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| 1 | High-density SNP-based genetic maps for the parents of an outcrossed and a selfed tetraploid garden rose cross, inferred from admixed progeny using the 68k rose SNP array显示文摘Dense genetic maps create a base for QTL analysis of important traits and future implementation of marker-assisted breeding.In tetraploid rose,the existing linkage maps include<300 markers to cover 28 linkage groups(4 homologous sets of 7 chromosomes).Here we used the 68k WagRhSNP Axiom single-nucleotide polymorphism(SNP)array for rose,in combination with SNP dosage calling at the tetraploid level,to genotype offspring from the garden rose cultivar‘Red New Dawn’.The offspring proved to be not from a single bi-parental cross.In rose breeding,crosses with unintended parents occur regularly.We developed a strategy to separate progeny into putative populations,even while one of the parents was unknown,using principle component analysis on pairwise genetic distances based on sets of selected SNP markers that were homozygous,and therefore uninformative for one parent.One of the inferred populations was consistent with self-fertilization of‘Red New Dawn’.Subsequently,linkage maps were generated for a bi-parental and a self-pollinated population with‘Red New Dawn’as the common maternal parent.The densest map,for the selfed parent,had 1929 SNP markers on 25 linkage groups,covering 1765.5 cM at an average marker distance of 0.9 cM.Synteny with the strawberry(Fragaria vesca)genome was extensive.Rose ICM1 corresponded to F.vesca pseudochromosome 7(Fv7),ICM4 to Fv4,ICM5 to Fv3,ICM6 to Fv2 and ICM7 to Fv5.Rose ICM2 corresponded to parts of F.vesca pseudochromosomes 1 and 6,whereas ICM3 is syntenic to the remainder of Fv6. | Mirjana Vukosavljev Paul Arens Roeland E Voorrips Wendy P C van't Westende G D Esselink Peter M Bourke Peter Cox W Eric van de Weg Richard G F Visser Chris Maliepaard Marinus J M Smulders | 2016 | Horticulture Research2016，3，1： | 6 |
| 2 | Differential diagnosis in patients with suspected bile acid synthesis defects显示文摘AIM: To investigate the clinical presentations associated with bile acid synthesis defects and to describe identification of individual disorders and diagnostic pitfalls. METHODS: We describe semiquantitative determination of 16 urinary bile acid metabolites by electrospray ionization-tandem mass spectrometry. Sample preparation was performed by solid-phase extraction. The total analysis time was 2 min per sample. We determined bile acid metabolites in 363 patients with suspected defects in bile acid metabolism. RESULTS: Abnormal bile acid metabolites were found in 36 patients. Two patients had bile acid synthesis defects but presented with atypical presentations. In 2 other patients who were later shown to be affected by biliary atresia and cystic fibrosis the profile of bile acid metabolites was initially suggestive of a bile acid synthesis defect. Three adult patients suffered from cerebrotendinous xanthomatosis. Nineteen patients had peroxisomal disorders, and 10 patients had cholestatic hepatopathy of other cause. CONCLUSION: Screening for urinary cholanoids should be done in every infant with cholestatic hepatopathy as well as in children with progressive neurological disease to provide specific therapy. | Dorothea Haas Hongying Gan-Schreier Claus-Dieter Langhans Tilman Rohrer Guido Engelmann Maura Heverin David W Russell Peter T Clayton Georg F Hoffmann Jürgen G Okun | 2012 | World Journal of Gastroenterology2012，18，10： | 2 |
