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621篇 您的检索式：作者名="Pearson L"

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	题名	作者	年代	出处	被引量
1	NOD2 and ATG16L1 polymorphisms affect monocyte responses in Crohn's disease显示文摘AIM:To assess whether polymorphisms in NOD2 and ATG16L1 affect cytokine responses and mycobacterium avium subspecies paratuberculosis (MAP) survival in monocytes from Crohn's disease (CD) patients.METHODS:Monocytes were isolated from peripheral blood of CD patients of known genotype for common single nucleotide polymorphisms of NOD2 and ATG16L1.Monocytes were challenged with MAP and bacterial persistence assessed at subsequent time-points.Cytokine responses were assayed using a Milliplex multi-analyte profiling assay for 13 cytokines.RESULTS:Monocytes heterozygous for a NOD2 polymorphism (R702W,P268S,or 1007fs) were more permissive for growth of MAP (P=0.045) than those without.There was no effect of NOD2 genotype on subsequent cytokine expression.The T300A polymorphism ofATG16L1 did not affect growth of MAP in our model (P=0.175),but did increase expression of cytokines interleukin (IL)-10 (P=0.047) and IL-6 (P=0.019).CONCLUSION:CD-associated polymorphisms affected the elimination of MAP fromex vivo monocytes (NOD2),or expression of certain cytokines (ATG16L1),implying independent but contributory roles in the pathogenesis of CD.	Dylan M Glubb Richard B Gearry Murray L Barclay Rebecca L Roberts John Pearson Jacqui I Keenan Judy McKenzie Robert W Bentley	2011	World Journal of Gastroenterology2011，17，23：	2
2	The role of the purchasing function: toward team participation显示文摘	Pearson J N	1994	International Journal of Distribution of Purchasing a nd Materials Management1994，29，3：	1
3	Molecular signatures in biopsy specimens of lung cancer显示文摘	Borczuk AC Shah L Pearson GD	2004	Am J Respir Crit Care Med2004，170，：	1
4	Natural gas hydrate deposits: a review of in-situ properties显示文摘	Pearson C F Halleck P M McGuire P L	1983	Journal of geophysical research1983，87，：	1
5	Metabolic relations to temperatures in the copepods Diaptomus dorsalis and Mesocyclopes edax from North-Central Texas显示文摘	Smith G A Fitzpatrick L C Pearson W D		0，，：	1
6	A multiplex qPCR targeting hepato-and neurotoxigenic cyanobacteria of global significance显示文摘	AL-TEBRINEH J PEARSON L A YASAR S A	2012	Harmful Algae2012，15，：	1
7	The applica- tion of laser ablation-inductively coupled plasma-mass spectrometry to in situ U-Pb zircon geochronology显示文摘	Jackson S E Pearson N J Griffin W L	2004	Chemical Geology2004，211，1：	1
8	Potentiation of VSV N J infection in mice by mosquito salive显示文摘	Limesand K H Higgs S Pearson L D	2000	Parascte Immunol2000，22，9：	1
9	Molecular signatures in biopsy specimens of lung cancer显示文摘	Borczuk A C Shah L Pearson G D	2004	Am J Respir Crit Care Med2004，170，2：	1
10	Food as a form of destination identity: A tourism destination brand perspective 显示文摘	Lin Y C Pearson T E Cai L P	2011	Tourism and Hospitality Research2011，1，1：	1
11	On the Nature, Consequences and Remedies of Workplace Incivility: No Time for Nice? Think Again显示文摘	PEARSON C M PORATH C L	2005	Academy of Management Executive2005，19，1：	1
12	Covert visual attention in children with ADHD:Evidence for developmental immaturity?显示文摘	Pearson D Yaffee L Loveland K	1995	Development and Psychopathology1995，7，2：	1
13	Resveratrol improves health and survival of mice on a high-calorie diet 显示文摘	Baur J A Pearson K J Price N L	2006	Nature2006，444，7117：	1
14	Chicken flavor: The identification of some chemical components and the importance of sulfur compounds in the cooked volatile fraction显示文摘	Minor L J Pearson A M Dawson L E	1965	Journal of Food Science1965，30，4：	1
15	The state of pediatric interfacility transport: consensus of the second National Pediatric and Neonatal Interfacility Transport Medicine Leadership Conference 显示文摘	Woodward G A Insoft R M Pearson Shaver A L	2002	Pediatr E- merg Care2002，18，1：	1
16	The Prediction of Teaching Autonomy显示文摘	Pearson L G	1998	Educational Research Quarterly1998，，1：	1
17	The Hf isotopecompositon of cratonic mantle: LA-MC-ICPMS analysis of zir-con megacrysts in kimberlites显示文摘	Griffin W L Pearson N J * Belousova E A	2000	Geochemica et CosmochimicaActa2000，64，：	1
18	Molecular signatures in biopsy specimens of lung cancer显示文摘	Borczuk A Shah L Pearson G	2004	Am J Resp Crit Care Med2004，170，2：	1
19	Smart grid cyber security for Europe显示文摘	Pearson I L G	2011	Energy Policy2011，39，9：	1
20	The Cost of Bad Behavior显示文摘	PORATH C L PEARSON C M	2010	Organizational Dynamics2010，39，1：	1

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