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| 1 | Glutamate triggers the expression of functional ionotropic and metabotropic glutamate receptors in mast cells显示文摘Mast cells are emerging as players in the communication between peripheral nerve endings and cells of the immune system.However,it is not clear the mechanism by which mast cells communicate with peripheral nerves.We previously found that mast cells located within healing tendons can express glutamate receptors,raising the possibility that mast cells may be sensitive to glutamate signaling.To evaluate this hypothesis,we stimulated primary mast cells with glutamate and showed that glutamate induced the profound upregulation of a panel of glutamate receptors of both the ionotropic type(NMDAR1,NMDAR2A,and NMDAR2B)and the metabotropic type(mGluR2 and mGluR7)at both the mRNA and protein levels.The binding of glutamate to glutamate receptors on the mast cell surface was confirmed.Further,glutamate had extensive effects on gene expression in the mast cells,including the upregulation of proinflammatory components such as IL-6 and CCL2.Glutamate also induced the upregulation of transcription factors,including Egr2,Egr3 and,in particular,FosB.The extensive induction of FosB was confirmed by immunofluorescence assessment.Glutamate receptor antagonists abrogated the responses of the mast cells to glutamate,supporting the supposition of a functional glutamate–glutamate receptor axis in mast cells.Finally,we provide in vivo evidence supporting a functional glutamate–glutamate receptor axis in the mast cells of injured tendons.Together,these findings establish glutamate as an effector of mast cell function,thereby introducing a novel principle for how cells in the immune system can communicate with nerve cells. | Md Abdul Alim Mirjana Grujic Paul W.Ackerman Per Kristiansson Pernilla Eliasson Magnus Peterson Gunnar Pejler | 2021 | Cellular & Molecular Immunology2021，18，10： | 2 |
| 2 | Human mast cell beta-tryptase is a gelatinase显示文摘 | Fajardo I Pejler G | 2003 | J Immunol2003，171，3： | 1 |
| 3 | Rotifer occurrence in relation to temperature显示文摘 | BERZINS B PEJLER B | 1989 | Hydrobiologia1989，175，3： | 1 |
| 4 | Formation of active monomers from tetrameric human beta-tryptase显示文摘 | Fajardo 1 Pejler G | 2003 | Biochern J2003，369，3： | 1 |
| 5 | Biological implications of preformed mast cell mediators显示文摘 | Lundequist A Pejler G | 2011 | Cell Mol Life Sci2011，68，6： | 1 |
| 6 | Rotifer occurrence in relation to trophic degree显示文摘 | BIRZI NS B PEJLER B | 1989 | Hydrobiologia1989，182，： | 1 |
| 7 | Rotifer occurrence in relation to pig 显示文摘 | Berzins B Pejler B | 1987 | Hydrobiologia1987，147，： | 1 |
| 8 | Serglycin is essential for maturation of mast cell secretory granule 显示文摘 | Abrink M Grujic M Pejler G | 2004 | J Biol Chem2004，279，40： | 1 |
| 9 | Biology of mast cell tryptase, An inflammatory mediator 显示文摘 | Hallgren J Pejler G | 2006 | FEBC J2006，273，9： | 1 |
| 10 | Zooplanktic indicators of trophy and their food显示文摘 | Pejler B | 1983 | Hydrobiologia1983，101，： | 1 |
| 11 | Intracellular proteoglycans 显示文摘 | Kolset SO Prydz K Pejler G | 2004 | Biochem J2004，379，2： | 1 |
| 12 | Neutrophil elastase depends on serglycin proteoglycan for localization in granules 显示文摘 | Niemann CU Abrink M Pejler G | 2007 | Blood2007，109，10： | 1 |
| 13 | Neutralization of heparin-related saccharides by histidine-rich glycoprotcin and platelet factor显示文摘 | Pejler G Flynn AM | 1986 | J Biol Chem1986，261，： | 1 |
| 14 | Human mast cell beta-tryptase is a gelatinase显示文摘 | Fajardo 1 Pejler G | 2003 | J lmmunol2003，171，3： | 1 |
| 15 | Biology of mast cell tryptase, an inflammatory mediator显示文摘 | Hallgren J Pejler G | 2006 | FEBS J2006，273，9： | 1 |
| 16 | Rotifer occurance in relation to temperature显示文摘 | BēRZIN? B PEJLER B | 1989 | Hydrobiologia1989，175，3： | 1 |
| 17 | Rotifer occurrence in relation to temperature显示文摘 | BERZINS B PEJLER B | 1989 | Hydrobiologia1989，175，3： | 1 |
| 18 | Serglycin proteoglycan: regulating the storage and activities of hematopoietic proteases 显示文摘 | Pejler G Abrink M Wernersson S | 2009 | Biofactors2009，35，1： | 1 |
| 19 | Mast cell proteases-multifaceted regulators of inflammatory disease 显示文摘 | Pejler G Ronnberg E Waern I | 2010 | Blood2010，115，24： | 1 |
| 20 | Mast cell depends;tit activation of pro matrix metalloprotease 2: a role for sergtycin proteoglycan-dependent mast cell proteases 显示文摘 | Lundequist A Abrink M Pejler G | 2006 | J Biol Chem2006，387，1011： | 1 |
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