(SRNS).Angiotensin converting enzyme(ACE)(I/D) gene association studies are important for detecting kidney disease and herein we assessed the association of ACE(I/D) polymorphism with nephrotic syndrome in South Indian children. We recruited 260 nephrotic syndrome(162 boys and 98 girls) and 218(140 boys and 78 girls) control subjects. ACE I/D polymorphism was analyzed by PCR using genotype allele specific primers. In ACE(I/D), we did not find significant association for the ungrouped data of nephrotic syndrome children and the control subjects. Kidney biopsies were done in 86 nephrotic syndrome cases(minimal change disease, n = 51;focal segmental glomerulosclerosis, n = 27;diffuse mesangial proliferation, n = 8). We segregated them into the minimal change disease/focal segmental glomerulosclerosis groups and observed that the ACE’D’ allele was identified with borderline significance in cases of focal segmental glomerulosclerosis and the ’Ⅰ’ allele was assessed as having very weak association in cases of minimal change disease. ’Ⅱ’ genotype was weakly associated with minimal change disease. Gender specific analysis revealed weak association of’ID’ genotype with female nephrotic syndrome in females. Dominant expression of DD genotype was observed in males with nephrotic syndrome. Our finding indicated that ACE(I/D) has moderate association with focal segmental glomerulosclerosis. However, due to the limited number of biopsy proven focal segmental glomerulosclerosis subjects enrolled, further studies are required to confirm these results. | Aravind Selvin Kumar Ramanathan Balakrishnan Karuppiah Murali Vijayan Kamaraj Raju Dhivakar Mani Rathika Chinniah Manikandan Thirunavukkarasu Padma Malini Ravi Jeyaram Illiayaraja Krishnan Prabha Senguttuvan | 2019 | The Journal of Biomedical Research2019，33，3： | 2 |
| 9 | Size dependency of nan oparticles-mediated gene transfection: Studies with fraelionl ted nanoparticles显示文摘 | Prabha S Zhou WZ Panyam J | 2002 | Int J l''haml2002，244，12： | 1 |
| 10 | Thyroid and parathyroid glands in the va- ginal wall: report of a case显示文摘 | Kurman R J Prabha C | 1973 | Am J Clin Pathol1973，59，4： | 1 |
| 11 | Circadian pattern of blood pressure in normal preg- nancy and preeclampsia显示文摘 | Hem Prabha Gupta R K Singh Urmila Singh Seema | 2011 | Journal of obstetrics and gy- naecology of India2011，61，4： | 1 |
| 12 | Lysosomal disruption preferentially targets acute myeloid leukemia cells and progenitors显示文摘 | Sukhai M A Prabha S Hurren R | 2013 | J Clin Invest2013，123，1： | 1 |
| 13 | Expression of Vimentin in the Developing, Adult and Rodents Testis 显示文摘 | Prabha SM Meistrich ML | 2006 | Reprod2006，131，3： | 1 |
| 14 | Size-dependency of nanoparticle-mediated gene transfection: studies with fractionated nanoparticles 显示文摘 | Prabha S Zhou W Z Panyam J | 2002 | Int I Pharm2002，244，12： | 1 |
| 15 | Antcolony optimization for group technology applica-tions显示文摘 | Aqrawal Anil Kumar Bhardwaj Prabhas Srivastava Vivek | 2011 | International Journal of Advanced Manufacturing Tech-nology2011，55，58： | 1 |
| 16 | Strategies for developing biomarkers of heart failure 显示文摘 | Jortani SA Prabha SD Valdes R Jr | 2004 | Clin Chem2004，50，2： | 1 |
| 17 | Leucocyte adherence inhibitionassay ( LAI) in cancer of the oral cavity 显示文摘 | Prabha B Kumary Vasudevan DM | 1984 | Eur J Cancer ClinOncol1984，20，7： | 1 |
| 18 | Carbohydrate metabolism inripening banana fruit显示文摘 | Prabha T N Bhagyalakshm N | 1998 | Phytochemistry1998，48，6： | 1 |
| 19 | Multiple forms of polygalacturonase from mango fruit显示文摘 | Prasanna V Prabha T N Tharanathan R N | 2006 | Food Chemistry2006，95，1： | 1 |
| 20 | Nano-engineered mes- enchymal stem cells as targeted therapeutic carriers 显示文摘 | Sadhukha T O'Brian TD Prabha S | 2014 | J Control Release2014，196，： | 1 |
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