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| 1 | Relationship between plasma D(-)-lactate and intestinal damage after severe injuries in rats显示文摘AIM To explore the kinetic changes in plasma D (-)lactate and lipopolysaccharide ( LPS ) levels, and investigate whether D (-)-lactate could be used as a marker of intestinal injury in rats following gut ischemia/reperfusion, burn, and acute necrotizing pancreatitis (ANP).METHODS Three models were developed in rats:gut ischemia/reperfusion obtained by one hour of superior severe burn injury created by 30% of total body surface induced by continuous inverse infusion of sodium taurocholate and trypsin into main pancreatic duct.Plasma levels of D( - )-lactate in systemic circulation and LPS in portal circulation were measured by enzymaticspectrophotometric method and limulus amebocyte lysate (LAL) test kit, respectively. Tissue samples of intestine were taken for histological analysis.RESULTS One hour gut ischemia followed by reperfusion injuries resulted in a significant elevation in plasma D( - )lactate and LPS levels, and there was a significant correlation between the plasma D( - )-lactate and LPS (r =0.719, P<0.05). The plasma concentrations of D(-)lactate and LPS increased significantly at 6 h postburn,and there was also a remarkable correlation between them (r = 0.877, P < 0.01). D ( - )-lactate and LPS levels elevated significantly at 2 h after ANP, with a similar significant correlation between the two levels (r-0.798,P < 0.01 ). The desquamation of intestine villi and infiltration of inflammatory cells in the lamina propria were observed in all groups.CONCLUSION The changes of plasma D( - )-lactate levels in systemic blood paralleled with LPS levels in the portal vein blood. The measurement of plasma D (-)-lactate level may be a useful marker to assess the intestinal injury and to monitor an increase of intestinal permeability and endotoxemia following severe injuries in early stage. | Xiao-Qing Sun Xiao-Bing Fu Rong-Zhan Yi Lü Qun Deng Xiao-Guo Jian Zhi-Yong Sheng Bum Institute, 304~(th)Hospital,Beijing 100037,China Department of General Surgery,Chinese PLA 304 Hospital,Beijing 100037,China | 2001 | World Journal of Gastroenterology2001，7，4： | 56 |
| 2 | Genetic structure of the European anchovy, Engraulis e ncrasicolus, in the north-west Mediterranean 显示文摘 | TUDELA S GARCfA-MARfN J L PLA C | 1999 | J Exp Mar Biol Ecol1999，234，1： | 1 |
| 3 | Diversity of Ia'odes ricinus tick associated bacterial communities from different forests显示文摘 | Van Overbeek L Gassner F van der Plas CL | 2008 | FEMS Microbiol Ecol2008，66，1： | 1 |
| 4 | Preparative purification of soybean agglutinin by affinity chromatography and its immobilization for polysaccharide isolation显示文摘 | FRANCO FRAGUAS L PLA A FERREIRA F | 2003 | Journal of Chromatography2003，790，： | 1 |
| 5 | Petrologic and stable isotope constraints on hydrothermal alteration and serpentinization of the EPR shallow mantle at Hess Deep (Site 895) 显示文摘 | FRUH-GREEN G L PLAS A LECUYER C | 1996 | Proceedings of Ocean Drilling Program: Scientific Results1996，147，： | 1 |
| 6 | Genetic structure of the European anchovy, Engraulis encrasicolus, in the northwest Mediterranean 显示文摘 | Tudela S Garca-Marn J L Pla C | 1999 | Journal of Experimental Marine Biology and Ecology1999，234，： | 1 |
| 7 | Ethylene perception is required for the expression of tomato ripening-related genes and associated physiological changes even at advanced stages of ripening显示文摘 | Hoeberichts FA Van Der Plas L HW Woltering EJ | 2002 | Postharvest Biol Technol2002，26，： | 1 |
| 8 | Ethylene perception is required for the expression of tomato ripening- related genes and associated physiological changes even at advanced stages of ripening显示文摘 | HOEBERICHTS F A van der PLAS L H WOLTERING E J | 2002 | Postharvest Biology and Technology2002，26，2： | 1 |
| 9 | 显示文摘 | Pla F Corriou J P | 1995 | Chemical Engineering Science1995，50，13： | 1 |
| 10 | Subehondral bone microstructural damage by increased remodelling aggravates experimental osteoarthritis preceded by osteoporosis显示文摘 | Bellido M Lugo L Romarr Plas JA | 2010 | Arthritis Res Ther2010，12，4： | 1 |
| 11 | Induced expression of the Candida albicans multidrug resistance gene CDR1 in response to fluconazole and other antifungals 显示文摘 | Gil C Pla J | 1998 | Yeast1998，14，： | 1 |
| 12 | EAU guidelines on urological trauma显示文摘 | Lynch TH Martínez-Pineiro L Plas E | | 0，，： | 1 |
| 13 | Changes in gene expression during programmed cell death in tomato cell suspensions显示文摘 | Hoeberichts F A Orzaez D Van der Plas L H W Woltering E J | 2001 | Plant Mol Biol2001，45，： | 1 |
| 14 | 查看详情显示文摘 | Fillol J.L Codolà Z Garcia-Bosch I Gómez L Pla J.J Costas M | | 0，，： | 1 |
| 15 | Effect ofbutternut {Cucurbita moschata Duchesne ex Poiret) fibres on breadmaking, quality and staling显示文摘 | ESCALADA PLA M ROJAS A GERSCHENSON L | 2013 | Food and Bioprocess Technology2013，6，3： | 1 |
| 16 | Effects of anaerobiosis on ethylene production, respiration and flowering in iris bulbs显示文摘 | Marissen N Kannoworff W A van der Plas L H W | 1991 | Physiol Plant1991，82，： | 1 |
| 17 | Influence of temperature, ethylene and cyanide on the occurrence ofalternation respiration in mitoehondria from iris bulbs 显示文摘 | Marissen N van der Plas L H W | 1986 | Plant Sci1986，45，： | 1 |
| 18 | Profile die design based on flow balancing 显示文摘 | SVABIK J PLA CEK L SAHA P | 1999 | Intern Polym Process1999，3，： | 1 |
| 19 | An evaluation of ceramic materialsfor use in non-cooled low-flow ICP torches 显示文摘 | plas V D Galan L | 1987 | Spectrochimica Acta(B)1987，42，1112： | 1 |
| 20 | Modeling and performance analysis of channel assembling in multichannel cognitive radio networkswith spectrum adaptation显示文摘 | JIAO L LI F Y PLA V | 2012 | IEEE Transactions on Vehicular Technology2012，11，6： | 1 |
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