|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Epigenetic regulation: methylation of histone and non-histone proteins显示文摘Histone methylation is believed to play important roles in epigenetic memory in various biological processes. However, questions like whether the methylation marks themselves are faithfully transmit- ted into daughter cells and through what mechanisms are currently under active investigation. Previ- ously, methylation was considered to be irreversible, but the recent discovery of histone lysine de- methylases revealed a dynamic nature of histone methylation regulation on four of the main sites of methylation on histone H3 and H4 tails (H3K4, H3K9, H3K27 and H3K36). Even so, it is still unclear whether demethylases specific for the remaining two sites, H3K79 and H4K20, exist. Furthermore, be- sides histone proteins, the lysine methylation and demethylation also occur on non-histone proteins, which are probably subjected to similar regulation as histones. This review discusses recent pro- gresses in protein lysine methylation regulation focusing on the above topics, while referring readers to a number of recent reviews for the biochemistry and biology of these enzymes. | LAN Fei1 & SHI Yang 2 1 Department of Biology, Constellation Pharmaceuticals, 148 Sidney Street, Cambridge, MA 02139, USA 2 Department of Pathology, Harvard Medical School, 77 Ave Louise Pasteur, Boston MA, 02115, USA | 2009 | Science China(Life Sciences)2009，52，4： | 27 |
| 2 | 球形芽孢杆菌C_3-41二元毒素基因在苏云金芽孢杆菌以色列亚种中的克隆和表达显示文摘球形芽孢杆菌C341是我国分离的一株对蚊幼虫有毒杀作用的高毒力菌株,对库蚊、按蚊幼虫的毒性高于2362菌株,Southern杂交证明C341总DNA中35KbHindII片段上带有419和514kD二元毒素基因,该片段由3479个核苷酸组成,核苷酸序列同2362菌株的二元毒素基因序列完全相同。含二元毒素基因的重组质粒pCW1和pCW2能在大肠杆菌中表达产生二元毒素蛋白,但表达量低,重组子杀蚊毒性低。无晶体型苏云金芽孢杆菌以色列亚种重组子在其芽孢形成中能产生以晶体形式存在的二元毒素蛋白,其全发酵液和纯化晶体蛋白的杀蚊活性与C341相近。 | 袁志明 Nielsen-LeRoux C Pasteur N Delecluse A Charles J-F Frutos R | 1999 | 微生物学报1999，39，1： | 5 |
| 3 | EPIGENETIC NATURE OF RADIATION CARCINOGENESIS AT LOW DOSES显示文摘The present paradigm of radiation-induced carcinogenesis has been based on somatic mutation theory initiating a mutation in somatic cells derived from DNA damage by ionizing radiation. A non-threshold linear model has been assumed from high doses to low doses. As an alternative to this, we are proposing a new model that epigenetic changes induced by low dose irradiation may be a first step of carcinogenesis. Our preliminary data suggesting the epigenetic nature and reports on various stress response to ionizing radiation are presented. | T. Sugahara and M. WatanabeHealth Research Foundation. Pasteur Building 5F. 103-5 Tanaka Monzencho. Sakyo-ku. Kyoto 606. JapanFaculty of Pharmaceutical Sciences. Nagasaki University. 1-14 Bunkyo-machi, Nagasaki 852, Japan | 1994 | Chinese Medical Journal1994，，6： | 4 |
| 4 | Factors influencing the yield of mesenteric angiography in lower gastrointestinal bleed显示文摘AIM: To assess if certain triaging rules could be established to optimize the yield of mesenteric angiography. METHODS: Medical records of 101 patients were retrospectively reviewed and parameters relating to age, gender, pulse rate, blood pressure, serum hemoglobin, intensive care unit(ICU) admission, and the number of packed red blood cells(PRBC) transfused in the 12 and 24 h prior to the angiography were tabulated in two groups with positive and negative angiography results. RESULTS: We found no correlation between gender, pulse rate, blood pressure or serum hemoglobin and positivity of the mesenteric angiogram. But patients with positive angiogram