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| 1 | Effect of rifaximin on gut microbiota composition in advanced liver disease and its complications显示文摘Liver cirrhosis is a paradigm of intestinal dysbiosis. The qualitative and quantitative derangement of intestinal microbial community reported in cirrhotic patients seems to be strictly related with the impairment of liver function. A kind of gut microbial 'fingerprint',characterized by the reduced ratio of 'good' to 'potentially pathogenic' bacteria has recently been outlined,and is associated with the increase in Model for End-Stage Liver Disease and Child Pugh scores. Moreover,in patients presenting with cirrhosis complications such as spontaneous bacterial peritonitis(SBP),hepatic encephalopathy(HE),and,portal hypertension intestinal microbiota modifications or the isolation of bacteria deriving from the gut are commonly reported. Rifaximin is a non-absorbable antibiotic used in the management of several gastrointestinal diseases. Beyond bactericidal/bacteriostatic,immune-modulating and anti-inflammatory activity,a little is known about its interaction with gut microbial environment. Rifaximin has been demonstrated to exert beneficial effects on cognitive function in patients with HE,and also to prevent the development of SBP,to reduce endotoxemia and to improve hemodynamics in cirrhotics. These results are linked to a shift in gut microbes functionality,triggering the production of favorable metabolites. The low incidence of drug-related adverse events due to the small amount of circulating drug makes rifaximin a relatively safe antibiotic for the modulation of gut microbiota in advanced liver disease. | Francesca Romana Ponziani Viviana Gerardi Silvia Pecere Francesca D'Aversa Loris Lopetuso Maria Assunta Zocco Maurizio Pompili | 2015 | World Journal of Gastroenterology2015，21，43： | 16 |
| 2 | Targeting TGF-β1 overexpression in renal disease: maximizing the antifibrotic action of angiotensin Ⅱ blockade 显示文摘 | Pecers H Border WA Noble NA | 1998 | Kidney Int1998，，： | 1 |
| 3 | Aloe-emodin is a new type of anticancer agent with selective activity against neuroectodermal tumors 显示文摘 | Pecere T Gazzola MV Mucignat C | 2000 | Cancer Res2000，60，11： | 1 |
| 4 | Content of potencially anticarcinogenic flavonoids of 28 vegetables and 9 fruits commonly cosumed in the Netherlands显示文摘 | Michael G L Hereog Pecer C H | 1992 | Agric Food Chem1992，40，： | 1 |
| 5 | Aloe-emodin is a new type of anticancer agent with selective activity against neuroectodermal tumors 显示文摘 | Pecere T Gazzola MV Mucignat C | 2000 | Cancer Res2000，60，11： | 1 |
| 6 | Involvement of p53 in specific anti - neuroectodermal tumor activity of aloe - emodin 显示文摘 | Pecere T Sarinella F Salata C | 2003 | Int J Cancer2003，，106： | 1 |
| 7 | Content: of Potencially anticareinogenic flavonoids of 28 vegeta- bles and 9 fruits commonly cosumed in the Netherlands显示文摘 | Michael G L Hereog Pecer C H | 1992 | Agrie Food Chem1992，40，： | 1 |
| 8 | An open - label, pilot studyto assess feasibility and safety of fecal microbiota transplantation in pa-tients with mild - moderate ulcerative colitis : preliminary results 显示文摘 | Scaldaferri F Pecere S Bruno G | 2014 | Inflamma Bowel Dise2014，20，1： | 1 |
| 9 | Aloe-emodin is a new type of anticancer agent with selective activity against neuroectodermal tumors显示文摘 | Pecere T Gazzola MV Mucignat C | 2000 | Cancer Research2000，60，11： | 1 |
| 10 | Involvement of p53in specific anti-neuroectodermal tumor activity of aloe-emo-din显示文摘 | Pecere T Sarinella F Salata C | 2003 | Int J Cancer2003，106，6： | 1 |
| 11 | Aloe - emodin is a new type of anticancer agent with selective activity against neuroectodermal tumors 显示文摘 | Pecere T | 2000 | Cancer Res2000，60，11： | 1 |
| 12 | Involvement of p53 in specific anti-neuroectodermal tumor activity of aloe-emodin 显示文摘 | Pecere T Sarinella F Salata C | 2003 | lnt J Cancer2003，106，8： | 1 |
| 13 | Aloe-emodin is a new type of anticancer agent with selective activity against neuroectodermal tumors显示文摘 | Pecere T | 2000 | Cancer Res2000，60，11： | 1 |
| 14 | Bacterial flora as a cause or treatment of chronic diarrhea 显示文摘 | Scaldaferri F Pizzoferrato M Pecere S | 2012 | Gastroenterol Clin North Am2012，41，3： | 1 |
| 15 | Aloe - emodin is a new type of anticancer agent with selective activity against neuroectodermal tumors显示文摘 | PECERE T | 2000 | Cancer Res2000，60，11： | 1 |
| 16 | Aloe-emodin is a new type of anticancer agent with selective activity against neuroectodermal tumors显示文摘 | Pecere T Gazzola M Y | 2000 | Cancer Research Baltimore2000，60，11： | 1 |
| 17 | Aloe-emodin is a new type of anticancer agent with selective acidity against neuro to demaltumors 显示文摘 | Pecere T Gazzola MV Mucignat C | 2000 | Cancer Res2000，60，11： | 1 |
| 18 | High performance liq-uid chromatographic assay for the determination of aloe emodin inmouse plasma显示文摘 | Zaffaroni M Mucignat C Pecere T | 2003 | J Chromatogr B2003，796，1： | 1 |
| 19 | Aloe-emodin is a new type of anticancer agent with selective activity against neuroectodermal tumors显示文摘 | Pecere T | 2000 | Cancer Res2000，60，11： | 1 |
| 20 | Aloe-emodin is a new type of anticancer agent with selective activity against neuroectodermal tumors 显示文摘 | PECERE T GAZZOLA M V MUCIGNAT C | 2000 | Cancer Res2000，60，11： | 1 |
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