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| 1 | Plasma phospholipid transfer protein (PLTP) modulates adaptive immune functions through alternation of T helper cell polarization显示文摘客观:血浆 phospholipid 转移蛋白质(PLTP ) 是脂蛋白新陈代谢的一个关键决定因素,并且动物和人的研究收敛显示 PLTP 支持 atherogenesis 和它的 thromboembolic 复杂并发症。而且, PLTP 调制发炎和有免疫力的回答,这最近被报导了。尽管从我们的组的更早的研究证明 PLTP 能修改巨噬细胞激活,在 T-cell-mediated 有免疫力的回答的调整的 PLTP 的含意从来没被调查过并且因此在现在的学习被探讨。途径和结果:在现在的学习,我们证明在老鼠的那 PLTP 缺乏在 CD4 + Th0 房间极化上有深刻效果,与向在正常、病理学的条件下面的反煽动性的 Th2 显型的移动。在接触超敏性的一个模型,对有 hapten-2,4-dinitrofluorobenzene (DNFB ) 的皮肤促进感受性的显著地损害的回答在 PLTP 缺乏的老鼠被观察与相比野类型(WT ) 老鼠。有趣地,在老鼠的 PLTP 缺乏没在外部血在全部的白血房间,淋巴细胞, granulocytes,或单核白血球的计数上施加效果。而且, PLTP 缺乏没修改 CD4 + 和 CD8 + T 淋巴细胞子集的数量。然而, PLTP 缺乏,与 Th2 显型的 upregulation 联系了,被重要减少在 pro-Th1 cytokine interleukin 的生产伴随 18 由附件房间。结论:第一次,这个工作向支持 inflammatory Th1 显型在 CD4 + T 房间的极化为 PLTP 报导一个生理的角色。 | Catherine Desrumau Stephanie Lemaire-Ewing Nicolas Ogier Akadiri Yessoufou Arlette Hammann Anabelle Sequeira-Le Grand Valerie Deckert Jean-Paul Pais de Barros Naig Le Guern Julien Guy Naim A Khan Laurent Lagrost | 2016 | Cellular & Molecular Immunology2016，13，6： | 3 |
| 2 | Gastrointestinal stromal tumors:clinical profile,pathogenesis,treatment strategies and prognosis显示文摘 | Nowain A BhAkta H Pais S | 2005 | J Gastroenterol Hepatol2005，20，6： | 1 |
| 3 | Improving hierarchical cluster analysis: a new method with outlier detection and automatic clustering显示文摘 | ALMEIDA J A S BARBOSA L M S PAIS A A C C | 2007 | Chemometrics and Intelligent Labora- tory Systems2007，87，2： | 1 |
| 4 | A new approach to dyna-mic security assessment using trajectory sensitivities显示文摘 | Laufenberg M J Pai M A | 1998 | IEEE Trans on Power Systems1998，13，3： | 1 |
| 5 | Prediction of asphalt pavement temperature using 3-D finite element method显示文摘 | Minhoto Manuel J C Pais Jorge C Pereira Paulo A | 2005 | Transportation Research Record2005，1919，184： | 1 |
| 6 | Bioequivalenee evaluation of two omeprazole enteric-coated formulations in humans显示文摘 | Farinha A Biea A Pais J P | 1999 | Eur J Pharm Sci1999，7，4： | 1 |
| 7 | Trajectory sensitivity analysis of hybrid systems显示文摘 | Hiskens I A Pai M A | 2000 | IEEE Transactions on Circuits and Systems I2000，47，2： | 1 |
| 8 | Iberian Universities: a Characterisation from ESI Ranldngs显示文摘 | Cova T F G G Pais A A C C Formosinho S O J | 2013 | Scientomet- tics2013，94，3： | 1 |
| 9 | High -sensitivity C- reactive protein as a biomarker of risk in coronary artery disease显示文摘 | Silva D Pais de Lacerda A | 2012 | Rev Port Cardiol2012，31，11： | 1 |
| 10 | Nanosecond repetitively pulsed discharges in air at atmospheric pressure—the spark regime显示文摘 | Pai D Z Lacoste D A Laux C O | 2010 | Plasma Sources Science and Technology2010，19，06： | 1 |
| 11 | Trajectory sensitivity analysis of hybrid systems显示文摘 | Hiskens I A pai M A | 2000 | IEEE Trans on Circuits and Systems2000，47，2： | 1 |
| 12 | Trajectory sensitivity analysis of hybrid systems显示文摘 | Hiskens I A Pai M A | 2000 | IEEE Trans on Circuits and Systems2000，47，2： | 1 |
| 13 | A fully nonlinear theory of curved and twisted composite rotor blades accounting for warpings and three-dimensional stress effects显示文摘 | Pai P F Nayfeh A H | 1994 | International Journal for Solids and Structure1994，31，9： | 1 |
| 14 | Risk of tuberculosis from exposure to tobacco smoke: a systematic review and meta-analysis 显示文摘 | Bates MN Khalakdina A Pai M | 2007 | Arch Intern Med2007，167，4： | 1 |
| 15 | Variability in the origin of the obturator artery 显示文摘 | Pai MM Krishnamurthy A Prabhu LV | 2009 | Clinics (Sao Paulo)2009，64，9： | 1 |
| 16 | Differential effects of cannabinoid receptor agonists on regional brain activity using pharmacological MRI显示文摘 | Chin C L Tovcimak A E Hradil V P Seifert T R Hollingsworth P R Chandran P Zhu C Z Gauvin D Pai M Wetter J Hsieh G C Honore P Frost J M Dart M J Meyer M D Yao B B Cox B F Fox G B | | 0，，02： | 1 |
| 17 | Systematic review:T-cell-based assays for the diagnosis of latent tuberculosis infection:an update显示文摘 | Pai M Zwerling A Menzies D | | 0，，03： | 1 |
| 18 | Study of home-monitored night blood pressure and its correlation with left ventriculm' hypertrophy in treatment-naive hypertensive patients显示文摘 | PAI A U CHAKRAPANI S BHASKARAN U | 2012 | Singapore Med J2012，53，2： | 1 |
| 19 | Sensitivity based selection of control parameters for multimachine power systems显示文摘 | Padiyar K R | 1980 | IEEE Trans on Power Apparatus and Systems1980，99，： | 1 |
| 20 | A complete equipment cir- cuit of a linear induction motor with sheet secondary 显示文摘 | PAI R M ION Boldea NASAR S A | 1988 | IEEE Transactions on Magnetics1988，24，1： | 1 |
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