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| 1 | Comparison between double-balloon and single-balloon enteroscopy in therapeutic ERC after Roux-en-Y entero-enteric anastomosis显示文摘AIM:To compare the efficacy of double-balloon enteroscopy (DBE) and single-balloon enteroscopy (SBE) in therapeutic endoscopic retrograde cholangiography (ERC) in patients with Roux-en-Y entero-enteric anastomosis.METHODS:Retrospective analysis of our patient cohort revealed 4 patients with enterobiliary anastomosis and Roux-en-Y entero-enteric anastomosis who underwent repeated ERC with DBE and SBE because of recurrent cholangitis.RESULTS:A total of 38 endoscopic retrograde cholangiopancreatography procedures were performed in 25 patients with Roux-en-Y entero-enteric anastomosis.DBE was used in 29 procedures and SBE in 9.The 4 patients who underwent repeated ERC with DBE and SBE suffered from recurrent cholangitis due to stenosis of the enterobiliary anastomosis.ERC was performed repeatedly to achieve balloon dilation with/without biliary stone extraction and multiple stent placement at the level of the enterobiliary anastomosis.In all 4 patients DBE and SBE were equally successful.Compared to DBE,SBE was equally effective in passing the Roux-en-Y entero-enteric anastomosis,reaching the enterobiliary anastomosis and performing therapeutic ERC.CONCLUSION:This retrospective comparison shows that DBE and SBE are equally successful in the performance of therapeutic ERC at the level of the enterobiliary anastomosis after Roux-en-Y entero-enteric anastomosis. | Tom G Moreels Paul A Pelckmans | 2010 | World Journal of Gastrointestinal Endoscopy2010，2，9： | 14 |
| 2 | Schistosoma mansoni proteins attenuate gastrointestinal motility disturbances during experimental colitis in mice显示文摘AIM:To investigate the therapeutic effect of Schistosoma mansoni(S.mansoni) soluble worm proteins on gastrointestinal motility disturbances during experimental colitis in mice. METHODS:Colitis was induced by intrarectal injection of trinitrobenzene sulphate(TNBS) and 6 h later,mice were treated ip with S.mansoni proteins.Experiments were performed 5 d after TNBS injection.Inflammationwas quantified using validated inflammation parameters. Gastric emptying and geometric center were measured to assess in vivo gastrointestinal motility.Peristaltic activity of distal colonic segments was studied in vitro using a modified Trendelenburg set-up.Cytokine profiles of T-lymphocytes isolated from the colon were determined by real time reverse transcriptase-polymerase chain reaction. RESULTS:Intracolonic injection of TNBS caused severe colitis.Treatment with S.mansoni proteins significantly ameliorated colonic inflammation after 5 d.TNBS did not affect gastric emptying but significantly decreased the geometric center and impaired colonic peristaltic activity 5 d after the induction of colitis.Treatment with S.mansoni proteins ameliorated these in vivo and in vitro motility disturbances.In addition,TNBS injection caused a downregulation of effector T cell cytokines after 5 d,whereas a S.mansoni protein effect was no longer observed at this time point. CONCLUSION:Treatment with S.mansoni proteins attenuated intestinal inflammation and ameliorated motility disturbances during murine experimental colitis. | Nathalie E Ruyssers Benedicte Y De Winter Joris G De Man Natacha D Ruyssers Ann J Van Gils Alex Loukas Mark S Pearson Joel V Weinstock Paul A Pelckmans Tom G Moreels | 2010 | World Journal of Gastroenterology2010，16，6： | 11 |
| 3 | Infliximab induces remission in cryptogenic multifocal ulcerous stenosing enteritis:First case显示文摘We present the case of a 29-year-old patient with a history of abdominal pain and vomiting.Based on wireless video capsule findings he was previously diagnosed with ileal Crohn's disease at a different institution,although the clinical and radiological picture was not typical and the response to corticosteroids was poor.We performed a single-balloon enteroscopy showing a short,ulcerous stenosis 50 cm proximal from Bauhin's valve.The endoscopic and clinical histopathological findings were compatible with cryptogenic multifocal ulcerous stenosing enteritis(CMUSE).High dose corticosteroids were again started,without effect.The monoclonal tumor necrosis factor-α(TNF-α) antibody infliximab was added to the medical therapy.After induction therapy,both clinical and endoscopic amelioration was obtained.Larger case studies are needed to confirm the efficacy of TNF-α inhibition in steroid refractory CMUSE. | De Schepper Heiko Macken Elisabeth Van Marck Veerle Spinhoven Maarten Pelckmans Paul Moreels Tom | 2013 | World Journal of Gastroenterology2013，19，10： | 10 |
| 4 | Acute necrotizing pancreatitis as fi rst manifestation of primary hyperparathyroidism显示文摘We report the case of a female patient with severe acute necrotizing pancreatitis associated with hypercalcemia as first manifestation of primary hyperparathyroidism caused by a benign parathyroid adenoma.Initially the acute pancreatitis was treated conservatively.The patient subsequently underwent surgical resection of the parathyroid adenoma and surgical clearance of a large infected pancreatic pseudocyst.Although the association of parathyroid adenoma-induced hypercalcemia and acute pancreatitis is a known medical entity,it is very uncommon.The pathophysiology of hypercalcemia-induced acute pancreatitis is therefore not well known,although some mechanisms have been proposed.It is important to treat the provoking factor.Therefore,the cause of hypercalcemia should be identif ied early.Surgical resection of the parathyroid adenoma is the ultimate therapy. | Jeroen I Lenz Jimmy M Jacobs Bart Op de Beeck Ivan A Huyghe Paul A Pelckmans Tom G Moreels | 2010 | World Journal of Gastroenterology2010，16，23： | 9 |