| 3 | 2004英国高血压学会高血压治疗指南(BHS-IV):概要显示文摘在高血压领域,不断出现的新证据已日益受到关注。例如:血压可作为心血管疾病的一个危险因素;改进生活方式对于预防和治疗高血压的重要意义;不同类型药物的有效性和安全性;高危高血压患者包括糖尿病患者的治疗;心血管疾病总体危险性评估的重要性以及使用他汀类药物所获得的额外益处。 | Bryan Williams Neil R Poulter Peter S Sever Morris J Brown Mark Davis Gordon T McInnes John F Potter 邱洪 | 2004 | 英国医学杂志中文版2004，7，5： | 2 |
| 4 | Severe valproic acid intoxication is associated with atrial tachycardia: secondary detoxication by hemoperfusion 显示文摘 | MEYER S KUHLMANN M K PETERS F T LIMBACH H G LINDINGER A | 2005 | Klin Padiatr2005，217，2： | 1 |
| 5 | A comparison study of improved Hilbert-Huang transform and wavelet transform:Application to fault diagnosis for rolling bearing显示文摘 | Peng Z K Peter W T Chu F L | | 0，，5： | 1 |
| 6 | A comparison study of improved Hilbert-Huang transform and wavelet transform:Application to fault diagnosis for rolling bearing显示文摘 | Peng Z K Peter W T Chu F L | 2005 | Mechanical Systems and Signal Processing2005，19，： | 1 |
| 7 | Remote sensing, diagnosis and collaborative maintenance with web-enabled virtual instruments and mini-servers 显示文摘 | Wang J F Peter W T He L S | 2004 | The International Journal of Advanced Manufacturing Technology2004，24，6： | 1 |
| 8 | 查看详情显示文摘 | Elaine M T Donald J L J John H.L Debbie A M Peter B F Karen B | | 0，，： | 1 |
| 9 | Increased density and male-male interactions reduce male longevity in the medfly,Ceratitis capitata显示文摘 | GASKIN T PETER F TRACEY C | 2002 | Animal Behaviour2002，63，： | 1 |
| 10 | An improved Hilbert-Huang transform and its application in vibration signal analysis显示文摘 | Peng Z K Peter W T Chu F L | 2005 | Journal of Sound and Vibration2005，286，： | 1 |
| 11 | Experimental determination of the fate of rising co2 droplets in seawater显示文摘 | PETER G B EDWARD T P GERNOT F | 2002 | Environ Sci Technol2002，36，： | 1 |
| 12 | Assessing the vulnerability of ecoenvironmental health to climate change 显示文摘 | Shilu T Peter M Gerry F | 2010 | International Journal of Environmental Research and Public Health2010，，7： | 1 |
| 13 | An Improved Hilbert-Huang Transform and Its Application in Vibration Analysis显示文摘 | Peng Z K Peter W T Chu F L | 2005 | Journal of Sound and Vibration2005，286，12： | 1 |
| 14 | Responses of antarctic pack-ice seals to environmental change and increasing krill fishing显示文摘 | Jaume F Philip N T Peter L B | 2012 | Biol Conserv2012，149，1： | 1 |
| 15 | The role of proteases in individual and collective cancer cell invasion显示文摘 | Peter F Katarina W Tube T | 2008 | Cancer Res2008，68，18： | 1 |
| 16 | Comparison of Total Hip Arthroplasty performed with and without cement:a randomized trial显示文摘 | Andreas L Robert B Cecil Ik David F Peter T Cindy W | 2002 | J Bone Joint Surg Am2002，84，10： | 1 |
| 17 | Molecular characterization of the first Austrilian isolation of Japanese encephalitis virus显示文摘 | David T Wang L F Peter W | 2000 | The FU Srain2000，81，： | 1 |
| 18 | Simulation of highly ductile fiber-reinforced cement-based composite components under cyclic loading 显示文摘 | Han T S Peter H F Billington S L | 2003 | ACI Structural Journal2003，100，6： | 1 |
| 19 | Pressure exchange system for energy recovery in reverse osmosis plants 显示文摘 | Geisler P Hahnenstein F U Krumm W Peters T | 1999 | Desalination1999，122，： | 1 |
| 20 | Comparison of commercial solid acid catalysts for the esterification of acetic acid with butanol显示文摘 | PETERS T A BENE N E HOLMEN A KEURENTJES J T F | 2006 | Appl Catal A2006，297，3： | 1 |
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