were found to be on average 7 years older(73.2 years vs 65.9 years old)(P = 0.02). Angiogram was positive in 39.3 %(11/28) of patientsadmitted in ICU vs 23.2%(17/73) who were admitted elsewhere in the hospital(P = 0.03). In the 12 and 24 h prior to angiography, patients with a positive angiogram received a mean of 2.7 ± 2.3 and 3.3 ± 2.6 units of PRBC s respectively, while patients with a negative angiogram had a mean of 1.6 ± 1.9(P = 0.02) and 2.1 ± 2.6 units(P = 0.04) received respectively in the same period. CONCLUSION: Older age, ICU admission, having received at least 4 units PRBC over 12 h or 5 units over 24 h prior to angiogram are leading indicators for a positive study. | Pasteur Rasuli Joseph Doumit Majdi Boulos Caroline Rizk Gaby Doumit | 2014 | World Journal of Radiology2014，6，5： | 2 |
| 5 | An investigation into causative factors in patients with bronchiectasis 显示文摘 | Pasteur MC Helliwell SM Houghton S J | 2000 | Am J Respir Crit Care Med2000，162，4： | 1 |
| 6 | Amplification of an es terase gene is responsible for insecticide resistance in a California Culex mosquito显示文摘 | Mouches C Pasteur N Berge JB | 1986 | Science1986，233，： | 1 |
| 7 | British Thoracic Society guideline for non-CF bronchiectasis显示文摘 | Pasteur MC Bilton D Hill AT | 2010 | Thorax2010，65，7： | 1 |
| 8 | Electrophoretie esterase patterns in in- secticide - resistant and susceptible mosquitoes 显示文摘 | Georgbiou G P N Pasteur | 1978 | J Econ Ento- mo11978，71，： | 1 |
| 9 | Introduction:Accountability through participation:Developing workable partnership models in the health sector显示文摘 | Cornwall· A Lucas· H & Pasteur· K | 2000 | IDS Bulletin2000，31，： | 1 |
| 10 | Nouvelle communication Sur la rage 显示文摘 | Pasteur L Chamberland M M Roux E | | C R Acad Sci (D) (Paris)0，98，： | 1 |
| 11 | British Thoracic Societyguideline for non-CF bronchiectasis 显示文摘 | Pasteur MC Bilton D Hill AT | 2010 | Thorax2010，651，： | 1 |
| 12 | Organophosphate resistance and esterase patterns in a natural population of the Southern house mosquito from California 显示文摘 | Georghiou G P N Pasteur | 1980 | J Econ Entomol1980，73，： | 1 |
| 13 | Demonstration of hypoperfusion surrounding intracerebral hemorrhage in humans显示文摘 | Sills C Villar Cordova C Pasteur W | 1996 | J Stroke Cerebrovasc Dis1996，6，： | 1 |
| 14 | British Thoracic Societyguideline for non - CF bronchiectasis显示文摘 | Pasteur MC Bilton D Hill AT | 2010 | Thorax2010，65，1： | 1 |
| 15 | High resistance to Bacillus sphaericus binary toxin in Culex pipiens (Diptera: Culicidae) : the complex situation of west Mediterranean countries 显示文摘 | Nielsen-Leroux C Pasteur N Pretre J | 2002 | J Med Entomol2002，39，5： | 1 |
| 16 | British Thoracic Society guideline for non-CF bronchiectasis显示文摘 | Pasteur MC Bilton D Hill AT | 2010 | Thorax2010，65，： | 1 |
| 17 | Filter paper test for rapid determination of phenotypes with high esterase activity in organophosphate resistante mosquitoes 显示文摘 | Pasteur N Georghiou GP | 1981 | Mosq News1981，41，1： | 1 |
| 18 | Insecticide Resistance Genes in Mosqutoes: Their Mutations, Migration and Selection in Field Populations显示文摘 | PASTEUR N RAYMOND M | 1996 | Hered1996，87，： | 1 |
| 19 | British Thoracic Society guideline for non-CF bronchiectasis显示文摘 | Pasteur MC Bilton D Hill AT | 2010 | Thorax2010，65，7： | 1 |
| 20 | Early presentation of hemispheric intracerebral hemorrhage: prediction of out-come and guidelines for treatment allocation 显示文摘 | Lisk DR Pasteur W Rhoades H | 1993 | Neurology1993，44，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员