| 5 | Neuroanatomy of lower gastrointestinal pain disorders显示文摘Chronic abdominal pain accompanying intestinal inflammation emerges from the hyperresponsiveness of neuronal,immune and endocrine signaling pathways within the intestines,the peripheral and the central nervous system.In this article we review how the sensory nerve information from the healthy and the hypersensitive bowel is encoded and conveyed to the brain.The gut milieu is continuously monitored by intrinsic enteric afferents,and an extrinsic nervous network comprising vagal,pelvic and splanchnic afferents.The extrinsic afferents convey gut stimuli to second order neurons within the superficial spinal cord layers.These neurons cross the white commissure and ascend in the anterolateral quadrant and in the ipsilateral dorsal column of the dorsal horn to higher brain centers,mostly subserving regulatory functions.Within the supraspinal regions and the brainstem,pathways descend to modulate the sensory input.Because of this multiple level control,only a small proportion of gut signals actually reaches the level of consciousness to induce sensation or pain.In inflammatory bowel disease(IBD)and irritable bowel syndrome(IBS)patients,however,long-term neuroplastic changes have occurred in the brain-gut axis which results in chronic abdominal pain.This sensitization may be driven on the one hand by peripheral mechanisms within the intestinal wall which encompasses an interplay between immunocytes,enterochromaffin cells,resident macrophages,neurons and smooth muscles.On the other hand,neuronal synaptic changes along with increased neurotransmitter release in the spinal cord and brain leads to a state of central wind-up.Also life factors such as but not limited to inflammation and stress contribute to hypersensitivity.All together,the degree to which each of these mechanisms contribute to hypersensitivity in IBD and IBS might be diseaseand even patient-dependent.Mapping of sensitization throughout animal and human studies may significantly improve our understanding of sensitization in IBD and IBS.On the long run,this knowledge can be put forward in potential therapeutic targets for abdominal pain in these conditions. | Wim Vermeulen Joris G De Man Paul A Pelckmans Benedicte Y De Winter | 2014 | World Journal of Gastroenterology2014，20，4： | 7 |
| 6 | 减少制革废水中盐含量的方法显示文摘 | Jan-Tiest Pelckmans Alois Puntener 朱晔 | 2005 | 中国皮革2005，34，1： | 5 |
| 7 | Subspace identification of hammerstein systems using least squares support vector machines显示文摘 | Goethals I Pelckmans K Suykens J K A | 2005 | IEEE Trans on Automatic Control:Special Issue on System Identification2005，50，10： | 1 |
| 8 | Non-adrenergic noncholineergic relaxation medicated by nitric oxide in the canine ileocolonic junction显示文摘 | Boeckxstanes GE Pelckmans PA Bult H | 1990 | Eur J Pharmacol1990，190，12： | 1 |
| 9 | Building sparse representations and structure determination on LS-SVM substrates neurocomputing显示文摘 | Pelckmans K Suykens J A K De Moor B | 2005 | Special Issue2005，64，： | 1 |
| 10 | Building sparserepresentations and structure determination on LSSVMsubstrates 显示文摘 | Pelckmans K Suykens Jak de Moor B | 2005 | Neurocomputing (Special Issue)2005，64，： | 1 |
| 11 | Building sparse representations and structure determination on least squares support vector machine substrates显示文摘 | Pelckmans K Suykens J A K De Moor B | 2005 | Neurocomputing (S0925-2312)2005，，： | 1 |
| 12 | Release of nitric oxide upon stimulation of nonadrenergic noncholinergic nerves in the rat gastric fundus显示文摘 | Boeckxstaens G E Pelckmans P A Bogers J J etal | 1991 | J Pharmacol Exp Ther1991，256，： | 1 |
| 13 | The Differogram: Non-parametric Noise Variance Es- timation and Its Use for Model Selection 显示文摘 | PELCKMANS K BRABANTER J D SUYKENS J | 2005 | Neurocomputing2005，69，3： | 1 |
| 14 | Handing missing values in support vector machine classifiers显示文摘 | Pelckmans K Brabanter J D Suykens J A K | 2005 | Neural Networks2005，18，56： | 1 |
| 15 | Learning transformation models for ranking and survival analysis显示文摘 | BELLE V V PELCKMANS K SUYKENS J | 2011 | Journal of Machine Learning Research2011，12，3： | 1 |
| 16 | Subspace identification of HaImmerstein systems using least squares support vector machines 显示文摘 | Goethals I Pelckmans K Suykens J A K | 2005 | IEEE Transactions on Automatic Control2005，50，10： | 1 |
| 17 | Subspace identification of hammerstein systems using least squares support vector machines显示文摘 | GOETHALS I PELCKMANS K SUYKENS J | | 0，，10： | 1 |
| 18 | Identi- fication of MIMO Hammerstein models using least squares support vector machines 显示文摘 | GOETHALS I PELCKMANS K SUYKENS J A K | 2005 | Automatica2005，41，7： | 1 |
| 19 | Building sparse representations and structure determination on LS-SVM substrates显示文摘 | PELCKMANS K SUYKENS JAK DE MOOR B | 2005 | Neurocomputing Special Issue2005，64，： | 1 |
| 20 | Gastrointestinal parasites potential therapy for refractory inflammatory bowel disease 显示文摘 | Moreels TG Pelckmans PA | 2005 | Inflamm Bowel Dis2005，11，1： | 1 |
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