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| 1 | Interaction of the major inflammatory bowel disease susceptibility alleles in Crohn’s disease patients显示文摘AIM:To investigate the interaction of interleukin-23 receptor(IL23R)(rs1004819 and rs2201841),autophagy-related 16-like 1(ATG16L1)(rs2241880), caspase recruitment domain-containing protein 15 (CARD15)genes,and IBD5 locus in Crohn's disease(CD) patients. METHODS:A total of 315 unrelated subjects with CD and 314 healthy controls were genotyped.Interactions and specific genotype combinations of a total of eight variants were tested.The variants of IBD5locus(IGR2198a_1 rs11739135 and IGR2096a_1 rs12521868),CARD15(R702W rs2066845 and L1007fs rs2066847),ATG16L1(rs2241880)and IL23R (rs1004819,rs2201841)genes were genotyped by PCR-RFLP,the G908R(rs2066844)in CARD15 was determined by direct sequencing. RESULTS:The association of ATG16L1 T300A with CD was confirmed[P=0.004,odds ratio(OR)=1.69, 95%CI:1.19-2.41],and both IL23R variants were found to represent significant risk for the disease(P= 0.008,OR=2.05,95%CI:1.20-3.50 for rs1004819 AA;P<0.001,OR=2.97,95%CI:1.65-5.33 for rs2201841 CC).Logistic regression analysis of pairwise interaction of the inflammatory bowel disease (IBD)loci indicated that IL23R,ATG16L1,CARD15 and IBD5(IGR2198a_1)contribute independently to disease risk.We also analysed the specific combina- tions by pair of individual ATG16L1,IL23R rs1004819, rs2201841,IGR2198a_1,IGR2096a_1 and CARD15 genotypes for disease risk influence.In almost all cases,the combined risk of susceptibility pairs was higher in patients carrying two different risk-associated gene variants together than individuals with just one polymorphism.The highest OR was found for IL23R rs2201841 homozygous genotype with combination of positive CARD15 status(P<0.001,OR=9.15,95% CI:2.05-40.74). CONCLUSION:The present study suggests a cumulative effect of individual IBD susceptibility loci. | Veronika Csngei Luca Járomi EnikSáfrány Csilla Sipeky Lili Magyari Bernadett Faragó Judit Bene Noémi Polgár Lilla Lakner Patrícia Sarlós Márta Varga Béla Melegh | 2010 | World Journal of Gastroenterology2010，16，2： | 2 |
| 2 | Fertilizing capacity of frozen boar semen following surgical insemination显示文摘 | Polge C Salamon S Wilmut I | 1970 | Vet Rec1970，87，15： | 1 |
| 3 | Artificial insemination in pigs 显示文摘 | Polge t3 | 1956 | Vet Rec1956，68，： | 1 |
| 4 | Diagnostic and prognostic value of heart-type fatty acid-binding protein (H-FABP),an early biochemical marker of myocardial injury显示文摘 | Bertinchant JP Polge A | 2005 | Archives Des Maladies Du Coeur Et Des Vaisseaux2005，，： | 1 |
| 5 | Artificial insemination in pigs 显示文摘 | Polge C | 1956 | Vet Rec1956，68，： | 1 |
| 6 | Evaluation of cardiac troponin I and T levels as markers of myocardial damage in doxorubicin-induced cardiomyopathy rats,and their relationship with echocardiographic and histological findings显示文摘 | Bertinchant JP Polge A Robert E | 2003 | Clin Chim Acta2003，329，12： | 1 |
| 7 | Artificial insemination inpigs显示文摘 | POLGE C | 1956 | Vet Pec1956，，68： | 1 |
| 8 | Evaluation of inci- dence, clinical significance, and prognostic value of circulat- ing cardiac troponin I and T elevation in hemodynamically stable patients with suspected myocardial contusion after blunt chest trauma 显示文摘 | Bertinchant JP Polge A Mohty D | 2000 | J Trauma2000，48，5： | 1 |
| 9 | Revival of spermatozoa after vitrification and dehydration at low temperatures 显示文摘 | POLGE C SMITH A U PAPKES A S | 1949 | Nature1949，164，4172： | 1 |
| 10 | Prognostic value of car diactroponin T in patients with both acute and chronic stable congestive heart failure:comparison with atrial natriuretic peptide,brain natriuretic peptide and plasma norepinephrine显示文摘 | Bertinchant JP Combes N Polge A | 2005 | Clin Chim Acta2005，352，12： | 1 |
| 11 | Survival of spermatozoa at low tempera- tures显示文摘 | Smith A U Polge C | 1950 | Nature1950，166，4225： | 1 |
| 12 | The effect of reducing the number of embryos during early stages of gestation on the maintenance of pregnancy in the pig显示文摘 | Polge C Rowson L E Chang M C | 1966 | J Reorod Fertil1966，12，2： | 1 |
| 13 | Evaluation of incidence, clinical significance, and prognostic value of circulation cardiactropanin 1 and T elevation in hemodynamically stable patients with suspected myocardial contusion after blunt chest trauma 显示文摘 | Bertinchant JP Polge A Mohty D | 2004 | J Trauma2004，48，5： | 1 |
| 14 | Revival of spermatozoa after vitrification and dehydration at low temperature显示文摘 | Polge C Smith A U | 1949 | Nature1949，164，： | 1 |
| 15 | Sex selection in cattle:A field trial显示文摘 | CRAN D G JOHNSON L A POLGE C | 1995 | Vet Rec1995，136，： | 1 |
| 16 | Revival of spermatozoa 'after vitrification and dehydration at low temprature 显示文摘 | Polge C Smith A U Parkes A S | 1949 | Nature1949，164，： | 1 |
| 17 | Extended X-ray Absorption Fine Structure Investigation of Arsenic in Hg Cd Te:the Effect of the Activation Anneal显示文摘 | Ballet P Polge B Biquard X | 2009 | J Electron Mater2009，38，17： | 1 |
| 18 | Comparison of the diagnostic value of cardiac troponin Ⅰ and T determinations for detecting early myocardial damage and the relationship with histological findings after isoprenaline-induced cardiac injury in rats显示文摘 | Bertinchant JP Robert E Polge A | 2000 | Clin Chim Acta2000，298，12： | 1 |
| 19 | Evaluation of incidence,clinical significance,and prognostic value of circulating cardiac troponin I and T elevation in hemodynamically stable patients with suspected myocardial contusion after blunt chest trauma显示文摘 | Bertinchant JP Polge A Mohty D | | Th0，，： | 1 |
| 20 | Insecticide and insecticide metabolite interactions with cytochrome P450 mediated activities in maize 显示文摘 | Baerg R J Barrett M Polge N D | 1996 | Pestic Biochem Physiol1996，55，1： | 1 |
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