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| 1 | Perspectives on new biomarkers in gastric cancer: Diagnostic and prognostic applications显示文摘Gastric cancer is considered one of the most deadly tumors worldwide. Even with the decline in its incidence, the mortality rate of this disease has remained high, mainly due to its late diagnosis and to the lack of precise prognostic markers. The main purpose of this review is to present genetic, epigenetic and proteomic molecular markers that may be used in a diagnostic and prognostic manner and to discuss the pros and cons of each type of marker for improving clinical practice. In this sense, we observed that the use of genetic markers, especially mutations and polymorphisms, should be carefully considered, as they are strongly affected by ethnicity. Proteomic-based markers show promise, but the higher costs of the associated techniques con-tinue to make this approach expensive for routine use. Alternatively, epigenetic markers appear to be very promising, as they can be detected in bodily fluids as well as tissues. However, such markers must be used carefully because epigenetic changes may occur due to environmental factors and aging. Despite the advances in technology and its access, to date, there are few defined biomarkers of prognostic and diagnostic use for gastric tumors. Therefore, the use of a panel of several approaches(genetic, epigenetic and proteomic) should be considered the best alternative for clinical practice. | Danilo do Rosário Pinheiro Wallax Augusto Silva Ferreira Mariceli Baia Leo Barros Mariana Diniz Araújo Symara Rodrigues-Antunes Bárbara do Nascimento Borges | 2014 | World Journal of Gastroenterology2014，20，33： | 4 |
| 2 | Microorganisms from canals of root-filled teeth with periapical lesions显示文摘 | PINHEIRO E T GOMES B P FERRAZ C C | 2003 | Int Endod J2003，36，1： | 1 |
| 3 | Determination of Formaldehyde by Acetaldehyde in Urine by HPLC显示文摘 | Deandrade J B Deandrade M V Pinheiro H L C | 1999 | American Laboratory1999，31，10： | 1 |
| 4 | Efficiency A- nalysis of Developing Country Agriculture: a Review of the Frontier Function Literature 显示文摘 | Bravo - Ureta B E Pinheiro A E | 1993 | Agricultural and Resource Economics Review1993，22，1： | 1 |
| 5 | A space vector PWM modulation scheme for back-to-back three-level diode-clamped converters显示文摘 | Grigoletto F B Pinheiro H | 2009 | IEEE Transactions on Power Electronics Conference2009，，： | 1 |
| 6 | Efficiency analysis of developing country agriculture 显示文摘 | BRAVO- UREAT B E PINHEIRO A E | 1993 | Agri Resour Econ Rev1993，22，： | 1 |
| 7 | Evaluation of root canal microorganisms isolated from teeth with endodontic failure and their antimicrobial susceptibility显示文摘 | PINHEIRO E T GOMES B P FERRAZ C C | 2003 | Oral Microbiol Immunol2003，18，2： | 1 |
| 8 | Extraction, purification and characterization of galactomannans from non-tradi- tional sources显示文摘 | Cerqueira M A Pinheiro A C Souza B W S | 2009 | Carbohydrate polymers2009，75，3： | 1 |
| 9 | Determination of formaldehyde and acetaldehyde in urine by HPLC显示文摘 | Deandrade J B Deandrade M V Pinheiro H L C | 1999 | American Laboratory1999，31，10： | 1 |
| 10 | Proteome analysis of secondary somaticembryogenesis in cassava(Manihot esculenta)显示文摘 | Baba A I Nogueira F C S Pinheiro C B | 2008 | Plant Science2008，175，： | 1 |
| 11 | Serologic immunoreactivity to Neospora caninurn antigens in dogs determined by indirect immunofluorescence,western blotting and dot-ELISA显示文摘 | Pinheiro A M Costa M F Paule B | 2005 | Vet Parasitol2005，130，12： | 1 |
| 12 | Pre - eclampsi- a: relationship between coagulation, fibrinolysis and inflammation 显示文摘 | DUSSE L M RIOS D R PINHEIRO M B | 2011 | Clin Chim Acta2011，412，12： | 1 |
| 13 | Fatigue analysis of damaged steel pipelines under cyclic internal pressure 显示文摘 | PINHEIRO B D C PASQUALINO I P | 2009 | International Journal of Fatigue2009，31，5： | 1 |
| 14 | EGFR amplifica- tion and lack of activating mutations in metaplastic breast carcino- mas显示文摘 | Reis-Filho J S Pinheiro C Lambros M B | 2006 | J Pathol2006，209，4： | 1 |
| 15 | The best approach for splenectomy in portal hypertension 显示文摘 | Andraus W Pinheiro R S Haddad L B | 2011 | Surgery2011，149，6： | 1 |
| 16 | A prospective study on habitual duration of sleep and incidence of breast cancer in a large cohort of women显示文摘 | Pinheiro S P Sehemhammer E S Tworoger S S Michels K B | 2006 | Cancer Res2006，66，10： | 1 |
| 17 | Chemometric classification of olives from three Portuguese cultivars of Olea europaea L显示文摘 | PINHEIRO P B M ESTEVES DA SILVA J C G | 2005 | Analytica Chimica Acta2005，544，12： | 1 |
| 18 | Detailed 2-D imaging of the Mediterranean Outflow and Med dies from Multichannel seismic data显示文摘 | Pinheiro L M Song H B Ruddick B Dubert J Ambar I | | Submitted to Journa of Marine system0，，： | 1 |
| 19 | Infrared laser light re- duces loading time of dental Implants : a Raman spectroscopic study 显示文摘 | Lopes C B Pinheiro A L B Sathaiah S | 2005 | Photomedicine and Laser Surgery2005，23，1： | 1 |
| 20 | The use of thermochemical pretreatments to improve the anaerobic biodegradability and biochemical methane potential of the sugarcane ba- gasse 显示文摘 | Costa A G Pinheiro G C Pinheiro F G C Dos Santos A B Santaella S T Leitao R C | 2014 | Chemical Engineering Journal2014，248，： | 1 |
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